Changes of cytokine profile measures during the treatment of rheumatoid arthritis with rituximab biosimilar (Acellbia, BIOCAD) and the original drug (MabThera, F. Hoffmann-La Roche Ltd., Switzerland) by A. S. Avdeeva, A. S. Artyukhov, E. B. Dashinimaeva, M. V. Cherkasova, E. L. Nasonov

Get full text

A Comparative Parallel Study of Pharmacokinetics and Immunogenicity Following Single Intravenous Administration of Bevacizumab Biosimilar RPH-001 (Manufactured by R-Pharm Group, Russia) and Avastin® (Manufactured by F. Hoffmann-La Roche Ltd., Switzerland) in Healthy Male Volunteers by M. A. Kolganova, N. S. Bagaeva, Yu. V. Medvedev, I. E. Shohin, A. V. Demchinskaya, T. N. Palkina, D. A. Salazanov, G. E. Konopleva, M. S. Sheremeteva, Sh. Z. Archuadze, Ya. V. Lavrovsky, A. Yu. Savchenko, M. Yu. Samsonov

“…To assess and compare pharmacokinetics and immunogenicity (safety) following single intravenous administration of Avastin® (manufactured by F. Hoffmann-La Roche Ltd., Switzerland) and bevacizumab biosimilar RPH-001 (manufactured by R-Pharm Group, Russia).Materials and methods. …”
Get full text

Targeting neuronal lysosomal dysfunction caused by β-glucocerebrosidase deficiency with an enzyme-based brain shuttle construct by Alexandra Gehrlein, Vinod Udayar, Nadia Anastasi, Martino L. Morella, Iris Ruf, Doris Brugger, Sophia von der Mark, Ralf Thoma, Arne Rufer, Dominik Heer, Nina Pfahler, Anton Jochner, Jens Niewoehner, Luise Wolf, Matthias Fueth, Martin Ebeling, Roberto Villaseñor, Yanping Zhu, Matthew C. Deen, Xiaoyang Shan, Zahra Ehsaei, Verdon Taylor, Ellen Sidransky, David J. Vocadlo, Per-Ola Freskgård, Ravi Jagasia

Get full text

Large-Scale Production of Human iPSC-Derived Macrophages for Drug Screening by Simon Gutbier, Florian Wanke, Nadine Dahm, Anna Rümmelin, Silke Zimmermann, Klaus Christensen, Fabian Köchl, Anna Rautanen, Klas Hatje, Barbara Geering, Jitao David Zhang, Markus Britschgi, Sally A. Cowley, Christoph Patsch

Get full text

High-throughput screening of BAM inhibitors in native membrane environment by Parthasarathi Rath, Adrian Hermann, Ramona Schaefer, Elia Agustoni, Jean-Marie Vonach, Martin Siegrist, Christian Miscenic, Andreas Tschumi, Doris Roth, Christoph Bieniossek, Sebastian Hiller

Get full text

The Evolving Landscape of Neuroscience Therapeutics: an Interplay of Multiple Modalities by Hendrik Knoetgen, Torsten Schindler, Felix F. Schumacher, Antonia F. Stepan, Alain C. Tissot, Jaclyn I. Wamsteeker Cusulin

Get full text

Racial and ethnic diversity in global neuroscience clinical trials by Loes Rutten-Jacobs, Tammy McIver, Adriana Reyes, Marta Pereira, Rachel Rosenthal, Christine T. Parusel, Kathryn R. Wagner, Rachelle Doody

“…Methods: We retrospectively reviewed the F. Hoffmann-La Roche database for global, multicenter, neuroscience clinical trials from February 2016 to February 2021 and summarized and stratified race and ethnicity distributions by clinical trial therapeutic area and by country. …”
Get full text

Forensic analysis of counterfeit psychotropic drugs by Klara Dégardin, Aurélie Guillemain, Alexandra Feng, Christian Saladin, Stéphanie Paratte, Raphaël Zurbach, Tobias Mohn

Get full text

Quantifying mutant huntingtin protein in human cerebrospinal fluid to support the development of huntingtin-lowering therapies by Stephanie Vauleon, Katharina Schutz, Benoit Massonnet, Nanda Gruben, Marianne Manchester, Alessandra Buehler, Eginhard Schick, Lauren Boak, David J. Hawellek

