A novel COL1A1 variant in a family with clinical features of hypermobile Ehlers‐Danlos syndrome that proved to be a COL1‐related overlap disorder by Malika Foy, Philippe De Mazancourt, Corinne Métay, Robert Carlier, Valérie Allamand, Corine Gartioux, Fabrice Gillas, Nawel Miri, Valérie Jobic, Ahmed Mekki, Pascale Richard, Caroline Michot, Karelle Benistan

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Matrix Metalloproteinases Inhibition by Doxycycline Rescues Extracellular Matrix Organization and Partly Reverts Myofibroblast Differentiation in Hypermobile Ehlers-Danlos Syndrome Dermal Fibroblasts: A Potential Therapeutic Target? by Nicola Chiarelli, Nicoletta Zoppi, Marina Venturini, Daniele Capitanio, Cecilia Gelfi, Marco Ritelli, Marina Colombi

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Progress in Clinical Diagnosis and Management of Hypermobility Spectrum Disorders by XU Kexin, LI Guozhuang, WU Zhihong, DISCO (Deciphering Disorders Involving Scoliosis & COmorbidities) Study Group, ZHANG Jianguo, WU Nan

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Pediatric joint hypermobility: a diagnostic framework and narrative review by Louise Jane Tofts, Jane Simmonds, Sarah B. Schwartz, Roberto M. Richheimer, Constance O’Connor, Ellen Elias, Raoul Engelbert, Katie Cleary, Brad T. Tinkle, Antonie D. Kline, Alan J. Hakim, Marion A. J. van Rossum, Verity Pacey

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Heritable Connective Tissue Disorders in Childhood: Increased Fatigue, Pain, Disability and Decreased General Health by Jessica Warnink-Kavelaars, Lisanne E. de Koning, Lies Rombaut, Mattijs W. Alsem, Leonie A. Menke, Jaap Oosterlaan, Annemieke I. Buizer, Raoul H. H. Engelbert, on behalf of the Pediatric Heritable Connective Tissue Disorders Study Group

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Corrigendum to “Cataldo E, Cinquantini F, Priola AM, et al. Spontaneous renal artery dissection in Ehler–Danlos syndrome.” Kidney Int Rep. 2019;4:1649–1652

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Case report: Mild phenotype of a patient with vascular Ehlers–Danlos syndrome and COL3A1 duplication mutation without alteration in the [Gly-X-Y] repeat sequence by Shujiro Hayashi, Tomomi Yamaguchi, Tomomi Yamaguchi, Tomomi Yamaguchi, Tomoki Kosho, Tomoki Kosho, Tomoki Kosho, Tomoki Kosho, Ken Igawa

Subjects: “…Vascular Ehlers–Danlos syndrome…”
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Erratum to “Management of shoulder instability in hypermobility-type Ehlers-Danlos syndrome” [2021;1:155-164; https://doi.org/10.1016/j.xrrt.2021.03.002]

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Idiopathic osteoporosis, Ehlers–Danlos syndrome, postural orthostatic tachycardia syndrome, and mast cell activation disorder in a 27‐year‐old male patient: A unique case presentation by Cameron Rattray

Subjects: “…Ehlers–Danlos syndrome…”
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Automated, Vision-Based Goniometry and Range of Motion Calculation in Individuals With Suspected Ehlers-Danlos Syndromes/Generalized Hypermobility Spectrum Disorders: A Comparison of Pose-Estimation Libraries to Goniometric Measurements by Andrea Sabo, Nimish Mittal, Amol Deshpande, Hance Clarke, Babak Taati

“…Generalized joint hypermobility (GJH) often leads clinicians to suspect a diagnosis of Ehlers Danlos Syndrome (EDS), but it can be difficult to objectively assess. …”
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Multi‐exon COL5A1 deletion in a child with classical Ehlers–Danlos syndrome: A case report expanding the allelic spectrum and showing evidence of parental gonosomal mosaicism by Sonja Strang‐Karlsson, Sylvia Keigwin, Anna‐Kaisa Anttonen, Duncan Baker, Kerry Bean, Eveliina Jakkula

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Endovascular repair of a common iliac artery aneurysm with an iliac branch device in a patient with vascular Ehlers-Danlos syndrome due to a null COL3A1 variant by Sherene Shalhub, MD, MPH, FACS, Peter H. Byers, MD

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Perioperative opioid-minimization approach as a useful protocol in the management of patients with Ehlers–Danlos syndrome-hypermobility type, craniocervical instability and severe chronic pain who are to undergo occipito-cervical fixation by Carlos Ramírez-Paesano, Claudia Rodiera Clarens, Allan Sharp Segovia, Alan Coila Bustinza, Josep Rodiera Olive, Albert Juanola Galceran

“…Abstract Patients suffering from connective tissue disorders like Ehlers–Danlos syndrome hypermobility type/joint hypermobility syndrome (EDS-HT/JHS) may be affected by craniocervical instability (CCI). …”
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RNA-Seq of Dermal Fibroblasts from Patients with Hypermobile Ehlers–Danlos Syndrome and Hypermobility Spectrum Disorders Supports Their Categorization as a Single Entity with Involvement of Extracellular Matrix Degrading and Proinflammatory Pathomechanisms by Marco Ritelli, Nicola Chiarelli, Valeria Cinquina, Nicoletta Zoppi, Valeria Bertini, Marina Venturini, Marina Colombi

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Congenital Defects in a Patient Carrying a Novel Homozygous <i>AEBP1</i> Variant: Further Expansion of the Phenotypic Spectrum of Ehlers–Danlos Syndrome Classical-like Type 2? by Niccolò Di Giosaffatte, Alessandro Ferraris, Federica Gaudioso, Valentina Lodato, Emanuele Savino, Claudia Celletti, Filippo Camerota, Simone Bargiacchi, Luigi Laino, Silvia Majore, Irene Bottillo, Paola Grammatico

Subjects: “…Ehlers–Danlos Syndrome…”
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Arabic translation, cultural adaptation, and validation of the Bristol Impact of Hypermobility questionnaire by Najla Alsiri, Meshal Alhadhoud, Asma Alhumaid, Shea Palmer

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Early intestinal perforation secondary to congenital mesenteric defects by Ingrid Anne Mandy Schierz, Mario Giuffrè, Mariaserena Lo Presti, Giuseppa Pinello, Cinzia Chiaramonte, Enrica Maria Agosta Cecala, Giovanni Corsello

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POTS and Pregnancy: A Review of Literature and Recommendations for Evaluation and Treatment by Morgan K, Smith A, Blitshteyn S

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Detailed Courses and Pathological Findings of Colonic Perforation without Diverticula in Sisters with Musculocontractural Ehlers–Danlos Syndrome Caused by Pathogenic Variant in <i>CHST14</i> (mcEDS-<i>CHST14</i>) by Tomoko Kobayashi, Fumiyoshi Fujishima, Kazuaki Tokodai, Chiaki Sato, Takashi Kamei, Noriko Miyake, Naomichi Matsumoto, Tomoki Kosho

Subjects: “…musculocontractural Ehlers–Danlos syndrome (mcEDS)…”
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Does brittle cornea syndrome have a bone fragility phenotype? by Tim Cundy, Andrea Vincent, Stephen Robertson

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