NF-κB/c-Rel deficiency causes Parkinson’s disease-like prodromal symptoms and progressive pathology in mice by Edoardo Parrella, Arianna Bellucci, Vanessa Porrini, Marina Benarese, Annamaria Lanzillotta, Gaia Faustini, Francesca Longhena, Giulia Abate, Daniela Uberti, Marina Pizzi

“…PD patients manifest a prodromal syndrome that includes olfactory and gastrointestinal dysfunctions years before the frank degeneration of nigrostriatal neurons and appearance of motor symptoms. …”
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Nuovi luoghi dell’abbandono: effetti collaterali dell’”Architettura Miracolosa” in Spagna by Dario Giordanelli

“…A cavallo tra il XX ed il XXI secolo, la Spagna è stata interessata da un florido periodo di investimenti sia pubblici che privati in architettura, guidato dal cosiddetto “Effetto Bilbao”, che si suppone abbia inizio con la costruzione del museo Guggenheim nella città basca, ad opera dell’architetto Frank Gehry. Tuttavia, la crisi globale ha determinato un periodo di stagnazione economica, che ha portato alla stasi edilizia. …”
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RETRACTED ARTICLE: A leptospiral AAA+ chaperone–Ntn peptidase complex, HslUV, contributes to the intracellular survival of Leptospira interrogans in hosts and the transmission of l... by Shi-Lei Dong, Wei-Lin Hu, Yu-Mei Ge, David M Ojcius, Xu'ai Lin, Jie Yan

“…Ojcius, Dexter Sun, Yumei Ge, Jinfang Zhao, X. Frank Yang, Lanjuan Li, Jie Yan, Identification of Collagenase as a Critical Virulence Factor for Invasiveness and Transmission of Pathogenic Leptospira Species, The Journal of Infectious Diseases, Volume 209, Issue 7, 1 April 2014, Pages 1105–1115, DOI: 10.1093/infdis/jit659When approached for an explanation, the authors were unable to provide an explanation or verify their original data. …”
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Invasive Cryptococcal Meningitis Presenting as a Skull Base Mass in An Immunocompetent Host: A Case Report by Joshua Prickett, Juan Altafulla, Anna Knisely, Zachary Litvack

“…Fungal sinusitis with frank invasion through the cranial base and subsequent seeding of the central nervous system is rare, but should be considered in the differential of patients presenting with meningitis and sinus/skull base lesions even without obvious immune compromise. …”
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Subclinical right ventricular dysfunction in patients with asymptomatic type 2 diabetes mellitus: A cross-sectional study by Prabhat Rijal, Barun Kumar, Shruti Barnwal, Meenakshi Khapre, Divas Rijal, Ravi Kant

“…This study emphasizes that the early identification of RV diastolic as well as systolic dysfunction in asymptomatic Type 2 diabetic patients can be a helpful tool in halting the progression of disease from subclinical to frank clinical cases, thereby preventing the morbidity and mortality associated with heart failure. …”
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Reflectance adaptive optics findings in a patient with Vogt-Koyanagi-Harada disease by Aarin Thuan Pham, Neil Onghanseng, Muhammad Sohail Halim, Maria Soledad Ormaechea, Muhammad Hassan, Amir Akhavanrezayat, Gunay Uludag, Anh NT. Tran, Moataz M. Razeen, Nripun Sredar, Alfredo Dubra, Quan Dong Nguyen

“…At the time of presentation, though vision was improving, and frank serous retinal detachments were absent, spectral domain optical coherence tomography (SD-OCT) showed presence of residual subretinal fluid with disruption of the photoreceptor inner segments and outer segments (IS/OS) involving OU. …”
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Deciphering the pathogenesis of the COL4‐related hematuric nephritis: A genotype/phenotype study by Vera Uliana, Paola Sebastio, Matteo Riva, Diana Carli, Claudio Ruberto, Laura Bianchi, Claudio Graziano, Irene Capelli, Flavio Faletra, Roberto Pillon, Teresa Mattina, Alberto Sensi, Francesco Bonatti, Antonio Percesepe

