#43 : Expression of miRNA-21-3p in Polycystic Ovary Syndrome and its Related Functions by Guoqing Zhang, B. Hamdan Mukhri, Lianwen Zheng

“…Besides, studies showed that AMSC-EXOs can rescue the polycystic phenotype and metabolic dysfunction in PCOS ovaries by transferring miR-21-5p to the livers of rats with PCOS, finally improve reproduction. …”
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Macrophage-derived CD36 + exosome subpopulations as novel biomarkers of Candida albicans infection by Shuo Li, Yanyan Xv, Yuanyuan Sun, Ziyi Shen, Ruiying Hao, Jingjing Yan, Mengru Liu, Zhao Liu, Tingting Jing, Xiaojing Li, Xiujuan Zhang

“…In this investigation, we focus on exosomes (Exos) secreted by macrophages, both uninfected and those infected with C. albicans. …”
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Cursos de Pedagogia no Brasil: o que dizem os dados do INEP/MEC? by Yoshie Ussami Ferrari Leite e Vanda Moreira Machado Lima

“…Observamos também que desde sua criação, em 1939, até a aprovação das recentes diretrizes, o curso de Pedagogia passou por várias legislações educacionais que provocaram alterações em sua estrutura e objetivos, além de suscitarem discussões, refl exões, debates, discordâncias e muitas pesquisas. …”
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Exosomal Circular RNA hsa_circ_0046060 of Umbilical Cord Mesenchymal Stromal Cell Ameliorates Glucose Metabolism and Insulin Resistance in Gestational Diabetes Mellitus via the miR... by Minkai Cao, Chaozhi Bu, Jingjing Zhang, Yongwei Ren, Guanlun Zhou, Chao Chen, Guorong Han, Shi-Wen Jiang, Juan Wen

“…Western blotting results showed that the reduced activation of IRS-1 induced by GDM (1.25 vs. 0.54, P=0.0001) could be rescued by the administration of si-circ-G-UMSC-EXOs (0.54 vs. 1.17, P=0.0001). Conclusion. Taken together, the inhibition of hsa_circ_0046060 expression in exosomes from GDM-derived UMSCs can alleviate GDM by reversing abnormal glucose metabolism and insulin resistance in vivo and in vitro.…”
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Human Umbilical Cord Mesenchymal Stem Cells-Derived Exosomal MicroRNA-18b-3p Inhibits the Occurrence of Preeclampsia by Targeting LEP by Qin Huang, Meng Gong, Tuantuan Tan, Yunong Lin, Yan Bao, Cuifang Fan

“…The morphology of the hucMSC and hucMSC-exosomes (Exos) was identified. The exosomes were infected with different lentivirus expressing miR-18b-3p to explore the role of miR-18b-3p in PE. …”
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Microglia-Derived Exosomal microRNA-151-3p Enhances Functional Healing After Spinal Cord Injury by Attenuating Neuronal Apoptosis via Regulating the p53/p21/CDK1 Signaling Pathway by Chengjun Li, Chengjun Li, Chengjun Li, Tian Qin, Tian Qin, Tian Qin, Yudong Liu, Yudong Liu, Yudong Liu, Haicheng Wen, Haicheng Wen, Haicheng Wen, Jinyun Zhao, Jinyun Zhao, Jinyun Zhao, Zixiang Luo, Zixiang Luo, Zixiang Luo, Wei Peng, Wei Peng, Wei Peng, Hongbin Lu, Hongbin Lu, Chunyue Duan, Chunyue Duan, Chunyue Duan, Yong Cao, Yong Cao, Yong Cao, Jianzhong Hu, Jianzhong Hu, Jianzhong Hu

“…In conclusion, our data demonstrated that microglia-derived exosomes (microglia-Exos) might be a promising, cell-free approach for the treatment of SCI. …”
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Exosomal KRAS mutation promotes the formation of tumor-associated neutrophil extracellular traps and causes deterioration of colorectal cancer by inducing IL-8 expression by Anquan Shang, Chenzheng Gu, Chen Zhou, Yibao Yang, Chen Chen, Bingjie Zeng, Junlu Wu, Wenying Lu, Weiwei Wang, Zujun Sun, Dong Li

“…The in vitro investigation results revealed that more NETs were formed in the presence of DKO-1-Exos, which were inhibited by DNAse. In addition, DKs-8- and DKO-1 cells-derived exosomes could adhere to NETs under static conditions in vitro. …”
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Proteomic analysis and functional validation reveal distinct therapeutic capabilities related to priming of mesenchymal stromal/stem cells with IFN-γ and hypoxia: potential implica... by Matteo Calligaris, Giovanni Zito, Rosalia Busà, Matteo Bulati, Gioacchin Iannolo, Alessia Gallo, Anna Paola Carreca, Nicola Cuscino, Salvatore Castelbuono, Claudia Carcione, Claudio Centi, Giandomenico Amico, Alessandro Bertani, Cinzia Maria Chinnici, Pier Giulio Conaldi, Simone Dario Scilabra, Vitale Miceli

“…Our investigation revealed that both types of priming improved the therapeutic efficacy of hAMSCs, and these improvements were related to the secretion of functional factors present in the conditioned medium (CM) and exosomes (EXOs), which play crucial roles in mediating the paracrine effects of MSCs. …”
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GPS2-mediated regulation of the adipocyte secretome modulates adipose tissue remodeling at the onset of diet-induced obesity by Justin English, Joseph Orofino, Carly T. Cederquist, Indranil Paul, Hao Li, Johan Auwerx, Andrew Emili, Anna Belkina, Dafne Cardamone, Valentina Perissi

“…Altered transcriptional regulation of factors secreted via adipocyte-derived exosomes (AdExos), in the absence of GPS2, contributes to the establishment of an anti-adipogenic, pro-fibrotic adipose tissue environment, and to hastened progression towards a metabolically dysfunctional phenotype.…”
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Identifying the Potential of miRNAs in Houttuynia cordata-Derived Exosome-Like Nanoparticles Against Respiratory RNA Viruses by Zhu H, Chang M, Wang Q, Chen J, Liu D, He W

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A performance review of novel adiposity indices for assessing insulin resistance in a pediatric Latino population by Mac B. McGraw, Lindsay N. Kohler, Lindsay N. Kohler, Gabriel Q. Shaibi, Lawrence J. Mandarino, Lawrence J. Mandarino, Dawn K. Coletta, Dawn K. Coletta, Dawn K. Coletta

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O cultivo da liberdade na Pedagogia de Tosltói by Luciana Fernandes Teixeira

“…Dessa maneira, em contraponto aos tradicionais métodos escolares opressores e especialmente relacionado ao pensamento libertário anarquista, as refl exões e experiências pedagógicas de Tolstói expõem uma concepção educativa de ampla feição humana, ética e cultural, desvelada numa busca e realização educacional contra os constrangimentos da inteligência e da criatividade, especialmente direcionada ao desenvolvimento infantil e juvenil. …”
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O que é uma aula? Análises sociológicas sobre a construção de uma atividade do trabalho docente by Frederico Assis Cardoso

“…O material tem por objetivo apresentar refl exões sobre o conceito de aula como uma categoria particular de atividade do trabalho docente em espaços formais e regulares de ensino. …”
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