The clinical effectiveness and cost-effectiveness of second-eye cataract surgery: a systematic review and economic evaluation by Geoff Frampton, Petra Harris, Keith Cooper, Andrew Lotery, Jonathan Shepherd

“…Objective: To conduct a systematic review of clinical effectiveness and analysis of cost-effectiveness of second-eye cataract surgery in England and Wales, based on an economic model informed by systematic reviews of cost-effectiveness and quality of life. …”
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The role of digital communication in patient-clinician communication for NHS providers of specialist clinical services for young people [the Long-term conditions Young people Netwo... by Griffiths, F, Armoiry, X, Atherton, H, Bryce, C, Buckle, A, Cave, J, Court, R, Hamilton, K, Dliwayo, T, Dritsaki, M, Elder, P, Forjaz, V, Fraser, J, Goodwin, R, Huxley, C, Ignatowicz, A, Karasouli, E, Kim, S, Kimani, P, Madan, J, Matharu, H, May, M, Musumadi, L, Paul, M, Raut, G, Sankaranarayanan, S, Slowther, A, Sujan, M, Sutcliffe, P, Svahnstrom, I, Taggart, F, Uddin, A, Verran, A, Walker, L, Sturt, J

“…<strong>Setting</strong> Twenty NHS specialist clinical teams from across England and Wales, providing care for 13 different long term physical or mental health conditions. …”

A novel peer-support intervention using motivational interviewing for breastfeeding maintenance: a UK feasibility study by Paranjothy, S, Copeland, L, Merrett, L, Grant, A, Phillips, R, Gobat, N, Sanders, J, Fitzsimmons, D, Hunter, B, Regan, S, Playle, R, Brown, A, Tedstone, S, Trickey, H, Robling, M

“…</p> <h4>Setting</h4> <p>Community maternity services in three areas with high levels of social deprivation and low breastfeeding initiation rates in England and Wales.</p> <h4>Participants</h4> <p>Pregnant women considering breastfeeding. …”

Cancer risk in children born after donor ART by Williams, CL, Bunch, KJ, Murphy, MFG, Stiller, CA, Botting, BJ, Wallace, WH, Davies, MC, Sutcliffe, AG

“…The work of the Childhood Cancer Research Group (CCRG) was supported by the charity CHILDREN with CANCER UK, the National Cancer Intelligence Network, the Scottish Government and the Department of Health for England and Wales. There are no competing interests. <br/><br/> <strong>TRIAL REGISTRATION NUMBER</strong> N/A.…”

Changes in health in the countries of the UK and 150 English Local Authority areas 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016 by Steel, N, Ford, JA, Newton, JN, Davis, ACJ, Vos, T, Naghavi, M, Glenn, S, Hughes, A, Dalton, AM, Stockton, D, Humphreys, C, Dallat, M, Schmidt, J, Flowers, J, Fox, S, Abubakar, I, Aldridge, RW, Baker, A, Brayne, C, Brugha, T, Capewell, S, Car, J, Cooper, C, Ezzati, M, Fitzpatrick, J, Greaves, F, Hay, R, Hay, S, Kee, F, Larson, HJ, Lyons, RA, Majeed, A, McKee, M, Rawaf, S, Rutter, H, Saxena, S, Sheikh, A, Smeeth, L, Viner, RM, Vollset, SE, Williams, HC, Wolfe, C, Woolf, A, Murray, CJL

“…</p> <h4>Methods</h4> <p>We extracted data from the GBD 2016 to estimate years of life lost (YLLs), years lived with disability (YLDs), disability-adjusted life-years (DALYs), and attributable risks from 1990 to 2016 for England, Scotland, Wales, Northern Ireland, the UK, and 150 English Upper-Tier Local Authorities. …”

Mercaptopurine versus placebo to prevent recurrence of Crohn's disease after surgical resection (TOPPIC): a multicentre, double-blind, randomised controlled trial by Mowat, C, Arnott, I, Cahill, A, Smith, M, Ahmad, T, Subramanian, S, Travis, S, Morris, J, Hamlin, J, Dhar, A, Nwokolo, C, Edwards, C, Creed, T, Bloom, S, Yousif, M, Thomas, L, Campbell, S, Lewis, S, Sebastian, S, Sen, S, Lal, S, Hawkey, C, Murray, C, Cummings, F, Goh, J, Lindsay, J, Arebi, N, Potts, L, McKinley, A, Thomson, J, Todd, J, Collie, M, Dunlop, M, Mowat, A, Gaya, D, Winter, J, Naismith, G, Ennis, H, Keerie, C, Lewis, S, Prescott, R, Kennedy, N, Satsangi, J, TOPPIC Study Group

“…</p><p> METHODS: We did a randomised, placebo-controlled, double-blind trial at 29 UK secondary and tertiary hospitals of patients (aged &gt;16 years in Scotland or &gt;18 years in England and Wales) who had a confirmed diagnosis of Crohn's disease and had undergone intestinal resection. …”

