Representation of Drought Events in the United Kingdom: Contrasting 200 years of News Texts and Rainfall Records by Carmen Dayrell, Cecilia Svensson, Jamie Hannaford, Jamie Hannaford, Tony McEnery, Tony McEnery, Lucy J. Barker, Helen Baker, Maliko Tanguy

“…An independent analysis of meteorological drought was undertaken using three sources: 1) the England and Wales Precipitation (EWP) series (back to 1800), 2) a statistically reconstructed version of the EWP which is more reliable in the early record (pre-1870), and 3) a high resolution gridded dataset (back to 1862) which is aggregated to NUTS1 regional scales. …”
Get full text

The prevalence of depressive symptoms among fathers and associated risk factors during the first seven years of their child’s life: findings from the Millennium Cohort Study by Selina Nath, Lamprini Psychogiou, Willem Kuyken, Tamsin Ford, Elizabeth Ryan, Ginny Russell

“…Methods Secondary data analysis was conducted using the UK Millennium cohort study, which consisted of data from England, Scotland, Wales and Northern Ireland of families with infants born in the year 2000/2001. …”
Get full text

Interrupted time-series analysis of regulations to reduce paracetamol (acetaminophen) poisoning. by Oliver W Morgan, Clare Griffiths, Azeem Majeed

“…We use interrupted time-series analysis to evaluate whether the recent fall in the number of paracetamol deaths is different to trends in fatal poisoning involving aspirin, paracetamol compounds, antidepressants, or nondrug poisoning suicide.We calculated directly age-standardised mortality rates for paracetamol poisoning in England and Wales from 1993 to 2004. We used an ordinary least-squares regression model divided into pre- and postintervention segments at 1999. …”
Get full text

Prehabilitation for frail patients undergoing total hip or knee replacement: protocol for the Joint PREP feasibility randomised controlled trial by Tanzeela Khalid, Yoav Ben-Shlomo, Wendy Bertram, Lucy Culliford, Clare England, Emily Henderson, Catherine Jameson, Marcus Jepson, Shea Palmer, Michael R. Whitehouse, Vikki Wylde

“…Sixty people who are ≥ 65 years of age, frail according to the self-reported Groningen Frailty Indicator, and scheduled to undergo total hip or knee replacement at 2–3 hospitals in England and Wales will be recruited and randomly allocated on a 1:1 ratio to the intervention or usual care group. …”
Get full text

Recovery-focused mental health care planning and co-ordination in acute inpatient mental health settings: a cross national comparative mixed methods study by Michael Coffey, Ben Hannigan, Sally Barlow, Martin Cartwright, Rachel Cohen, Alison Faulkner, Aled Jones, Alan Simpson

“…Methods A cross-national comparative mixed-methods study involving 19 mental health wards in six service provider sites in England and Wales. This included a survey using established standardised measures of service users (n = 301) and staff (n = 290) and embedded case studies involving interviews with staff, service users and carers (n = 76). …”
Get full text

Behavioural Activation for Social IsoLation (BASIL+) trial (Behavioural activation to mitigate depression and loneliness among older people with long-term conditions): Protocol for... by Lauren Burke, Elizabeth Littlewood, Samantha Gascoyne, Dean McMillan, Carolyn A Chew-Graham, Della Bailey, Claire Sloan, Caroline Fairhurst, Kalpita Baird, Catherine Hewitt, Andrew Henry, Eloise Ryde, Leanne Shearsmith, Peter Coventry, Suzanne Crosland, Elizabeth Newbronner, Gemma Traviss-Turner, Rebecca Woodhouse, Andrew Clegg, Tom Gentry, Andrew Hill, Karina Lovell, Sarah Dexter Smith, Judith Webster, David Ekers, Simon Gilbody

“…Participants will be recruited via participating general practices across England and Wales. Participants must be aged ≥65 with two or more long-term conditions, or a condition that may indicate they are within a 'clinically extremely vulnerable' group in relation to COVID-19, and have scored ≥5 on the Patient Health Questionnaire (PHQ9), to be eligible for inclusion. …”
Get full text

Death and Emergency Readmission of Infants Discharged After Interventions for Congenital Heart Disease: A National Study of 7643 Infants to Inform Service Improvement by Sonya Crowe, Deborah A. Ridout, Rachel Knowles, Jenifer Tregay, Jo Wray, David J. Barron, David Cunningham, Roger C. Parslow, Martin Utley, Rodney Franklin, Catherine Bull, Katherine L. Brown

