REST: a preoperative tailored sleep intervention for patients undergoing total knee replacement – feasibility study for a randomised controlled trial by Simon White, Rachael Gooberman-Hill, Emma Johnson, Joel Glynn, Vikki Wylde, Chris Penfold, Katie Whale, Nicholas Howells, Ashley Blom, Amanda Burston, Wendy Bertram, Dane Rayment

“…Objectives To test the feasibility of a randomised controlled trial (RCT) of a novel preoperative tailored sleep intervention for patients undergoing total knee replacement.Design Feasibility two-arm two-centre RCT using 1:1 randomisation with an embedded qualitative study.Setting Two National Health Service (NHS) secondary care hospitals in England and Wales.Participants Preoperative adult patients identified from total knee replacement waiting lists with disturbed sleep, defined as a score of 0–28 on the Sleep Condition Indicator questionnaire.Intervention The REST intervention is a preoperative tailored sleep assessment and behavioural intervention package delivered by an Extended Scope Practitioner (ESP), with a follow-up phone call 4 weeks postintervention. …”
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The Prognosis in Palliative care Study II (PiPS2): A prospective observational validation study of a prognostic tool with an embedded qualitative evaluation. by P C Stone, A Kalpakidou, C Todd, J Griffiths, V Keeley, K Spencer, P Buckle, D Finlay, V Vickerstaff, R Z Omar, PiPS2 investigators’ group

“…Validation study participants were adults with incurable cancer; with or without capacity; recently referred to community, hospital and hospice palliative care services across England and Wales. Sub-study participants were patients, caregivers and HPs. 1833 participants were recruited. …”
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An exploration of the experiences and self-generated strategies used when navigating everyday life with Long Covid by Fiona J. Leggat, Celayne Heaton-Shrestha, Jessica Fish, Aloysius Niroshan Siriwardena, Anne Domeney, Carol Rowe, Ian Patel, Judith Parsons, John Blair, Fiona Jones

“…Participants aged over 18 years, who self-identified with Long Covid, were recruited from England and Wales. Data were analysed with patient contributors using a reflexive thematic analysis. …”
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Occupational differences in COVID-19 incidence, severity, and mortality in the United Kingdom: Available data and framework for analyses [version 1; peer review: 1 approved, 2 appr... by Neil Pearce, Sarah Rhodes, Katie Stocking, Lucy Pembrey, Karin van Veldhoven, Elizabeth B. Brickley, Steve Robertson, Donna Davoren, Vahe Nafilyan, Ben Windsor-Shellard, Tony Fletcher, Martie van Tongeren

“…For example, mortality data suffer from problems of coding of COVID-19 deaths, and the deaths (in England and Wales) that have been referred to the coroner are unavailable. …”
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Playing sport injured is associated with osteoarthritis, joint pain and worse health-related quality of life: a cross-sectional study by Garrett S. Bullock, Gary S. Collins, Nick Peirce, Nigel K. Arden, Stephanie R. Filbay

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Problem-based learning and legal education – a case study in integrated experiential study by Richard Grimes

“…<p>This work describes the legal education system as it currently exists in England and Wales (the rest of the UK has a somewhat different structure) and highlights perceived shortcomings in that system. …”
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Relative Survival After Transcatheter Aortic Valve Implantation: How Do Patients Undergoing Transcatheter Aortic Valve Implantation Fare Relative to the General Population? by Glen P. Martin, Matthew Sperrin, William Hulme, Peter F. Ludman, Mark A. de Belder, William D. Toff, Oras Alabas, Neil E. Moat, Sagar N. Doshi, Iain Buchan, John E. Deanfield, Chris P. Gale, Mamas A. Mamas

“…Methods and ResultsNational cohort data (n=6420) from the 2007 to 2014 UK TAVI registry were matched by age, sex, and year to mortality rates for England and Wales (population, 57.9 million). The Ederer II method related observed patient survival to that expected from the matched general population. …”
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BabyBreathe trial: protocol for a randomised controlled trial of a complex intervention to prevent postpartum return to smoking by Felix Naughton, Caitlin Notley, Linda Bauld, Allan B Clark, David Turner, Tracey J Brown, Mei-See Man, Michael Ussher, Tess Harris, Wendy Hardeman, Richard Holland, Vicky Gilroy, Dan Smith, Sharon Duneclift, Gregory Howard

