Effectiveness and cost-effectiveness of a web-based cardiac rehabilitation programme for people with chronic stable angina: protocol for the ACTIVATE (Angina Controlled Trial Inves... by Kate Jolly, Gregory Y H Lip, Ben Hardwick, Sally J Singh, Michael Fisher, Brendan Collins, Ian Jones, Susanna Dodd, Sophie Hennessy, Penelope Ralph, Nefyn H Williams, Dick Thijssen, Deirdre Lane, Terence J Comerford, Erica Morgan

“…The objectives of this study are to compare the effectiveness and cost-effectiveness of the ‘Activate Your Heart’ cardiac rehabilitation programme for people with chronic stable angina compared with usual care.Methods and analysis ACTIVATE is a multicentre, parallel-group, two-arm, superiority, pragmatic randomised controlled trial, with recruitment from primary and secondary care centres in England and Wales and a target sample size of 518 (1:1 allocation; allocation sequence by minimisation programme with built-in random element). …”
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Development of a Gas-Tight Syringe Headspace GC-FID Method for the Detection of Ethanol, and a Description of the Legal and Practical Framework for Its Analysis, in Samples of Engl... by Luke Taylor, Lili Saskőy, Tara Brodie, Vytautas Remeškevičius, Hannah Jayne Moir, James Barker, John Fletcher, Baljit Kaur Thatti, Gavin Trotter, Brian Rooney

“…The method has an expanded uncertainty at 99.73% confidence of 3.64% at 80 mg/100 mL, which is the blood alcohol limit for drink driving in England and Wales. In addition, at 200 mg%—the limit at which a custodial sentence may be imposed on the defendant—the expanded uncertainty was 1.95%. …”
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Improving our understanding of the social determinants of mental health: a data linkage study of mental health records and the 2011 UK census by Robert Stewart, Amelia Jewell, Matthew Hotopf, Jayati Das-Munshi, Megan Pritchard, Craig Morgan, Natasha Chilman, Michael Dewey, Lukasz Cybulski, Rosanna Hildersley, Rachel Huck, Milena Wuerth

“…Objectives To address the lack of individual-level socioeconomic information in electronic healthcare records, we linked the 2011 census of England and Wales to patient records from a large mental healthcare provider. …”
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The role of loneliness in the development of depressive symptoms among partnered dementia caregivers: Evidence from the English Longitudinal Study of Aging by J. P. Saadi, E. Carr, M. Fleischmann, E. Murray, J. Head, A. Steptoe, R. A. Hackett, B. Xue, D. Cadar

“…The sample consisted of 4,672 partnered adults aged 50–70 living in England and Wales, followed up between 2006–2007 and 2014–2015. …”
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Wealth, Families and Death: Socio-Legal Perspectives on Wills and Inheritance: Introduction by Daniel Monk, Daphna Hacker

“…This special issue, which brings together eight papers coming from six different countries (and eight different jurisdictions): Belgium, England and Wales, Israel, Spain (Catalonia and the Basque Country), Switzerland and the USA, demonstrates the breadth of inheritance as a field of study in a number of ways and at the same time opens up important new lines of enquiry. …”
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Association between opioid use during mechanical ventilation in preterm infants and evidence of brain injury: a propensity score-matched cohort studyResearch in context by Lisa Szatkowski, Don Sharkey, Helen Budge, Shalini Ojha

“…Methods: In this retrospective propensity score-matched cohort study, we used routinely recorded data from the National Neonatal Research Database to study infants born at 22–31 weeks gestational age who were admitted to neonatal units in England and Wales (between Jan 1, 2012, and Dec 31, 2020) and who were mechanically ventilated on one or more days during their hospital stay. …”
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Remote Consultations Versus Standard Face-to-Face Appointments for Liver Transplant Patients in Routine Hospital Care: Feasibility Randomized Controlled Trial of myVideoClinic by Sarah Damery, Janet Jones, Elaine O'Connell Francischetto, Kate Jolly, Richard Lilford, James Ferguson

“… BackgroundUsing technology to reduce the pressure on the National Health Service (NHS) in England and Wales is a key government target, and the NHS Long-Term Plan outlines a strategy for digitally enabled outpatient care to become mainstream by 2024. …”
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Protective Factors for Early Psychotic Phenomena Among Children of Mothers With Psychosis by Simon Riches, Simon Riches, Louise Arseneault, Raha Bagher-Niakan, Manar Alsultan, Eloise Crush, Helen L. Fisher

