Distinct roles of KLF4 in mesenchymal cell subtypes during lung fibrogenesis by Rachana R. Chandran, Yi Xie, Eunate Gallardo-Vara, Taylor Adams, Rolando Garcia-Milian, Inamul Kabir, Abdul Q. Sheikh, Naftali Kaminski, Kathleen A. Martin, Erica L. Herzog, Daniel M. Greif

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Novel Therapeutic Potentials of Taxifolin for Obesity-Induced Hepatic Steatosis, Fibrogenesis, and Tumorigenesis by Takayuki Inoue, Bin Fu, Miwako Nishio, Miyako Tanaka, Hisashi Kato, Masashi Tanaka, Michiko Itoh, Hajime Yamakage, Kozue Ochi, Ayaka Ito, Yukihiro Shiraki, Satoshi Saito, Masafumi Ihara, Hideo Nishimura, Atsuhiko Kawamoto, Shian Inoue, Kumiko Saeki, Atsushi Enomoto, Takayoshi Suganami, Noriko Satoh-Asahara

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Calcium Regulation on the Atrial Regional Difference of Collagen Production Activity in Atrial Fibrogenesis by Cheng-Chih Chung, Yung-Kuo Lin, Yao-Chang Chen, Yu-Hsun Kao, Yung-Hsin Yeh, Yi-Jen Chen

“…This study investigated whether differences in Ca²⁺ homeostasis contribute to differential fibrogenesis in LA and RA fibroblasts. Methods: Ca²⁺ imaging, a patch clamp assay and Western blotting were performed in isolated rat LA and RA fibroblasts. …”
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Endothelin-converting enzyme-1 expression in acute and chronic liver injury in fibrogenesis by Tae-Jun Cho, Hyo-Jung Kim, Jaejin Cho

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The dietary antioxidant quercetin reduces hallmarks of bleomycin-induced lung fibrogenesis in mice by Agnes W. Boots, Carmen Veith, Catrin Albrecht, Roger Bartholome, Marie-José Drittij, Sandra M. H. Claessen, Aalt Bast, Martin Rosenbruch, Leonie Jonkers, Frederik-Jan van Schooten, Roel P. F. Schins

“…Therefore, the aim of the present study was to investigate if the dietary antioxidant quercetin can exert anti-fibrotic effects in a mouse model of bleomycin-induced pulmonary fibrogenesis through Nrf2-dependent restoration of redox imbalance. …”
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The significance of the detoxification system disorders in fibrogenesis in Chronic Viral Hepatitis С in children by E. A. Galova, V. V. Krasnov

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Capillaria hepatica-induced septal fibrosis in rats: a contribution to the study of liver fibrogenesis Contribuição para o estudo da fibrogenesis hepática em ratos infectados com Capillaria hepatica by Valter Lucas Chaves Barbosa, Zilton de Araújo Andrade

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Sonodynamic Therapy Inhibits Fibrogenesis in Rat Cardiac Fibroblasts Induced by TGF-β1 by Yuanyuan Guo, Zengxiang Dong, Yuanqi Shi, Wei Wang, Lu Wang, Jing Sun, Xin Sun, Zhen Tian, Jianting Yao, Zhitao Li, Jiali Cheng, Ye Tian

“…In the present study, we evaluated the effects SDT on fibrogenesis in rat cardiac fibroblasts. Methods: The primary cardiac fibroblasts were isolated from rats, and induced to fibrogenesis with TGF-β1. …”
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FoxO3 an important player in fibrogenesis and therapeutic target for idiopathic pulmonary fibrosis by Hamza M Al‐Tamari, Swati Dabral, Anja Schmall, Pouya Sarvari, Clemens Ruppert, Jihye Paik, Ronald A DePinho, Friedrich Grimminger, Oliver Eickelberg, Andreas Guenther, Werner Seeger, Rajkumar Savai, Soni S Pullamsetti

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Andrographolide Ameliorates Inflammation and Fibrogenesis and Attenuates Inflammasome Activation in Experimental Non-Alcoholic Steatohepatitis by Daniel Cabrera, Alexander Wree, Davide Povero, Nancy Solís, Alejandra Hernandez, Margarita Pizarro, Han Moshage, Javiera Torres, Ariel E. Feldstein, Claudio Cabello-Verrugio, Enrique Brandan, Francisco Barrera, Juan Pablo Arab, Marco Arrese

