Complex transcription units in Saccharomyces cerevisiae Yazar: Nguyen, T

“…However, despite its prevalence, a bona fide biological consequence or function of overlapping transcription has yet to be ascribed, with the exception of a few locus-specific examples. …”

Proteome analysis of rhoptry-enriched fractions isolated from Plasmodium merozoites. Yazar: Sam-Yellowe, T, Florens, L, Wang, T, Raine, J, Carucci, D, Sinden, R, Yates, JR

“…To distinguish abundant cellular contaminants from bona fide organellar proteins, a differential analysis comparing the proteins in the rhoptry-enriched fractions to proteins identified from whole cell lysates of P. berghei mixed asexual blood stages was undertaken. …”

Whole-genome analysis of Nigerian patients with breast cancer reveals ethnic-driven somatic evolution and distinct genomic subtypes Yazar: Ansari-Pour, N, Zheng, Y, Yoshimatsu, TF, Sanni, A, Ajani, M, Reynier, J-B, Tapinos, A, Pitt, JJ, Dentro, S, Woodard, A, Rajagopal, PS, Fitzgerald, D, Gruber, AJ, Odetunde, A, Popoola, A, Falusi, AG, Babalola, CP, Ogundiran, T, Ibrahim, N, Barretina, J, Van Loo, P, Chen, M, White, KP, Ojengbede, O, Obafunwa, J, Huo, D, Wedge, DC, Olopade, OI

“…We also find non-coding mutations in bona fide drivers (ZNF217 and SYPL1) and a previously unreported INDEL signature strongly associated with African ancestry proportion, underscoring the need to expand inclusion of diverse populations in biomedical research. …”

Jumonji domain containing protein 6 (Jmjd6) modulates splicing and specifically interacts with arginine-serine-rich (RS) domains of SR- and SR-like proteins. Yazar: Heim, A, Grimm, C, Müller, U, Häußler, S, Mackeen, M, Merl, J, Hauck, S, Kessler, B, Schofield, C, Wolf, A, Böttger, A

“…We describe further evidence for the role of Jmjd6 in the regulation of pre-mRNA processing including interactions of Jmjd6 with multiple arginine-serine-rich (RS)-domains of SR- and SR-related proteins including U2AF65, Luc7-like protein 3 (Luc7L3), SRSF11 and Acinus S', but not with the bona fide RS-domain of SRSF1. The identified Jmjd6 target proteins are involved in different mRNA processing steps and play roles in exon dependent alternative splicing and exon definition. …”

Emergence of young human genes after a burst of retroposition in primates. Yazar: Marques, A, Dupanloup, I, Vinckenbosch, N, Reymond, A, Kaessmann, H

“…Extensive comparative sequencing and expression studies coupled with evolutionary analyses and simulations suggest that a significant proportion of recent retrocopies represent bona fide human genes. We estimate that at least one new retrogene per million years emerged on the human lineage during the past approximately 63 million years of primate evolution. …”

Emergence of young human genes after a burst of retroposition in primates Yazar: Marques, A, Dupanloup, I, Vinckenbosch, N, Reymond, A, Kaessmann, H

“…Extensive comparative sequencing and expression studies coupled with evolutionary analyses and simulations suggest that a significant proportion of recent retrocopies represent bona fide human genes. We estimate that at least one new retrogene per million years emerged on the human lineage during the past ∼63 million years of primate evolution. …”

Identification of a class of human cancer germline genes with transcriptional silencing refractory to the hypomethylating drug 5-aza-2'-deoxycytidine. Yazar: Almatrafi, A, Feichtinger, J, Vernon, E, Escobar, N, Wakeman, J, Larcombe, L, McFarlane, R

“…Bona fide germline genes have expression restricted to the germ cells of the gonads. …”

Limited liability through registered companies and patnerships / Mahdi Yusuf Yazar: Yusuf, Mahdi

“…There is no doubt that partners are liable to the last cent of their fortune, but this is not so in the case of a bona fide lender. To put it simply, one can go ahead and invest in partnership but never be a partner there of and so escape personal liability. …”
Tam Metin Erişim

Linear rational finite difference solution for solving first-order fredholm integro-differential equations Yazar: X. M. Ming, Jumat Sulaiman, L.B. Ali

“…In this paper, we deal with the application of the linear rational finite difference (LRFD) method together with the first-order quadrature scheme to derive the first-order quadrature-rational finite difference approximation equation for first-order linear Fredholm integro-differential equations (FIDE). Derivation of this approximation equation, the linear system can be generated in which its coefficient matrix is large and dense. …”
Tam Metin Erişim
Tam Metin Erişim

Discovery of surrogate agonists for visceral fat Treg cells that modulate metabolic indices in vivo Yazar: Fernandes, Ricardo A, Li, Chaoran, Wang, Gang, Yang, Xinbo, Savvides, Christina S, Glassman, Caleb R, Dong, Shen, Luxenberg, Eric, Sibener, Leah V, Birnbaum, Michael E, Benoist, Christophe, Mathis, Diane, Garcia, K Christopher