“…Abstract Background Alport syndrome (ATS) is a hereditary progressive hematuric nephropathy associated with sensorineural deafness and ocular abnormalities, which is caused by mutations in the COL4A5 gene (X‐linked ATS) and in two autosomal genes, COL4A4 and COL4A3, responsible of both recessive ATS and, when present in heterozygosity, of a spectrum of phenotypes ranging from isolated hematuria to frank renal disease. Methods Retrospective analysis of the clinical and genetic features of 76 patients from 34 unrelated ATS families (11 with mutations in COL4A5, 11 in COL4A3, and 12 in COL4A4) and genotype/phenotype correlation for the COL4A3/COL4A4 heterozygotes (34 patients from 14 families). …”
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Acknowledgment of Reviewers 2021

“…Bei-Hung Chang Huiping Chen Elizabeth Collins Lori Constantine Joseph Cooke Sebastian Cousins Patrick Coyne LaVera Crawley Sarah Cross Constance Dahlin Barbara Daly Bethany-Rose Daubman Kate Davidoff Amy Davis Horace DeLisser Rony Dev Mindy Dickerman Megan Doherty Julia Downing Emily Earl-Royal Frank Elsner Mary Engel Peter Engeser Emma Ernst Elyse Everett Regina Fink MaryBeth Foglia Liz Forbat Anessa Foxwell Jessica Fry Angelica Fuentes Armesto Brittany Gatta Barbara Given Ali Haider Erin Haley Dana Hansen Takaaki Hasegawa Joshua Hauser Rachel Havyer Kerstin Karen Hein Melissa Hoffman Ryan Hughes Kengo Imai Kenji Ina Anand Iyer Annemarie Jagielo Jill Ann Jarrell Zhimeng Jia Gina Johnson Danielle Jonas Christopher Jones Karen Jooste Ryan Jozwiak Miguel Juli?…”
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Body Composition, Energy Availability, Risk of Eating Disorder, and Sport Nutrition Knowledge in Young Athletes by Meghan K. Magee, Margaret T. Jones, Jennifer B. Fields, Julie Kresta, Chinguun Khurelbaatar, Christopher Dodge, Brandon Merfeld, Abby Ambrosius, Makenna Carpenter, Andrew R. Jagim

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Association of Treatment Duration and Clinical Outcomes in Dry Eye Treatment with Sutureless Cryopreserved Amniotic Membrane by McDonald M, Janik SB, Bowden FW, Chokshi A, Singer MA, Tighe S, Mead OG, Nanda S, Qazi MA, Dierker D, Shupe AT, McMurren BJ

“…Marguerite McDonald,1 Susan B Janik,2 Frank W Bowden,3 Amit Chokshi,4 Michael A Singer,5 Sean Tighe,6,7 Olivia G Mead,6 Seema Nanda,8 Mujtaba A Qazi,9 Damon Dierker,10 Adam T Shupe,11 Brittany J McMurren12 1Ophthalmic Consultants of Long Island, Lynbrook, NY, USA; 2Solinsky Eye Care, Kensington, CT, USA; 3Bowden Eye & Associates, Jacksonville, FL, USA; 4Florida Eye Specialists, Jacksonville, FL, USA; 5Medical Center Ophthalmology Associates, San Antonio, TX, USA; 6BioTissue Holdings, Inc, Miami, FL, USA; 7Florida International University Herbert Wertheim College of Medicine, Miami, FL, USA; 8Nanda Dry Eye & Vision Institute, Houston, TX, USA; 9Pepose Vision Institute, Chesterfield, MO, USA; 10Eye Surgeons of Indiana, Indianapolis, IN, USA; 11Royo Eye Care, Marysville, CA, USA; 12Werner Optometry, San Diego, CA, USACorrespondence: Sean Tighe, 7300 Corporate Center Drive, Suite 700, Miami, FL, 33126, USA, Email stighe@biotissue.comBackground: While sutureless, cryopreserved amniotic membrane (cAM) has been shown to significantly improve signs and symptoms of dry eye disease (DED), no studies have assessed the association of cAM treatment duration to the differential response in clinical outcomes.Methods: A multi-center, retrospective study was conducted on patients with moderate-to-severe DED who were treated with self-retained cAM (Prokera® Slim) for 2 to 7 days. …”
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Sleep Disturbance in Musculoskeletal Conditions: Impact of a Digital Care Program by Scheer JK, Costa F, Janela D, Molinos M, Areias AC, Moulder RG, Lains J, Bento V, Yanamadala V, Correia FD

