Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk by Finucane, Hilary Kiyo, Sarkar, Abhishek Kulshreshtha

“…Mendelian randomization analyses suggest causal inverse associations, independent of body mass index (BMI), between puberty timing and risks for breast and endometrial cancers in women and prostate cancer in men. …”
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Targeting Ovarian Cancer with Chalcone Derivatives: Cytotoxicity and Apoptosis Induction in HGSOC Cells by Elif Merve Aydin, İdil Su Canıtez, Eleonora Colombo, Salvatore Princiotto, Daniele Passarella, Sabrina Dallavalle, Michael S. Christodoulou, Irem Durmaz Şahin

“…Ovarian cancer ranks as the eighth most prevalent form of cancer in women across the globe and stands as the third most frequent gynecological cancer, following cervical and endometrial cancers. Given its resistance to standard chemotherapy and high recurrence rates, there is an urgent imperative to discover novel compounds with potential as chemotherapeutic agents for treating ovarian cancer. …”
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Women's health, hormonal balance, and personal autonomy by Ignacio Segarra, Ignacio Segarra, Micaela Menárguez, María Victoria Roqué, María Victoria Roqué

“…We reviewed its main adverse effects and mechanisms on accelerated ovarian aging, mental health (emotional disruptions, depression, and suicide), sexuality (reduced libido), cardiovascular (brain stroke, myocardial infarction, hypertension, and thrombosis), and oncological (breast, cervical, and endometrial cancers). Other “collateral damage” includes negative effects on communication, scientific mistrust, poor physician–patient relationships, increased patient burden, economic drain on the healthcare system, and environmental pollution. …”
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PreMSIm: An R package for predicting microsatellite instability from the expression profiling of a gene panel in cancer by Lin Li, Qiushi Feng, Xiaosheng Wang

“…Using the RNA-Seq pan-cancer datasets for three cancer cohorts (colon, gastric, and endometrial cancers) from The Cancer Genome Atlas (TCGA) program, we developed an algorithm (PreMSIm) for predicting MSI from the expression profiling of a 15-gene panel in cancer. …”
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Lung metastasis of endometrioid carcinoma aberrantly expressing thyroid transcription factor-1 by Mitsuhiro Tachibana, Masao Saito, Jun Kobayashi, Yutaka Tsutsumi

“…It is known that thyroid transcription factor-1(TTF-1) is expressed in a small percentage of primary gynecological adenocarcinomas, including endometrial cancers. However, this is the first time this phenomenon has been reported that metastatic endometrioid carcinoma (EC) was induced TTF-1 by pulmonary niche. …”
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The Relevant Participation of Prolactin in the Genesis and Progression of Gynecological Cancers by Adrián Ramírez-de-Arellano, Julio César Villegas-Pineda, Julio César Villegas-Pineda, Christian David Hernández-Silva, Ana Laura Pereira-Suárez, Ana Laura Pereira-Suárez

“…This work aims to review the most important findings regarding the PRL/PRLR axis in cervical, ovarian, and endometrial cancers and its molecular mechanisms to support carcinogenesis.…”
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MSIMEP: Predicting microsatellite instability from microarray DNA methylation tumor profiles by Martín Santamarina-García, Jenifer Brea-Iglesias, Jesper Bertram Bramsen, Mar Fuentes-Losada, Francisco Javier Caneiro-Gómez, José Ángel Vázquez-Bueno, Héctor Lázare-Iglesias, Natalia Fernández-Díaz, Laura Sánchez-Rivadulla, Yoel Z. Betancor, Miriam Ferreiro-Pantín, Pablo Conesa-Zamora, José Ramón Antúnez-López, Masahito Kawazu, Manel Esteller, Claus Lindbjerg Andersen, Jose M.C. Tubio, Rafael López-López, Juan Ruiz-Bañobre

“…Moreover, we tested its consistency in other tumor types with high prevalence of MSI such as gastric and endometrial cancers. Finally, we demonstrated better performance of both MSIMEP models vis-à-vis a MLH1 promoter methylation-based one in colorectal cancer.…”
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MSI-low, a real phenomenon which varies in frequency among cancer types. by Halford, SE, Sawyer, E, Lambros, M, Gorman, P, Macdonald, N, Talbot, I, Foulkes, W, Gillett, C, Barnes, D, Akslen, L, Lee, K, Jacobs, I, Hanby, A, Ganesan, T, Salvesen, H, Bodmer, W, Tomlinson, I, Roylance, R

“…It was found that MSI-L was present in 30 of 87 (35%) colorectal cancers, 2 of 59 (3%) grade III breast carcinomas, 1 of 35 (3%) lobular breast cancers, 16 of 50 (32%) endometrial cancers, and 9 of 34 (26%) ovarian cancers. …”

DREMECELS: A Curated Database for Base Excision and Mismatch Repair Mechanisms Associated Human Malignancies. by Ankita Shukla, Ahmed Moussa, Tiratha Raj Singh

“…DREMECELS was designed considering the malignancies with frequent alterations in DNA repair pathways, that is, colorectal and endometrial cancers, associated with Lynch syndrome (also known as HNPCC). …”
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Onkologie und Bewegung by Schmid D, Steindorf K, Leitzmann MF

