Genome‐wide association study of café‐au‐lait macule number in neurofibromatosis type 1 by Heejong Sung, Paula L. Hyland, Alexander Pemov, Jeremy A. Sabourin, Andrea M. Baldwin, Sara Bass, Kedest Teshome, Wen Luo, Frederick National Laboratory for Cancer Research, Brigitte C. Widemann, Douglas R. Stewart, Alexander F. Wilson

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OP 2.4 – 00145 No Evidence of Ongoing Viral Replication in SIV-Infected Macaques on Combination Antiretroviral Therapy Initiated in the Chronic Phase of Infection Despite Elevated... by G.Q. Del Prete, M. Nag, T. Immonen, C. Fennessey, W. Bosch, A. Conchas, A.E. Swanstrom, J. Lifson, B.F. Keele, A. Macairan, K. Oswald, R. Fast, R. Shoemaker, L. Silipino, M. Hull, D. Donohue, T. Malys, G. Muthua, M. Breed, J. Kramer

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Producing recombinant proteins in Vibrio natriegens by Matthew Smith, José Sánchez Hernández, Simon Messing, Nitya Ramakrishnan, Brianna Higgins, Jennifer Mehalko, Shelley Perkins, Vanessa E. Wall, Carissa Grose, Peter H. Frank, Julia Cregger, Phuong Vi Le, Adam Johnson, Mukul Sherekar, Morgan Pagonis, Matt Drew, Min Hong, Stephanie R. T. Widmeyer, John-Paul Denson, Kelly Snead, Ivy Poon, Timothy Waybright, Allison Champagne, Dominic Esposito, Jane Jones, Troy Taylor, William Gillette

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KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation by Timothy H. Tran, Albert H. Chan, Lucy C. Young, Lakshman Bindu, Chris Neale, Simon Messing, Srisathiyanarayanan Dharmaiah, Troy Taylor, John-Paul Denson, Dominic Esposito, Dwight V. Nissley, Andrew G. Stephen, Frank McCormick, Dhirendra K. Simanshu

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Membrane interactions of the globular domain and the hypervariable region of KRAS4b define its unique diffusion behavior by Debanjan Goswami, De Chen, Yue Yang, Prabhakar R Gudla, John Columbus, Karen Worthy, Megan Rigby, Madeline Wheeler, Suman Mukhopadhyay, Katie Powell, William Burgan, Vanessa Wall, Dominic Esposito, Dhirendra K Simanshu, Felice C Lightstone, Dwight V Nissley, Frank McCormick, Thomas Turbyville

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No evidence for ongoing replication on ART in SIV-infected macaques by Taina T. Immonen, Christine M. Fennessey, Leslie Lipkey, Laura Newman, Agatha Macairan, Marjorie Bosche, Nora Waltz, Gregory Q. Del Prete, Jeffrey D. Lifson, Brandon F. Keele

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PP 2.15 – 00169 Macrophages are the primary source of virus in semen and male genital tract organs in acutely and chronically infected rhesus macaques by C. Deleage, C. Fennessey, J. Harper, S. Florea, L. Lipkey, R. Fast, M. Paiardini, J. Lifson, B. Keele

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Structural dynamics of RAF1-HSP90-CDC37 and HSP90 complexes reveal asymmetric client interactions and key structural elements by Lorenzo I. Finci, Mayukh Chakrabarti, Gulcin Gulten, Joseph Finney, Carissa Grose, Tara Fox, Renbin Yang, Dwight V. Nissley, Frank McCormick, Dominic Esposito, Trent E. Balius, Dhirendra K. Simanshu

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Reduced dynamic complexity allows structure elucidation of an excited state of KRASG13D by Fa-An Chao, Albert H. Chan, Srisathiyanarayanan Dharmaiah, Charles D. Schwieters, Timothy H. Tran, Troy Taylor, Nitya Ramakrishnan, Dominic Esposito, Dwight V. Nissley, Frank McCormick, Dhirendra K. Simanshu, Gabriel Cornilescu

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Circulating tumor DNA sequencing provides comprehensive mutation profiling for pediatric central nervous system tumors by Erin R. Bonner, Robin Harrington, Augustine Eze, Miriam Bornhorst, Cassie N. Kline, Heather Gordish-Dressman, Adam Dawood, Biswajit Das, Li Chen, Rini Pauly, P. Mickey Williams, Chris Karlovich, Amanda Peach, D’andra Howell, James Doroshow, Lindsay Kilburn, Roger J. Packer, Sabine Mueller, Javad Nazarian

