Symptom profiles of community cases infected by influenza, RSV, rhinovirus, seasonal coronavirus, and SARS-CoV-2 variants of concern by Cyril Geismar, Vincent Nguyen, Ellen Fragaszy, Madhumita Shrotri, Annalan M. D. Navaratnam, Sarah Beale, Thomas E. Byrne, Wing Lam Erica Fong, Alexei Yavlinsky, Jana Kovar, Susan Hoskins, Isobel Braithwaite, Robert W. Aldridge, Andrew C. Hayward

“…Flu Watch (2006–2011) and Virus Watch (2020–2022) are household community cohort studies monitoring the epidemiology of influenza, respiratory syncytial virus, rhinovirus, seasonal coronavirus, and SARS-CoV-2, in England and Wales. This study describes and compares the proportion of symptoms reported during illnesses infected by common respiratory viruses. …”
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Public health surveillance in the UK revolutionises our understanding of the invasive Salmonella Typhimurium epidemic in Africa by Philip M. Ashton, Siân V. Owen, Lukeki Kaindama, Will P. M. Rowe, Chris R. Lane, Lesley Larkin, Satheesh Nair, Claire Jenkins, Elizabeth M. de Pinna, Nicholas A. Feasey, Jay C. D. Hinton, Timothy J. Dallman

“…Typhimurium from patients in England and Wales were ST313 and were associated with gastrointestinal infection. …”
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 Patient safety in orthopedic surgery: prioritizing key areas of iatrogenic harm through an analysis of 48,095 incidents reported to a national database of errors by Panesar SS, Carson-Stevens A, Salvilla SA, Patel B, Mirza SB, Mann B

“…The National Reporting and Learning System (NRLS) in England and Wales is an underused resource which collects intelligence from reports about health care error.Methods: Using methods akin to case-control methodology, we have identified a method of prioritizing the areas of a national database of errors that have the greatest propensity for harm. …”
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Use of the confusion assessment method in multicentre delirium trials: training and standardisation by John R. Green, Jane Smith, Elizabeth Teale, Michelle Collinson, Michael S. Avidan, Eva M. Schmitt, Sharon K. Inouye, John Young

“…The setting was eight acute care hospitals in England and Wales. Participants were research assistants working on a multicentre feasibility study of delirium prevention. …”
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Ischaemic stroke, haemorrhage, and mortality in older patients with chronic kidney disease newly started on anticoagulation for atrial fibrillation: A population based study from U... by Kumar, S, De Lusignan, S, McGovern, A, Correa, A, Hriskova, M, Gatenby, P, Jones, S, Goldsmith, D, Camm, A

“…SETTING:The Royal College of General Practitioners Research and Surveillance Centre database population of almost 2.73 million patients from 110 general practices across England and Wales. PARTICIPANTS:Patients aged 65 years and over with a new diagnosis of atrial fibrillation and estimated glomerular filtration rate (eGFR) of <50 mL/min/1.73m2, calculated using the chronic kidney disease epidemiology collaboration creatinine equation. …”

Trends in response rates and respondent characteristics in five National Maternity Surveys in England during 1995–2018 by Harrison, S, Alderdice, F, Henderson, J, Redshaw, M, Quigley, MA

“…All women aged 16 years and over who gave birth in England (and Wales in 1995) during specified time periods from 1995 to 2018 were eligible to be selected. …”

The prevalence of depressive symptoms among fathers and associated risk factors during the first seven years of their child's life: findings from the Millennium Cohort Study by Nath, S, Psychogiou, L, Kuyken, W, Ford, T, Ryan, E, Russell, G

“…<strong>Methods</strong> Secondary data analysis was conducted using the UK Millennium cohort study, which consisted of data from England, Scotland, Wales and Northern Ireland of families with infants born in the year 2000/2001. …”

ORthopaedic trauma hospital outcomes - Patient operative delays (ORTHOPOD) Study: The management of day-case orthopaedic trauma in the United Kingdom by Wei, N, Baldock, TE, Elamin-Ahmed, H, Walshaw, T, Walker, R, Trompeter, A, Eardley, WPG

“…Dominant pathways (>50% patients listed at that episode) in England and Wales were uncommon but the most frequently seen was listing patients in the emergency department, 16 of 80 hospitals (20%). …”

Effect of 2-y n-3 long-chain polyunsaturated fatty acid supplementation on cognitive function in older people: a randomized, double-blind, controlled trial. by Dangour, A, Allen, E, Elbourne, D, Fasey, N, Fletcher, A, Hardy, P, Holder, G, Knight, R, Letley, L, Richards, M, Uauy, R

“…DESIGN: At total of 867 cognitively healthy adults, aged 70-79 y, from 20 general practices in England and Wales were randomly assigned into a double-blind controlled trial of daily capsules providing 200 mg EPA plus 500 mg DHA or olive oil for 24 mo. …”

Oral steroids for resolution of otitis media with effusion in children (OSTRICH): a double-blinded, placebo-controlled randomised trial by Francis, N, Cannings-John, R, Waldron, C, Thomas-Jones, E, Winfield, T, Shepherd, V, Harris, D, Hood, K, Fitzsimmons, D, Roberts, A, Powell, C, Gal, M, Butler, C

“…Participants were recruited from 20 ear, nose, and throat (ENT), paediatric audiology, and audiovestibular medicine outpatient departments in England and Wales. Participants were randomly allocated (1:1) to sequentially numbered identical prednisolone (oral steroid) or placebo packs by use of computer-generated random permuted block sizes stratified by site and child's age. …”

An independent external validation and evaluation of QRISK cardiovascular risk prediction: A prospective open cohort study by Collins, G, Altman, D

