Hemangioendothelioma of the eyelid can mimic chalazion by Yasser H Al-Faky, Salem Al Malki, Emad Raddaoui

Get full text

Orbital T-cell lymphoma in youngest recorded patient – early diagnosis, management, and successful outcome: a case report and review of the literature by Hind Manaa Alkatan, Saleh Hamad Alrashed, Ammar C. Al-Rikabi, Yasser H. Al-Faky

Get full text

Demographics and histopathological characteristics of enucleated microphthalmic globes by Hind M. Alkatan, Khalid M. Bedaiwi, Yasser H. Al-Faky, Azza M. Y. Maktabi

Get full text

Medial canthus retiform hemangioendothelioma by Yasser H Al-Faky, Abdul Rahman Al-Mosallam, Ammar C Al-Rikabi, Mohammed O Al-Sohaibani

Get full text

Eyelid Soft Tissue Chondroma: A Case Report by Abeer A. AlHazzani, Rawan H. Malaikah, Faisal A. Altahan, Maria A. Arafah, Yasser H. Al-Faky

Get full text

Association between Ramadan Fasting and cerebrovascular diseases by Abdullah Faky Yazdeen, Mutaz Fadhil Hummadi, Namir G. Al-Tawil, Ihsan K. AlShimmery, Srood N Jarjees

Get full text

Congenital myasthenic syndrome due to homozygous CHRNE mutations: report of patients in Arabia. by Salih, M, Oystreck, D, Al-Faky, Y, Kabiraj, M, Omer, M, Subahi, E, Beeson, D, Abu-Amero, K, Bosley, T

Modified Anterior Lamellar Recession for All Grades of Upper Eyelid Trachomatous Cicatricial Entropion by Ibrahim ENA, Tharwat E, Khalil MMAA, Mohammed AR, Mohammed MF, Alkady AMM, Ezzeldin ER, Hassan Ahmed RE, Al-Faky YH, Hassanein M, Elsayed AN, Abd El-Salam ME

“…Ezzat Nabil Abbas Ibrahim,1,* Ehab Tharwat,2,* Mahmoud Mohammed Ahmed Ali Khalil,1 Ahmed Rabie Mohammed,1 Mostafa F Mohammed,1 Ahmed Mohammed Madinah Alkady,1 Ezzeldin Ramadan Ezzeldin,2 Riad Elzaher Hassan Ahmed,2 Yasser H Al-Faky,3 Mohamed Hassanein,1 Ahmed N Elsayed,1 Mohammed Eid Abd El-Salam1,* 1Department of Ophthalmology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt; 2Department of Ophthalmology, Faculty of Medicine, Al-Azhar University, Damietta, Egypt; 3Department of Ophthalmology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudia Arabia*These authors contributed equally to this workCorrespondence: Ehab Tharwat, Department of Ophthalmology, Faculty of Medicine, Al-Azhar University, Alkawthar Building at Alshenawy St, from Algeish St, Mansoura, Dakahlia, Egypt, Tel +20 10 06952497, Fax +20 50 2507370, Email ehabtharwat71@domazhermedicine.edu.egPurpose: This study aims to assess the combination of anterior lamellar recession (ALR) with blepharoplasty, suprasternal fixation, and internal eyelash bulb extirpation of aberrant lashes posteriorly located in patients with any grade of upper eyelid trachomatous cicatricial entropion.Patients and Methods: We reviewed the clinical data of eighty-six patients (143 eyelids) including age, gender, systemic medical illnesses, and comprehensive ophthalmological assessment. …”
Get full text

Redox modulation of FAK controls melanoma survival--role of NOX4. by Cristiane Ribeiro-Pereira, João Alfredo Moraes, Mariele de Jesus Souza, Francisco R Laurindo, Maria Augusta Arruda, Christina Barja-Fidalgo

“…NOX4 is likely to be involved in these effects, since silencing of NOX4 significantly inhibited basal ROS production, reduced FAKY397 phosphorylation and decreased tumor cell viability. …”
Get full text

Probing relevant molecules in modulating the neurite outgrowth of hippocampal neurons on substrates of different stiffness. by Wei-Hsin Chen, Sin-Jhong Cheng, Jason T C Tzen, Chao-Min Cheng, Yi-Wen Lin

“…However, when we used a fibronectin (FN) coating, we found that pFAKy397 and pFAKy925 expression were higher in glass group than in the 15:1 or 35: 1 PDMS groups, but pPKCα and pERK1/2 expression were higher in the 35:1 PDMS group than in the glass group. …”
Get full text

Galectin-3 Negatively Regulates Hippocampus-Dependent Memory Formation through Inhibition of Integrin Signaling and Galectin-3 Phosphorylation by Yan-Chu Chen, Yun-Li Ma, Cheng-Hsiung Lin, Sin-Jhong Cheng, Sin-Jhong Cheng, Wei-Lun Hsu, Eminy H.-Y. Lee, Eminy H.-Y. Lee

“…Transfection of the rat CA1 area with small interfering RNA against galectin-3 facilitated fear memory and increased phosphorylated focal adhesion kinase (FAK) levels, effects that were blocked by co-transfection of the FAK phosphorylation-defective mutant Flag-FAKY397F. Notably, levels of serine-phosphorylated galectin-3 were decreased by fear conditioning training. …”
Get full text

