Outcomes after metal-on-metal hip revision surgery depend on the reason for failure: a propensity score matched study by Matharu, G, Judge, A, Murray, D, Pandit, H

“…</p><p> Methods: This retrospective observational study involved all patients undergoing MoMHR from the National Joint Registry (NJR) for England and Wales subsequently revised for any indication between 2008 and 2014. …”

Planned delivery for pre-eclampsia between 34 and 37 weeks of gestation: the PHOENIX RCT by Chappell, LC, Brocklehurst, P, Green, M, Hardy, P, Hunter, R, Beardmore-Gray, A, Bowler, U, Brockbank, A, Chiocchia, V, Cox, A, Duhig, K, Fleminger, J, Gill, C, Greenland, M, Hendy, E, Kennedy, A, Leeson, P, Linsell, L, McCarthy, FP, O'Driscoll, J, Placzek, A, Poston, L, Robson, S, Rushby, P, Sandall, J, Scholtz, L, Seed, PT, Sparkes, J, Stanbury, K, Tohill, S, Thilaganathan, B, Townend, J, Juszczak, E, Marlow, N, Shennan, A

“…Methods We undertook an individually randomised, triple non-masked controlled trial in 46 maternity units across England and Wales, with an embedded health economic evaluation, comparing planned delivery and expectant management (usual care) in women with late preterm pre-eclampsia. …”

Heparin versus citrate anticoagulation for continuous renal replacement therapy in intensive care: the RRAM observational study by Gould, DW, Doidge, J, Sadique, MZ, Borthwick, M, Hatch, R, MacEwen, C, Young, JD, Watkinson, P

“…</p> <p><strong>Setting:</strong>&nbsp;The setting was NHS adult general intensive care units in England and Wales.</p> <p><strong>Participants:</strong>&nbsp;Participants were adults receiving continuous renal replacement therapy in an intensive care unit participating in the Intensive Care National Audit &amp; Research Centre Case Mix Programme national clinical audit between 1 April 2009 and 31 March 2017.…”

Written information for patients (or parents of child patients) to reduce the use of antibiotics for acute upper respiratory tract infections in primary care by O'Sullivan, JW, Harvey, RT, Glasziou, PP, McCullough, A

“…Both studies only recruited children with acute URTIs (adults were not involved in either study): 558 children from 61 general practices in England and Wales; and 269 primary care doctors who provided data on 33,792 patient-doctor consultations in Kentucky, USA. …”

A national registry to assess the value of cardiovascular magnetic resonance imaging after primary percutaneous coronary intervention pathway activation: a feasibility cohort study by Jessica M Harris, Rachel C Brierley, Maria Pufulete, Chiara Bucciarelli-Ducci, Elizabeth A Stokes, John P Greenwood, Stephen H Dorman, Richard A Anderson, Chris A Rogers, Sarah Wordsworth, Sunita Berry, Barnaby C Reeves

“…Setting: Four 24/7 PPCI hospitals in England and Wales (two with and two without a dedicated CMR facility). …”
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Enzyme-linked immunosorbent assays for monitoring TNF-alpha inhibitors and antibody levels in people with rheumatoid arthritis: a systematic review and economic evaluation by Irina A Tikhonova, Huiqin Yang, Segun Bello, Andrew Salmon, Sophie Robinson, Mohsen Rezaei Hemami, Sophie Dodman, Andriy Kharechko, Richard C Haigh, Meghna Jani, Timothy J McDonald, Martin Hoyle

“…Conclusions: Based on the available evidence, no firm conclusions could be made about the cost-effectiveness of therapeutic drug monitoring in England and Wales. Future work: Further controlled trials are required to assess the impact of using enzyme-linked immunosorbent assays for monitoring the anti-tumour necrosis factors in people with rheumatoid arthritis. …”
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The effectiveness and cost-effectiveness of donepezil, galantamine, rivastigmine and memantine for the treatment of Alzheimer’s disease (review of Technology Appraisal No. 111): a... by M Bond, G Rogers, J Peters, R Anderson, M Hoyle, A Miners, T Moxham, S Davis, P Thokala, A Wailoo, M Jeffreys, C Hyde

“…Objectives: Review and update guidance to the NHS in England and Wales on the clinical effectiveness and cost-effectiveness of donepezil, galantamine, rivastigmine [acetylcholinesterase inhibitors (AChEIs)] and memantine within their licensed indications for the treatment of AD, which was issued in November 2006 (amended September 2007 and August 2009). …”
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Impact on alcohol selection and online purchasing of changing the proportion of available non-alcoholic versus alcoholic drinks: A randomised controlled trial by Natasha Clarke, Anna K. M. Blackwell, Jennifer Ferrar, Katie De-Loyde, Mark A. Pilling, Marcus R. Munafò, Theresa M. Marteau, Gareth J. Hollands

