C-, O- and Sr-isotope stratigraphy across the Lower-Middle Cambrian transition of the Cantabrian Zone (Spain) and the Montagne Noire (France), West Gondwana by Wotte, T, Alvaro, J, Shields, G, Brown, B, Brasier, M, Veizer, J

“…The base of the Leonian (Middle Cambrian) is regionally defined by the first appearance of the trilobite Acadoparadoxides mureroensis, which is well constrained in the Cantabrian Zone but absent in the Montagne Noire. …”

Characterization of the complete genome sequence of the recombinant norovirus GII.P16/GII.4_Sydney_2012 revealed in Russia by E. V. Zhirakovskaia, A. Y. Tikunov, S. N. Sokolov, B. I. Kravchuk, E. I. Krasnova, N. V. Tikunova

“…In Novosibirsk, the first appearance of the new recombinant genotype GII.P16/GII.4_Sydney_2012 was recorded in spring 2016. …”
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IL-23 blockade with guselkumab potentially modifies psoriasis pathogenesis: rationale and study protocol of a phase 3b, randomised, double-blind, multicentre study in participants... by Kristian Reich, Kilian Eyerich, Knut Schäkel, Peter Weisenseel, Andreas Pinter, Khusru Asadullah, Sven Wegner, Ernesto J Muñoz-Elias, Holger Bartz, Friedmann J H Taut

“…Early intervention with guselkumab may result in changes to the clinical disease course versus later intervention.Methods and analysis Here we present the rationale and design of a phase 3b, randomised, double-blind, multicentre study (GUIDE), comparing treatment effects of guselkumab in patients with short (≤2 years) or longer (>2 years) duration of plaque-type psoriasis, measured from first appearance of psoriatic plaques. Participants achieving skin clearance (Psoriasis Area and Severity Index (PASI)=0) by week 20 and maintaining complete clearance at week 28 visit (‘super-responders’ (SRe)) will be randomised to continue approved maintenance dosing every 8 weeks (q8w) versus an investigational maintenance dosing interval of 16 weeks (q16w) until week 68. …”
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Efficacy and safety of epigallocatechin-3-gallate in treatment acute severe dermatitis in patients with cancer receiving radiotherapy: a phase I clinical trial by Jingjing Xie, Li Jia, Peng Xie, Xiaoyan Yin, Wanqi Zhu, Hong Zhao, Xin Wang, Xiangjiao Meng, Ligang Xing, Hanxi Zhao, Xiaolin Li

“…EGCG solution was sprayed to the radiation field when grade III radiation-induced dermatitis (RID) first appearance. EGCG concentration escalated from 660 to 2574 μmol/L using modified-Fibonacci dose-escalation. …”
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Individual Characteristics as Prognostic Factors of the Evolution of Hospitalized COVID-19 Romanian Patients: A Comparative Observational Study between the First and Second Waves B... by Alexandra Mocanu, Gratiela Georgiana Noja, Alin Viorel Istodor, Georgiana Moise, Marius Leretter, Laura-Cristina Rusu, Adina Maria Marza, Alexandru Ovidiu Mederle

“…The symptomatology at first appearance also strongly depends on the age of the patients (positive correlation) and of the fact that the patient is a smoker or non-smoker and has other comorbidities. …”
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The ichnologic signature of deep-sea colonization during the Ordovician radiation by Luis A. Buatois, M. Gabriela Mángano, Maximiliano Paz, Nicholas J. Minter, Kai Zhou

“…The main architectural designs of deep-marine trace fossils (e.g. regular networks, delicate spiral burrows, guided meandering graphoglyptids) were established in the deep sea by the Early Ordovician, recording the first appearance of the Nereites Ichnofacies. Lower to Middle Ordovician deep-marine ichnofaunas are moderately diverse, and fodinichnia commonly dominates rather than graphoglyptids. …”
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Características de las familias del municipio de Rionegro, entre el cambio y la tradición.Characteristics of the families in the municipality of Rionegro, between change and tradit... by Wilmar Evelio Gil Valencia, Eyised Andrea Ramírez