“…Setting: 274 practices from England and Wales contributing to the THIN database. Participants: 1.07 million patients, registered between 1 January 1995 and 1 April 2006, aged 35-74 years (5.4 million person years) with 43 990 cardiovascular events. …”

Feasibility of a reconfigured domestic violence and abuse training and support intervention responding to affected women, men, children and young people through primary care by Szilassy, E, Coope, C, Emsley, E, Williamson, E, Barbosa, EC, Johnson, M, Dowrick, A, Feder, G

“…Our study tested the feasibility of the adapted IRIS&thinsp;+&thinsp;intervention in England and Wales between 2019&ndash;21.</p> <p><strong>Methods:</strong>&nbsp;We used mixed method analysis to triangulate data from various sources (pre/post intervention questionnaires with primary care clinicians; data extracted from medical records and DVA agencies; semi-structured interviews with clinicians, service providers and referred adults and children) to assess the feasibility and acceptability of the IRIS&thinsp;+&thinsp;intervention.…”

How long do revised and multiply revised knee replacements last? A retrospective observational study of the National Joint Registry by Deere, K, Whitehouse, MR, Kunutsor, SK, Sayers, A, Price, AJ, Mason, J, Blom, AW

“…Methods We did a retrospective observational registry-based study of the National Joint Registry in England and Wales, UK. Knee replacement revision procedures linked to a primary episode were included; duplicates, records with missing information, and records with an unknown sequence of revision procedures were not included. …”

Failure of unicompartmental knee replacement by Liddle, A

“…</p> <p>A comprehensive comparison of matched patients undergoing TKR and UKR was undertaken using a large dataset from the National Joint Registry for England and Wales (NJR). Failure rates (revision, reoperation, complications and mortality), length of stay and patient-reported outcomes (PROMs) were studied. …”

British Thoracic Society Guideline for the investigation and management of malignant pleural mesothelioma by Woolhouse, I, Bishop, L, Darlison, L, De Fonseka, D, Edey, A, Edwards, J, Faivre-Finn, C, Fennell, D, Holmes, S, Kerr, K, Nakas, A, Peel, T, Rahman, N, Slade, M, Steele, J, Tsim, S, Maskell, N

“…</p> <br/> <p>The largest dataset of MPM in the UK comes from the National Lung Cancer Audit report, which described 8740 cases seen in hospitals in England and Wales between 2008 and 2012.3 Eighty-three per cent of patients were male and the median age at diagnosis was 73 years. …”

Improving the diagnosis and treatment of urinary tract infection in young children in primary care: Results from the DUTY prospective diagnostic cohort study. by Hay, A, Sterne, J, Hood, K, Little, P, Delaney, B, Hollingworth, W, Wootton, M, Howe, R, MacGowan, A, Lawton, M, Busby, J, Pickles, T, Birnie, K, O'Brien, K, Waldron, C, Dudley, J, Van Der Voort, J, Downing, H, Thomas-Jones, E, Harman, K, Lisles, C, Rumsby, K, Durbaba, S, Whiting, P, Butler, C

“…</p> <h4>Methods</h4> <p>We recruited acutely unwell children aged under 5 years from 233 primary care sites across England and Wales. Index tests were parent-reported symptoms, clinician-reported signs, urine dipstick results, and clinician opinion of UTI likelihood (clinical diagnosis before dipstick and culture). …”

Effect of surgical caseload on revision rate following total and unicompartmental knee replacement by Liddle, A, Pandit, H, Judge, A, Murray, D

“…The aim of this study was to quantify the effect of surgical caseload on survival of both TKR and UKR.This study was based on 459,280 patient records (422,149 TKRs and 37,131 UKRs) from the National Joint Registry for England and Wales. The caseload-outcome relationship was characterized graphically and quantified using regression techniques. …”

Mortality in treated heterozygous familial hypercholesterolaemia: implications for clinical management. Scientific Steering Committee on behalf of the Simon Broome Register Group. by Neil, H, Betteridge, D, Broome, K, Durrington, P, Hawkins, M, Humphries, SE, Mann, J, Miller, J, Thompson, G, Thorogood, M, Potok, M, Mathews, F, Arnsten, K, Flemming, S, Betteridge, D, Durrington, P, Alkeles, R, Finnie, R, Galton, D, Hillson, R, Hughes, E, Laker, M, Lewis, B, Wierzbicki, A, Lorimer, R

“…Absolute mortality was calculated, and relative risk was expressed as the ratio of the number of observed deaths to the number expected in the general population of England and Wales. Forty six of the 73 deaths were due to coronary heart disease. …”

Advance Decision Making in Bipolar: A Systematic Review by Lucy A. Stephenson, Tania Gergel, Astrid Gieselmann, Matthé Scholten, Alex Ruck Keene, Larry Rifkin, Gareth Owen

“…Statutory provision for ADM is likely to be introduced to mental health legislation in England and Wales, which will support planning for mental health crises. …”
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Feasibility of a reconfigured domestic violence and abuse training and support intervention responding to affected women, men, children and young people through primary care by Eszter Szilassy, Caroline Coope, Elizabeth Emsley, Emma Williamson, Estela Capelas Barbosa, Medina Johnson, Anna Dowrick, Gene Feder

“…Our study tested the feasibility of the adapted IRIS + intervention in England and Wales between 2019–21. Methods We used mixed method analysis to triangulate data from various sources (pre/post intervention questionnaires with primary care clinicians; data extracted from medical records and DVA agencies; semi-structured interviews with clinicians, service providers and referred adults and children) to assess the feasibility and acceptability of the IRIS + intervention. …”
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