“…The most convincing epidemiologic data in support of a beneficial effect of physical activity on cancer risk exists for colon, breast, and endometrial cancers. Evidence is weaker for cancers of the lung, pancreas, stomach, prostate, and ovary. …”
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Argon Plasma Coagulation for the Treatment of Hemorrhagic Radiation Colitis by Mindy C.W. Lam, Matthew Parliament, Clarence K.W. Wong

“…Both patients received pelvic radiation for recurrent endometrial cancers and were referred for active bleeding secondary to radiation colitis that had required numerous transfusions. …”
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Prevalence and Genotype-Phenotype Correlation of Lynch Syndrome in a Selected High-Risk Cohort from Qatar’s Population by Mariem Sidenna, Houssein Khodjet-El-khil, Hajar Al Mulla, Mashael Al-Shafai, Hind Hassan Habish, Reem AL-Sulaiman, Salha Bujassoum Al-Bader

“…Lynch syndrome (LS) is the most common cause of hereditary colorectal cancers (CRC) and is associated with an increased risk for ovarian and endometrial cancers. There is lack of knowledge on the epidemiology of LS in the non-Caucasian populations especially in Qatar. …”
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Integrated genomic characterization of endometrial carcinoma by Park, Peter J., Lander, Eric Steven

“…Our results classified endometrial cancers into four categories: POLE ultramutated, microsatellite instability hypermutated, copy-number low, and copy-number high. …”
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Synchronous uterine adenocarcinoma and leiomyosarcoma – a case study by Kamila Dudzik, Agnieszka Krzysteczko, Leon Kolny, Agnieszka Bąk, Ewelina Stawicka-Ociepka, Krzysztof Nowosielski

“…The presence of synchronous endometrial adenocarcinoma and gynecological tract neoplasia is rare – the most commonly described is synchronous adenocarcinoma and endometrial ovarian cancer (accounting for 15-20% of ovarian neoplasia and 5% of endometrial cancers). Concomitant uterine carcinosarcoma and ovarian cancer, or endometrial adenocarcinoma are extremely rare. …”
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FOXA2 suppresses endometrial carcinogenesis and epithelial-mesenchymal transition by regulating enhancer activity by Subhransu S. Sahoo, Susmita G. Ramanand, Yunpeng Gao, Ahmed Abbas, Ashwani Kumar, Ileana C. Cuevas, Hao-Dong Li, Mitzi Aguilar, Chao Xing, Ram S. Mani, Diego H. Castrillon

“…FOXA2 encodes a transcription factor mutated in 10% of endometrial cancers (ECs), with a higher mutation rate in aggressive variants. …”
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Gene expression profiling predicts a three-gene expression signature of endometrial adenocarcinoma in a rat model by Klinga-Levan Karin, Olsson Björn, Karlsson Sandra

“…<p>Abstract</p> <p>Background</p> <p>In the Western world, endometrial cancers are the most common gynaecological neoplastic disorders among women. …”
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Reprogramming of Fatty Acid Metabolism in Gynaecological Cancers: Is There a Role for Oestradiol? by Azilleo Kristo Mozihim, Ivy Chung, Nur Akmarina B. M. Said, Amira Hajirah Abd Jamil

“…This is becoming a renewed research interest, given the recently established association between obesity and incidence of many gynaecological cancers, including breast, ovarian, cervical and endometrial cancers. This review article, hence, comprehensively discusses how FA metabolism is altered in these gynaecological cancers, highlighting the emerging role of oestradiol on the actions of key regulatory enzymes of lipid metabolism, either directly through its classical ER pathways, or indirectly via the IGIFR pathway. …”
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How Should We Test for Lynch Syndrome? A Review of Current Guidelines and Future Strategies by Richard Gallon, Peter Gawthorpe, Rachel L. Phelps, Christine Hayes, Gillian M. Borthwick, Mauro Santibanez-Koref, Michael S. Jackson, John Burn

“…There is increasing pressure to expand guidelines to include molecular screening of endometrial cancers, the most frequent cancer in female LS carriers. …”
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Assessment of G Protein-Coupled Oestrogen Receptor Expression in Normal and Neoplastic Human Tissues Using a Novel Rabbit Monoclonal Antibody by Maria Bubb, Anna-Sophia Lieselott Beyer, Pooja Dasgupta, Daniel Kaemmerer, Jörg Sänger, Katja Evert, Ralph M. Wirtz, Stefan Schulz, Amelie Lupp

“…GPER was also expressed in hepatocellular, pancreatic, renal, and endometrial cancers, pancreatic neuroendocrine tumours, and pheochromocytomas. …”
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Risk of cancer for patients with rheumatoid arthritis versus general population: a national claims database cohort studyResearch in context by Maxime Beydon, Sandrine Pinto, Yann De Rycke, Bruno Fautrel, Xavier Mariette, Raphaèle Seror, Florence Tubach

“…Some cancers were less frequent than in the general population such as pancreatic (SIR 0.90, 95% CI [0.83–0.97]) as well as breast and endometrial cancers (SIR 0.91, 95% CI [0.88–0.94] and SIR 0.77, 95% CI [0.71–0.84] respectively). …”
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