“…We found that the nuclear family is the first appearance in Rionegro, followed by the parent and finally extensive. …”
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Sourcing Oldowan and Acheulean stone tools in Eastern Africa: Aims, methods, challenges, and state of knowledge by Julien Favreau

“…Second, the fragmentation of technological activities across the palaeolandscape emerged as a behavioural characteristic among Oldowan toolmakers before the first appearance datum of the Acheulean. Third, hominins across Eastern Africa preferentially utilised igneous rock types followed by metamorphic and sedimentary lithologies mirroring the regional lithostratigraphy. …”
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论风月片对《金瓶梅》的重新诠释 ——以《金瓶梅2：爱的奴隶》为例 = Fengyue film’s reinterpretation of "Jin Ping Mei": A case study of "The Forbidden Legend Sex & Chopsticks 2"... by 朱羽萱 Zhu, Yuxuan

“…Due to its bold and erotic descriptions, research on the book has been ongoing since its first appearance. However, there are few studies done on the comparison of novel and the films adapted from it, especially those sexually explicit ones. …”
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SARS-CoV-2 viral dynamics in a placebo-controlled phase 2 study of patients infected with the SARS-CoV-2 Omicron variant and treated with pomotrelvir by Katyna Borroto-Esoda, David Wilfret, Xiao Tong, Andrew Plummer, Brian Kearney, Ann D. Kwong

“…ABSTRACTCurrent guidelines recommend that individuals with moderate COVID-19 disease isolate for 5 days after the first appearance of symptoms or a positive SARS-CoV-2 test. …”
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The Health Care Utilization and Medical Costs in Long-Term Follow-Up of Children Diagnosed With Leukemia, Solid Tumor, or Brain Tumor: Population-Based Study Using the National Hea... by James S Miser, Ben-Chang Shia, Yi-Wei Kao, Yen-Lin Liu, Shih-Yen Chen, Wan-Ling Ho

“…A total of 33,105 children had survived for at least 5 years after the first appearance of a diagnostic code of cancer or a benign brain tumor before the age of 18 years from 2000 to 2010 with follow-up to 2015. …”
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Introduction and spread of vancomycin-resistant Enterococcus faecium (VREfm) at a German tertiary care medical center from 2004 until 2010: a retrospective whole-genome sequencing... by Aila Caplunik-Pratsch, Bärbel Kieninger, Veronika A. Donauer, Johanna M. Brauer, Vanessa M. K. Meier, Corinna Seisenberger, Anca Rath, Daniel Loibl, Anja Eichner, Jürgen Fritsch, Wulf Schneider-Brachert

“…In this study, we investigated the molecular epidemiology of VREfm isolates from the first appearance at our university hospital in 2004 until 2010. …”
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Two large squirrels (Rodentia, Mammalia) from the Junggar Basin of northwestern China demonstrate early radiation among squirrels and suggest forested paleoenvironment in the late... by Qiang Li, Qiang Li, Qiang Li, Xijun Ni, Xijun Ni, Xijun Ni, Thomas A. Stidham, Thomas A. Stidham, Thomas A. Stidham, Chao Qin, Chao Qin, Hao Gong, Hao Gong, Limin Zhang, Limin Zhang

“…In addition, these extinct lineages push the age of the first appearance of Sciuridae in northern Asia into the late Eocene. …”
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Structure and sedimentation environment of the Silurian and Devonian boundary deposits in the west of Zeravshan-Gissar mountain region (Obi-Safit section, Kitab State Geological Re... by Elena D. Mihaylova, Аnna B. Tarasenko, Utkir Zh. Rakhmonov, Мaiya V. Erina, Svetlana T. Remizova

