FACTORS ASSOCIATED WITH ANXIETY AND DEPRESSION SPECTRUM DISORDERS IN BEHCHET’S DISEASE by P. S. Ovcharov, T. A. Lisitsyna, D. Yu. Veltishchev, O. F. Seravina, O. B. Kovalevskaya, S. I. Glukhova, Z. S. Alekberova, E. L. Nasonov

“…Multivariate analysis and linear regression were used to build a predictive model, from which it follows that ADSDs in patients with BD are primarily associated with sleep disorders (β=0.412), asthenia (β=0.149), CI (β=0.137), chronic stress (β=-0.010) and its severity (β=0.134), early childhood psychic trauma (ECPT) before the age 7 years (β=0.152), the development of ADSD before the onset of BD (β =0.160), older age of eye involvement in the pathological process (β=0.089), gastrointestinal tract (GIT) involvement within BD (β=0.096), high C-reactive protein (CRP) levels (β=0.177), and poor subjective status of patients (β=0.120) (area under the ROC-curve, 0.940).Conclusion. …”
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The infected and the affected: A longitudinal study of the impact of the COVID-19 pandemic on schoolchildren in Florida by Sarah L. McKune, Daniel Acosta, Yui Fujii, Diana Joyce-Beaulieu, Md Abu Sayeed, Md Abu Sayeed, Emilee Cato, Katelyn E. Flaherty, Ashton Creasy-Marrazzo, Ashton Creasy-Marrazzo, Ruiyu Pu, Ruiyu Pu, Subhashinie Kariyawasam, Anantha Arukha, Derek A. T. Cummings, Derek A. T. Cummings, Maureen T. Long, Maureen T. Long, Anthony T. Maurelli, Anthony T. Maurelli, Eric J. Nelson, Eric J. Nelson, Eric J. Nelson

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Childhood-Onset Schizophrenia: A Systematic Overview of Its Genetic Heterogeneity From Classical Studies to the Genomic Era by Arnaud Fernandez, Arnaud Fernandez, Arnaud Fernandez, Malgorzata Marta Drozd, Susanne Thümmler, Susanne Thümmler, Emmanuelle Dor, Emmanuelle Dor, Maria Capovilla, Florence Askenazy, Florence Askenazy, Barbara Bardoni, Barbara Bardoni

“…Different mutations associated with COS are probably still unknown, and pathogenesis might also be explained by the association of different genetic variations (two or more CNVs or CNVs and SNVs) as well as association with early acquired brain lesions such as infection, hypoxia, or early childhood trauma.…”
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Intersecções do cuidado à saúde nos centros de educação infantil: percepção das mães [Health care intersections at child day care centers: perceptions of mothers] by Bruna Caroline Rodrigues, Eloana Ferreira D’Artibale, Mayara Caroline Barbieri, Luciana Olga Bercini, Ieda Harumi Higarashi

“…ABSTRACT: This research aimed at analyzing business-family relations and learning needs about child healthcare within a Center for Early Childhood Education (CEI), from the mothers’ standpoint. …”
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Prevalence and predictive determinants of overweight and obesity in children aged 0-24 months in Morocco: a cross-sectional study by Fatima Zohra Benayad, Samia El Hilali, Rachid Razine, Karim Sbai Idrissi, Redouane Abouqal, Hajar Belhaj, Ahmed Kharbach, Majdouline Obtel

“…Preventing overweight and obesity in early childhood is a priority for healthcare systems worldwide due to the harmful effects on health and economy over the medium and long term. …”
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Perceived Stress From Childhood to Adulthood and Cardiometabolic End Points in Young Adulthood: An 18‐Year Prospective Study by Fangqi Guo, Xinci Chen, Steve Howland, Phoebe Danza, Zhongzheng Niu, W. James Gauderman, Rima Habre, Rob McConnell, Mingzhu Yan, Lora Whitfield, Yanjie Li, Howard N. Hodis, Carrie V. Breton, Theresa M. Bastain, Shohreh F. Farzan

