Therapeutic Targeting of Myeloperoxidase Attenuates NASH in Mice by Anja Christina Koop, Nina Doreen Thiele, David Steins, Erik Michaëlsson, Malte Wehmeyer, Ludger Scheja, Babett Steglich, Samuel Huber, Julian Schulze zur Wiesch, Ansgar W. Lohse, Jörg Heeren, Johannes Kluwe

“…We could establish by immunohistochemistry that MPO‐positive cells were recruited to the liver in various mouse models of fibrogenic liver injury, including bile duct ligation, carbon tetrachloride (CCl4) treatment, spontaneous liver fibrogenesis in multidrug resistance 2 knockout (MDR2 KO) mice, and NASH‐inducing diet. …”
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Systematic Review with Meta-Analysis: Diagnostic Accuracy of Pro-C3 for Hepatic Fibrosis in Patients with Non-Alcoholic Fatty Liver Disease by Anne Linde Mak, Jenny Lee, Anne-Marieke van Dijk, Yasaman Vali, Guruprasad P. Aithal, Jörn M. Schattenberg, Quentin M. Anstee, M. Julia Brosnan, Mohammad Hadi Zafarmand, Dewkoemar Ramsoekh, Stephen A. Harrison, Max Nieuwdorp, Patrick M. Bossuyt, Adriaan G. Holleboom

“…The aim of this work was to summarize the performance of Pro-C3, a biomarker of active fibrogenesis, in detecting significant fibrosis (F ≥ 2), advanced fibrosis (F ≥ 3), cirrhosis (F4) and non-alcoholic steatohepatitis (NASH) in patients with NAFLD. …”
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Thioredoxin reductase 1 regulates hepatic inflammation and macrophage activation during acute cholestatic liver injury by Colin T. Shearn, Aimee L. Anderson, Colin G. Miller, Reed C. Noyd, Michael W. Devereaux, Nata Balasubramaniyan, David J. Orlicky, Edward E. Schmidt, Ronald J. Sokol

“…Compared with sham controls, BDL mice exhibited increased inflammation, necrosis, and increased mRNA expression of pro-inflammatory cytokines, fibrogenesis, the NLRP3 inflammatory complex, and increased activation of NFkB, all of which were ameliorated in TrxR1LKO mice. …”
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Let-7 suppresses liver fibrosis by inhibiting hepatocyte apoptosis and TGF-β production by Jiahui Song, Haining Lv, Beibei Liu, Mingjun Hao, Hugh S. Taylor, Xuchen Zhang, Da Li, Yingqun Huang

“…Decreased miRNA let-7 expression in the livers of patients and animals with fibrosis suggests a mechanistic link of let-7 to hepatic fibrogenesis. Methods: Using transient transfection we tested the effects of let-7 overexpression and TET3 siRNA knockdown on FAS and TGF-β1 expression and FAS-mediated apoptosis in human and mouse primary hepatocytes. …”
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Blockade of the pentraxin 3/CD44 interaction attenuates lung injury‐induced fibrosis by Jhih‐Ying Chi, Yu‐Wei Hsiao, Hsin‐Yin Liang, Tang‐Hsiu Huang, Feng‐Wei Chen, Chen‐Yang Chen, Chiung‐Yuan Ko, Chao‐Chun Cheng, Ju‐Ming Wang

“…Background Fibrosing interstitial lung diseases (fILD) are potentially fatal with limited therapeutic options and no effective strategies to reverse fibrogenesis. Myofibroblasts are chief effector cells in fibrosis that excessively deposit collagen in the pulmonary interstitium and lead to progressive impairment of gaseous exchange. …”
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Adipocyte Fatty Acid Binding Protein Promotes the Onset and Progression of Liver Fibrosis via Mediating the Crosstalk between Liver Sinusoidal Endothelial Cells and Hepatic Stellat... by Xiaoping Wu, Lingling Shu, Zixuan Zhang, Jingjing Li, Jiuyu Zong, Lai Yee Cheong, Dewei Ye, Karen S. L. Lam, Erfei Song, Cunchuan Wang, Aimin Xu, Ruby L. C. Hoo

“…Although the pathological function of various hepatic cells in fibrogenesis is identified, the crosstalk between them remains obscure. …”
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Targeting Follistatin like 1 ameliorates liver fibrosis induced by carbon tetrachloride through TGF-β1-miR29a in mice by Xin-Yi Xu, Yan Du, Xue Liu, Yilin Ren, Yingying Dong, Hong-Yu Xu, Jin-Song Shi, Dianhua Jiang, Xin Xu, Lian Li, Zheng-Hong Xu, Yan Geng

