Ebola virus disease and the search for a cure by André Kalil

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Molecular determinants of Ebola virus virulence in mice. by Hideki Ebihara, Ayato Takada, Darwyn Kobasa, Steven Jones, Gabriele Neumann, Steven Theriault, Mike Bray, Heinz Feldmann, Yoshihiro Kawaoka

“…To understand the pathogenesis underlying the extreme virulence of Ebola virus (EBOV), here we identified the mutations responsible for the acquisition of the high virulence of the adapted Mayinga strain in mice, by using reverse genetics. …”
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Ebola Virus Disease – Global Scenario & Bangladesh by Md Rezwanur Rahman

“…Ebola virus disease (EVD), caused by one of the Ebola virus strains is an acute, serious illness which is often fatal when untreated. …”
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Modeling Ebola Virus Transmission Using Ferrets by Marc-Antoine de La Vega, Geoff Soule, Kaylie N. Tran, Kevin Tierney, Shihua He, Gary Wong, Xiangguo Qiu, Gary P. Kobinger

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Quantification of Ebola virus replication kinetics in vitro. by Laura E Liao, Jonathan Carruthers, Sophie J Smither, CL4 Virology Team, Simon A Weller, Diane Williamson, Thomas R Laws, Isabel García-Dorival, Julian Hiscox, Benjamin P Holder, Catherine A A Beauchemin, Alan S Perelson, Martín López-García, Grant Lythe, John N Barr, Carmen Molina-París

“…Mathematical modelling has successfully been used to provide quantitative descriptions of many viral infections, but for the Ebola virus, which requires biosafety level 4 facilities for experimentation, modelling can play a crucial role. …”
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Immunotherapeutics for Ebola Virus Disease: Hope on the Horizon by O'Donnell KL, Marzi A

“…Kyle L O’Donnell, Andrea Marzi Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USACorrespondence: Andrea Marzi Email marzia@niaid.nih.govAbstract: Ebola virus disease (EVD) remains among the biggest public health threats in Africa, even though recently a vaccine was approved for human use. …”
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Ebola virus disease: an emerging global threat by Alladi Mohan, Aditya Kumar Pemmaraju Venkata

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Structural and Functional Aspects of Ebola Virus Proteins by Sahil Jain, Ekaterina Martynova, Albert Rizvanov, Svetlana Khaiboullina, Manoj Baranwal

Subjects: “…Ebola virus…”
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Ebola Virus Epidemic in West Africa and Beyond by Oscar G Gómez-Duarte

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Numerical Simulation of the Fractal-Fractional Ebola Virus by H. M. Srivastava, Khaled M. Saad

Subjects: “…fractal-fractional ebola virus…”
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Ebola Virus Persistence in Semen Ex Vivo by Robert J. Fischer, Seth D. Judson, Kerri Miazgowicz, Trent Bushmaker, Vincent J. Munster

Subjects: “…Ebola virus disease…”
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Ebola Virus Antibodies in Fruit Bats, Bangladesh by Kevin J. Olival, Ariful Islam, Meng Yu, Simon J. Anthony, Jonathan H. Epstein, Shahneaz Ali Khan, Salah Uddin Khan, Gary Crameri, Lin-Fa Wang, W. Ian Lipkin, Stephen P. Luby, Peter Daszak

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Effective treatment strategies against Ebola virus by Amina Yaqoob, Umara Shehzad, Zarnab Ahmad, Nadia Naseer, Saliha Bashir

“…Ebola virus (EBOV), a member of order Mononegavirales is most famous for causing the endemics of hemorrhagic fever in different countries of the world. …”
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Disabling of lymphocyte immune response by Ebola virus. by Patrick Younan, Mathieu Iampietro, Alexander Bukreyev

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Ebola virus outbreaks in Africa: Past and present by J.J. Muyembe-Tamfum, S. Mulangu, Justin Masumu, J.M. Kayembe, A. Kemp, Janusz T. Paweska

“…The two outbreaks were caused by two distinct species of Ebola virus named Zaire ebolavirus (ZEBOV) and Sudan ebolavirus (SEBOV). …”
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Therapeutic Strategies against Ebola Virus Infection by Ching-Hsuan Liu, Yee-Tung Hu, Shu Hui Wong, Liang-Tzung Lin

Subjects: “…Ebola virus…”
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Experimental treatment of Ebola virus disease with brincidofovir by Dunning, J, Kennedy, S, Antierens, A, Whitehead, J, Ciglenecki, I, Carson, G, Kanapathipillai, R, Castle, L, Howell-Jones, R, Pardinaz-Solis, R, Grove, J, Scott, J, Lang, T, Olliaro, P, Horby, P

“…Based on in vitro data suggesting an antiviral effect against Ebola virus, brincidofovir was included in the World Health Organisation list of agents that should be prioritised for clinical evaluation in patients with Ebola virus disease (EVD) during the West African epidemic.In this single-arm phase 2 trial conducted in Liberia, patients with laboratory-confirmed EVD (two months of age or older, enrolment bodyweight ≥50 kg) received oral brincidofovir 200 mg as a loading dose on day 0, followed by 100 mg brincidofovir on days 3, 7, 10, and 14. …”

Toremifene interacts with and destabilizes the Ebola virus glycoprotein by Zhao, Y, Ren, J, Harlos, K, Jones, D, Zeltina, A, Bowden, T, Padilla-Parra, S, Fry, E, Stuart, D

“…Ebola viruses (EBOVs) are responsible for repeated outbreaks of fatal infections, including the recent deadly epidemic in West Africa. …”

Toremifene interacts with and destabilizes the Ebola virus glycoprotein. by Zhao, Y, Ren, J, Harlos, K, Jones, D, Zeltina, A, Bowden, T, Padilla-Parra, S, Fry, E, Stuart, D

“…Ebola viruses (EBOVs) are responsible for repeated outbreaks of fatal infections, including the recent deadly epidemic in West Africa. …”

Histology, immunohistochemistry, and in situ hybridization reveal overlooked Ebola virus target tissues in the Ebola virus disease guinea pig model by Timothy K. Cooper, Louis Huzella, Joshua C. Johnson, Oscar Rojas, Sri Yellayi, Mei G. Sun, Sina Bavari, Amanda Bonilla, Randy Hart, Peter B. Jahrling, Jens H. Kuhn, Xiankun Zeng

“…Abstract Survivors of Ebola virus infection may become subclinically infected, but whether animal models recapitulate this complication is unclear. …”
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