“…<h4>Methods and results</h4> Adults (n = 737) residing in England and Wales who regularly purchased alcohol online were recruited between March and July 2021. …”
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Potential effects of minimum unit pricing at local authority level on alcohol-attributed harms in North West and North East England: a modelling study by Alan Brennan, Colin Angus, Robert Pryce, Penny Buykx, Madeleine Henney, Duncan Gillespie, John Holmes, Petra S Meier

“…Previous modelling estimated the impact of minimum unit pricing for England, Scotland, Wales and Northern Ireland. Decision-makers want to know the potential effects of minimum unit pricing for local authorities in England; the premise of this study is that estimated effects of minimum unit pricing would vary by locality. …”
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Best-practice prevention alone or with conventional or biological caries management for 3- to 7-year-olds: the FiCTION three-arm RCT by Anne Maguire, Jan E Clarkson, Gail VA Douglas, Vicky Ryan, Tara Homer, Zoe Marshman, Elaine McColl, Nina Wilson, Luke Vale, Mark Robertson, Alaa Abouhajar, Richard D Holmes, Ruth Freeman, Barbara Chadwick, Christopher Deery, Ferranti Wong, Nicola PT Innes

“…Setting: This trial was set in primary dental care in Scotland, England and Wales. Participants: Participants were NHS patients aged 3–7 years who were at a high risk of tooth decay and had at least one primary molar tooth with decay into dentine, but no pain/sepsis. …”
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Developing a serocorrelate of protection against invasive group B streptococcus disease in pregnant women: a feasibility study by Clara Carreras-Abad, Madeleine Cochet, Tom Hall, Laxmee Ramkhelawon, Asma Khalil, Elisabeth Peregrine, Latha Vinayakarao, Sharmila Sivarajan, Rosol Hamid, Tim Planche, Elizabeth Sheridan, Stephen Winchester, Jane Plumb, Abdelmajid Djennad, Nick Andrews, Kirsty Le Doare, Paul Heath

“…National iGBS disease surveillance was conducted in all trusts in England and Wales. Participants: Pregnant women aged ≥ 18 years who were delivering at one of the selected hospitals and who provided consent during the study period. …”
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Prognostic models of survival in patients with advanced incurable cancer: the PiPS2 observational study by Patrick Stone, Anastasia Kalpakidou, Chris Todd, Jane Griffiths, Vaughan Keeley, Karen Spencer, Peter Buckle, Dori-Anne Finlay, Victoria Vickerstaff, Rumana Z Omar

“…Setting: Community, hospital and hospice palliative care services across England and Wales. Participants: For the validation study, the participants were adults with incurable cancer, with or without capacity to consent, who had been recently referred to palliative care services and had sufficient English language. …”
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Platelet-rich plasma injection for adults with acute Achilles tendon rupture: the PATH-2 RCT by Joseph Alsousou, David J Keene, Paul Harrison, Philippa Hulley, Susan Wagland, Jacqueline Y Thompson, Scott R Parsons, Christopher Byrne, Michael M Schlüssel, Heather M O’Connor, Susan J Dutton, Sarah E Lamb, Keith Willett

“…Setting: This trial was set in trauma and orthopaedic surgery departments in 19 NHS hospitals in England and Wales. Participants: Adults with acute ATR presenting within 12 days of injury to be treated non-surgically were eligible. …”
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Everolimus, lutetium-177 DOTATATE and sunitinib for advanced, unresectable or metastatic neuroendocrine tumours with disease progression: a systematic review and cost-effectiveness... by Ruben Mujica-Mota, Jo Varley-Campbell, Irina Tikhonova, Chris Cooper, Ed Griffin, Marcela Haasova, Jaime Peters, Stefano Lucherini, Juan Talens-Bou, Linda Long, David Sherriff, Mark Napier, John Ramage, Martin Hoyle

“…Conclusions: Given NICE’s current stated range of £20,000–30,000 per QALY for the cost-effectiveness threshold, based on list prices, only sunitinib might be considered good value for money in England and Wales. Future work: Further analysis of individual patient data from RADIANT-3 would allow assessment of the robustness of our findings. …”
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Surgical fixation compared with cast immobilisation for adults with a bicortical fracture of the scaphoid waist: the SWIFFT RCT by Joseph Dias, Stephen Brealey, Liz Cook, Caroline Fairhurst, Sebastian Hinde, Paul Leighton, Surabhi Choudhary, Matthew Costa, Catherine Hewitt, Stephen Hodgson, Laura Jefferson, Kanagaratnam Jeyapalan, Ada Keding, Matthew Northgraves, Jared Palmer, Amar Rangan, Gerry Richardson, Nicholas Taub, Garry Tew, John Thompson, David Torgerson

