FGF21 and cardiac physiopathology by Anna ePlanavila, Ibon eRedondo-Angulo, Francesc eVillarroya

“…The heart is not traditionally considered either a target or a site of fibroblast growth factor-21 (FGF21) production. However, recent findings indicate that FGF21 can act as a cardiomyokine; that is, it is produced by cardiac cells at significant levels and acts in an autocrine manner on the heart itself. …”
Get full text

FGF21 as a Stress Hormone: The Roles of FGF21 in Stress Adaptation and the Treatment of Metabolic Diseases by Kook Hwan Kim, Myung-Shik Lee

“…Fibroblast growth factor 21 (FGF21) is an endocrine hormone that is primarily expressed in the liver and exerts beneficial effects on obesity and related metabolic diseases. …”
Get full text

Analysis of Functional Promoter of Camel FGF21 Gene and Identification of Small Compounds Targeting FGF21 Protein by Fang Yong, Meilin Yan, Lili Zhang, Wangye Ji, Shuqin Zhao, Yuan Gao

Subjects: “…camel FGF21…”
Get full text

Paradoxical regulation of human FGF21 by both fasting and feeding signals: is FGF21 a nutritional adaptation factor? by Takashi Uebanso, Yutaka Taketani, Hironori Yamamoto, Kikuko Amo, Hirokazu Ominami, Hidekazu Arai, Yuichiro Takei, Masashi Masuda, Ayako Tanimura, Nagakatsu Harada, Hisami Yamanaka-Okumura, Eiji Takeda

“…Fibroblast growth factor 21 (FGF21) has recently emerged as a metabolic hormone involved in regulating glucose and lipid metabolism in mouse, but the regulatory mechanisms and actions of FGF21 in humans remain unclear. …”
Get full text

FGF21 as Modulator of Metabolism in Health and Disease by Caterina Tezze, Caterina Tezze, Vanina Romanello, Vanina Romanello, Marco Sandri, Marco Sandri, Marco Sandri, Marco Sandri

Subjects: “…FGF21…”
Get full text

FGF-21 levels in polyuria-polydipsia syndrome by Julie Refardt, Clara Odilia Sailer, Bettina Winzeler, Matthias Johannes Betz, Irina Chifu, Ingeborg Schnyder, Martin Fassnacht, Wiebke Fenske, Mirjam Christ-Crain

Subjects: “…FGF21…”
Get full text

Leptin as a Potential Regulator of FGF21 by Mohamed Asrih, Christelle Veyrat-Durebex, Anne-Laure Poher, Jacqueline Lyautey, Françoise Rohner-Jeanrenaud, François R. Jornayvaz

Subjects: “…FGF21…”
Get full text

FGF21 Levels in Pheochromocytoma/Functional Paraganglioma by Judita Klímová, Tomáš Zelinka, Ján Rosa, Branislav Štrauch, Denisa Haluzíková, Martin Haluzík, Robert Holaj, Zuzana Krátká, Jan Kvasnička, Viktorie Ďurovcová, Martin Matoulek, Květoslav Novák, David Michalský, Jiří Widimský Jr., Ondřej Petrák

Subjects: “…FGF21…”
Get full text

The role of FGF21 in the pathogenesis of cardiovascular disease by Ying Zhang, Dan Liu, Xiao-Xue Long, Qi-Chen Fang, Wei-Ping Jia, Hua-Ting Li, Yan-Jie Yin, Xiu-Yuan Hao

“…In conclusion, FGF21 is a promising target for the treatment of CVDs, however, its clinical application requires further clarification of the precise role of FGF21 in CVDs.…”
Get full text

Metabolic effects of FGF-21: thermoregulation and beyond by Bin eNi, Jared S. Farrar, Janina A. Vaitkus, Francesco S Celi