“…Here, we developed an Ab-peptide library that enabled unbiased screening of peptides recognized by a bona fide murine Treg cell clone isolated from the visceral adipose tissue (VAT), and identified surrogate agonist peptides, with differing affinities and signaling potencies. …”
Tam Metin Erişim

Three-dimensional chromatin organization in brain function and dysfunction Yazar: Dileep, Vishnu, Tsai, Li-Huei

“…The three-dimensional (3D) organization of chromatin within the nucleus is now recognized as a bona fide epigenetic property influencing genome function, replication, and maintenance. …”
Tam Metin Erişim

Shutoff of host transcription triggers a toxin-antitoxin system to cleave phage RNA and abort infection Yazar: Guegler, Chantal K, Laub, Michael T

“…Toxin-antitoxin (TA) systems are widespread in bacteria, but their activation mechanisms and bona fide targets remain largely unknown. Here, we characterize a type III TA system, toxIN, that protects E. coli against multiple bacteriophages, including T4. …”
Tam Metin Erişim

Evidence for existence of an apoptosis‐inducing BH3‐only protein, sayonara, in Drosophila Yazar: Ikegawa, Yuko, Combet, Christophe, Groussin, Mathieu, Navratil, Vincent, Safar‐Remali, Sabrina, Shiota, Takuya, Aouacheria, Abdel, Yoo, Sa K.

“…To our knowledge, this is the first identification of a bona fide BH3‐only protein in Drosophila, thus providing a unique example of how cell death mechanisms can evolve both through time and across taxa.…”
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A Systematic Survey Identifies Prions and Illuminates Sequence Features of Prionogenic Proteins Yazar: Kapila, Atul, Halfmann, Randal Arthur, Lindquist, Susan, King, Oliver D., Alberti, Simon

“…At least one of these prion proteins, Mot3, produces a bona fide prion in its natural context that increases population-level phenotypic heterogeneity. …”
Tam Metin Erişim
Tam Metin Erişim

A new approach to design artificial 3D microniches with combined chemical, topographical, and rheological cues Yazar: Stoecklin, Celine, Yue, Zhang, Chen, Wilhelm W., de Mets, Richard, Fong, Eileen, Studer, Vincent, Viasnoff, Virgile

“…It is demonstrated how the lamination of through‐hole polymeric biofunctionalized membranes can be implemented to create complex bona fide microniches with differential 3D environmental properties using photoactive materials. …”
Tam Metin Erişim

ZNF185 is a p53 target gene following DNA damage Yazar: Smirnov, A, Cappello, A, Lena, A, Anemona, L, Mauriello, A, Di Daniele, N, Annicchiarico-Petruzzelli, M, Melino, G, Candi, E

“…ChIP-seq analysis, chromatin crosslinking immune-precipitation experiments and luciferase assays demonstrate that ZNF185 is a bona fide p53 target gene. Upon genotoxic stress, caused by DNA-damaging drug etoposide and UVB irradiation, ZNF185 expression is up-regulated and in etoposide-treated cells, ZNF185 depletion does not affect cell proliferation and apoptosis, but interferes with actin cytoskeleton remodelling and cell polarization. …”

Extensive non-redundancy in a recently duplicated developmental gene family Yazar: Baker, EA, Gilbert, SPR, Shimeld, SM, Woollard, A

“…While having lost a bona fide Hedgehog gene, most nematodes have evolved an expanded repertoire of Hedgehog-related genes, ten of which reside within the Warthog family.…”

Systems genetics of nonsyndromic orofacial clefting provides insights into its complex aetiology Yazar: Razaghi-Moghadam, Z, Namipashaki, A, Farahmand, S, Ansari-Pour, N

“…In addition, we identified bona fide candidate genes based on topological features and dysregulation (e.g. …”

Volcanogenic pseudo-fossils from the ~3.48 Ga Dresser Formation, Pilbara, Western Australia Yazar: Wacey, D, Noffke, N, Saunders, M, Guagliardo, P, Pyle, D

“…However, reworked, isolated and silicified microstructures of this type may prove particularly problematical in early or extraterrestrial life studies since they adsorb carbon onto their surfaces and are readily pyritised, mimicking a common preservation mechanism for bona fide microfossils. In those cases nano-scale analysis of wall ultrastructure would be required to firmly exclude a biological origin.…”

Optical spectroscopic classification and membership of young M dwarfs in star-forming regions Yazar: Riddick, F, Roche, P, Lucas, P

“…Confirmation of candidate young stars and brown dwarfs as bona fide cluster members may be accomplished with moderate resolution spectra in the optical region by an analysis of the strength of the gravity-sensitive Na doublet. …”