Fowlpox virus recombinants expressing HPV-16 E6 and E7 oncogenes for the therapy of cervical carcinoma elicit humoral and cell-mediated responses in rabbits by Pacchioni Sole, Pozzi Eleana, Radaelli Antonia, Zanotto Carlo, Morghen Carlo

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Safety of recombinant fowlpox strain FP9 and modified vaccinia virus Ankara vaccines against liver-stage P. falciparum malaria in non-immune volunteers. by Webster, D, Dunachie, S, McConkey, S, Poulton, I, Moore, A, Walther, M, Laidlaw, S, Peto, T, Skinner, M, Gilbert, S, Hill, A

“…We report on two such vaccine constructs, modified vaccinia virus Ankara and FP9 (an attenuated fowlpox virus) both expressing the pre-erythrocytic malaria antigen thrombospondin-related adhesion protein and a string of CD8+ epitopes (ME-TRAP). …”

Negligible effect of chicken cytokine IL-12 integration into recombinant fowlpox viruses expressing avian influenza virus neuraminidase N1 on host cellular immune responses by Nor Majid, Nadzreeq, Omar, Abdul Rahman, Abdul Razak, Mariatulqabtiah

“…This study describes the construction and cellular responses of recombinant fowlpox viruses (rFWPV) strain FP9, co-expressing NA N1 gene of AIV A/Chicken/Malaysia/5858/2004, and chicken IL-12 gene. …”
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Verification of H5 gene expression from H5-recombinant fowlpox viruses co-expressing host cytokine using indirect immunofluorescence antibody test (IFAT) by Steffi, Julan Wan

“…Fowlpox virus (FWPV) has been used in vaccine development against avian influenza virus (AIV) by the expression of the AIV haemagglutinin (HA) gene. …”
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Verification of H5 and IL-15 gene expressions from H5-recombinant fowlpox viruses coexpressing host cytokine by using sds-page and western blotting by Zulkifli, Nurul Farhana

“…In this study, the recombinant fowlpox virus (rFWPV) were analysed by using SDS-PAGE and Western blotting to verify the expression of H5 and IL-15 genes. …”
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NY-ESO-1 specific antibody and cellular responses in melanoma patients primed with NY-ESO-1 protein in ISCOMATRIX and boosted with recombinant NY-ESO-1 fowlpox virus. by Chen, J, Dawoodji, A, Tarlton, A, Gnjatic, S, Tajar, A, Karydis, I, Browning, J, Pratap, S, Verfaille, C, Venhaus, R, Pan, L, Altman, D, Cebon, J, Old, L, Nathan, P, Ottensmeier, C, Middleton, M, Cerundolo, V

“…To address this question, we carried out a randomized clinical trial in 39 high-risk, resected melanoma patients vaccinated with NY-ESO-1 ISCOMATRIX, and then boosted with repeated injections of either recombinant fowlpox virus encoding full length NY-ESO-1 (rF-NY-ESO-1) (Arm A) or NY-ESO-1 ISCOMATRIX alone (Arm B). …”

Induction of a strong HIV-specific CD8+ T cell response in mice using a fowlpox virus vector expressing an HIV-1 multi-CTL-epitope polypeptide. by Vázquez Blomquist, D, Green, P, Laidlaw, S, Skinner, M, Borrow, P, Duarte, C

“…Here, we report the expression of a multiepitope polypeptide (TAB9) composed of the central 15 amino acids of the V3 loop from six different isolates of HIV-1 in a fowlpox virus (FWPV) vector, and the use of this vector (FPTAB9LZ) to induce strong HIV-specific CD8+ T cell responses in mice. …”

Enhanced CD8+ T cell immune responses and protection elicited against Plasmodium berghei malaria by prime boost immunization regimens using a novel attenuated fowlpox virus. by Anderson, R, Hannan, C, Gilbert, S, Laidlaw, S, Sheu, E, Korten, S, Sinden, R, Butcher, G, Skinner, M, Hill, A

“…In this study, we have investigated the use of attenuated fowlpox virus (FPV) strains as recombinant vaccine vectors for eliciting CD8(+) T cells against Plasmodium berghei. …”

Genomic characteristics of an avipoxvirus 282E4 strain by Lingcong Deng, Cunxia Liu, Letian Li, Pengfei Hao, Maopeng Wang, Ningyi Jin, Ronglan Yin, Shouwen Du, Chang Li

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Safety profile of the viral vectors of attenuated fowlpox strain FP9 and modified vaccinia virus Ankara recombinant for either of 2 preerythrocytic malaria antigens, ME-TRAP or the circumsporozoite protein, in children and adults in Kenya by Bejon, P, Peshu, N, Gilbert, S, Lowe, B, Molyneux, C, Forsdyke, J, Lang, T, Hill, A, Marsh, K

“…These vaccines used the attenuated fowlpox strain FP9 and the MVA recombinant for either of 2 preerythrocytic malaria antigens, multiple preerythrocytic-stage epitopes joined with the preerythrocytic-stage antigen TRAP (ME-TRAP) and the circumsporozoite protein (CS). …”

