Steviol glycosides enhance pancreatic beta-cell function and taste sensation by potentiation of TRPM5 channel activity by Philippaert, K, Pironet, A, Mesuere, M, Sones, W, Vermeiren, L, Kerselaers, S, Pinto, S, Segal, A, Antoine, N, Gysemans, C, Laureys, J, Lemaire, K, Gilon, P, Cuypers, E, Tytgat, J, Mathieu, C, Schuit, F, Rorsman, P, Talavera, K, Voets, T, Vennekens, R

Hypoxia Produces Pro-arrhythmic Late Sodium Current in Cardiac Myocytes by SUMOylation of NaV1.5 Channels by Leigh D. Plant, Dazhi Xiong, Jesus Romero, Hui Dai, Steve A.N. Goldstein

“…Here, we show the underlying mechanism: hypoxia induces rapid SUMOylation of NaV1.5 channels so they reopen when normally inactive, late in the action potential. …”
Get full text

Improved functional expression of human cardiac kv1.5 channels and trafficking-defective mutants by low temperature treatment. by Wei-Guang Ding, Yu Xie, Futoshi Toyoda, Hiroshi Matsuura

Get full text

Modeling Nanoscale III–V Channel MOSFETs with the Self-Consistent Multi-Valley/Multi-Subband Monte Carlo Approach by Enrico Caruso, David Esseni, Elena Gnani, Daniel Lizzit, Pierpaolo Palestri, Alessandro Pin, Francesco Maria Puglisi, Luca Selmi, Nicolò Zagni

“…It is then shown how to use the MV–MSMC to calibrate a Technology Computer Aided Design (TCAD) simulation deck based on the drift–diffusion model that allows much faster simulations and opens the doors to variability studies in III–V channel MOSFETs.…”
Get full text

Characterization of an N-terminal Nav1.5 channel variant – a potential risk factor for arrhythmias and sudden death? by Stefanie Scheiper-Welling, Paolo Zuccolini, Oliver Rauh, Britt-Maria Beckmann, Christof Geisen, Anna Moroni, Gerhard Thiel, Silke Kauferstein

“…Results Electrophysiological measurements indicated, that the detected missense variant alters Nav1.5 channel functionality leading to a gain-of-function effect. …”
Get full text

Remarkable Progress with Small-Molecule Modulation of TRPC1/4/5 Channels: Implications for Understanding the Channels in Health and Disease by Aisling Minard, Claudia C. Bauer, David J. Wright, Hussein N. Rubaiy, Katsuhiko Muraki, David J. Beech, Robin S. Bon

“…We review evidence for the formation of different TRPC1/4/5 tetramers, give an overview of recently developed small-molecule TRPC1/4/5 activators and inhibitors, highlight examples of biological roles of TRPC1/4/5 channels in different tissues and pathologies, and discuss how high-quality chemical probes of TRPC1/4/5 modulators can be used to understand the involvement of TRPC1/4/5 channels in physiological and pathophysiological processes.…”
Get full text

Identification of Sodium Transients Through NaV1.5 Channels as Regulators of Differentiation in Immortalized Dorsal Root Ganglia Neurons by Antón L. Martínez, José Brea, Eduardo Domínguez, María J. Varela, Catarina Allegue, Raquel Cruz, Xavier Monroy, Manuel Merlos, Javier Burgueño, Ángel Carracedo, Ángel Carracedo, María Isabel Loza

“…Moreover, pharmacologic inhibition of the NaV1.5 channel during differentiation hinders the acquisition of phenotypic features of neuronal cells and the hyperexcitability increase in response to changes in the extracellular medium ionic composition. …”
Get full text

Inhibition of Wnt/β‐catenin signaling upregulates Nav1.5 channels in Brugada syndrome iPSC‐derived cardiomyocytes by Aizhu Lu, Ruonan Gu, Cencen Chu, Ying Xia, Jerry Wang, Darryl R. Davis, Wenbin Liang

“…Abstract The voltage‐gated Nav1.5 channels mediate the fast Na+ current (INa) in cardiomyocytes initiating action potentials and cardiac contraction. …”
Get full text

Kinetic model of Nav1.5 channel provides a subtle insight into slow inactivation associated excitability in cardiac cells. by Zheng Zhang, Zhiwen Zhao, Yongfeng Liu, Wei Wang, Ying Wu, Jiuping Ding

“…This model can simulate the Nav1.5 channel in not only steady state processes, but also various transient processes. …”
Get full text

Acute Treatment with a Novel TRPC4/C5 Channel Inhibitor Produces Antidepressant and Anxiolytic-Like Effects in Mice. by Li-Ping Yang, Fang-Jie Jiang, Gui-Sheng Wu, Ke Deng, Meng Wen, Xiaoju Zhou, Xuechuan Hong, Michael X Zhu, Huai-Rong Luo