Get full text

Modeling early pathophysiological phenotypes of diabetic retinopathy in a human inner blood-retinal barrier-on-a-chip by Thomas L. Maurissen, Alena J. Spielmann, Gabriella Schellenberg, Marc Bickle, Jose Ricardo Vieira, Si Ying Lai, Georgios Pavlou, Sascha Fauser, Peter D. Westenskow, Roger D. Kamm, Héloïse Ragelle

Get full text

Structure of the malaria vaccine candidate antigen CyRPA and its complex with a parasite invasion inhibitory antibody by Paola Favuzza, Elena Guffart, Marco Tamborrini, Bianca Scherer, Anita M Dreyer, Arne C Rufer, Johannes Erny, Joerg Hoernschemeyer, Ralf Thoma, Georg Schmid, Bernard Gsell, Araceli Lamelas, Joerg Benz, Catherine Joseph, Hugues Matile, Gerd Pluschke, Markus G Rudolph

Get full text

PB2377: PREDICTING CELL OF ORIGIN FROM DIGITIZED IMAGES OF HEMATOXYLIN AND EOSIN-STAINED SLIDES OF DIFFUSE LARGE B-CELL LYMPHOMAS USING A CELL-BASED DEEP-LEARNING MODEL by Anil Yuce, Jacob Gildenblat, Samaneh Abbasi-Sureshjani, Camille Laurent, Konstanty Korski

Get full text

Details Matter in Structure-based Drug Design by Bernd Kuhn, Jens-Uwe Peters, Markus G. Rudolph, Peter Mohr, Martin Stahl, Andreas Tosstorff

Get full text

Selective oxytocin receptor activation prevents prefrontal circuit dysfunction and social behavioral alterations in response to chronic prefrontal cortex activation in male rats by Philipp Janz, Frederic Knoflach, Konrad Bleicher, Sara Belli, Barbara Biemans, Patrick Schnider, Martin Ebeling, Christophe Grundschober, Madhurima Benekareddy, Madhurima Benekareddy

Get full text

A randomized, double‐blind phase 1b study evaluating the safety, tolerability, pharmacokinetics and pharmacodynamics of the NLRP3 inhibitor selnoflast in patients with moderate to... by Barbara Klughammer, Luca Piali, Alexandra Nica, Sandra Nagel, Lorna Bailey, Christoph Jochum, Stanislav Ignatenko, Angela Bläuer, Sabrina Danilin, Pratiksha Gulati, Joanne Hayward, Petar Scepanovic, Jitao David Zhang, Satish Bhosale, Chui Fung Chong, Andreas Christ

Get full text

445 The relationship between immune-related adverse events (irAEs) and ctDNA status: exploratory analysis from IMvigor010 by Thomas Powles, Sanjeev Mariathasan, Rajat Mohindra, G Scott Chandler, Corey Carter, Katrin Madjar, Bogdana I Balas, Laurent Essioux, Viraj Degaonkar

TGFβ1 Induces Senescence and Attenuated VEGF Production in Retinal Pericytes by Dragana Avramovic, Sébastien A. Archaimbault, Alicia M. Kemble, Sabine Gruener, Mirjana Lazendic, Peter D. Westenskow

Get full text

Identifying opportunities for late-stage C-H alkylation with high-throughput experimentation and in silico reaction screening by David F. Nippa, Kenneth Atz, Alex T. Müller, Jens Wolfard, Clemens Isert, Martin Binder, Oliver Scheidegger, David B. Konrad, Uwe Grether, Rainer E. Martin, Gisbert Schneider

Get full text

Translational PK/PD for the Development of Novel Antibiotics—A Drug Developer’s Perspective by Caterina Bissantz, Claudia Zampaloni, Pascale David-Pierson, Guennaelle Dieppois, Andreas Guenther, Andrej Trauner, Lotte Winther, William Stubbings

Get full text

Preliminary validity of the Draw a Shape Test for upper extremity assessment in multiple sclerosis by Jennifer S. Graves, Marco Ganzetti, Frank Dondelinger, Florian Lipsmeier, Shibeshih Belachew, Corrado Bernasconi, Xavier Montalban, Johan vanBeek, Michael Baker, Christian Gossens, Michael Lindemann

Get full text