“…It is caused by the disappearance of isolation of this territory, the subsequent penetration of waters of an open sea basin and fixed by the presence of the numerous crinoid fragments in the upper part of the IX cyclotema. The first appearance of abundant fragments of crinoid stems is located on the 295 meter of the section.…”
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SARS-CoV-2 nsp13, nsp14, nsp15 and orf6 function as potent interferon antagonists by Chun-Kit Yuen, Joy-Yan Lam, Wan-Man Wong, Long-Fung Mak, Xiaohui Wang, Hin Chu, Jian-Piao Cai, Dong-Yan Jin, Kelvin Kai-Wang To, Jasper Fuk-Woo Chan, Kwok-Yung Yuen, Kin-Hang Kok

“…ABSTRACTThe Coronavirus disease 2019 (COVID-19), which is caused by the novel SARS-CoV-2 virus, is now causing a tremendous global health concern. Since its first appearance in December 2019, the outbreak has already caused over 5.8 million infections worldwide (till 29 May 2020), with more than 0.35 million deaths. …”
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Response of water quality to climate warming and atmospheric deposition in an alpine lake of Tianshan Mountains, Central Asia by Fei Han, Tie Liu, Yue Huang, Chanjuan Zan, Xiaohui Pan, Zhu Xu

“…Climate warming seemed equally crucial synergistically to stimulate phytoplankton growth, the first appearance of phytoplankton blooms corresponded to the beginning of the warm period. …”
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Deficiency in fibroblast PPARβ/δ reduces nonmelanoma skin cancers in mice by Tan, Mark Wei Yi, Sng, Ming Keat, Cheng, Hong Sheng, Low, Zun Siong, Leong, Benjamin Jia Juin, Chua, Damien, Tan, Eddie Han Pin, Chan, Jeremy Soon Kiat, Yip, Yun Sheng, Lee, Yin Hao, Pal, Mintu, Wang, Xiaomeng, Wahli, Walter, Tan, Nguan Soon

“…In vivo, we detected the differential phosphorylation profiles of B-Raf, MEK1/2, PTEN, Src, and AKT in the vehicle-treated and chemically treated epidermis of FSPCre-Pparb/dex4 mice compared with that in Pparb/dfl/fl mice, prior to the first appearance of tumors in Pparb/dfl/fl. Our study revealed a role for fibroblast PPARβ/δ in the epithelial-mesenchymal communication involved in cellular redox homeostasis.…”
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Protoconodont fossils for refining the Cambrian bottom and the contribution to shale gas formation along the southwest margin of Yangtze Block by Jun-ping Liu, Si-cun Song, Wei Wang, Feng Tang, Jing Li, Xiang-dong Duan, Xiao-hu Wang, Bai-dong Sun, Sai-ying Yu, Shao-bin Hu, Wen-ting Duan

“…Through this interval with continuous collections, the first appearance datums (FADs) of the protoconodont (Fomitchella cf. inchoate Yang et He, Protohertzina cf. anabarica Missarzhevsky) and globular embryos fossil (Olivooides sp.) earlier than these in the Lower Cambrian strata of the Meishucun Formation were discovered. …”
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Middle–Late Ordovician organic- walled phytoplankton from Sweden: diversity and early radiation by Claudia V. Rubinstein, Vivi Vajda

“…Here we show that the first appearances of these advanced taxa already occurred ca 15 Ma earlier, suggesting that a possible combination of factors such as sea level changes and volcanism triggered these changes, instead of a major event such as the Hirnantian glaciation. …”
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Genomic diversity of SARS-CoV-2 in Malaysia by Noorliza Mohamad Noordin, Joon Liang Tan, Chee Kheong Chong, Yu Kie Chem, Norazimah Tajudin, Rehan Shuhada Abu Bakar, Selvanesan Sengol, Hannah Yik Phing Phoon, Nurul Aina Murni Che Azid, W Nur Afiza W Mohd Arifin, Zirwatul Adilah Aziz, Hani Hussin, Nurul Syahida Ibrahim, Aziyati Omar, Ushananthiny Ravi, Kamal Hisham Kamarul Zaman, Mohd Asri Yamin, Yun Fong Ngeow

“…Background More than a year after its first appearance in December 2019, the COVID-19 pandemic is still on a rampage in many parts of the world. …”
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