“…Target sample size is 880, recruiting across midwifery services at four hubs in England and Scotland and through remote advertising in England, Scotland, Wales and Northern Ireland. Outcomes are collected at 6 and 12 months. …”
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General practice wide adaptations to support patients affected by DVA during the COVID-19 pandemic: a rapid qualitative study by Sharon Dixon, Anna De Simoni, Eszter Szilassy, Elizabeth Emsley, Vari Wileman, Gene Feder, Lucy Downes, Estela Capelas Barbosa, Jasmina Panovska-Griffiths, Chris Griffiths, Anna Dowrick

“…Methods Remote semi-structured interviews were conducted by telephone with staff from six localities in England and Wales where the Identification and Referral to Improve Safety (IRIS) primary care DVA programme is commissioned.  …”
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Variations in presentation, management, and patient outcomes of urinary tract infection: a prospective four-country primary care observational cohort study by Butler, C, Francis, N, Thomas-Jones, E, Llor, C, Bongard, E, Moore, M, Little, P, Bates, J, Lau, M, Pickles, T, Gal, M, Wootton, M, Kirby, N, Gillespie, D, Rumbsy, K, Brugman, C, Hood, K, Verheij, T

“…Participants were slightly younger in Wales, had less severe symptoms in Spain, and had waited longer before consulting in the Netherlands. 259 (35·7%, 95% CI 32·3 to 39·2) were urine culture positive for UTI, with similar proportions in England and Wales but much higher in Spain and the Netherlands. …”

C-reactive protein testing to guide antibiotic prescribing for COPD exacerbations by Butler, C, Gillespie, D, White, P, Bates, J, Lowe, R, Thomas-Jones, E, Wootton, M, Hood, K, Phillips, R, Melbye, H, Llor, C, Cals, J, Naik, G, Kirby, N, Gal, M, Riga, E, Francis, N

“…</p> <p><strong>Methods</strong> We performed a multicenter, open-label, randomized, controlled trial involving patients with a diagnosis of COPD in their primary care clinical record who consulted a clinician at 1 of 86 general medical practices in England and Wales for an acute exacerbation of COPD. The patients were assigned to receive usual care guided by CRP point-of-care testing (CRP-guided group) or usual care alone (usual-care group). …”

Childhood encephalitis in the United Kingdom - epidemiology, trends in hospital admissions and the role of intravenous immunoglobulin by Iro, M

“…</p> <p>To contribute to ongoing work currently addressing these issues globally, I conducted a 30-year review of childhood encephalitis hospital admissions in England, and also a 10- year review of paediatric intensive care unit (PICU) admissions in England and Wales (E&amp;W;). Through these projects, I defined the incidence of all-cause childhood encephalitis in England, and severe encephalitis in E&amp;W.; I described hospital admission trends for childhood encephalitis in England, and evaluated how these had varied with introduction of the combined measles, mumps, rubella vaccine. …”

Timely Digital Patient-Clinician Communication in Specialist Clinical Services for Young People:A Mixed-Methods Study (The LYNC Study) by Griffiths, F, Bryce, C, Cave, J, Dritsaki, M, Fraser, J, Hamilton, K, Huxley, C, Ignatowicz, A, Kim, S, Kimani, P, Madan, J, Slowther, A, Sujan, M, Sturt, J, LYNC Study Group

“…<br/><br/> Methods<br/> Mixed method case studies of 20 NHS specialist clinical teams from across England and Wales and their current practice providing care for 13 different long-term physical or mental health conditions. …”

Serial interval of COVID-19 and the effect of Variant B.1.1.7: analyses from prospective community cohort study (Virus Watch) [version 1; peer review: 2 approved] by Cyril Geismar, Ellen Fragaszy, Vincent Nguyen, Wing Lam Erica Fong, Madhumita Shrotri, Sarah Beale, Alison Rodger, Vasileios Lampos, Thomas Byrne, Jana Kovar, Annalan M D Navaratnam, Parth Patel, Robert W Aldridge, Andrew Hayward, on behalf of Virus Watch Collaborative