A Delphi consensus statement for digital surgery by Kyle Lam, Michael D. Abràmoff, José M. Balibrea, Steven M. Bishop, Richard R. Brady, Rachael A. Callcut, Manish Chand, Justin W. Collins, Markus K. Diener, Matthias Eisenmann, Kelly Fermont, Manoel Galvao Neto, Gregory D. Hager, Robert J. Hinchliffe, Alan Horgan, Pierre Jannin, Alexander Langerman, Kartik Logishetty, Amit Mahadik, Lena Maier-Hein, Esteban Martín Antona, Pietro Mascagni, Ryan K. Mathew, Beat P. Müller-Stich, Thomas Neumuth, Felix Nickel, Adrian Park, Gianluca Pellino, Frank Rudzicz, Sam Shah, Mark Slack, Myles J. Smith, Naeem Soomro, Stefanie Speidel, Danail Stoyanov, Henry S. Tilney, Martin Wagner, Ara Darzi, James M. Kinross, Sanjay Purkayastha

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Multiplex tests to identify gastrointestinal bacteria, viruses and parasites in people with suspected infectious gastroenteritis: a systematic review and economic analysis by Karoline Freeman, Hema Mistry, Alexander Tsertsvadze, Pam Royle, Noel McCarthy, Sian Taylor-Phillips, Rohini Manuel, James Mason

“…Objective: To systematically review the evidence for GPP tests [xTAG® (Luminex, Toronto, ON, Canada), FilmArray (BioFire Diagnostics, Salt Lake City, UT, USA) and Faecal Pathogens B (AusDiagnostics, Beaconsfield, NSW, Australia)] and to develop a de novo economic model to compare the cost-effectiveness of GPP tests with conventional testing in England and Wales. Data sources: Multiple electronic databases including MEDLINE, EMBASE, Web of Science and the Cochrane Database were searched from inception to January 2016 (with supplementary searches of other online resources). …”
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Using nationwide ‘big data’ from linked electronic health records to help improve outcomes in cardiovascular diseases: 33 studies using methods from epidemiology, informatics, econ... by Harry Hemingway, Gene S Feder, Natalie K Fitzpatrick, Spiros Denaxas, Anoop D Shah, Adam D Timmis

“…Setting: 230 NHS hospitals and 226 general practices in England and Wales. Participants: Up to 2 million initially healthy adults, 100,000 people with stable coronary artery disease (SCAD) and up to 300,000 patients with acute coronary syndrome. …”
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A novel peer-support intervention using motivational interviewing for breastfeeding maintenance: a UK feasibility study by Shantini Paranjothy, Lauren Copeland, Laura Merrett, Aimee Grant, Rhiannon Phillips, Nina Gobat, Julia Sanders, Deborah Fitzsimmons, Billie Hunter, Sian Regan, Rebecca Playle, Amy Brown, Sally Tedstone, Heather Trickey, Mike Robling

“…Setting: Community maternity services in three areas with high levels of social deprivation and low breastfeeding initiation rates in England and Wales. Participants: Pregnant women considering breastfeeding. …”
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Talking in primary care (TIP): protocol for a cluster-randomised controlled trial in UK primary care to assess clinical and cost-effectiveness of communication skills e-learning fo... by Christian Mallen, Jennifer Bostock, Taeko Becque, Beth Stuart, Jeremy Howick, Jane Vennik, Paul Little, Matthew J Ridd, Kirsty Garfield, Paul H Lee, Helen Atherton, Felicity L Bishop, Nazrul Islam, Michelle E Robinson, Geraldine M Leydon, Emma Teasdale, Jacqui Nuttall, Leanne Morrison, Lorna Clarson, Hazel A Everitt, Amy Herbert, Nadia Cross, Rachel Dewar-Haggart, Sebastien Pollet

“…This paper presents the protocol for determining the effectiveness and cost-effectiveness of a rigorously developed brief eLearning tool, EMPathicO, among patients with and without musculoskeletal pain.Methods and analysis A cluster randomised controlled trial in general practitioner (GP) surgeries in England and Wales serving patients from diverse geographic, socioeconomic and ethnic backgrounds. …”
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Assessment of short-term heat effects on cardiovascular mortality and vulnerability factors using small area data in Europe by Siqi Zhang, Susanne Breitner, Masna Rai, Nikolaos Nikolaou, Massimo Stafoggia, Francesca de' Donato, Evangelia Samoli, Sofia Zafeiratou, Klea Katsouyanni, Shilpa Rao, Alfonso Diz-Lois Palomares, Antonio Gasparrini, Pierre Masselot, Kristin Aunan, Annette Peters, Alexandra Schneider