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FGF21 protects against hepatic lipotoxicity and macrophage activation to attenuate fibrogenesis in nonalcoholic steatohepatitis by Cong Liu, Milena Schönke, Borah Spoorenberg, Joost M Lambooij, Hendrik JP van der Zande, Enchen Zhou, Maarten E Tushuizen, Anne-Christine Andreasson, Andrew Park, Stephanie Oldham, Martin Uhrbom, Ingela Ahlstedt, Yasuhiro Ikeda, Kristina Wallenius, Xiao-Rong Peng, Bruno Guigas, Mariëtte R Boon, Yanan Wang, Patrick CN Rensen

“…Collectively, hepatic FGF21 overexpression limits hepatic lipotoxicity, inflammation, and fibrogenesis. Mechanistically, FGF21 blocks hepatic lipid influx and accumulation through combined endocrine and autocrine signaling, respectively, which prevents KC activation and lowers the presence of lipid- and scar-associated macrophages to inhibit fibrogenesis.…”
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TGF-β Isoforms Affect the Planar and Subepithelial Fibrogenesis of Human Conjunctival Fibroblasts in Different Manners by Megumi Watanabe, Yuri Tsugeno, Tatsuya Sato, Araya Umetsu, Nami Nishikiori, Masato Furuhashi, Hiroshi Ohguro

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A model of human lung fibrogenesis for the assessment of anti-fibrotic strategies in idiopathic pulmonary fibrosis by Katy M. Roach, Amanda Sutcliffe, Laura Matthews, Gill Elliott, Chris Newby, Yassine Amrani, Peter Bradding

“…This 7 day ex vivo model of human lung fibrogenesis recapitulates pro-fibrotic events evident in IPF and is sensitive to KCa3.1 channel inhibition. …”
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Empagliflozin suppressed cardiac fibrogenesis through sodium-hydrogen exchanger inhibition and modulation of the calcium homeostasis by Cheng-Chih Chung, Yung-Kuo Lin, Yao-Chang Chen, Yu-Hsun Kao, Yung-Hsin Yeh, Nguyen Ngoc Trang, Yi-Jen Chen

“…Cardiac fibrosis plays a pivotal role in the pathophysiology of HF and atrial myopathy, but the effect of SGLT2i on fibrogenesis remains to be elucidated. This study investigated whether SGLT2i directly modulates fibroblast activities and its underlying mechanisms. …”
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Environmental tobacco smoke exposure exaggerates bleomycin-induced collagen overexpression during pulmonary fibrogenesis by Qixin Wang, Chiara Goracci, Isaac Kirubakaran Sundar, Irfan Rahman

“…The old mice (17 months old) were exposed to ETS and treated with bleomycin to induce fibrogenesis which is considered as an aging-associated disease. …”
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Prominin‐1‐expressing hepatic progenitor cells induce fibrogenesis in murine cholestatic liver injury by Michael Fenlon, Celia Short, Jiabo Xu, Nicolas Malkoff, Elaa Mahdi, Michelle Hough, Alison Glazier, Calvin Lee, Kinji Asahina, Kasper S. Wang

“…Previously, we demonstrated that in biliary atresia, Prom1(+) HPCs are present within developing fibrosis and that null mutation of Prom1 significantly abrogates fibrogenesis. Here, we hypothesized that these activated Prom1‐expressing HPCs promote fibrogenesis in cholestatic liver injury. …”
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Molecular Crosstalk between the Hepatitis C Virus and the Extracellular Matrix in Liver Fibrogenesis and Early Carcinogenesis by Emma Reungoat, Boyan Grigorov, Fabien Zoulim, Eve-Isabelle Pécheur

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Periostin/Filamin-A: A Candidate Central Regulatory Axis for Valve Fibrogenesis and Matrix Compaction by Suniti Misra, Shibnath Ghatak, Ricardo A. Moreno-Rodriguez, Russell A. Norris, Vincent C. Hascall, Roger R. Markwald

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Hepatic stellate cell‐expressed endosialin balances fibrogenesis and hepatocyte proliferation during liver damage by Carolin Mogler, Matthias Wieland, Courtney König, Junhao Hu, Anja Runge, Claudia Korn, Eva Besemfelder, Katja Breitkopf‐Heinlein, Dorde Komljenovic, Steven Dooley, Peter Schirmacher, Thomas Longerich, Hellmut G Augustin

“…Collectively, the study establishes a critical role of HSC in the reciprocal regulation of fibrogenesis vs. hepatocyte proliferation and identifies endosialin as a therapeutic target in non‐neoplastic settings.…”
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Dendritic Cell and T Cell Crosstalk in Liver Fibrogenesis and Hepatocarcinogenesis: Implications for Prevention and Therapy of Liver Cancer by Isabella Lurje, Linda Hammerich, Frank Tacke

“…While inflammatory injury drives both fibrogenesis and carcinogenesis, the tolerogenic microenvironment of the liver conveys immunosuppressive effects that encourage tumor growth. …”
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