Оценка состояния питания и пищевого статуса детей раннего возраста южного региона = Assessment of the nutrition status of infants in South region... by V. I. Velichko, G. A. Danilchuk, L. I. Kolotvin, A. V. Chernetskaya

“…Unbalanced nutrition in early childhood often leads to disruption of the state of children's health, including mental retardation, disturbance of the mechanisms of adaptation and reduction of immunological protection. …”
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Sickle cell nephropathy. Clinical manifestations and new mechanisms involved in kidney injury by Salvador Payán-Pernía, Anna Ruiz Llobet, Ángel Francisco Remacha Sevilla, Jesús Egido, José Aurelio Ballarín Castán, Juan Antonio Moreno

“…This is universal and appears in early childhood. Microscopic and macroscopic haematuria also occur, in part related to renal papillary necrosis when the infarcts are extensive. …”
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Level of exposure to fluorides by the consumption of different types of milk in residents from an area of Mexico with endemic hydrofluorosis by Liliana Valdez Jiménez, Jaqueline Calderón Hernández, Rosa Isela Córdova Atilano, Selene Yasmín Sandoval Aguilar, Jorge Alejandro Alegría Torres, Rogelio Costilla Salazar, Diana Rocha Amador

“…Introduction: Several studies have shown the presence of fluorosis (DF) in primary dentition, suggesting an exposure to fluorides (F−) in early childhood. Breast milk is recommended as an exclusive food until 6 months of age. …”
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Cardiovascular Health at Age 5 Years: Distribution, Determinants, and Association With Neurodevelopment by Rachel E. Climie, Rachel E. Climie, Rachel E. Climie, Muriel Tafflet, Thomas van Sloten, Thomas van Sloten, Blandine de Lauzon-Guillain, Jonathan Y. Bernard, Jonathan Y. Bernard, Patricia Dargent-Molina, Sabine Plancoulaine, Sandrine Lioret, Xavier Jouven, Marie-Alines Charles, Barbara Heude, Jean-Philippe Empana

“…BackgroundEarly childhood may represent an opportune time to commence primordial prevention of cardiovascular disease (CVD, i.e., prevention of risk factors onset), but epidemiological evidence is scarce. …”
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Development of an early comprehensive care system for children with disabilities in educational and healthcare institutions by G. A. Butko, T. A. Katelson, S. P. Oltu

“…The article summarizes the experience of the Moscow City’s early assistance services, which were part of the experimental site of the North-Eastern Administrative District “Enabling Children with Pre-school and Early Childhood Care in the Educational Space” in 2012-2014, as well as the currently functioning early-warning services of the city of Moscow. …”
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CCNB1 is a novel prognostic biomarker and promotes proliferation, migration and invasion in Wilms tumor by Bin Xiang, Mei-Lin Chen, Zhi-Qiang Gao, Tao Mi, Qin-Lin Shi, Jun-Jun Dong, Xiao-Mao Tian, Feng Liu, Guang-Hui Wei

“…Abstract Background Wilms tumour (WT) is a mixed type of embryonal tumour that usually occurs in early childhood. However, our knowledge of the pathogenesis or progression mechanism of WT is inadequate, and there is a scarcity of beneficial therapeutic strategies. …”
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Metabolomics in plasma of Malawian children 7 years after surviving severe acute malnutrition: “ChroSAM” a cohort studyResearch in context by Celine Bourdon, Natasha Lelijveld, Debbie Thompson, Prasad S. Dalvi, Gerard Bryan Gonzales, Dominic Wang, Misagh Alipour, Eytan Wine, Emmanuel Chimwezi, Jonathan C. Wells, Marko Kerac, Robert Bandsma, Moffat J. Nyirenda

“…Current stunting was associated with IGF1 (β = 15·2, SE = 3·5, partial R2 = 12%, p < 0·0001) and this relationship could be influenced by early childhood SAM (β = 17·4, SE = 7·7, partial R2 = 2·8%, p = 0·025). …”
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Acute Septic Arthritis of the Knee Caused by Kingella kingae in a 5-Year-Old Cameroonian Boy by Nawal El Houmami, Dimitri Ceroni, Karine Codjo Seignon, Jean-Christophe Pons, Cédric Lambert, Guillaume André Durand, Philippe Minodier, Léopold Lamah, Philippe Bidet, Jacques Schrenzel, Didier Raoult, Pierre-Edouard Fournier

