An Engineered Human Fc variant With Exquisite Selectivity for FcγRIIIaV158 Reveals That Ligation of FcγRIIIa Mediates Potent Antibody Dependent Cellular Phagocytosis With GM-CSF-Di... by Tae Hyun Kang, Chang-Han Lee, George Delidakis, Jiwon Jung, Odile Richard-Le Goff, Jiwon Lee, Jin Eyun Kim, Wissam Charab, Pierre Bruhns, Pierre Bruhns, George Georgiou, George Georgiou, George Georgiou, George Georgiou

Subjects: “…Fc engineering…”
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Engineered Fc-glycosylation switch to eliminate antibody effector function by Qun Zhou, Julie Jaworski, Yanfeng Zhou, Delphine Valente, Joanne Cotton, Denise Honey, Ekaterina Boudanova, Jochen Beninga, Ercole Rao, Ronnie Wei, Christine Mauriac, Clark Pan, Anna Park, Huawei Qiu

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Progress and Challenges in the Design and Clinical Development of Antibodies for Cancer Therapy by Juan C. Almagro, Tracy R. Daniels-Wells, Sonia Mayra Perez-Tapia, Manuel L. Penichet, Manuel L. Penichet, Manuel L. Penichet, Manuel L. Penichet, Manuel L. Penichet

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Monoclonal Antibodies for Bacterial Pathogens: Mechanisms of Action and Engineering Approaches for Enhanced Effector Functions by Fabiola Vacca, Claudia Sala, Rino Rappuoli

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Dual Fc optimization to increase the cytotoxic activity of a CD19-targeting antibody by Carina Lynn Gehlert, Pegah Rahmati, Ammelie Svea Boje, Dorothee Winterberg, Steffen Krohn, Thomas Theocharis, Elisa Cappuzzello, Anja Lux, Falk Nimmerjahn, Ralf J. Ludwig, Marta Lustig, Thies Rösner, Thomas Valerius, Denis Martin Schewe, Christian Kellner, Katja Klausz, Matthias Peipp

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Developability profiling of a panel of Fc engineered SARS-CoV-2 neutralizing antibodies by Andrew Dippel, Austin Gallegos, Vineela Aleti, Arnita Barnes, Xiaoru Chen, Elizabeth Christian, Jared Delmar, Qun Du, Reza Esfandiary, Erika Farmer, Andrew Garcia, Qing Li, Jia Lin, Weiyi Liu, LeeAnn Machiesky, Neil Mody, Arun Parupudi, Meagan Prophet, Keith Rickert, Kim Rosenthal, Song Ren, Harini Shandilya, Reena Varkey, Kevin Wons, Yuling Wu, Yueh-Ming Loo, Mark T. Esser, Nicole L. Kallewaard, Sarav Rajan, Melissa Damschroder, Weichen Xu, Gilad Kaplan

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Regulatory considerations in the design, development and quality of monoclonal antibodies and related products for the diagnosis and treatment of cancer by Marjorie A. Shapiro

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Pharmacokinetics of novel Fc-engineered monoclonal and multispecific antibodies in cynomolgus monkeys and humanized FcRn transgenic mouse models by Delphine Valente, Christine Mauriac, Thorsten Schmidt, Ingo Focken, Jochen Beninga, Brian Mackness, Huawei Qiu, Pascale Vicat, Abdullah Kandira, Katarina Radošević, Srini Rao, John Darbyshire, Mostafa Kabiri

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Therapeutic Antibodies: What Have We Learnt from Targeting CD20 and Where Are We Going? by Michael J. E. Marshall, Richard J. Stopforth, Mark S. Cragg

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Asymmetric Fc Engineering for Bispecific Antibodies with Reduced Effector Function by Eric Escobar-Cabrera, Paula Lario, Jason Baardsnes, Joseph Schrag, Yves Durocher, Surjit Dixit

Subjects: “…Fc engineering…”
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Controlled release of enhanced cross-hybrid IgGA Fc PD-L1 inhibitors using oncolytic adenoviruses by Firas Hamdan, Michaela Feodoroff, Salvatore Russo, Manlio Fusciello, Sara Feola, Jacopo Chiaro, Gabriella Antignani, Francesca Greco, Jeanette Leusen, Erkko Ylösmäki, Mikaela Grönholm, Vincenzo Cerullo