“…Methods and ResultsCardiac procedures performed in infants between 2005 and 2010 in England and Wales from the UK National Congenital Heart Disease Audit were linked to intensive care records. …”
Get full text

The Prognosis in Palliative care Study II (PiPS2): study protocol for a multi-centre, prospective, observational, cohort study by Anastasia K. Kalpakidou, Chris Todd, Vaughan Keeley, Jane Griffiths, Karen Spencer, Victoria Vickerstaff, Rumana Z. Omar, Patrick Stone

“…Methods This is a national, multi-centre, prospective, observational cohort study, aiming to recruit 1778 patients via palliative care services across England and Wales. Eligible patients have advanced, incurable cancer and have recently been referred to palliative care services. …”
Get full text

A 10-Year Review of Sunburn Injuries Presenting to the Manchester Adult and Paediatric Specialist Burn Services by Lewis A. Dingle, Poh Tan, Parisha Malik, Samantha McNally

“…Conclusion: This 10-year retrospective cohort study demonstrates an increasing trend of sunburn injury presentations to the Manchester specialist burns services; a pattern replicated in national data from England and Wales. The majority of sunburn injuries do not present to specialist burn services; therefore, these reported injuries reflect only a fraction of the true burden of sunburn nationwide. …”
Get full text

Improving the Utility of Voluntary Ovine Fallen Stock Collection and Laboratory Diagnostic Submission Data for Animal Health Surveillance Purposes: A Development Cycle by Sue C. Tongue, Jude I. Eze, Jude I. Eze, Carla Correia-Gomes, Franz Brülisauer, George J. Gunn

“…Initially, to determine if similar methods could be applied to ovine fallen stock collections from England and Wales for the same time period. Additionally, Scottish contemporaneous laboratory diagnostic submission data were analyzed to see if they could provide further insight for interpretation of statistical alarms. …”
Get full text

A Global Community of Courts? Modelling the Use of Persuasive Authority as a Complex Network by D. Hoadley, M. Bartolo, R. Chesterman, A. Faus, W. Hernandez, B. Kultys, A. P. Moore, A. P. Moore, A. P. Moore, E. Nemsic, N. Roche, N. Roche, N. Roche, J. Shangguan, B. Steer, K. Tylinski, N. West

“…Notwithstanding that judgments emanating from the United Kingdom (chiefly from the courts of England and Wales) constitute the most frequently consulted body of jurisprudence, we find evidence that domestic courts favor citing the case law of countries that are geographically proximal.…”
Get full text

The Use of Neuroscience and Psychological Measurement in England's Court of Protection by Andrew McWilliams, Andrew McWilliams, Andrew McWilliams, Stephen M. Fleming, Stephen M. Fleming, Anthony S. David, Gareth Owen

“…The 2005 Mental Capacity Act of England and Wales provides a description in statute law of a test determining if a person lacks “mental capacity” to take a particular decision and describes how the “best interests” of such a person should be determined. …”
Get full text

Twins Early Development Study (TEDS): A genetically sensitive investigation of mental health outcomes in the mid‐twenties by Celestine Lockhart, Joanna Bright, Yasmin Ahmadzadeh, Gerome Breen, Shannon Bristow, Andy Boyd, Johnny Downs, Matthew Hotopf, Elisavet Palaiologou, Kaili Rimfeld, Jessye Maxwell, Margherita Malanchini, Tom A. McAdams, Andrew McMillan, Robert Plomin, Thalia C. Eley

“…Abstract The Twins Early Development Study (TEDS) is a longitudinal study following a cohort of twins born 1994–1996 in England and Wales. Of the 13,759 families who originally consented to take part, over 10,000 families remain enrolled in the study. …”
Get full text

Relative Age Effects in Male Cricket: A Personal Assets Approach to Explain Immediate, Short-Term, and Long-Term Developmental Outcomes by Adam L. Kelly, Thomas Brown, Rob Reed, Jean Côté, Jennifer Turnnidge