“…Although increasing reports indicate that this organism is the leading agent of bone and joint infections in early childhood, data on K. kingae infections from resource-limited settings are scarce, and none has yet been reported in Africa. …”
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Novel bi-allelic variants of CHMP1A contribute to pontocerebellar hypoplasia type 8: additional clinical and genetic evidence by Tiantian He, Tiantian He, Tiantian He, Huaqin Sun, Huaqin Sun, Bocheng Xu, Bocheng Xu, Bocheng Xu, Haibo Qu, Haibo Qu, Xiaotang Cai, Xiaotang Cai, Hui Zhou, Hui Zhou, Yanyan Liu, Yanyan Liu, Yanyan Liu, Ziyuan Lin, Ziyuan Lin, Xuemei Zhang, Xuemei Zhang, Xuemei Zhang

“…In this study, we investigated the phenotype and genotype in a human subject with global developmental delay, including clinical data from the prenatal stage through early childhood. Prenatally, the mother had polyhydramnios, and the bilateral ventricles of the fetus were slightly widened. …”
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Adverse childhood experiences and biomarkers of inflammation in a diverse cohort of early school-aged children by Nia Heard-Garris, Matthew M. Davis, Ryne Estabrook, James Burns, Margaret Briggs-Gowan, Norrina Allen, Mercedes Carnethon, Liliana Aguayo, Lauren Wakschlag, Frank Penedo

“…Objective: The objective of this study was to evaluate the relationship between ACEs and inflammatory profiles (i.e., pro- and anti-) in early childhood and to examine whether patterns differ for racial/ethnic subgroups. …”
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Dosis de exposición a fluoruros por el consumo de diferentes tipos de leche en residentes de una zona con hidrofluorosis endémica en México by Liliana Valdez Jiménez, Jaqueline Calderón Hernández, Rosa Isela Córdova Atilano, Selene Yasmín Sandoval Aguilar, Jorge Alejandro Alegría Torres, Rogelio Costilla Salazar, Diana Rocha Amador

“…Abstract: Introduction: Several studies have shown the presence of fluorosis (DF) in primary dentition, suggesting an exposure to fluorides (F−) in early childhood. Breast milk is recommended as an exclusive food until 6 months of age. …”
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乘勢而起？「翻轉教育」在臺灣觸發與構連歷程之脈絡性分析 Rising With the Momentum? The Contextual Analysis of Initiating and Networking Process of “Flipped Education” in Taiwan... by 李淑菁 Shu-Ching Lee, 蘇品如 Pin-Ru Su

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First Attack and Clinical Presentation of Hemiplegic Migraine in Pediatric Age: A Multicenter Retrospective Study and Literature Review by Irene Toldo, Francesco Brunello, Veronica Morao, Egle Perissinotto, Massimiliano Valeriani, Dario Pruna, Elisabetta Tozzi, Filomena Moscano, Giovanni Farello, Roberto Frusciante, Marco Carotenuto, Carlo Lisotto, Silvia Ruffatti, Ferdinando Maggioni, Cristiano Termine, Gabriella Di Rosa, Margherita Nosadini, Stefano Sartori, Pier Antonio Battistella

“…Children present fewer non-motor auras as compared to adults and in some cases the first attack is preceded by transient neurological signs and symptoms in early childhood. In SHM cases, attacks were less frequent but more severe and prolonged, while FHM patients had less intense but more frequent attacks and a longer phase of active disease. …”
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Growth and development and their environmental and biological determinants by Kelly da Rocha Neves, Rosane Luzia de Souza Morais, Romero Alves Teixeira, Priscilla Avelino Ferreira Pinto

“…Methods: This was a cross-sectional, predictive correlation study with all 92 children aged 24–36 months who attended the municipal early childhood education network in a town in the Vale do Jequitinhonha region, in 2011. …”
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Association between maternal occupational exposure to cleaning chemicals during pregnancy and childhood wheeze and asthma by Melissa A. Herrin, Allison R. Sherris, Logan C. Dearborn, Christine T. Loftus, Adam A. Szpiro, Paul E. Moore, Margaret A. Adgent, Emily S. Barrett, Emily S. Barrett, Ruby H. N. Nguyen, Kecia N. Carroll, Kecia N. Carroll, Catherine J. Karr, Catherine J. Karr, Catherine J. Karr