Focal Adhesion Kinase Promotes Hepatic Stellate Cell Activation by Regulating Plasma Membrane Localization of TGFβ Receptor 2 by Yunru Chen, Qing Li, Kangsheng Tu, Yuanguo Wang, Xianghu Wang, Dandan Liu, Chen Chen, Donglian Liu, Rendong Yang, Wei Qiu, Ningling Kang

“…In this study, we tested whether FAK phosphorylated TGFβ receptor 2 (TGFβR2) and regulated TGFβR2 intracellular trafficking in HSCs. The FAKY397F mutant and PF‐573,228 were used to inhibit the kinase activity of FAK, the TGFβR2 protein level was quantitated by immunoblotting, and HSC differentiation into myofibroblast was assessed by expression of HSC activation markers, alpha‐smooth muscle actin, fibronectin, or connective tissue growth factor. …”
Get full text

PRR11 induces filopodia formation and promotes cell motility via recruiting ARP2/3 complex in non-small cell lung cancer cells by Zhili Wei, Ru Wang, Xun Yin, lian Zhang, Yunlong Lei, Ying Zhang, Yi Li, Jiaqian Wu, Youquan Bu, Guoxiang Jin, Chundong Zhang

“…In addition, PRR11-depletion inhibited filopodial actin filaments assembly and increased the level of active integrin β1 in the cell surface, whereas reduced the phosphorylation level of focal adhesion kinase (FAKY397) to repress focal adhesion turnover and cell motility in NSCLC cells. …”
Get full text

Inhibition of focal adhesion kinase enhances antitumor response of radiation therapy in pancreatic cancer through CD8+ T cells by Arsen Osipov, Alex B. Blair, Juliane Liberto, Jianxin Wang, Keyu Li, Brian Herbst, Yao Xu, Shiqi Li, Nan Niu, Rufiaat Rashid, Ding Ding, Yanan Liu, Zaiqi Wang, Christopher L. Wolfgang, Richard A. Burkhart, Daniel Laheru, Lei Zheng

“…Antitumor activity of the combination of FAKi and RT is T cell dependent. FAKi in combination with RT enhanced CD8+ T cell infiltration significantly in comparison to the radiation or FAKi treatment alone (P < 0.05). …”
Get full text

Overcoming resistance of stroma-rich pancreatic cancer with focal adhesion kinase inhibitor combined with G47Δ and immune checkpoint inhibitors by Tomoharu Yamada, Ryosuke Tateishi, Miwako Iwai, Minoru Tanaka, Hideaki Ijichi, Makoto Sano, Kazuhiko Koike, Tomoki Todo

“…Focal adhesion kinase inhibitor (FAKi), a non-receptor type tyrosine kinase inhibitor, reduces the tumor stroma. …”
Get full text

Combination Treatment of Retinoic Acid Plus Focal Adhesion Kinase Inhibitor Prevents Tumor Growth and Breast Cancer Cell Metastasis by Ana Carla Castro-Guijarro, Fiorella Vanderhoeven, Joselina Magali Mondaca, Analía Lourdes Redondo, Felipe Carlos Martin Zoppino, Juan Manuel Fernandez-Muñoz, Angel Matias Sanchez, Marina Inés Flamini

“…In this work, we hypothesize that the RA plus FAKi (RA + FAKi) approach could improve the inhibition of tumor progression. …”
Get full text

Metabolic radiolabeling and in vivo PET imaging of cytotoxic T lymphocytes to guide combination adoptive cell transfer cancer therapy by Dehua Lu, Yanpu Wang, Ting Zhang, Feng Wang, Kui Li, Shixin Zhou, Hua Zhu, Zhi Yang, Zhaofei Liu

“…Moreover, 64Cu-OVA-CTLs PET imaging revealed that PLGA-FAKi induced a significant increase in OVA-CTL infiltration into tumors, suggesting the potential for a combined therapy comprising OVA-CTLs and PLGA-FAKi. …”
Get full text

Focal adhesion kinase inhibitor TAE226 combined with Sorafenib slows down hepatocellular carcinoma by multiple epigenetic effects by Ilaria Romito, Manuela Porru, Maria Rita Braghini, Luca Pompili, Nadia Panera, Annalisa Crudele, Daniela Gnani, Cristiano De Stefanis, Marco Scarsella, Silvia Pomella, Stefano Levi Mortera, Emmanuel de Billy, Adrian Libenzio Conti, Valeria Marzano, Lorenza Putignani, Manlio Vinciguerra, Clara Balsano, Anna Pastore, Rossella Rota, Marco Tartaglia, Carlo Leonetti, Anna Alisi

“…The aim of this study was to investigate the antitumor effects of three different FAK inhibitors (FAKi), alone or in combination with SOR, using in vitro and in vivo models of HCC. …”
Get full text

Hiyazat al-'Iqar fi al-fiqh al-Islami / by 191143 Al-Thayib Al-Faki Musa

Spatial tree risk determination in Universiti Teknologi Malaysia / by Omer Elsayedfaki Elsayedmohamednour Faki