“…However, to what extent the TRPC4/C5 channels are involved in psychiatric disorders remains unexplored. …”
Get full text

Predictive QSAR model confirms flavonoids in Chinese medicine can activate voltage-gated calcium (CaV) channel in osteogenesis by Ki Chan, Henry Chi Ming Leung, James Kit-Hon Tsoi

“…Based on statistical algorithm, QSAR provides a reasonable basis for establishing a predictive correlation model by a variety of molecular descriptors that are able to identify as well as analyse the biochemical features of flavonoids that engaged in activating or inhibiting the CaV channels for osteoblasts. Results The model has shown these flavonoids have high activating effects on CaV channel for osteogenesis. …”
Get full text

Modular analysis of the control of flagellar Ca2+-spike trains produced by CatSper and CaV channels in sea urchin sperm. by Daniel A Priego-Espinosa, Alberto Darszon, Adán Guerrero, Ana Laura González-Cota, Takuya Nishigaki, Gustavo Martínez-Mekler, Jorge Carneiro

Get full text

Acidosis differentially modulates inactivation in NaV1.2, NaV1.4, and NaV1.5 channels by Yury Y. Vilin, Colin H. Peters, Peter eRuben

“…NaV channels play a crucial role in neuronal and muscle excitability. …”
Get full text

Identification of positive modulators of TRPM5 channel from a high-throughput screen using a fluorescent membrane potential assay by Caterina Virginio, Laura Aldegheri, Selena Nola, Daniela Brodbeck, Laurent Brault, Luca F. Raveglia, Alessio Barilli, Mark Sabat, Richard Myers

“…By employing these assays, we conducted a primary screening campaign and identified hit compounds as TRPM5 channel positive modulators. An initial selectivity profile confirmed hit selectivity to TRPM5 and is presented here. …”
Get full text

Deletion of <i>Trpm4</i> Alters the Function of the Na_v1.5 Channel in Murine Cardiac Myocytes by Lijo Cherian Ozhathil, Jean-Sébastien Rougier, Prakash Arullampalam, Maria C. Essers, Daniela Ross-Kaschitza, Hugues Abriel

Get full text

Real-Life Traffic Data Based ITS-G5 Channel Load Simulations of a Major Hungarian C-ITS Deployment Site by András Wippelhauser, Tamás Attila Tomaschek, Máté Verdes, László Bokor

Get full text

A role of canonical transient receptor potential 5 channel in neuronal differentiation from A2B5 neural progenitor cells. by Hye Young Shin, Yun Hwa Hong, Sung Soo Jang, Hong Gu Chae, Seung Leal Paek, Hyo Eun Moon, Dong Gyu Kim, Jun Kim, Sun Ha Paek, Sang Jeong Kim

Get full text

Haploinsufficiency of KCNAB3 causes sudden cardiac death through delayed inactivation of Kv1.5 channel upon depolarization and induced myocardial apoptosis by He-Yu Ji, Zhao-Jing Lin, Chan Chen, Jun-Mei Xu, Rong Yu, Lv Liu

Get full text

Subtype-specific responses of hKv7.4 and hKv7.5 channels to polyunsaturated fatty acids reveal an unconventional modulatory site and mechanism by Damon JA Frampton, Koushik Choudhury, Johan Nikesjö, Lucie Delemotte, Sara I Liin

“…Therefore, the mechanisms that regulate KV7.4 and KV7.5 channel function are of interest. Here, we study the effect of polyunsaturated fatty acids (PUFAs) on human KV7.4 and KV7.5 channels expressed in Xenopus oocytes. …”
Get full text

Differential Effect of Three Macrolide Antibiotics on Cardiac Pathology and Electrophysiology in a Myocardial Infarction Rat Model: Influence on Sodium Nav1.5 Channel Expression by Noha E. Farag, Mohamed K. El-Kherbetawy, Hussein M. Ismail, Ahmed M. Abdelrady, Eman A. Toraih, Walid Kamal Abdelbasset, Rehab M. Lashine, Mohammed EL-dosoky, Sally Yussef Abed, Khalid M. Ibraheem, Manal S. Fawzy, Sawsan A. Zaitone

“…In conclusion, the current findings suggested the potential cardiotoxic effects of chronic doses of macrolide antibiotics in rats with MI as manifested by abnormal ECG changes and pathological findings in addition to downregulation of Nav1.5 channels. Furthermore, in the current dose ranges, azithromycin produced the least toxicity compared to clarithromycin and erythromycin.…”
Get full text