“…Cleaning chemicals are commonly encountered in occupational settings, yet few studies have examined the potential link between prenatal occupational exposures to cleaning chemicals and risk of childhood wheeze and asthma.MethodsWe evaluated the potential influence of maternal occupational exposure to cleaning chemicals during pregnancy on pediatric asthma and wheeze at child age 4–6 years in 453 mother-child pairs from two longitudinal pregnancy cohorts, TIDES and GAPPS, part of the ECHO prenatal and early childhood pathways to health (ECHO-PATHWAYS) consortium. …”
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Case report: Dupilumab treatment improved type 2 disorders in a patient with IPEX syndrome diagnosis by C. Caruso, L. Laterza, C. R. Settanni, S. Colantuono, C. Di Mario, B. Tolusso, F. Castrì, E. Gremese, E. Gremese, F. Scaldaferri, F. Scaldaferri, A. Armuzzi, A. Armuzzi, C. De Simone, K. Peris, A. Chiricozzi, A. Gasbarrini, A. Gasbarrini, A. Gasbarrini

“…IPEX syndrome is a rare and generally fatal genetic disorder characterized by immune dysregulation, polyendocrinopathy and enteropathy, mostly diagnosed in early childhood. Nonetheless, cases reported in the last 20 years demonstrated that IPEX clinical spectrum encompasses more than the classical triad of early-onset intractable diarrhea, type 1 diabetes and eczema. …”
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Self-Reported Maternal Parenting Stress From 9 m Is Longitudinally Associated With Child ADHD Symptoms at Age 12: Findings From a Population-Based Birth Cohort Study by Kaori Endo, Daniel Stanyon, Syudo Yamasaki, Miharu Nakanishi, Miharu Nakanishi, Junko Niimura, Sho Kanata, Shinya Fujikawa, Yuko Morimoto, Mariko Hosozawa, Kaori Baba, Nao Oikawa, Naomi Nakajima, Kazuhiro Suzuki, Mitsuhiro Miyashita, Shuntaro Ando, Shuntaro Ando, Mariko Hiraiwa-Hasegawa, Kiyoto Kasai, Kiyoto Kasai, Atsushi Nishida

“…BackgroundAttention-deficit/hyperactivity disorder (ADHD) develops in early childhood and carries lifelong impact, but early identification and intervention ensure optimal clinical outcomes. …”
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Gut Microbiota Features in Young Children With Autism Spectrum Disorders by Lorena Coretti, Lorena Coretti, Lorena Coretti, Lorella Paparo, Maria Pia Riccio, Felice Amato, Felice Amato, Mariella Cuomo, Alessandro Natale, Luca Borrelli, Luca Borrelli, Giusi Corrado, Carmen De Caro, Marika Comegna, Marika Comegna, Elisabetta Buommino, Elisabetta Buommino, Giuseppe Castaldo, Giuseppe Castaldo, Carmela Bravaccio, Lorenzo Chiariotti, Lorenzo Chiariotti, Lorenzo Chiariotti, Roberto Berni Canani, Roberto Berni Canani, Roberto Berni Canani, Roberto Berni Canani, Francesca Lembo, Francesca Lembo

“…Here we report unbalance of GM structure with a shift in colonization by gut beneficial bacterial species in ASD patients as off early childhood.…”
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Loss of Asxl1 Alters Self-Renewal and Cell Fate of Bone Marrow Stromal Cells, Leading to Bohring-Opitz-like Syndrome in Mice by Peng Zhang, Caihong Xing, Steven D. Rhodes, Yongzheng He, Kai Deng, Zhaomin Li, Fuhong He, Caiying Zhu, Lihn Nguyen, Yuan Zhou, Shi Chen, Khalid S. Mohammad, Theresa A. Guise, Omar Abdel-Wahab, Mingjiang Xu, Qian-Fei Wang, Feng-Chun Yang

“…Summary: De novo ASXL1 mutations are found in patients with Bohring-Opitz syndrome, a disease with severe developmental defects and early childhood mortality. The underlying pathologic mechanisms remain largely unknown. …”
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SS-31 Peptide Reverses the Mitochondrial Fragmentation Present in Fibroblasts From Patients With DCMA, a Mitochondrial Cardiomyopathy by Pranav Machiraju, Xuemei Wang, Rasha Sabouny, Joshua Huang, Tian Zhao, Fatima Iqbal, Melissa King, Dimple Prasher, Arijit Lodha, Nerea Jimenez-Tellez, Amir Ravandi, Bob Argiropoulos, Bob Argiropoulos, David Sinasac, David Sinasac, Aneal Khan, Aneal Khan, Aneal Khan, Timothy E. Shutt, Timothy E. Shutt, Timothy E. Shutt, Steven C. Greenway, Steven C. Greenway, Steven C. Greenway, Steven C. Greenway, Steven C. Greenway

“…Until recently no effective therapies had been identified and affected patients frequently died in early childhood from intractable heart failure. Skin fibroblasts from four pediatric patients with DCMA were used to establish parameters of mitochondrial dysfunction. …”
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