“…Perceived stress (Perceived Stress Scale) was initially reported by participants' parents for themselves during early childhood (mean age, 6.3 years), and later self‐reported during adolescence (13.3 years) and young adulthood (23.6 years). …”
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Immunomodulatory Effects of Rhinovirus and Enterovirus Infections During the First Year of Life by Terhi Ruohtula, Anita Kondrashova, Jussi Lehtonen, Sami Oikarinen, Anu-Maaria Hämäläinen, Onni Niemelä, Aleksandr Peet, Vallo Tillmann, Janne K. Nieminen, Jorma Ilonen, Mikael Knip, Mikael Knip, Mikael Knip, Mikael Knip, Outi Vaarala, Heikki Hyöty, Heikki Hyöty, the DIABIMMUNE Study Group, Mikael Knip, Taina Härkönen, Samppa Ryhänen, Heli Siljander, Katriina Koski, Matti Koski, Janne Nieminen, Terhi Ruohtula, Outi Vaarala, Onni Niemelä, Anu-Maaria Hämäläinen, Anne Ormisson, Aleksandr Peet, Vallo Tillmann, Valentina Ulich, Elena Kuzmicheva, Sergei Mokurov, Svetlana Markova, Svetlana Pylova, Marina Isakova, Elena Shakurova, Vladimir Petrov, Natalya V. Dorshakova, Tatyana Karapetyan, Tatyana Varlamova, Jorma Ilonen, Minna Kiviniemi, Kristi Alnek, Helis Janson, Raivo Uibo, Tiit Salum, Erika von Mutius, Juliane Weber, Helena Ahlfors, Henna Kallionpää, Essi Laajala, Riitta Lahesmaa, Harri Lähdesmäki, Robert Moulder, Heikki Hyöty, Hanna Honkanen, Anita Kondrashova, Sami Oikarinen, Hermie J. M. Harmsen, Marcus C. De Goffau, Gjalt Welling, Kirsi Alahuhta, Suvi M. Virtanen

“…Early childhood infections have been implicated in the development of immune-mediated diseases, such as allergies, asthma, and type 1 diabetes. …”
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Analisis Perkembangan Bahasa Semantik Dan Sintaksis Anak Dalam Kegiatan Belajar Dari Rumah by Nikmatul Azizah, Anita Candra Dewi

“…Keywords: language development, semantics, syntax, early childhood, BDR References Dhieni, N., & Azizah, M. (2012). …”
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Penanaman Karakter Kewirausahaan Di TK Alam Al-Azhar Kutai Kertanegara by Wildan Saugi, Iin Sundari, Agustiah Agustiah

“…Learning Through Play: Strengthening Learning Through Play in Early Childhood Education Programmes. UNICEF. https://www.unicef.org/sites/default/files/2018-12/UNICEF-Lego-Foundation-Learning-through-Play.pdf…”
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Childhood antibiotics as a risk factor for Crohn's disease: The ENIGMA International Cohort Study by Joyce W Y Mak, Sun Yang, Annalise Stanley, Xiaoqing Lin, Mark Morrison, Jessica Y L Ching, Junkun Niu, Amy L Wilson‐O'Brien, Rui Feng, Whitney Tang, Amy L Hamilton, Leo Or, Gina L Trakman, Winnie Y Y Lin, Joseph J Y Sung, Ming Hu Chen, Yinglei Mao, Michael A Kamm, Siew C Ng

“…Attention should be paid to identifying modifiable environmental risk factors in early childhood, especially in at‐risk families.…”
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CD70 Deficiency Associated With Chronic Epstein-Barr Virus Infection, Recurrent Airway Infections and Severe Gingivitis in a 24-Year-Old Woman by Renate Krüger, Emmanuel Martin, Jasmin Dmytrus, Jasmin Dmytrus, Jasmin Dmytrus, Cornelia Feiterna-Sperling, Christian Meisel, Christian Meisel, Nadine Unterwalder, Nadine Unterwalder, Uwe Kölsch, Volker Wahn, Jörg Hofmann, Paula Korn, Sylvain Latour, Sylvain Latour, Kaan Boztug, Kaan Boztug, Kaan Boztug, Kaan Boztug, Kaan Boztug, Horst von Bernuth, Horst von Bernuth, Horst von Bernuth

“…Most of the few patients with homozygous CD70 deficiency described to date suffered from EBV-related malignancies in early childhood. We present a woman with CD70 deficiency diagnosed in adulthood. …”
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Rapid BMI Increases and Persistent Obesity in Small-for-Gestational-Age Infants by Dan Wu, Jianzheng Zhu, Xiulian Wang, Huiqing Shi, Yanyan Huo, Meiyan Liu, Fanfan Sun, Hongyan Lan, Chong Guo, Honghua Liu, Tingting Li, Lian Jiang, Xiangying Hu, Tianshu Li, Jing Xu, Guoying Yao, Guowei Zhu, Guangjun Yu, Jinjin Chen

“…In addition, we screened out 6,959 children from 23,871 children to further evaluate the dynamic changes of early childhood BMI. We divided the school-age children into groups as non-obese (BAZ < 2) and obese (BAZ > 2), and determined the association between changes in BMI and school-age obesity.Results: From the perspective of BMI distribution, the interpolated growth trajectory indicated that SGA children reaching overweight status or developing obesity by 3 years of age, continued to have obesity until school age (R2, 0.65; R2, 0.21). …”
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Association of Fatigue Severity With Maladaptive Coping in Multiple Sclerosis: A Data-Driven Psychodynamic Perspective by Gesa E. A. Pust, Gesa E. A. Pust, Jennifer Randerath, Jennifer Randerath, Lutz Goetzmann, Roland Weierstall, Michael Korzinski, Stefan M. Gold, Stefan M. Gold, Stefan M. Gold, Christian Dettmers, Christian Dettmers, Barbara Ruettner, Roger Schmidt, Roger Schmidt, Roger Schmidt