“…However, the precise functions and regulation mechanisms of Fstl1 in liver fibrogenesis remains unclear. Methods Hepatic stellate cell (HSC) line LX-2 stimulated by TGF-β1, primary culture of mouse HSCs and a model of liver fibrosis induced by CCl4 in mice was used to assess the effect of Fstl1 in vitro and in vivo. …”
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Inhibitors of Arg-Gly-Asp-Binding Integrins Reduce Development of Pancreatic Fibrosis in MiceSummary by Barbara Ulmasov, Brent A. Neuschwander-Tetri, Jinping Lai, Vladimir Monastyrskiy, Trisha Bhat, Matthew P. Yates, Jonathan Oliva, Michael J. Prinsen, Peter G. Ruminski, David W. Griggs

“…Conclusions: Based on studies of a mouse model of CP and cultured PSCs, integrins that bind RGD sequences activate PSCs and promote the development of pancreatic fibrogenesis in mice. Small-molecule antagonists of this interaction might be developed for treatment of pancreatic fibrotic diseases. …”
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Topical issues of clinical symptoms and diagnostics of septic shock by Olga Y. Leplina, Marina A. Tikhonova, Ilona V. Meledina, Olga I. Zheltova, Ekaterina Y. Shevela, Alexander A. Ostanin, Elena R. Chernykh

“…Monocytes, capable of migrating to the liver and participating in inflammation and fibrogenesis, play an important role in the LC pathogenesis as confirmed by the association of certain monocyte subsets with the disease severity and mortality in alcoholic and biliary LC. …”
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Anti-fibrotic efficacy of nintedanib in pulmonary fibrosis via the inhibition of fibrocyte activity by Seidai Sato, Shintaro Shinohara, Shinya Hayashi, Shun Morizumi, Shuichi Abe, Hiroyasu Okazaki, Yanjuan Chen, Hisatsugu Goto, Yoshinori Aono, Hirohisa Ogawa, Kazuya Koyama, Haruka Nishimura, Hiroshi Kawano, Yuko Toyoda, Hisanori Uehara, Yasuhiko Nishioka

“…Fibrocytes are bone marrow-derived progenitor cells that produce growth factors and contribute to fibrogenesis in the lungs. However, the effects of nintedanib on the functions of fibrocytes remain unclear. …”
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Detrimental role of sphingosine kinase 1 in kidney damage in DOCA-salt hypertensive model: evidence from knockout mice by Bingqing Lyu, Weili Wang, Xin-Ying Ji, Joseph K. Ritter, Ningjun Li

“…Renal mRNA levels of SphK1 were measured by real-time RT-PCR. Markers for fibrogenesis and immune cell infiltration in kidneys were detected using Western blot and immunohistochemistray analysis, respectively. …”
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Liver Fibrosis and Steatosis in Alström Syndrome: A Genetic Model for Metabolic Syndrome by Silvia Bettini, Giancarlo Bombonato, Francesca Dassie, Francesca Favaretto, Luca Piffer, Paola Bizzotto, Luca Busetto, Liliana Chemello, Marco Senzolo, Carlo Merkel, Paolo Angeli, Roberto Vettor, Gabriella Milan, Pietro Maffei

“…Patients with ALMS displayed enhanced steatosis, an early increased age-dependent LS that is associated with obesity and T2DM but also linked to genetic alterations, suggesting that <i>ALMS1</i> could be involved in liver fibrogenesis.…”
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Skeletal muscle healing by M1-like macrophages produced by transient expression of exogenous GM-CSF by Leonardo Martins, Camila Congentino Gallo, Tâmisa Seeko Bandeira Honda, Patrícia Terra Alves, Roberta Sessa Stilhano, Daniela Santoro Rosa, Timothy Jon Koh, Sang Won Han

“…The sequence of M1 and M2 macrophage accumulation and the duration of each subtype in the injured area may help to direct the relative extent of fibrogenesis and myogenesis during healing. We hypothesized that increasing the number of M1 macrophages early after traumatic muscle injury would produce more cellular and molecular substrates for myogenesis and fewer substrates for fibrosis, leading to better muscle healing. …”
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TFH cells in systemic sclerosis by Pauline Beurier, Laure Ricard, Deborah Eshagh, Florent Malard, Lama Siblany, Olivier Fain, Mohamad Mohty, Béatrice Gaugler, Arsène Mekinian