“…Justin K Scheer,1 Fabíola Costa,2 Dora Janela,2 Maria Molinos,2 Anabela C Areias,2 Robert G Moulder,3 Jorge Lains,4,5 Virgílio Bento,2 Vijay Yanamadala,2,6,7 Fernando Dias Correia2,8 1Department of Neurological Surgery, University of California, San Francisco, CA, USA; 2Sword Health, Inc, Draper, UT, USA; 3Institute for Cognitive Science, University of Colorado Boulder, Boulder, CO, USA; 4Rovisco Pais Medical and Rehabilitation Centre, Tocha, Portugal; 5Faculty of Medicine, Coimbra University, Coimbra, Portugal; 6Department of Surgery, Quinnipiac University Frank H. Netter School of Medicine, Hamden, CT, USA; 7Department of Neurosurgery, Hartford Healthcare Medical Group, Westport, CT, USA; 8Neurology Department, Centro Hospitalar e Universitário do Porto, Porto, PortugalCorrespondence: Fernando Dias Correia, Sword Health Inc, 13937 Sprague Lane Ste 100, Draper, UT, 84020, USA, Tel +1 385-308-8034, Fax +1 801-206-3433, Email fcorreia@swordhealth.comBackground: Musculoskeletal (MSK) pain is highly prevalent worldwide, resulting in significant disability, and comorbid sleep disturbances. …”
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HER2 Low Expression in Primary Male Breast Cancer by Nobbe K, Erices-Leclercq M, Foerster F, Förster R, Baldus SE, Rudlowski C, Schröder L, Lubig S

“…Katleen Nobbe,1 Melanie Erices-Leclercq,1 Frank Foerster,2,3 Robert Förster,4 Stephan E Baldus,5 Christian Rudlowski,1,6 Lars Schröder,7 Sabine Lubig1 1Breast Unit, Lutheran Hospital Bergisch Gladbach, Bergisch Gladbach, Germany; 2Department of Economical Sciences, University of Applied Sciences, Zwickau, Germany; 3Outpatient Department of Gynaecological Oncology and Palliative Care, Chemnitz, Germany; 4Institute for Radiation Oncology, Cantonal Hospital Winterthur, Winterthur, Switzerland; 5Institute for Pathology, Cytology and Molecular Pathology, Bergisch Gladbach, Germany; 6Department of Gynecology, University Hospital Bonn, Bonn, Germany; 7Department of Gynaecology and Obstetrics, Ketteler Krankenhaus, Offenbach, GermanyCorrespondence: Christian Rudlowski, Breast Unit, Lutheran Hospital Bergisch Gladbach, Ferrenbergstrasse 24, Bergisch Gladbach, 51465, Germany, Email c.rudlowski@evk.dePurpose: The introduction of HER2-targeting antibody drug conjugates (ADCs) offers new treatment options for female breast cancer patients (FBC) expressing low levels of HER2 (HER2 low). …”
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Feasibility of a Vertically Integrated Teaching Strategy during a Surgical Clerkship Event—Learning Methods Matter by Miklos C. Fogarasi, Christine Van Cott, Richard S. Feinn, Steven A. Hirshorn, Eugene H. Lewis, Susan V. Fernandez, Lori Ratchelous, Julia A. O’Connor, Larry D. Gruppen

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Impacts of the Early COVID-19 Pandemic on Depressive Symptoms and Mental Health Among Student-Athletes by Ahmad CS, Hellwinkel JE, Ahmed R, Alexander FJ, Reynolds AW, Piasecki DP, Bottiglieri TS, Lynch TS, Popkin CA, Saltzman BM, Trofa DP

