The clinical effectiveness and cost-effectiveness of the PROGENSA® prostate cancer antigen 3 assay and the Prostate Health Index in the diagnosis of prostate cancer: a systematic r... by Amanda Nicholson, James Mahon, Angela Boland, Sophie Beale, Kerry Dwan, Nigel Fleeman, Juliet Hockenhull, Yenal Dundar

“…Setting: The perspective of the evaluation was the NHS in England and Wales. Participants: Men suspected of having prostate cancer for whom the results of an initial prostate biopsy were negative or equivocal. …”
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Cross-national mixed-methods comparative case study of recovery-focused mental health care planning and co-ordination in acute inpatient mental health settings (COCAPP-A) by Alan Simpson, Michael Coffey, Ben Hannigan, Sally Barlow, Rachel Cohen, Aled Jones, Alison Faulkner, Alexandra Thornton, Jitka Všetečková, Mark Haddad, Karl Marlowe

“…Design: A cross-national comparative mixed-methods study involving 19 mental health wards in six NHS sites in England and Wales included a metanarrative synthesis of policies and literature; a survey of service users (n = 301) and staff (n = 290); embedded case studies involving interviews with staff, service users and carers (n = 76); and a review of care plans (n = 51) and meetings (n = 12). …”
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Health and social care services for older male adults in prison: the identification of current service provision and piloting of an assessment and care planning model by J Senior, K Forsyth, E Walsh, K O'Hara, C Stevenson, A Hayes, V Short, R Webb, D Challis, S Fazel, A Burns, J Shaw

“…Methods: The research programme was a mixed-methods study comprising four parts: (1) a study of all prisons in England and Wales housing older adult men, establishing current availability and degree of integration between health and social care services through a national survey and qualitative interviews; (2) establishing the health and social care needs of older men entering prison, including experiences of reception into custody, through structured (n = 100) and semistructured (n = 27) interviews; (3) the development and implementation of an intervention to identify and manage the health, social care and custodial needs of older men entering prison; and (4) exploration of the health and social care needs of older men released from prison into the community through qualitative interviews with older prisoners prior to and following discharge from prison. …”
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The IMPROVE trial: study protocol for a pragmatic cluster randomised controlled trial to assess the effectiveness of using lay health workers to improve uptake and completion of pu... by Gill Gilworth, Katherine Harris, Toby L. Morgan, Salma Ayis, Julia Fox-Rushby, Emma Godfrey, Nicholas S. Hopkinson, Simon Lewin, Ka Keat Lim, Arietta Spinou, Stephanie J. C. Taylor, Patrick White

“…Methods The IMPROVE trial is a pragmatic, open, cluster randomised controlled trial planned in 38 PR services across England and Wales. PR services will be randomised to either intervention arm—offering support from PR buddies to patients with chronic obstructive pulmonary disease—or to usual care as the control arm. …”
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The contribution of unstable housing to HIV and hepatitis C virus transmission among people who inject drugs globally, regionally, and at country level: a modelling study by Jack Stone, PhD, Adelina Artenie, PhD, Matthew Hickman, ProfPhD, Natasha K Martin, ProfDPhil, Louisa Degenhardt, ProfPhD, Hannah Fraser, PhD, Peter Vickerman, ProfDPhil

“…Country-level tPAFs were strongly associated with the prevalence of unstable housing. tPAFs were greater in high-income countries (HIV 17·2% [95% CrI 5·1–30·0]; HCV 19·4% [95% CrI 13·8–26·0]) than in low-income or middle-income countries (HIV 6·6% [95% CrI 1·8–13·1]; HCV 8·3% [95% CrI 5·5–11·7]). tPAFs for HIV and HCV were highest in Afghanistan, Czech Republic, India, USA, England, and Wales where unstable housing contributed more than 20% of new HIV and HCV infections. …”
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STOP— a training intervention to optimise treatment for smoking cessation in community pharmacies: cluster randomised controlled trial by Sandra Jumbe, Vichithranie W. Madurasinghe, Wai Yee James, Colin Houlihan, Samantha L. Jumbe, Tammy Yau, Florian Tomini, Sandra Eldridge, Borislava Mihaylova, Liz Steed, Ratna Sohanpal, Darush Attar, Stephanie J. C. Taylor, Chris Griffiths, Robert Walton