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Organoids and metastatic orthotopic mouse model for mismatch repair-deficient colorectal cancer by Yurong Song, Travis D. Kerr, Chelsea Sanders, Lisheng Dai, Shaneen S. Baxter, Brandon Somerville, Ryan N. Baugher, Stephanie D. Mellott, Todd B. Young, Heidi E. Lawhorn, Teri M. Plona, Bingfang Xu, Lei Wei, Qiang Hu, Song Liu, Alan Hutson, Baktiar Karim, Sandra Burkett, Simone Difilippantonio, Ligia Pinto, Johannes Gebert, Matthias Kloor, Steven M. Lipkin, Shizuko Sei, Robert H. Shoemaker

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Kaposi sarcoma herpesvirus viral load as a biomarker for leptomeningeal involvement by primary effusion lymphoma by Kathryn Lurain, Ramya Ramaswami, Vickie Marshall, Elena M. Cornejo Castro, Nazzarena Labo, Wendell Miley, Kyle Moore, Romin Roshan, Ralph Mangusan, Elaine S. Jaffe, Stefania Pittaluga, Hao-Wei Wang, Mark Roth, Armando C. Filie, Thomas S. Uldrick, Denise Whitby, Robert Yarchoan

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Complete Genome Sequence of Herpes Simplex Virus 2 Strain G by Weizhong Chang, Xiaoli Jiao, Hongyan Sui, Suranjana Goswami, Brad T. Sherman, Caroline Fromont, Juan Manuel Caravaca, Bao Tran, Tomozumi Imamichi

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Structural insights into isoform-specific RAS-PI3Kα interactions and the role of RAS in PI3Kα activation by Daniel Czyzyk, Wupeng Yan, Simon Messing, William Gillette, Takashi Tsuji, Mitsuhiro Yamaguchi, Shinji Furuzono, David M. Turner, Dominic Esposito, Dwight V. Nissley, Frank McCormick, Dhirendra K. Simanshu

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Interleukin-27 promotes autophagy in human serum-induced primary macrophages via an mTOR- and LC3-independent pathway by Sylvain Laverdure, Ziqiu Wang, Jun Yang, Takuya Yamamoto, Tima Thomas, Toyotaka Sato, Kunio Nagashima, Tomozumi Imamichi

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A novel retinoic acid receptor-γ agonist antagonizes immune checkpoint resistance in lung cancers by altering the tumor immune microenvironment by Cheng-Hsin Wei, Lu Huang, Blair Kreh, Xiuxia Liu, Liliya Tyutyunyk-Massey, Masanori Kawakami, Zibo Chen, Mi Shi, Serguei Kozlov, King C. Chan, Thorkell Andresson, Mary Carrington, Vidyasagar Vuligonda, Martin E. Sanders, Amir Horowitz, Patrick Hwu, Weiyi Peng, Ethan Dmitrovsky, Xi Liu

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Interleukin-27-polarized HIV-resistant M2 macrophages are a novel subtype of macrophages that express distinct antiviral gene profiles in individual cells: implication for the anti... by Tomozumi Imamichi, Jun Yang, Qian Chen, Suranjana Goswami, Mayra Marquez, Udeshika Kariyawasam, Homa Nath Sharma, Rosana Wiscovitch-Russo, Xuan Li, Akihiro Aioi, Joseph W. Adelsberger, Weizhong Chang, Jeanette Higgins, Hongyan Sui

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Long-acting lenacapavir protects macaques against intravenous challenge with simian-tropic HIVResearch in context by Adrienne E. Swanstrom, Robert J. Gorelick, Jorden L. Welker, Fabian Schmidt, Bing Lu, Kelly Wang, William Rowe, Matthew W. Breed, Kristin E. Killoran, Joshua A. Kramer, Duncan Donohue, James D. Roser, Paul D. Bieniasz, Theodora Hatziioannou, Cathi Pyle, James A. Thomas, Charles M. Trubey, Jim Zheng, Wade Blair, Stephen R. Yant, Jeffrey D. Lifson, Gregory Q. Del Prete

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Longitudinal Assessment of BNT162b2- and mRNA-1273-Induced Anti-SARS-CoV-2 Spike IgG Levels and Avidity Following Three Doses of Vaccination by Jimmie L. Bullock, Thomas E. Hickey, Troy J. Kemp, Jordan Metz, Sarah Loftus, Katarzyna Haynesworth, Nicholas Castro, Brian T. Luke, Douglas R. Lowy, Ligia A. Pinto

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Improvement of RG1-VLP vaccine performance in BALB/c mice by substitution of alhydrogel with the next generation polyphosphazene adjuvant PCEP by Sarah M. Valencia, Athina Zacharia, Alexander Marin, Rebecca L. Matthews, Chia-Kuei Wu, Breana Myers, Chelsea Sanders, Simone Difilippantonio, Reinhard Kirnbauer, Richard B. Roden, Ligia A. Pinto, Robert H. Shoemaker, Alexander K. Andrianov, Jason D. Marshall

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