“…Methods: We collected daily counts of CVD deaths aggregated at the small-area level in Norway (small-area level: municipality), England and Wales (lower super output areas), and Germany (district) during the warm season (May-September) from 1996 to 2018. …”
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The effectiveness of the Older prisoner Health and Social Care Assessment and Plan (OHSCAP): a randomised controlled trial by Katrina Forsyth, Laura Archer-Power, Jane Senior, Rachel Meacock, Roger Webb, Richard Emsley, Dawn Edge, Elizabeth Walsh, Stuart Ware, David Challis, Adrian Hayes, Kate O’Hara, Alistair Burns, Jenny Shaw

“…Background: Older people are the fastest-growing group in prisons in England and Wales and have complex health and social care needs that often remain unmet. …”
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Evaluation of Array Comparative genomic Hybridisation in prenatal diagnosis of fetal anomalies: a multicentre cohort study with cost analysis and assessment of patient, health prof... by Stephen C Robson, Lyn S Chitty, Stephen Morris, Talitha Verhoef, Gareth Ambler, Diana G Wellesley, Ruth Graham, Claire Leader, Jane Fisher, John A Crolla

“…Setting: A total of 20 fetal medicine units and nine cytogenetic laboratories across England and Wales. Participants: Women with a fetus undergoing quantitative fluorescent polymerase chain reaction (QF-PCR) and karyotyping for clinical indications with (1) one or more structural anomalies identified on ultrasound or (2) an isolated nuchal translucency (NT) of ≥ 3.5 mm. …”
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The effect of statins on muscle symptoms in primary care: the StatinWISE series of 200 N-of-1 RCTs by Emily Herrett, Elizabeth Williamson, Kieran Brack, Alexander Perkins, Andrew Thayne, Haleema Shakur-Still, Ian Roberts, Danielle Prowse, Danielle Beaumont, Zahra Jamal, Ben Goldacre, Tjeerd van Staa, Thomas M MacDonald, Jane Armitage, Michael Moore, Maurice Hoffman, Liam Smeeth

“…Setting: Participants were recruited from 50 general practices in England and Wales. Participants: Patients who were considering discontinuing statin use and those who had discontinued statin use in the last 3 years because of perceived muscle symptoms. …”
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Singapore’s judicial system (experience in the 2020 pandemic) by А.S. Slabospitsky

“…Access to justice – Final Report to the Lord Chancellor on the civil justice system in England and Wales. London, 1996 https://www.goodreads.com/book/show/1632182.Access_to_Justice. …”
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Lenvatinib and sorafenib for differentiated thyroid cancer after radioactive iodine: a systematic review and economic evaluation by Nigel Fleeman, Rachel Houten, Adrian Bagust, Marty Richardson, Sophie Beale, Angela Boland, Yenal Dundar, Janette Greenhalgh, Juliet Hounsome, Rui Duarte, Aditya Shenoy

“…Background: Thyroid cancer is a rare cancer, accounting for only 1% of all malignancies in England and Wales. Differentiated thyroid cancer (DTC) accounts for ≈94% of all thyroid cancers. …”
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Behavioural activation versus guided self-help for depression in adults with learning disabilities: the BeatIt RCT by Andrew Jahoda, Richard Hastings, Chris Hatton, Sally-Ann Cooper, Nicola McMeekin, Dave Dagnan, Kim Appleton, Katie Scott, Lauren Fulton, Robert Jones, Alex McConnachie, Rachel Zhang, Rosie Knight, Dawn Knowles, Christopher Williams, Andy Briggs, Craig Melville

“…Setting: Participants were recruited from community learning disability teams and services and from Improving Access to Psychological Therapies services in Scotland, England and Wales. Participants: Participants were aged ≥ 18 years, with clinically significant depression, assessed using the Diagnostic Criteria for Psychiatric Disorders for use with Adults with Learning Disabilities. …”
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Developing a model of mental health self-care support for children and young people through an integrated evaluation of available types of provision involving systematic review, me... by Steven Pryjmachuk, Rebecca Elvey, Susan Kirk, Sarah Kendal, Peter Bower, Roger Catchpole

“…Setting: Global (systematic reviews); England and Wales (mapping exercise and case study). Participants (case study): Fifty-two individuals (17 CYP, 16 family members and 19 staff) were interviewed across six sites. …”
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Identification of heart failure hospitalization from NHS Digital data: comparison with expert adjudication by Fardad Soltani, Joshua Bradley, Antonio Bonandi, Nicholas Black, John P. Farrant, Adam Pailing, Christopher Orsborne, Simon G. Williams, Erik B. Schelbert, Susanna Dodd, Richard Williams, Niels Peek, Matthias Schmitt, Theresa McDonagh, Christopher A. Miller

“…Three code sets commonly used to identify HHF were applied to the data and compared with expert adjudication (I50: International Classification of Diseases‐10 codes beginning I50; OIS: Clinical Commissioning Groups Outcomes Indicator Set; and NICOR: National Institute for Cardiovascular Outcomes Research, used as the basis for the National Heart Failure Audit in England and Wales). Five hundred four patients underwent expert adjudication, of which 10 (2%) were adjudicated to have experienced HHF. …”
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