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Structural studies of chemotaxis in prokaryotes and higher eukaryotes
Publicado em 2011“...In this thesis, chemotactic signal transduction pathways in bacteria, in particular two component signalling in <em>R. sphaeroides</em>, and eukaryotes, in particular human axon guidance, are studied by means of X-ray crystallography complemented with biophysical, biochemical and cellular studies....”
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Asymmetric mechanosensitivity in a eukaryotic ion channel
Publicado em 2017“...Our results reveal how the asymmetric structure of TREK-2 allows it to distinguish a broad profile of forces within the membrane, and illustrate the mechanisms that eukaryotic mechanosensitive ion channels may use to detect and fine-tune their responses to different mechanical stimuli....”
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Cyclin-dependent kinases: masters of the eukaryotic universe
Publicado em 2023“...A family of structurally related cyclin-dependent protein kinases (CDKs) drives many aspects of eukaryotic cell function. Much of the literature in this area has considered individual members of this family to act primarily either as regulators of the cell cycle, the context in which CDKs were first discovered, or as regulators of transcription. ...”
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Humanizing glycosylation pathways in eukaryotic expression systems
Publicado em 2017“...However, glycosylation profile of eukaryotic expression systems differs from human. Glycosylation strategies have been proposed for humanizing the glycosylation pathways in expression hosts which is the main theme of this review. ...”
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Rule-Based Design of Synthetic Transcription Factors in Eukaryotes
Publicado em 2016“...Here, we develop a grammar for the design of synthetic transcription factors (sTFs) in eukaryotic cells and implement it within GenoCAD, a Computer-Aided Design (CAD) software for synthetic biology. ...”
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Impact of DNA accessibility and sequence on eukaryotic origin licensing
Publicado em 2017Obter o texto integral
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Single-molecule studies of the mechanism of eukaryotic helicase activation
Publicado em 2021Obter o texto integral
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Ecological forces affecting microbial eukaryotes in the coastal ocean
Publicado em 2024“...Marine microbial eukaryotes (protists) play a central role in the global biogeochemical cycles. ...”
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Positive selection for unpreferred codon usage in eukaryotic genomes
Publicado em 2010“...We looked for evidence of directional selection resulting in increased unpreferred codon usage (and presumably reduced translational efficiency) in three divergent clusters of eukaryotic genomes using a simple optimal-codon-based metric (Kp/Ku). ...”
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Exaptive origins of regulated mRNA decay in eukaryotes
Publicado em 2016“...Eukaryotic gene expression is extensively controlled at the level of mRNA stability and the mechanisms underlying this regulation are markedly different from their archaeal and bacterial counterparts. ...”
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Unified nomenclature for the subunits of eukaryotic initiation factor 3.
Publicado em 2001Journal article -
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Eukaryotic domain evolution inferred from genome comparisons.
Publicado em 2003“...Comparative analyses of eukaryotic genomes are providing insights into the mode and tempo of domain family evolution. ...”
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Okazaki fragment processing during eukaryotic DNA replication
Publicado em 1998“... <p style="text-align:justify;"> Okazaki fragments containing an RNA primer are synthesised on the lagging strand of the eukaryotic replication fork. Major advances have recently been made in our understanding of the complex process of Okazaki fragment processing to form high molecular weight daughter DNA, identifying distinct stages. ...”
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Dyneins across eukaryotes: a comparative genomic analysis.
Publicado em 2007“...Here, we used genome sequence data from 24 diverse eukaryotes to assess the distribution of DHCs, ICs, LICs and LCs across Eukaryota. ...”
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The Svanbergfjellet Formation: Eukaryotic life in a Tonian sea
Publicado em 2025“...<p>Exceptionally preserved organic-walled microfossils of the Svanbergfjellet Formation, Svalbard document the diversity of eukaryotes in a Tonian (1,000–720 million years ago) shallow sea. ...”
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Cdc45: the missing RecJ ortholog in eukaryotes?
Publicado em 2011“...The likely orthology between Cdc45 and RecJ reveals new lines of enquiry into DNA replication mechanisms in eukaryotes....”
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Novel domains and orthologues of eukaryotic transcription elongation factors.
Publicado em 2002“...The passage of RNA polymerase II across eukaryotic genes is impeded by the nucleosome, an octamer of histones H2A, H2B, H3 and H4 dimers. ...”
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Phylogenomics of eukaryotes: impact of missing data on large alignments.
Publicado em 2004“...Resolving the relationships between Metazoa and other eukaryotic groups as well as between metazoan phyla is central to the understanding of the origin and evolution of animals. ...”
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