“…Methods We randomised 60 pharmacies in England and Wales to the STOP intervention or usual practice in a pragmatic, parallel-group, controlled trial over 11 months. …”
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Harmonising electronic health records for reproducible research: challenges, solutions and recommendations from a UK-wide COVID-19 research collaboration by Hoda Abbasizanjani, Fatemeh Torabi, Stuart Bedston, Thomas Bolton, Gareth Davies, Spiros Denaxas, Rowena Griffiths, Laura Herbert, Sam Hollings, Spencer Keene, Kamlesh Khunti, Emily Lowthian, Jane Lyons, Mehrdad A. Mizani, John Nolan, Cathie Sudlow, Venexia Walker, William Whiteley, Angela Wood, Ashley Akbari, CVD-COVID-UK/COVID-IMPACT Consortium

“…Here we describe the reproducible harmonisation method developed using large-scale EHRs in Wales to accommodate the fast and efficient implementation of cross-nation analysis in England and Wales as part of the CVD-COVID-UK programme. …”
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The privatisation of non-custodial measures: an uneasy balance between legitimacy and immediacy by Alison Hogg

“…The use of these in the United States, Canada, England and Wales, Sweden and Spain is briefly overviewed as well as the contribution of the private sector. …”
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The care of dying people in nursing homes and intensive care units: a qualitative mixed-methods study by Elizabeth Perkins, Maureen Gambles, Rachel Houten, Sheila Harper, Alan Haycox, Terri O’Brien, Sarah Richards, Hong Chen, Kate Nolan, John E Ellershaw

“…Background: In England and Wales the two most likely places of death are hospitals (52%) and nursing homes (22%). …”
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A mixed methods analysis of lithium-related patient safety incidents in primary care by Richard Simon Young, Paul Deslandes, Jennifer Cooper, Huw Williams, Joyce Kenkre, Andrew Carson-Stevens

“…Data from healthcare organisations in England and Wales were extracted from the NRLS database. …”
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Development of a social inclusion index to capture subjective and objective life domains (Phase II): psychometric development study by P Huxley, S Evans, S Madge, M Webber, T Burchardt, D McDaid, M Knapp

“…Participants: The community sample was randomly selected from the postal address file in five areas in England and Wales. Forty people in this sample were subgrouped as having a CMD based on their responses to the Mental Health Index five items. …”
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Recruiting care homes to a randomised controlled trial by Alison Ellwood, Jennifer Airlie, Robert Cicero, Bonnie Cundill, David R Ellard, Amanda Farrin, Mary Godfrey, Liz Graham, John Green, Vicki McLellan, Najma Siddiqi, Anne Forster, On behalf of the REACH Programme Team

“…Abstract Background There are more than a quarter of a million individuals aged ≥ 65 years who are resident in care homes in England and Wales. Care home residents have high levels of cognitive impairment, physical disability, multimorbidity and polypharmacy. …”
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Understanding approaches to continence care for people living with dementia in acute hospital settings: an ethnographic study by Katie Featherstone, Andy Northcott, Paula Boddington, Deborah Edwards, Sofia Vougioukalou, Sue Bale, Karen Harrison Dening, Karen Logan, Rosie Tope, Daniel Kelly, Aled Jones, Jackie Askey, Jane Harden

“…Setting: This ethnography was carried out for 180 days, across 12 months, in six wards in three hospitals across England and Wales that were purposefully selected to represent a range of hospital types, geographies and socioeconomic catchments. …”
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The UK stand together trial: protocol for a multicentre cluster randomised controlled trial to evaluate the effectiveness and cost-effectiveness of KiVa to reduce bullying in prima... by Suzy Clarkson, Lucy Bowes, Elinor Coulman, Matthew R. Broome, Rebecca Cannings-John, Joanna M. Charles, Rhiannon Tudor Edwards, Tamsin Ford, Richard P. Hastings, Rachel Hayes, Paul Patterson, Jeremy Segrott, Julia Townson, Richard Watkins, Julia Badger, Judy Hutchings, the Stand Together Team