Safety profile of the viral vectors of attenuated fowlpox strain FP9 and modified vaccinia virus Ankara recombinant for either of 2 preerythrocytic malaria antigens, ME-TRAP or the circumsporozoite protein, in children and adults in Kenya. by Bejon, P, Peshu, N, Gilbert, S, Lowe, B, Molyneux, C, Forsdyke, J, Lang, T, Hill, A, Marsh, K

“…These vaccines used the attenuated fowlpox strain FP9 and the MVA recombinant for either of 2 preerythrocytic malaria antigens, multiple preerythrocytic-stage epitopes joined with the preerythrocytic-stage antigen TRAP (ME-TRAP) and the circumsporozoite protein (CS). …”

Evidence of a Possible Viral Host Switch Event in an Avipoxvirus Isolated from an Endangered Northern Royal Albatross (<i>Diomedea sanfordi</i>) by Subir Sarker, Timothy R. Bowden, David B. Boyle

“…Here we report evidence for a possible host switching event with a fowlpox-like virus recovered from an endangered northern royal albatross (<i>Diomodea sanfordi</i>)—a species of <i>Procellariiformes</i>, unrelated to <i>Galliformes</i>, not previously known to have been infected with fowlpox-like viruses. …”
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Heterologous priming-boosting immunization of cattle with Mycobacterium tuberculosis 85A induces antigen-specific T-cell responses. by Taracha, E, Bishop, R, Musoke, A, Hill, A, Gilbert, S

“…T-cell responses induced by priming with either plasmid DNA or fowlpox virus 85A constructs were enhanced by boosting with modified vaccinia virus Ankara expressing the same antigen administered intradermally. …”

Positive selection in the hemagglutinin-neuraminidase gene of Newcastle disease virus and its effect on vaccine efficacy by Hu Shunlin, Yao Chunfeng, Cao Yongzhong, Xu Lijun, Liu Wujie, Gu Min, Liu Xiufan

“…Two groups of SPF chickens, 18 each, were vaccinated with the two recombinant fowlpox viruses and challenged by Go/JS6/05 at 3 weeks post-immunization. …”
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Safety, immunogenicity, and efficacy of prime-boost immunization with recombinant poxvirus FP9 and modified vaccinia virus Ankara encoding the full-length Plasmodium falciparum cir... by Walther, M, Thompson, F, Dunachie, S, Keating, S, Todryk, S, Berthoud, T, Andrews, L, Andersen, R, Moore, A, Gilbert, S, Poulton, I, Dubovsky, F, Tierney, E, Correa, S, Huntcooke, A, Butcher, G, Williams, J, Sinden, R, Hill, A

“…Here we report a series of trials assessing recombinant fowlpox virus and modified vaccinia virus Ankara encoding the Plasmodium falciparum circumsporozoite protein in various prime-boost combinations, doses, and application routes. …”

Avipoxviruses: infection biology and their use as vaccine vectors by Tryland Morten, Weli Simon C

“…APVs are transmitted by aerosols and biting insects, particularly mosquitoes and arthropods and are usually named after the bird species from which they were originally isolated. The virus species Fowlpox virus (FWPV) causes disease in poultry and associated mortality is usually low, but in flocks under stress (other diseases, high production) mortality can reach up to 50%. …”
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Enhanced T cell-mediated protection against malaria in human challenges by using the recombinant poxviruses FP9 and modified vaccinia virus Ankara. by Webster, D, Dunachie, S, Vuola, J, Berthoud, T, Keating, S, Laidlaw, S, McConkey, S, Poulton, I, Andrews, L, Andersen, R, Bejon, P, Butcher, G, Sinden, R, Skinner, M, Gilbert, S, Hill, A

“…Here, we report that substitution of plasmid DNA as the priming vector with a specific attenuated recombinant fowlpox virus, FP9, vaccine in such prime-boost regimes can elicit complete sterile protection that can last for 20 months. …”

Progress in DNA-based heterologous prime-boost immunization strategies for malaria. by Moore, A, Hill, A

“…We have evaluated this heterologous prime-boost approach using the Plasmodium berghei mouse model for immunogenicity and protective efficacy against malaria challenge using combinations of plasmid DNA, recombinant modified vaccinia virus Ankara, fowlpox virus, and non-replicating adenovirus. We have proceeded to test immunogenicity and efficacy of successful heterologous prime-boost vaccines in phase I/IIa trials in malaria naïve subjects in the UK and in semi-immune individuals in The Gambia. …”

Immunogenicity of the candidate malaria vaccines FP9 and modified vaccinia virus Ankara encoding the pre-erythrocytic antigen ME-TRAP in 1-6 year old children in a malaria endemic... by Bejon, P, Mwacharo, J, Kai, O, Todryk, S, Keating, S, Lang, T, Gilbert, S, Peshu, N, Marsh, K, Hill, A

“…The regimes used two recombinant viral vectors, attenuated fowlpox strain FP9 and modified vaccinia virus Ankara (MVA). …”

Alternating vector immunizations encoding pre-erythrocytic malaria antigens enhance memory responses in a malaria endemic area. by Bejon, P, Kai, O, Mwacharo, J, Keating, S, Lang, T, Gilbert, S, Peshu, N, Marsh, K, Hill, A

“…The component vaccinations were recombinant attenuated viruses, either fowlpox (FP) 9 or modified vaccinia virus Ankara (MVA). …”