“…Setting: Orthopaedic departments of 31 hospitals in England and Wales recruited from July 2013, with final follow-up in September 2017. …”
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The clinical effectiveness and cost-effectiveness of enzyme replacement therapy for Gaucher's disease: a systematic review. by Connock, M, Burls, A, Frew, E, Fry-Smith, A, Juarez-Garcia, A, McCabe, C, Wailoo, A, Abrams, K, Cooper, N, Sutton, A, O'Hagan, A, Moore, D

“…The mean cost per patient treated was approximately pounds sterling 86,000 per annum in England and Wales. The cost per patient varied considerably by dose. …”

A national registry to assess the value of cardiovascular magnetic resonance imaging after primary percutaneous coronary intervention pathway activation: a feasibility cohort study by Harris, J, Brierley, R, Pufulete, M, Bucciarelli-Ducci, C, Stokes, E, Greenwood, J, Dorman, S, Anderson, R, Rogers, C, Wordsworth, S, Berry, S, Reeves, B

“…</jats:p> </jats:sec> <jats:sec id="abs1-4"> <jats:title>Setting</jats:title> <jats:p>Four 24/7 PPCI hospitals in England and Wales (two with and two without a dedicated CMR facility).…”

Anaesthetic–analgesic ear drops to reduce antibiotic consumption in children with acute otitis media: the CEDAR RCT by Alastair D Hay, Harriet Downing, Nick A Francis, Grace J Young, Clare Clement, Sue D Harris, Aideen Ahern, Behnaz Schofield, Tammy E Thomas, Jeremy Horwood, Peter S Blair, William Hollingworth, Victoria Wilson, Chris Metcalfe, Peter Stoddart, Desmond Nunez, Mark D Lyttle, Paul Little, Michael V Moore

“…Setting: Primary care practices in England and Wales. Participants: 1- to 10-year-old children presenting within 1 week of suspected AOM onset with ear pain during the preceding 24 hours and not requiring immediate antibiotics. …”
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Imiquimod versus podophyllotoxin, with and without human papillomavirus vaccine, for anogenital warts: the HIPvac factorial RCT by Richard Gilson, Diarmuid Nugent, Kate Bennett, Caroline J Doré, Macey L Murray, Jade Meadows, Lewis J Haddow, Charles Lacey, Frank Sandmann, Mark Jit, Kate Soldan, Michelle Tetlow, Emilia Caverly, Mayura Nathan, Andrew J Copas

“…Setting: The setting was 22 sexual health clinics in England and Wales. Participants: Participants were patients with a first or repeat episode of anogenital warts who had not been treated in the previous 3 months and had not previously received quadrivalent human papillomavirus vaccine. …”
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Magnitude and determinants of excess total, age-specific and sex-specific all-cause mortality in 24 countries worldwide during 2020 and 2021: results on the impact of the COVID-19... by Laust Hvas Mortensen, Andreas Charalambous, Julia Critchley, Bo Burström, Kairat Davletov, Annalisa Quattrocchi, Tianyu Liu, Marie Chan Sun, Giuseppe Ambrosio, Eva Schernhammer, Qian Huang, Nolwenn Le Meur, Elena Critselis, Andreas Artemiou, Terje P Hagen, Fabrizio Stracci, Kostas Athanasakis, Catherine M Bennett, Manuel Barrón, Stefania Papatheodorou, Lucy Goldsmith, Jose M Rodriguez-Llanes, Souzana Achilleos, Chryso Th. Pallari, John Gabel, Maria Athanasiadou, Mohammad Reza Rahmanian Haghighi, Claudia Zimmermann, Natalia Bustos Sierra, Reindert Ekelson, Jackeline Lobato, Laylla Macedo, Gleb Denissov, Levan Kandelaki, Binyamin Binyaminy, Tamar Maor, Nataliya Glushkova, Cyndy Martial, Mario Chong, Błażej Łyszczarz, Ivan Erzen, Pedro Arcos Gonzalez, Nataliia Pidmurniak, Olesia Verstiuk, Antonis Polemitis, Christiana A. Demetriou

“…The association of country and pandemic-related variables with excess mortality was investigated using simple and multilevel regression models.Results Excess cumulative mortality for both 2020 and 2021 was found in Austria, Brazil, Belgium, Cyprus, England and Wales, Estonia, France, Georgia, Greece, Israel, Italy, Kazakhstan, Mauritius, Northern Ireland, Norway, Peru, Poland, Slovenia, Spain, Sweden, Ukraine, and the USA. …”
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