“…As such, this study was comprised of three aims: (a) examine the birth quarter (BQ) distribution of players throughout the England and Wales Cricket Board (ECB) national talent pathway (i.e., Regional U15, Regional U17, England U19, England Lions, England T20, England ODI, and England Test; <i>n</i> = 1800; immediate timescale), (b) explore the youth-to-senior transitions based on BQ and skill-set (i.e., batters and bowlers; short-term timescale), and (c) analyse the average number of games played at senior levels based on BQ and skill-set (i.e., long-term timescale). …”
Get full text

The influence of social media on recruitment to surgical trials by Carly Nichola Bisset, Ben Carter, Jennifer Law, Jonathan Hewitt, Kat Parmar, Susan Joan Moug, on behalf of the ELF Study Group Collaborative Authorship

“…Results After 90 days of data collection, 49 sites from Scotland, England and Wales recruited 952 consecutive patients undergoing emergency laparotomy, with data logged into a database created on REDCap. …”
Get full text

Gross pathology of high pathogenicity avian influenza virus H5N1 2021–2022 epizootic in naturally infected birds in the United Kingdom by Fabian Z.X. Lean, Ana Gómez Vitores, Scott M. Reid, Ashley C. Banyard, Ian H. Brown, Alejandro Núñez, Rowena D.E. Hansen

“…High pathogenicity avian influenza virus (HPAIV) clade 2.3.4.4b has re-emerged in the United Kingdom in 2021–2022 winter season, with over 90 cases of HPAIV detected among poultry and captive birds in England, Scotland, Wales, and Northern Ireland. Globally, HPAIV H5N1 has also had a wide geographical dispersion, causing outbreaks in Europe, North America, Asia, and Africa, impacting on socioeconomic and wildlife conservation. …”
Get full text

Factors associated with implant survival following total hip replacement surgery: A registry study of data from the National Joint Registry of England, Wales, Northern Ireland and... by Jonathan Thomas Evans, Ashley William Blom, Andrew John Timperley, Paul Dieppe, Matthew James Wilson, Adrian Sayers, Michael Richard Whitehouse

“…<h4>Methods and findings</h4>We analyzed a national, mandatory, prospective, cohort study (National Joint Registry for England, Wales, Northern Ireland and the Isle of Man [NJR]) of all THRs performed in England and Wales. We included the 664,761 patients with records in the NJR who have received a stemmed primary THR between 1 April 2003 and 31 December 2017 in one of 461 hospitals, with osteoarthritis as the only indication. …”
Get full text

Time intervals and distances travelled for prehospital ambulance stroke care: data from the randomised-controlled ambulance-based Rapid Intervention with Glyceryl trinitrate in Hyp... by Philip M Bath, Jason P Appleton, Lisa J Woodhouse, Julia Williams, Polly Scutt, Diane Havard, Mark Dixon, Aloysius Niroshan Siriwardena, Lee J Haywood

“…In this study, we investigated the conduct of a hyperacute stroke study in the ambulance-based setting with a particular focus on timings and logistics of trial delivery.Design Multicentre prospective, single-blind, parallel group randomised controlled trial.Setting Eight National Health Service ambulance services in England and Wales; 54 acute stroke centres.Participants Paramedics enrolled 1149 patients assessed as likely to have a stroke, with Face, Arm, Speech and Time score (2 or 3), within 4 hours of symptom onset and systolic blood pressure &gt;120 mm Hg.Interventions Paramedics administered randomly assigned active transdermal glyceryl trinitrate or sham.Primary and secondary outcomes Modified Rankin scale at day 90. …”
Get full text

Cervical screening at age 50-64 years and the risk of cervical cancer at age 65 years and older: population-based case control study. by Alejandra Castañón, Rebecca Landy, Jack Cuzick, Peter Sasieni

“…<h4>Methods and findings</h4>Cases were women (n = 1,341) diagnosed with cervical cancer at age 65-83 y between 1 April 2007 and 31 March 2012 in England and Wales; age-matched controls (n = 2,646) were randomly selected from population registers. …”
Get full text

Offering HCV treatment to prisoners is an important opportunity: key principles based on policy and practice assessment in Europe by H. Stöver, F. Meroueh, A. Marco, K. Keppler, P. Saiz de la Hoya, R. Littlewood, N. Wright, F. Nava, F. Alam, S. Walcher, L. Somaini

“…Prisoner population requiring HCV treatment is not known; estimated numbers based on analysis of evidence: England and Wales, 9000, France, 8000, Spain, 6000, Italy, 6000, Germany, 6000. …”
Get full text