“…We also clarified T follicular helper-like cells involvement in fibrogenesis in both human and mouse model. Finally, because T follicular helper cells are involved in both fibrosis and autoimmune abnormalities in systemic sclerosis patients, we presented the different strategies could be used to target T follicular helper cells in systemic sclerosis, the therapeutic trials currently being carried out and the future perspectives from other auto-immune diseases and graft-versus-host-disease models.…”
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Metabolic Hijacking of Hexose Metabolism to Ascorbate Synthesis Is the Unifying Biochemical Basis of Murine Liver Fibrosis by Diren Beyoğlu, Pinzhu Huang, Disha Skelton-Badlani, Christine Zong, Yury V. Popov, Jeffrey R. Idle

“…All hepatotoxins resulted in similar metabolic changes during active fibrogenesis, despite different etiology and resultant scarring pattern. …”
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Systematic review of overlapping microRNA patterns in COVID-19 and idiopathic pulmonary fibrosis by Julien Guiot, Monique Henket, Claire Remacle, Maureen Cambier, Ingrid Struman, Marie Winandy, Catherine Moermans, Edouard Louis, Michel Malaise, Clio Ribbens, Renaud Louis, Makon-Sébastien Njock

“…Objective To identify miRNAs presenting similar alteration in COVID-19 and IPF, and describe their impact on fibrogenesis. Methods A systematic review of the literature published between 2010 and January 2022 (PROSPERO, CRD42022341016) was conducted using the key words (COVID-19 OR SARS-CoV-2) AND (microRNA OR miRNA) or (idiopathic pulmonary fibrosis OR IPF) AND (microRNA OR miRNA) in Title/Abstract. …”
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Activation of pancreatic stellate cells attenuates intracellular Ca2+ signals due to downregulation of TRPA1 and protects against cell death induced by alcohol metabolites by Agnieszka A. Kusiak, Monika A. Jakubowska, Kinga B. Stopa, Xiaoying Zhang, Wei Huang, Julia V. Gerasimenko, Oleg V. Gerasimenko, Robert Sutton, Ole H. Petersen, Pawel E. Ferdek

“…Although the role of non-oxidative alcohol metabolites and dysregulated Ca2+ signalling in enzyme-storing pancreatic acinar cells is well established as the core mechanism of pancreatitis, signals in PSCs that trigger fibrogenesis are less clear. Here, we investigate real-time Ca2+ signalling, changes in mitochondrial potential and cell death induced by ethanol metabolites in quiescent vs TGF-β-activated PSCs, compare the expression of Ca2+ channels and pumps between the two phenotypes and the consequences these differences have on the pathogenesis of alcoholic pancreatitis. …”
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Enhanced US/CT/MR imaging of integrin αvβ3 for liver fibrosis staging in rat by Xueyao Tang, Xueyao Tang, Xuan Li, Xuan Li, Mingxing Li, Xiaoling Zhong, Wenguang Fu, Wenguang Fu, Meng Ao, Jiqing Xuan

“…The main cell types expressing integrin αvβ3 during liver fibrogenesis were the aHSCs. The protein levels of αv and β3 expressed on aHSCs increased with the progression of liver fibrosis. …”
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Cocaine Induces Cytoskeletal Changes in Cardiac Myocytes: Implications for Cardiac Morphology by Avnish Verma, Ayse Orme Merve, Vytautas Remeškevičius, Pola Sobiecka, Luke Taylor, Scott Lawton, Ben P Jones, Elena Polycarpou, Jason Bennett, Brian Rooney

“…These results highlight the importance of cocaine in mediating cardiomyocyte function and cytotoxicity associated with the possible loss of intercellular contacts required to maintain normal cell viability, with implications for cardiotoxicity relating to hypertrophy and fibrogenesis.…”
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Adherent invasive Escherichia coli (AIEC) strain LF82, but not Candida albicans, plays a profibrogenic role in the intestine by Dina Chokr, Marjorie Cornu, Christel Neut, Clovis Bortolus, Rogatien Charlet, Pierre Desreumaux, Silvia Speca, Boualem Sendid

“…However, the factors that cause chronicity and promote fibrogenesis are not yet understood. Aims In the present study, we evaluated the profibrotic effects of adherent-invasive Escherichia coli (AIEC) LF82 strain and Candida albicans in the gut. …”
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