Evaluación de la fibrogénesis hepática en pacientes con esteatohepatitis no alcohólica tratados con propóleos rojo oral cubano by Pedro E. Velbes Marquetti, Suseily Martínez Barrios, Josánne Soto Matos, Jorge L. Hernández Castro, Adolfo Pérez Piñero

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Dual-delivery of FGF-2/CTGF from Silk Fibroin/PLCL-PEO Coaxial Fibers Enhances MSC Proliferation and Fibrogenesis by Ruodan Xu, Huiling Zhao, Hanif Muhammad, Mingdong Dong, Flemming Besenbacher, Menglin Chen

“…FGF-2 plays an important role in stem cell proliferation and, meanwhile when accompanied with CTGF, has a slightly additive effect on fibrogenic differentiation of MSCs, whereas CTGF promotes fibrogenesis and alleviates osteogenesis, chondrogenesis and adipogenesis.…”
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Honokiol inhibits arecoline-induced oral fibrogenesis through transforming growth factor-β/Smad2/3 signaling inhibition by Pei-Yin Chen, Dennis Chun-Yu Ho, Yi-Wen Liao, Pei-Ling Hsieh, Kai-Hsi Lu, Lo-Lin Tsai, Sheng-Hua Su, Cheng-Chia Yu

“…Conclusion: Our data suggest that honokiol may be a promising compound to alleviate the progression of oral fibrogenesis and prevent the transformation of OSF oral epithelium into cancer.…”
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The Ultrastructure of Hepatic Stellate Cell–Macrophage Intercellular Crosstalk as a New Morphological Insight into Phenomenon of Fibrogenesis in Pediatric Autoimmune Hepatitis by Joanna Maria Łotowska, Maria Elżbieta Sobaniec-Łotowska, Anna Bobrus-Chociej, Piotr Sobaniec

“…Conclusions: Our qualitative TEM observations indicate a key role of T-HSCs in liver fibrogenesis in pediatric AIH, with the essential involvement of activated KCs/MPs that directly adhere to them. …”
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Autocrine TGF-β-positive feedback in profibrotic AT2-lineage cells plays a crucial role in non-inflammatory lung fibrogenesis by Yasunori Enomoto, Hiroaki Katsura, Takashi Fujimura, Akira Ogata, Saori Baba, Akira Yamaoka, Miho Kihara, Takaya Abe, Osamu Nishimura, Mitsutaka Kadota, Daisuke Hazama, Yugo Tanaka, Yoshimasa Maniwa, Tatsuya Nagano, Mitsuru Morimoto

“…Moreover, the autocrine TGF-β-positive feedback loop in AT2-lineage cells is a critical cellular system in non-inflammatory lung fibrogenesis. These findings provide insights into the mechanism of IPF and potential therapeutic targets.…”
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Up-regulation of microRNA-93 inhibits TGF-β1-induced EMT and renal fibrogenesis by down-regulation of Orai1 by Jifang Ma, Lei Zhang, Jianbing Hao, Naqi Li, Jie Tang, Lirong Hao

“…SiRNA targeting Orai1 was sufficient to suppress TGF-β1-induced EMT and fibrogenesis in HK2 cells. Furthermore, Overexpression of Orai1 partially reversed the protective effect of miR-93 overexpression on TGF-β1-mediated EMT and fibrogenesis in HK2 cells. …”
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Incomplete Recovery from the Radiocontrast-Induced Dysregulated Cell Cycle, Adhesion, and Fibrogenesis in Renal Tubular Cells after Radiocontrast (Iohexol) Removal by Hsing-Yu Chen, Yi-Hong Wu, Cheng-Yu Wei, Zhi-Yao Liao, Hsiao-Ting Wu, Yung-Chang Chen, Jong-Hwei S. Pang

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Silencing Heat Shock Protein 47 (HSP47) in Fibrogenic Precision-Cut Lung Slices: A Surprising Lack of Effects on Fibrogenesis? by Mitchel J. R. Ruigrok, Khaled E. M. El Amasi, Diana J. Leeming, Jannie M. B. Sand, Henderik W. Frijlink, Wouter L. J. Hinrichs, Peter Olinga

“…After silencing HSP47, only the secretion of fibronectin was reduced while other aspects of fibrogenesis remained unaffected (e.g., myofibroblast differentiation as well as collagen secretion and deposition). …”
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The histone demethylase KDM4D promotes hepatic fibrogenesis by modulating Toll-like receptor 4 signaling pathwayResearch in context by Fangyuan Dong, Shuheng Jiang, Jun Li, Yahui Wang, Lili Zhu, Yiqin Huang, Xin Jiang, Xiaona Hu, Qi Zhou, Zhigang Zhang, Zhijun Bao