“…Christopher S Ahmad,1 Justin E Hellwinkel,1 Rifat Ahmed,1 Frank J Alexander,1 Alan W Reynolds,1 Dana P Piasecki,2,3 Thomas S Bottiglieri,1 T Sean Lynch,1 Charles A Popkin,1 Bryan M Saltzman,2,3 David P Trofa1 1Department of Orthopedic Surgery, Columbia University Irving Medical Center, New York, NY, 10032, USA; 2Sports Medicine Center, OrthoCarolina, Charlotte, NC, 28207, USA; 3Musculoskeletal Institute, Atrium Health, Charlotte, NC, 28207, USACorrespondence: David P Trofa, Columbia University Irving Medical Center, 622 West 168 St, PH-11, New York, NY, 10032, Email dpt2103@cumc.columbia.eduObjective: Social distancing protocols due to the COVID-19 pandemic resulted in premature ending of athletic seasons and cancellation of upcoming seasons, placing significant stress on young athletes. …”
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Racial differences in the associations between adiposity, placental growth hormone and inflammatory cytokines in pregnant women by Camille Y. Williams, Camille Y. Williams, Amanda Wylie, Amanda Wylie, Verina Ghobrial, Christopher L. Coe, Sarah J. Short, Sarah J. Short

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Digital Technologies Role in the Preservation of Jewish Cultural Heritage: Case Study Heyman House, Oradea, Romania by Vasile Grama, Gabriela Ilies, Bahodirhon Safarov, Alexandru Ilies, Tudor Caciora, Nicolaie Hodor, Dorina Camelia Ilies, Damiannah Kieti, Zharas Berdenov, Ioana Josan, Kurmanbek Narynbek uulu

“…The Jewish community of Oradea had an important representative in Éva Heyman, a child of the Holocaust, nicknamed “<i>Anne Frank of Transylvania</i>”, which became famous. …”
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Changes Seen, Foreseen and Unforeseen by Michael Kirby Justice

“…The disciplined Pat Lane, comfortable in the analytical jurisprudence then so dominant in the constitutional law of the High Court of Australia. The mercurial Frank Hutley, whose unpredictable examination questions on the law of succession were every law student’s nightmare. …”
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Latanoprostene Bunod 0.024% in Patients with Open-Angle Glaucoma Switched from Prior Pharmacotherapy: A Retrospective Chart Review by Okeke CO, Cothran NL, Brinkley DA, Rahmatnejad K, Rodiño FJ, Deom JE

“…Constance O Okeke,1 Nora Lee Cothran,2 Desirae A Brinkley,3 Kamran Rahmatnejad,4 Frank J Rodiño,5 James E Deom6 1Virginia Eye Consultants/CVP, Norfolk, VA, USA; 2The Eye Institute of West Florida, Largo, FL, USA; 3Eye Specialty Group, Memphis, TN, USA; 4Eastern Virginia Medical School, Norfolk, VA, USA; 5Churchill Outcomes Research, Red Bank, NJ, USA; 6Hazleton Eye Specialists, Hazle Township, PA, USACorrespondence: Constance O Okeke, Virginia Eye Consultants/CVP, 241 Corporate Blvd, Norfolk, VA, 23320, USA, Tel +1 757-622-2200, Fax +1 757-622-4866, Email cokeke@cvphealth.comIntroduction: Latanoprostene bunod 0.024% (LBN, Vyzulta®) is a nitric oxide-donating prostaglandin analog (PGA). …”
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From learned value to sustained bias: how reward conditioning changes attentional priority by Kristin N. Meyer, Joseph B. Hopfinger, Elena M. Vidrascu, Charlotte A. Boettiger, Charlotte A. Boettiger, Charlotte A. Boettiger, Charlotte A. Boettiger, Donita L. Robinson, Donita L. Robinson, Donita L. Robinson, Margaret A. Sheridan, Margaret A. Sheridan, Margaret A. Sheridan

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A regional comparative analysis of empirical and theoretical flood peak-volume relationships by Szolgay Ján, Gaál Ladislav, Bacigál Tomáš, Kohnová Silvia, Hlavčová Kamila, Výleta Roman, Parajka Juraj, Blöschl Günter

“…Extreme value copulas (Galambos, Gumbel and Hüsler-Reiss) show the best performance both for synoptic and flash floods, while the Frank copula shows the best performance for snowmelt floods. …”
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