Subjects: Get full text

CREBH Improves Diet-Induced Obesity, Insulin Resistance, and Metabolic Disturbances by FGF21-Dependent and FGF21-Independent Mechanisms by Aoi Satoh, Song-iee Han, Masaya Araki, Yoshimi Nakagawa, Hiroshi Ohno, Yuhei Mizunoe, Kae Kumagai, Yuki Murayama, Yoshinori Osaki, Hitoshi Iwasaki, Motohiro Sekiya, Morichika Konishi, Nobuyuki Itoh, Takashi Matsuzaka, Hirohito Sone, Hitoshi Shimano

“…Summary: Mice overexpressing the nuclear form of CREBH mainly in the liver (CREBH-Tg) showed suppression of high-fat high-sucrose (HFHS) diet-induced obesity accompanied by an increase in plasma fibroblast growth factor 21 (FGF21) levels. CREBH overexpression induced browning in inguinal white adipose tissue (WAT) and whole-body energy expenditure, which was canceled in Fgf21−/− mice. …”
Get full text

Lower cerebrospinal fluid/plasma fibroblast growth factor 21 (FGF21) ratios and placental FGF21 production in gestational diabetes. by Bee K Tan, Kavitha Sivakumar, Muhammad F Bari, Manu Vatish, Harpal S Randeva

“…OBJECTIVES: Circulating Fibroblast Growth Factor 21 (FGF21) levels are increased in insulin resistant states such as obesity, type 2 diabetes mellitus and gestational diabetes mellitus (GDM). …”
Get full text

The Hepatokine FGF21 Increases the Human Spermatozoa Motility by Guillaume Bourdon, Anthony Estienne, Claire Chevaleyre, Christelle Ramé, Fabrice Guérif, Jean-Sébastien Brun, Claudine Vasseur, Gaelle Fromont, Ingrid Plotton, Diane Dufour-Rainfray, Erika Caldas-Silveira, Joëlle Dupont, Pascal Froment, Pierre-Henri Ducluzeau, Pierre-Henri Ducluzeau

Subjects: Get full text

Stressed Liver and Muscle Call on Adipocytes with FGF21 by Yongde eLuo, Wallace L. McKeehan

“…Fibroblast growth factor 21 (FGF21) is an emerging regulator of local and systemic metabolic homeostasis. …”
Get full text

Advances in Biological Functions and Clinical Studies of FGF21 by Lin W, Zhang T, Zhou Y, Zheng J, Lin Z

“…This review focused on the metabolic modulation and protective effect of FGF21 and summarized the molecular mechanisms and clinical research developments.Keywords: fibroblast growth factor 21, molecular mechanisms, metabolic modulation, protective effect, clinical application…”
Get full text

FGF19 and FGF21: In NASH we trust by Saswata Talukdar, Alexei Kharitonenkov

Subjects: “…FGF21…”
Get full text

FGF21 requires βklotho to act in vivo. by Andrew C Adams, Christine C Cheng, Tamer Coskun, Alexei Kharitonenkov

“…FGF21 has gradually become a focal point in metabolic research given its intriguing and complex biology and relevance to drug discovery. …”
Get full text

The role of FGF21 and its analogs on liver associated diseases by Kimia Falamarzi, Kimia Falamarzi, Mahdi Malekpour, Mahdi Malekpour, Mobin Fallah Tafti, Mobin Fallah Tafti, Negar Azarpira, Mehrdad Behboodi, Mehrdad Behboodi, Mohammad Zarei, Mohammad Zarei

Subjects: “…fibroblast growth factor 21 (FGF21)…”
Get full text

Metabolic actions of FGF21: molecular mechanisms and therapeutic implications by Xuan Ge, Yu Wang, Karen SL Lam, Aimin Xu

Subjects: Get full text

Hepatic hormone FGF21 and its analogues in clinical trials by Weijuan Shao, Tianru Jin

“…Abstract Fibroblast growth factor 21 (FGF21) is a fasting or stress inducible metabolic hormone produced mainly in the liver. …”
Get full text