“…Mechanistically, KDM4D catalyzed histone 3 on lysine 9 (H3K9) di-, and tri-demethylation, which promoted TLR4 expression, and subsequently prompted liver fibrogenesis by activating NF-κB signaling pathways. …”
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Author Correction: The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis by Hannah V. Woodcock, Jessica D. Eley, Delphine Guillotin, Manuela Platé, Carmel B. Nanthakumar, Matteo Martufi, Simon Peace, Gerard Joberty, Daniel Poeckel, Robert B. Good, Adam R. Taylor, Nico Zinn, Matthew Redding, Ellen J. Forty, Robert E. Hynds, Charles Swanton, Morten Karsdal, Toby M. Maher, Andrew Fisher, Giovanna Bergamini, Richard P. Marshall, Andy D. Blanchard, Paul F. Mercer, Rachel C. Chambers

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Th2 Cell Activation in Chronic Liver Disease Is Driven by Local IL33 and Contributes to IL13-Dependent FibrogenesisSummary by Johanna Reißing, Marie Berres, Pavel Strnad, Alexander Wree, Maria Eugenia Inzaugarat, Christian Trautwein, Tony Bruns, Henning Wolfgang Zimmermann

“…Conclusion: In patients with chronic liver disease, the alarmin IL33 promotes the recruitment and activation of CD4+ T cells with Th2-like properties, which activate paracrine HSC in an IL13-dependent manner and promotes fibrogenesis.…”
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The phenolic compounds tyrosol and hydroxytyrosol counteract liver fibrogenesis via the transcriptional modulation of NADPH oxidases and oxidative stress-related miRNAs by Daniela Gabbia, Sara Carpi, Samantha Sarcognato, Ilaria Zanotto, Katia Sayaf, Martina Colognesi, Beatrice Polini, Maria Digiacomo, Marco Macchia, Paola Nieri, Maria Carrara, Nora Cazzagon, Francesco Paolo Russo, Maria Guido, Sara De Martin

“…Tyr and HTyr reduces fibrogenesis in vitro and in vivo, by downregulating all fibrotic markers. …”
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Silencing COX-2 blocks PDK1/TRAF4-induced AKT activation to inhibit fibrogenesis during skeletal muscle atrophy by Hongtao Chen, Zhanyang Qian, Sheng Zhang, Jian Tang, Le Fang, Fan Jiang, Dawei Ge, Jie Chang, Jiang Cao, Lei Yang, Xiaojian Cao

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Fibrogenesis and collagen resorption in the heart and skeletal muscle of Calomys callosus experimentally infected with Trypanosoma cruzi: immunohistochemical identification of extracellular matrix components by Isis F Magalhães-Santos, Elianita S Lima, Sonia G Andrade

“…Inflammatory lesions and fibrogenesis were prominent at the early phase of infection and significantly decreased during late infection. …”
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Sulfasalazine inhibits inflammation and fibrogenesis in pancreas via NF-κB signaling pathway in rats with oxidative stress-induced pancreatic injury by Wang YR, Tian FL, Yan MX, Fan JH, Wang LY, Kuang RG, Li YQ

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Imaging of fibrogenesis in the liver by [18F]TZ-Z09591, an Affibody molecule targeting platelet derived growth factor receptor β by Olivia Wegrzyniak, Bo Zhang, Johanna Rokka, Maria Rosestedt, Bogdan Mitran, Pierre Cheung, Emmi Puuvuori, Sofie Ingvast, Jonas Persson, Helena Nordström, John Löfblom, Fredrik Pontén, Fredrik Y. Frejd, Olle Korsgren, Jonas Eriksson, Olof Eriksson

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Inhibition of pancreatic stellate cell activation by the vitamin A and vitamin E as a therapy for prevention fibrogenesis in experimental chronic alcoholic pancreatitis by Nichitaylo M. E., Kravchenko D.A., Medvetskii E.B., Shpon’ka I.S., Savitskaia I.M.

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TGF-β1 stimulation and VDR-dependent activation modulate calcitriol action on skeletal muscle fibroblasts and Smad signalling-associated fibrogenesis by Ratchakrit Srikuea, Muthita Hirunsai

“…Abstract Fibroblasts play a pivotal role in fibrogenesis after skeletal muscle injury. Excess fibrous formation can disrupt contractile functions and delay functional recovery. …”
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Astaxanthin Attenuates the Changes in the Expression of MicroRNAs Involved in the Activation of Hepatic Stellate Cells by Minkyung Bae, Mi-Bo Kim, Ji-Young Lee

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Hyperdynamic circulatory syndrome in a mouse model transgenic for SerpinB3 by Gianmarco Villano, Alberto Verardo, Andrea Martini, Silvia Brocco, Paola Pesce, Erica Novo, Maurizio Parola, David Sacerdoti, Marco Di Pascoli, Marny Fedrigo, Chiara Castellani, Annalisa Angelini, Patrizia Pontisso, Massimo Bolognesi

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