MicroRNA 3′ ends shorten during adolescent brain maturation by Kristen T. Thomas, Anaïs Vermare, Suzannah O. Egleston, Yong-Dong Wang, Ashutosh Mishra, Tong Lin, Junmin Peng, Junmin Peng, Junmin Peng, Stanislav S. Zakharenko

“…MicroRNA (miRNA) dysregulation is well-documented in psychiatric disease, but miRNA dynamics remain poorly understood during adolescent and early adult brain maturation, when symptoms often first appear. Here, we use RNA sequencing to examine miRNAs and their mRNA targets in cortex and hippocampus from early-, mid-, and late-adolescent and adult mice. …”
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Characterization of the Cynomolgus Macaque Model of Marburg Virus Disease and Assessment of Timing for Therapeutic Treatment Testing by Elizabeth E. Zumbrun, Carly B. Garvey, Jay B. Wells, Ginger C. Lynn, Sean Van Tongeren, Jesse T. Steffens, Kelly S. Wetzel, Laura M. Gomba, Kristan A. O’Brien, Franco D. Rossi, Xiankun Zeng, Eric D. Lee, Jo Lynne W. Raymond, Diana A. Hoffman, Alexandra N. Jay, Elizabeth S. Brown, Paul A. Kallgren, Sarah L. Norris, Jean Cantey-Kiser, Humza Kudiya, Chris Arthur, Christiana Blair, Darius Babusis, Victor C. Chu, Bali Singh, Roy Bannister, Danielle P. Porter, Tomas Cihlar, John M. Dye

“…Clinically observable signs of MARV disease first appeared on Day 5 PI, when 6 of the 12 animals exhibited reduced responsiveness. …”
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SARS-CoV-2 Prevalence on and Incidence after Arrival in Travelers on Direct Flights from Cape Town, South Africa to Munich, Germany Shortly after Occurrence of the Omicron Variant... by Cornelia Seidl, Liza Coyer, Nikolaus Ackermann, Katharina Katz, Jan Walter, Siegfried Ippisch, Martin Hoch, Merle M. Böhmer

“…The highly transmissible SARS-CoV-2-variant B.1.1.529 (Omicron) first appeared in South Africa in November 2021. In order to study Omicron entry to Germany, its occurrence related to incoming airline travel, symptomatology and compliance with entry regulations and recommendations, we conducted a cross-sectional study, followed by a retrospective cohort study among passengers and crew on 19 direct flights from Cape Town, South Africa, to Munich, Germany, between 26 November and 23 December 2021. …”
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Population Genetics of California Gray Foxes Clarify Origins of the Island Fox by Benjamin N. Sacks, Mark J. Statham, Laurel E. K. Serieys, Seth P. D. Riley

“…We used mitochondrial sequences and nuclear microsatellites to investigate population structure of gray foxes (<i>Urocyon cinereoargenteus</i>) and the evolutionary origins of the endemic island fox (<i>Urocyon littoralis</i>), which first appeared in the northern Channel Islands <13,000 years ago and in the southern Channel Islands <6000 years ago. …”
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Fahlbands of the Keret archipelago, White Sea: the composition of rocks and minerals, ore mineralization by Laysan I. Salimgaraeva, Sergey G. Skublov, Aleksey V. Berezin, Olga L. Galankina

“…The term “fahlband” first appeared in the silver mines of Kongsberg in the 17th century. …”
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Immunohistochemical profile of multicentric cutaneous epitheliotropic T-cell lymphoma with generalised lymphadenopathy in a Holstein-Friesian cow: a case report by I. Otrocka-Domagala, Z. Procajlo, K. Pazdzior, M. Gesek, T. Rotkiewicz, W. Szweda

“…The skin lesions included multiple hypotrichous to alopecic nodules, often with ulceration, which first appeared three months after calving and progressed quickly to cover the entire body. …”
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Role of Serotonin (5-HT) in GDM Prediction Considering Islet and Liver Interplay in Prediabetic Mice during Gestation by Melissa Asuaje Pfeifer, Moritz Liebmann, Till Beuerle, Katharina Grupe, Stephan Scherneck

“…Gestational diabetes (GDM) is characterized by a glucose tolerance disorder. This may first appear during pregnancy or pre-exist before conception as a form of prediabetes, but there are few data on the pathogenesis of the latter subtype. …”
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Mechanical performances of shield tunnel segments under asymmetric unloading induced by pit excavation by Gang Wei, Feifan Feng, Chengbao Hu, Jiaxuan Zhu, Xiao Wang

“…The concrete internal force exhibited a directional transformation at different load stages. Cracks first appeared at the 180° inner arc surface of the bottom standard block and then expanded to both sides, while the rate of crack propagation of the outer arc surface was relatively lower. …”
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Deformation and failure law of coal roadway supported by concrete filled steel tube supports in Nanguan mine by Kong Xiangsong, Shan Renliang, Xiao Yuhang, Bao Tiantian, Yuan Honghu