“…Our integrated process evaluation will assess implementation fidelity, identify influences on KiVa implementation across England and Wales and examine intervention mechanisms. …”
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Adaptation and multicentre validation of a patient-centred outcome scale for people severely ill with COVID (IPOS-COV) by Mevhibe B. Hocaoglu, Fliss E. M. Murtagh, Catherine Walshe, Rachel L. Chambers, Matthew Maddocks, Katherine E. Sleeman, Adejoke O. Oluyase, Lesley Dunleavy, Andy Bradshaw, Sabrina Bajwah, Lorna K. Fraser, Nancy Preston, Irene J. Higginson, the CovPall study team

“…Data from 572 patients with COVID from across England and Wales seen by palliative care services were included. …”
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Bayesian spatial modelling for quasi-experimental designs: An interrupted time series study of the opening of Municipal Waste Incinerators in relation to infant mortality and sex r... by A. Freni-Sterrantino, R.E. Ghosh, D. Fecht, M.B. Toledano, P. Elliott, A.L. Hansell, M. Blangiardo

“…Methods: We specified a Bayesian hierarchical model to investigate the annual risks of infant mortality and sex-ratio (female relative to male) within 10 km of eight MWIs in England and Wales, during the period 1996–2012. We included comparative areas matched one-to-one of similar size and area characteristics. …”
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The clinical and cost-effectiveness of stratified care for patients with sciatica: the SCOPiC randomised controlled trial protocol (ISRCTN75449581) by Nadine E. Foster, Kika Konstantinou, Martyn Lewis, Reuben Ogollah, Kate M. Dunn, Danielle van der Windt, Ruth Beardmore, Majid Artus, Bernadette Bartlam, Jonathan C. Hill, Sue Jowett, Jesse Kigozi, Christian Mallen, Benjamin Saunders, Elaine M. Hay

“…We will recruit 470 adult patients with sciatica from general practices in England and Wales, over 24 months. Patients will be randomised to stratified care or non-stratified care, and treated in physiotherapy and spinal specialist services, in participating NHS services. …”
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Health and social care services for older male adults in prison: the identification of current service provision and piloting of an assessment and care planning model by J Senior, K Forsyth, E Walsh, K O'Hara, C Stevenson, A Hayes, V Short, R Webb, D Challis, S Fazel, A Burns, J Shaw

“…Methods: The research programme was a mixed-methods study comprising four parts: (1) a study of all prisons in England and Wales housing older adult men, establishing current availability and degree of integration between health and social care services through a national survey and qualitative interviews; (2) establishing the health and social care needs of older men entering prison, including experiences of reception into custody, through structured (n = 100) and semistructured (n = 27) interviews; (3) the development and implementation of an intervention to identify and manage the health, social care and custodial needs of older men entering prison; and (4) exploration of the health and social care needs of older men released from prison into the community through qualitative interviews with older prisoners prior to and following discharge from prison. …”
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A multi-centre, pragmatic, three-arm, individually randomised, non-inferiority, open trial to compare immediate orally administered, immediate topically administered or delayed ora... by Kathryn Curtis, Michael Moore, Christie Cabral, Vasa Curcin, Jeremey Horwood, Richard Morris, Vibhore Prasad, Anne Schilder, Nicholas Turner, Scott Wilkes, Alastair D. Hay, Jodi Taylor

“…Abstract Background Acute otitis media (AOM) is a common painful infection in children, with around 2.8 million cases presenting to primary care in England and Wales annually. Nearly all children who present to their general practitioner (GP) with AOM or AOM with discharge (AOMd) are treated with orally administered antibiotics. …”
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Protocol for Take-home naloxone In Multicentre Emergency (TIME) settings: feasibility study by Matthew Jones, Fiona Bell, Jonathan Benger, Sarah Black, Penny Buykx, Simon Dixon, Tim Driscoll, Bridie Evans, Adrian Edwards, Gordon Fuller, Steve Goodacre, Rebecca Hoskins, Jane Hughes, Ann John, Jenna Jones, Chris Moore, Fiona Sampson, Alan Watkins, Helen Snooks

“…Available from: http://www.unodc.org/wdr2018/ ; Deaths related to drug poisoning in England and Wales - Office for National Statistics [Internet]. …”
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