“…In the current study we investigate whether these factors also protect against the development of sub-clinical psychotic phenomena among children and adolescents in this cohort who are at high-risk of psychosis by having a mother with psychosis.Methods: Data were utilized from the E-Risk Longitudinal Twin Study, a nationally-representative cohort of 2,232 twin children born in England and Wales in 1994–1995 followed to age 18. Psychotic phenomena were assessed in private interviews with children at ages 12 and 18, and mothers were interviewed about their own experiences of psychosis when children were aged 10 and 12. …”
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Paramedic Acute Stroke Treatment Assessment (PASTA): study protocol for a randomised controlled trial by Christopher I. Price, Lisa Shaw, Peter Dodd, Catherine Exley, Darren Flynn, Richard Francis, Saiful Islam, Mehdi Javanbakht, Rachel Lakey, Joanne Lally, Graham McClelland, Peter McMeekin, Helen Rodgers, Helen Snooks, Louise Sutcliffe, Pippa Tyrell, Luke Vale, Alan Watkins, Gary A. Ford

“…Setting: National Health Service ambulance services, emergency departments and hyper-acute stroke units within three geographical regions of England and Wales. Randomisation: Ambulance stations within each region are the units of randomisation. …”
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Public views of and reactions to the COVID-19 pandemic in England: a qualitative study with diverse ethnicities by Leah Ffion Jones, Manish Pareek, Laura Nellums, Donna M Lecky, Ines Campos-Matos, Amy Thomas, Colin S Brown, Cliodna McNulty, Atiya Kamal, Rashmi Shukla, Mahendra Patel, Eirwen Sides, Rowshonara B Syeda, Awatif Kaissi, Loretta Sollars, Jane Greenway

“…Data were transcribed and analysed through inductive thematic analysis.Setting England and Wales, June to October 2020.Participants 100 participants from 19 diverse ‘self-identified’ ethnic groups.Results Dismay, frustration and altruism were reported across all ethnic groups during the first 6–9 months of the COVID-19 pandemic. …”
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Suicide in England in the COVID-19 pandemic: Early observational data from real time surveillance by Louis Appleby, Nicola Richards, Saied Ibrahim, Pauline Turnbull, Cathryn Rodway, Nav Kapur

“…Its aim is to promote quality improvement in patient outcomes, and in particular, to increase the impact that clinical audit, outcome review programs and registries have on healthcare quality in England and Wales. HQIP holds the contract to commission, manage, and develop the National Clinical Audit and Patient Outcomes Program (NCAPOP), comprising around 40 projects covering care provided to people with a wide range of medical, surgical and mental health conditions. …”
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Completeness, agreement, and representativeness of ethnicity recording in the United Kingdom’s Clinical Practice Research Datalink (CPRD) and linked Hospital Episode Statistics (HE... by Suhail I. Shiekh, Mia Harley, Rebecca E. Ghosh, Mark Ashworth, Puja Myles, Helen P. Booth, Eleanor L. Axson

“…Additionally, CPRD-HES was compared to the experimental ethnic distributions for England and Wales from the Office for National Statistics in 2019 (ONS2019) and the English ethnic distribution from May 2021 from NHS Digital’s General Practice Extraction Service Data for Pandemic Planning and Research with HES data linkage (GDPPR-HES). …”
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Salutogenesis: A sense of coherence and health among British military veterans exposed to impactful life challenges - the emergence of post-traumatic growth and positive deviance w... by Jacqueline Maria Dias, Muhammad Arsyad Subu, Nabeel Al-Yateem, Wegdan Bani-Issa, Fatma Refaat Ahmed, Mini Sara Abraham, Richard Mottershead, Mustafa Muhamad Habeb, Nafi Alonaizi

“…The life stories of 17 in-depth interviews were conducted across England and Wales, allowing for insight into the lived experiences of two life story trajectories of the health of military veterans. …”
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Use of the out-of-hours emergency dental service at two south-east London hospitals by Wright Desmond, Jones Kate, Austin Rupert, Donaldson Nora, Gallagher Jennifer E