“…Taking the coal roadway in Nanguan mine of Fenxi mining area as the prototype, relying on the nested similarity simulation experimental system, the physical similarity model was established to study the stress distribution, displacement and deformation failure characteristics of the surrounding rock of coal roadway supported by concrete filled steel tube support.FLAC^3D 5.0 software was used to establish the calculation model of concrete filled steel tube support roadway, which simulated the depth of 100 m to 1000 m respectively;the deformation and failure law of coal roadway and the characteristics of support stress were analyzed.The results showed that, concrete-filled steel tube support can improve the radial support pressure of roadway.At the initial stage of loading, the stability of roadway is maintained, however, with the increase of load, the convergence of sidewall is greater than that of roof and floor.Fissures first appear in the sidewall and develop to the roof and floor, then the sidewall and the roof are unstable successively.It can be seen that the sidewall is the weak link of support.Under the action of concrete filled steel tube support, the stress distribution on the roadway surface is serrated, which indicates that the support has an effective support range for surrounding rock, and the support between the supports is also the weak part of the support.The axial force and moment of the support casing are larger, and the casing is easy to be damaged, which leads to the loss of the bearing capacity of the support.It can be seen that the key to ensure the stability of concrete filled steel tube support in Nanguan mine is to control the deformation and failure of sidewall and support casing and to improve its strength.…”
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ARE TIDAL EFFECTS RESPONSIBLE FOR EXOPLANETARY SPIN–ORBIT ALIGNMENT? by Li, Gongjie, Winn, Joshua N.

“…Thus, while we find both problems to be more nuanced than they first appeared, the tidal model still has serious shortcomings.…”
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COMPOSITIONAL HOMOGENEITY OF CM PARENT BODIES by Vernazza, P., Marsset, M., Beck, P., Binzel, R. P., Birlan, M., Cloutis, E. A., DeMeo, F. E., Dumas, C., Hiroi, T.

“…Here, we provide new constraints on the collisional and thermal history of CM-like bodies from a comparison between newly acquired spectral measurements of main-belt Ch/Cgh-type asteroids (70 objects) and existing laboratory spectral measurements of CM chondrites. It first appears that the spectral variation observed among CM-like bodies is essentially due to variations in the average regolith grain size. …”
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Effect of Covid-19 Patients Flow Rate from ER to LPD on Covid-19 Patients Healing Rates at RSUP Dr. Sardjito’s ER by Arifin, Muchammad Choerul, Muna, Naelufa Syifna Wifaqotul, Yuliana, Arizka, Mahardika, Lingga Sanjaya Putra, Santoso, Albert Hosea, Ertiningsih, Dwi

“…COVID-19 or Coronavirus Disease-19 which first appeared in December 2019 has spread around the world, one of which is Indonesia. …”
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Experiments on the flow over a hill covered by a canopy in stably stratified conditions by John J. Finnigan, John J. Finnigan, Ian N. Harman, Dale E. Hughes

“…The gravity current first appears at the ground surface, despite cooling profiles that are concentrated in the upper canopy. …”
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Radiodont frontal appendages from the Fezouata Biota (Morocco) reveal high diversity and ecological adaptations to suspension-feeding during the Early Ordovician by Gaëtan J.-M. Potin, Gaëtan J.-M. Potin, Pierre Gueriau, Allison C. Daley

“…The Fezouata Shale preserves abundant remains of ancient marine organisms, including hundreds of specimens of radiodonts, a diverse and globally distributed group of stem lineage arthropods that first appeared as raptorial predators during the Cambrian Explosion.MethodsIn this work, we study 121 radiodont frontal appendages from the Fezouata Shale. …”
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Study of Dynamic Viscoelasticity of a Mineral Oil-Based Magnetic Fluid by Zhanxian Li, Yifei Guo, Hujun Wang, Chengyao Deng, Jiahao Dong, Zhongru Song, Zhenkun Li

“…At large amplitude, the loss modulus will first appear as a peak and then decrease. The frequency sweep experiment showed that the storage modulus and loss modulus increased with the increase in angular frequency, and the greater the magnetic field intensity, the longer the internal structure relaxation time. …”
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Gravity Wave Activity in the Stratosphere before the 2011 Tohoku Earthquake as the Mechanism of Lithosphere-atmosphere-ionosphere Coupling by Shih-Sian Yang, Masashi Hayakawa

“…The active region of the precursory AGW first appeared around the EQ epicenter, and then expanded omnidirectionally, but mainly toward the east, covering a wide area of 2500 km (in longitude) by 1500 km (in latitude). …”
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Polysaccharide composition during cotton seed fibre development: temporal differences between species and in different seasons by Filomena A. Pettolino, Dina Yulia, Antony Bacic, Danny J. Llewellyn

“…Abstract Background Cotton seed fibres are long single-celled epidermal trichomes that first appear on the surface of the ovule at anthesis and then elongate rapidly over a period of 15–25 days until a secondary cell wall (SCW) begins to develop through a rapid increase in the deposition of microfibrillar cellulose between the plasma membrane and the primary cell wall that eventually terminates elongation. …”
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Expression of acetylated tubulin in the postnatal developing mouse cochlea by Wenjing Liu, Chuanxi Wang, Hao Yu, Shaofeng Liu, Jun Yang

“…At P5, acetylated tubulin first appeared in the phalangeal processes of Deiters’ cells. …”
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Dramatic Entropy and Self Ambiguity in Samuel Beckett’s Works via the Frame work of Choas Theory. [In Persian] by Saeid Rahimipour

“…The idea of ​​entropy first appeared in the philosophy of Socrates. These ideas gradually found their way into the dramatic works of Greek playwrights, in their tragedy was redefined as a kind of atropy or the second law of thermodynamics. …”
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Two new species of Mesozoic tree ferns (Osmundaceae: Osmundacaulis) in Eurasia as evidence of long-term geographic isolation by Yeming Cheng, Fengxiang Liu, Xiaonan Yang, Tongxing Sun

“…The fossil records suggest that Osmundacaulis species may have evolved from a common ancestor, which first appeared in the Australian portion of Pangaea, and then spread to ancient northern North America and ancient East Asia. …”
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