“…Recent research suggests a link to early childhood adversities and psychological trait variables. …”
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Evaluating the effects between metal mixtures and serum vaccine antibody concentrations in children: a prospective birth cohort study by Barrett M. Welch, Adam Branscum, G. John Geldhof, Sharia M. Ahmed, Perry Hystad, Ellen Smit, Sakila Afroz, Meghan Megowan, Mostofa Golam, Omar Sharif, Mahmuder Rahman, Quazi Quamruzzaman, David C. Christiani, Molly L. Kile

“…Exposure samples were taken during pregnancy, toddlerhood, and early childhood. Multiple linear regression models (MLRs) with single or combined metal predictors were used to determine the association with antibody outcomes. …”
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Acute otitis media management: A survey of European primary care pediatricians by Guadalupe Del Castillo-Aguas, César García-Vera, Jacob Urkin, Marilena Moretto, Mareja Vintar Spreitzer, Pirkko Keronen, Andreas Werner, Laura Reali, Karin Geitmann, Péter Poloskey, Beata Kartousova, Werner Sauseng, Mario Schumacher, Stephen Reingold, Concepción Sánchez-Pina

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Myosin Binding Protein-C Forms Amyloid-Like Aggregates In Vitro by Liya G. Bobyleva, Sergey A. Shumeyko, Elmira I. Yakupova, Alexey K. Surin, Oxana V. Galzitskaya, Hiroshi Kihara, Alexander A. Timchenko, Maria A. Timchenko, Nikita V. Penkov, Alexey D. Nikulin, Mariya Yu. Suvorina, Nikolay V. Molochkov, Mikhail Yu. Lobanov, Roman S. Fadeev, Ivan M. Vikhlyantsev, Alexander G. Bobylev

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The Healthy Primary School of the Future: study protocol of a quasi-experimental study by M. Willeboordse, M. W. Jansen, S. N. van den Heijkant, A. Simons, B. Winkens, R.H.M. de Groot, N. Bartelink, S. P. Kremers, P. van Assema, H. H. Savelberg, E. de Neubourg, L. Borghans, T. Schils, K. M. Coppens, R. Dietvorst, R. ten Hoopen, F. Coomans, S. Klosse, M.H.J. Conjaerts, M. Oosterhoff, M. A. Joore, I. Ferreira, P. Muris, H. Bosma, H. L. Toppenberg, C. P. van Schayck

“…Abstract Background Unhealthy lifestyles in early childhood are a major global health challenge. These lifestyles often persist from generation to generation and contribute to a vicious cycle of health-related and social problems. …”
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Case report: Incomplete penetrance of autosomal dominant myotonia congenita caused by a rare CLCN1 variant c.1667T>A (p.I556N) in a Malaysian family by Nurul Huda Musa, Nurul Huda Musa, Karuppiah Thilakavathy, Karuppiah Thilakavathy, Nur Afiqah Mohamad, Nur Afiqah Mohamad, Marina L. Kennerson, Marina L. Kennerson, Liyana Najwa Inche Mat, Wei Chao Loh, Anna Misyail Abdul Rashid, Janudin Baharin, Azliza Ibrahim, Wan Aliaa Wan Sulaiman, Fan Kee Hoo, Hamidon Basri, Abdul Hanif Khan Yusof Khan

“…We report a clinical case of a 50-year-old woman presents with muscle stiffness and cramp episodes that started in early childhood. She had difficulty initiating muscle movement and presented with transient muscle weakness after rest, which usually improved after repeated contraction (warm-up phenomenon). …”
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Malaria incidence and prevalence during the first year of life in Nanoro, Burkina Faso: a birth-cohort study by Hamtandi Magloire Natama, Eduard Rovira-Vallbona, M. Athanase Somé, Serge Henri Zango, Hermann Sorgho, Pieter Guetens, Maminata Coulibaly-Traoré, Innocent Valea, Petra F. Mens, Henk D. F. H. Schallig, Luc Kestens, Halidou Tinto, Anna Rosanas-Urgell

“…This study aimed to determine malaria morbidity and infection during early childhood in rural Burkina Faso. Methods Malariometric indices were determined over 1-year follow-up in a birth cohort of 734 infants living in Nanoro health district. …”
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Interações sociais de crianças pré-escolares com Síndrome de Down durante atividades extracurriculares Interacciones sociales de niños en edad preescolar con síndrome de Down duran... by Renata Valdívia Lucisano, Luzia Iara Pfeifer, Maria Paula Panuncio Pinto, Jair Lício Ferreira Santos, Patrícia Páfaro Gomes Anhão

“…<br>The aim of this research was to identify the process of social interaction of children with Down Syndrome (DS) during extracurricular activities in the regular early childhood education in Ribeirão Preto-SP, Brazil. …”
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