“…<p>Abstract</p> <p>Background</p> <p>Prior to the introduction of the 2006 NHS dental contract in England and Wales, general dental practitioners (GDPs) were responsible for the provision of out-of-hours (OOH) emergency dental services (EDS); however there was great national variation in service provision. …”
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Evidence review group approaches to the critical appraisal of manufacturer submissions for the NICE STA process: a mapping study and thematic analysis by E Kaltenthaler, A Boland, C Carroll, R Dickson, P Fitzgerald, D Papaioannou

“…Background: The National Institute for Health and Clinical Excellence (NICE) single technology appraisal (STA) process was set up as a rapid way to appraise new technologies for use within the NHS in England and Wales and has been in place since 2005. Objectives: This study had five primary objectives: (1) to provide a map of the STA process to date; (2) to identify current approaches to the critical appraisal of manufacturers’ submissions (MSs) by Evidence Review Groups (ERGs); (3) to identify recurring themes in clarification letters sent to manufacturers; (4) to provide recommendations for possible alternative approaches to be used in the critical appraisal process; and (5) to revise the current ERG report template. …”
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Involving underrepresented groups: How unpaid carers influenced our data analysis by Anna Lawrence-Jones, Jodie Chan, Evgeniy Galimov, Roberto Fernandez Crespo, Sandeep Prashar, Clare McCrudden, Thomas Lewis, Shereen Aloysius, Jacob Oguntimehin, Rachel McCarthy, Helena Gavrielides, Melanie Leis, Alex Bottle, Matthew Chisambi

“… Objectives The recent census found that five million people in England and Wales provide unpaid care. With social services struggling, unpaid carers face increasing pressure. …”
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Influenza and respiratory virus surveillance, vaccine uptake, and effectiveness at a time of cocirculating COVID-19: Protocol for the English primary care Sentinel system for 2020-... by de Lusignan, S, Lopez Bernal, J, Byford, R, Amirthalingam, G, Ferreira, F, Akinyemi, O, Andrews, N, Campbell, H, Dabrera, G, Deeks, A, Elliot, AJ, Krajenbrink, E, Liyanage, H, McGagh, D, Okusi, C, Parimalanathan, V, Ramsay, M, Smith, G, Tripathy, M, Williams, J, Victor, W, Zambon, M, Howsam, G, Nicholson, BD, Tzortziou Brown, V, Butler, CC, Joy, M, Hobbs, FDR

“…<br> <strong>Methods:</strong> The RCGP RSC network comprises over 1700 general practices in England and Wales. We will extract pseudonymized data twice weekly and are migrating to a system of daily extracts. …”

The meaning in grandiose delusions: measure development and cohort studies in clinical psychosis and non-clinical general population groups in the UK and Ireland by Isham, L, Loe, BS, Hicks, A, Wilson, N, Bird, JC, Bentall, RP, Freeman, D

“…<p><strong>Methods</strong></p> We did a cross-sectional self-report questionnaire study in two cohorts: non-clinical participants aged 18 years and older, with UK or Irish nationality or residence; and patients with affective or non-affective psychosis diagnoses, aged 16 years and older, and accessing secondary care mental health services in 39 National Health Service providers in England and Wales. Participants with high grandiosity completed two large item pools: one assessing the experience of meaning in grandiose delusions (Grandiosity Meaning Measure [termed gram]) and one assessing the sources of meaning (Grandiosity Meaning Measure–Sources [termed grams]). …”

The UK stand together trial: protocol for a multicentre cluster randomised controlled trial to evaluate the effectiveness and cost-effectiveness of KiVa to reduce bullying in prima... by Clarkson, S, Bowes, L, Coulman, E, Broome, MR, Cannings-John, R, Charles, JM, Edwards, RT, Ford, T, Hastings, RP, Hayes, R, Patterson, P, Segrott, J, Townson, J, Watkins, R, Badger, J, Hutchings, J

“…Our integrated process evaluation will assess implementation fidelity, identify influences on KiVa implementation across England and Wales and examine intervention mechanisms. …”

Uneven Adherence to Professional Guidelines and Potential Ethnic Bias in Service Provision Evidenced in Virtual Reference Service Interactions by Scott Goldstein

“…The messages were signed with one of six names representing the largest distinct ethnic population groups in England and Wales: Hazel Oakland (White British), Natasza Sakowicz (White Other), Zhao Jinghua (North Asian), Priya Chakrabarti (South Asian), Ebunoluwa Nweke (Black African), and Aaliyah Hajjar (Arab). …”
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