“…Methods: The Virus Watch study is an online, prospective, community cohort study following up entire households in England and Wales during the COVID-19 pandemic. Putative household infector-infectee pairs were identified where more than one person in the household had a positive swab matched to an illness episode. …”
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Refusal and resistance to care by people living with dementia being cared for within acute hospital wards: an ethnographic study by Katie Featherstone, Andy Northcott, Jane Harden, Karen Harrison Denning, Rosie Tope, Sue Bale, Jackie Bridges

“…Setting: This ethnography was carried out on 155 days (over 18 months) in 10 wards within five hospitals across England and Wales, which were purposefully selected to represent a range of hospital types, geographies and socioeconomic catchments. …”
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The feasibility of team care for women seeking to plan a vaginal breech birth (OptiBreech 1): an observational implementation feasibility study in preparation for a pilot trial by Shawn Walker, Emma Spillane, Kate Stringer, Amy Meadowcroft, Tisha Dasgupta, Siân M. Davies, Jane Sandall, Andrew Shennan, the OptiBreech Collaborative

“…Methods Our design was an observational implementation feasibility assessment across England and Wales, January 2021–June 2022. Our objectives were to determine whether Trusts could provide attendants with advanced training (implementation feasibility), who deliver protocol-consistent care (fidelity), within existing resources (costs), while maintaining low neonatal admission rates (safety) and adequate recruitment rates (trial feasibility). …”
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Occupational differences in COVID-19 incidence, severity, and mortality in the United Kingdom: Available data and framework for analyses [version 2; peer review: 1 approved, 2 appr... by Neil Pearce, Sarah Rhodes, Karin van Veldhoven, Katie Stocking, Steve Robertson, Lucy Pembrey, Elizabeth B. Brickley, Vahe Nafilyan, Donna Davoren, Tony Fletcher, Ben Windsor-Shellard, Martie van Tongeren

“…For example, mortality data suffer from problems of coding of COVID-19 deaths, and the deaths (in England and Wales) that have been referred to the coroner are unavailable. …”
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Determining the Prevalence and Incidence of SARS-CoV-2 Infection in Prisons in England: Protocol for a Repeated Panel Survey and Enhanced Outbreak Study by Emma Plugge, Danielle Burke, Maciej Czachorowski, Kerry Gutridge, Fiona Maxwell, Nuala McGrath, Oscar O'Mara, Eamonn O'Moore, Julie Parkes

“… BackgroundThere are over 80,000 people imprisoned in England and Wales in 117 prisons. The management of the COVID-19 pandemic presents particular challenges in this setting where confined, crowded, and poorly ventilated conditions facilitate the rapid spread of infectious diseases. …”
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Clinical and cost-effectiveness of paramedic administered fascia iliaca compartment block for emergency hip fracture (RAPID 2)—protocol for an individually randomised parallel-grou... by Mark Kingston, Jenna Jones, Sarah Black, Bridie Evans, Simon Ford, Theresa Foster, Steve Goodacre, Marie-Louise Jones, Sian Jones, Leigh Keen, Mirella Longo, Ronan A. Lyons, Ian Pallister, Nigel Rees, Aloysius Niroshan Siriwardena, Alan Watkins, Julia Williams, Helen Wilson, Helen Snooks

“…Hospital clinicians in five sites (paired ambulance services and receiving hospitals) in England and Wales will train 220 paramedics to administer FICB. …”
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Attitudes towards coronavirus (COVID-19) vaccine and sources of information across diverse ethnic groups in the UK: a qualitative study from June to October 2020 by Leah Ffion Jones, Manish Pareek, Laura Nellums, Donna M Lecky, Ines Campos-Matos, Amy Thomas, Rowshonara Syeda, Colin S Brown, Cliodna McNulty, Atiya Kamal, Rashmi Shukla, Mahendra Patel, Eirwen Sides, Awatif Kaissi, Loretta Sollars, Jane Greenway, Emma Pawson

“…Data were transcribed and analysed through inductive thematic analysis and mapped to the Theoretical Domains Framework.Setting England and Wales.Participants 100 participants from 19 self-identified ethnic groups.Results Mistrust and doubt were reported across ethnic groups. …”
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