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The Dual Targeting of FcRn and FcγRs via Monomeric Fc Fragments Results in Strong Inhibition of IgG-Dependent Autoimmune Pathologies by Céline Monnet, Emilie Jacque, Christophe de Romeuf, Alexandre Fontayne, Toufik Abache, Nathalie Fournier, Gilles Dupont, Delphine Derache, Anais Engrand, Aurélie Bauduin, Aurélie Terrier, Alexander Seifert, Cécile Beghin, Alain Longue, Nicholas Masiello, Laetitia Danino, Michel Nogre, Anais Raia, Frederic Dhainaut, Louis Fauconnier, Dieudonnée Togbe, Carmen Reitinger, Falk Nimmerjahn, Wil Stevens, Sami Chtourou, Philippe Mondon

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A novel Fc-enhanced humanized monoclonal antibody targeting B7-H3 suppresses the growth of ESCC by Huiting Wu, Chang Liu, Qiang Yuan, Yan Qiao, Yongwei Ding, Lina Duan, Wenjing Li, Mengjia Zhang, Xuhua Zhang, Yanan Jiang, Jing Lu, Ziming Dong, Tao Wang, Kangdong Liu, Jimin Zhao

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Engineering a pure and stable heterodimeric IgA for the development of multispecific therapeutics by Florian Heinkel, Meghan M. Verstraete, Siran Cao, Janessa Li, Patrick Farber, Elizabeth Stangle, Begonia Silva-Moreno, Fangni Peng, Surjit Dixit, Martin J. Boulanger, Thomas Spreter Von Kreudenstein, Eric Escobar-Cabrera

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Structure and Dynamics of a Site-Specific Labeled Fc Fragment with Altered Effector Functions by D. Travis Gallagher, Chris McCullough, Robert G. Brinson, Joomi Ahn, John P. Marino, Nazzareno Dimasi

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A VHH-Fc Fusion Targeted to the Chloroplast Thylakoid Lumen Assembles and Neutralizes Enterohemorrhagic E. coli O157:H7 by Adam Chin-Fatt, Adam Chin-Fatt, Rima Menassa, Rima Menassa

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Fc-Engineered Therapeutic Antibodies: Recent Advances and Future Directions by Dalia T. Abdeldaim, Katharina Schindowski

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Complement Activation by an Anti-Dengue/Zika Antibody with Impaired Fcγ Receptor Binding Provides Strong Efficacy and Abrogates Risk of Antibody-Dependent Enhancement by Zenjiro Sampei, Christine Xing’er Koo, Frannie Jiuyi Teo, Ying Xiu Toh, Taku Fukuzawa, Siok Wan Gan, Takeru Nambu, Adrian Ho, Kiyofumi Honda, Tomoyuki Igawa, Fariyal Ahmed, Cheng-I Wang, Katja Fink, Junichi Nezu

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Generation of bispecific antibodies by structure-guided redesign of IgG constant regions by Yordkhwan W. Iwasaki, Kannan Tharakaraman, Vidya Subramanian, Amnart Khongmanee, Andrew Hatas, Eduardo Fleischer, Troy T. Rurak, Patchara Ngok-ngam, Phanthakarn Tit-oon, Mathuros Ruchirawat, Mathuros Ruchirawat, Jutamaad Satayavivad, Jutamaad Satayavivad, Jutamaad Satayavivad, Mayuree Fuangthong, Mayuree Fuangthong, Mayuree Fuangthong, Ram Sasisekharan, Ram Sasisekharan

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Elimination of plasma soluble antigen in cynomolgus monkeys by combining pH-dependent antigen binding and novel Fc engineering by Yuji Hori, Ken Ohmine, Hitoshi Katada, Yuki Noguchi, Kazuki Sato, Takeru Nambu, Lam Runyi Adeline, Gan Siok Wan, Kenta Haraya, Kazuhisa Ozeki, Masahiko Nanami, Tatsuhiko Tachibana, Zenjiro Sampei, Taichi Kuramochi, Junichi Nezu, Kunihiro Hattori, Tomoyuki Igawa

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