The small molecule inhibitor BX-795 uncouples IL-2 production from inhibition of Th2 inflammation and induces CD4+ T cells resembling iTreg by Peter A. Tauber, Bernhard Kratzer, Philipp Schatzlmaier, Ursula Smole, Cordula Köhler, Lisa Rausch, Jan Kranich, Doris Trapin, Alina Neunkirchner, Maja Zabel, Sabrina Jutz, Peter Steinberger, Gabriele Gadermaier, Thomas Brocker, Hannes Stockinger, Sophia Derdak, Winfried F. Pickl, Winfried F. Pickl

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Editorial: Macrophage Metabolism and Immune Responses by Héctor Rodríguez, Rafael Prados-Rosales, José Luis Lavín, Massimiliano Mazzone, Massimiliano Mazzone, Juan Anguita, Juan Anguita

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Regulation of microtubule nucleation in mouse bone marrow-derived mast cells by ARF GTPase-activating protein GIT2 by Vadym Sulimenko, Vladimíra Sládková, Tetyana Sulimenko, Eduarda Dráberová, Věra Vosecká, Lubica Dráberová, Omar Skalli, Pavel Dráber

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Sequential Anti-PD1 Therapy Following Dendritic Cell Vaccination Improves Survival in a HER2 Mammary Carcinoma Model and Identifies a Critical Role for CD4 T Cells in Mediating the... by Krithika N. Kodumudi, Ganesan Ramamoorthi, Colin Snyder, Amrita Basu, Yongsheng Jia, Yongsheng Jia, Sabrina Awshah, Amber P. Beyer, Doris Wiener, Lian Lam, Hongtao Zhang, Mark I. Greene, Ricardo L. B. Costa, Ricardo L. B. Costa, Brian J. Czerniecki, Brian J. Czerniecki

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Development of Immune Cells in the Intestinal Mucosa Can Be Affected by Intensive and Extensive Farm Environments, and Antibiotic Use by Zoe Christoforidou, Rachel Burt, Imke Mulder, Bhupinder P. Gill, John Pluske, Denise Kelly, Christopher R. Stokes, Michael Bailey, Marie C. Lewis

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The Sequence of Chemotherapy and Toripalimab Might Influence the Efficacy of Neoadjuvant Chemoimmunotherapy in Locally Advanced Esophageal Squamous Cell Cancer—A Phase II Study by Wenqun Xing, Lingdi Zhao, Yan Zheng, Baoxing Liu, Xianben Liu, Tiepeng Li, Yong Zhang, Baozhen Ma, Yonghao Yang, Yiman Shang, Xiaomin Fu, Guanghui Liang, Dongfeng Yuan, Jinrong Qu, Xiaofei Chai, He Zhang, Zibing Wang, Hongwei Lin, Liang Liu, Xiubao Ren, Jiangong Zhang, Quanli Gao

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Nuclear Receptors Regulate Intestinal Inflammation in the Context of IBD by Victoria Klepsch, Alexander R. Moschen, Herbert Tilg, Gottfried Baier, Natascha Hermann-Kleiter

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Case Report: Successful Treatment of Alopecia Universalis With Tofacitinib and Increased Cytokine Levels: Normal Therapeutic Reaction or Danger Signal? by Ling Yu, Huiqian Yu, Shuai Zhang, Yanzhao Hao, Shoumin Zhang

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The Role of Transforming Growth Factor Beta-1 in the Progression of HIV/AIDS and Development of Non-AIDS-Defining Fibrotic Disorders by Annette J. Theron, Annette J. Theron, Ronald Anderson, Theresa M. Rossouw, Helen C. Steel

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Extracellular matrix metalloproteinase inducer in brain ischemia and intracerebral hemorrhage by Yang Liu, Yang Liu, Yanling Mu, Yanling Mu, Zhe Li, Zhe Li, Voon Wee Yong, Mengzhou Xue, Mengzhou Xue

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Chimeric Antigen Receptor-Engineered NK-92 Cells: An Off-the-Shelf Cellular Therapeutic for Targeted Elimination of Cancer Cells and Induction of Protective Antitumor Immunity by Congcong Zhang, Congcong Zhang, Congcong Zhang, Pranav Oberoi, Sarah Oelsner, Anja Waldmann, Aline Lindner, Torsten Tonn, Torsten Tonn, Torsten Tonn, Torsten Tonn, Winfried S. Wels, Winfried S. Wels, Winfried S. Wels

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Comparative Analysis of the Regulatory T Cells Dynamics in Peripheral Blood in Human and Porcine Polytrauma by Rafael Serve, Ramona Sturm, Lukas Schimunek, Philipp Störmann, David Heftrig, Michel P. J. Teuben, Elsie Oppermann, Klemens Horst, Roman Pfeifer, Tim P. Simon, Yannik Kalbas, Hans-Christoph Pape, Frank Hildebrand, Ingo Marzi, Borna Relja

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Therapeutic Vaccination of Hematopoietic Cell Transplantation Recipients Improves Protective CD8 T-Cell Immunotherapy of Cytomegalovirus Infection by Kerstin M. Gergely, Jürgen Podlech, Sara Becker, Kirsten Freitag, Steffi Krauter, Nicole Büscher, Rafaela Holtappels, Bodo Plachter, Matthias J. Reddehase, Niels A. W. Lemmermann

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Schistosoma mansoni SmKI-1 or Its C-Terminal Fragment Induces Partial Protection Against S. mansoni Infection in Mice by Suellen B. Morais, Suellen B. Morais, Barbara C. Figueiredo, Barbara C. Figueiredo, Barbara C. Figueiredo, Natan R. G. Assis, Natan R. G. Assis, Jane Homan, Fábio S. Mambelli, Rodrigo M. Bicalho, Cláudia Souza, Vicente P. Martins, Carina S. Pinheiro, Sergio C. Oliveira, Sergio C. Oliveira

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Expression of the Inhibitory Receptor TIGIT Is Up-Regulated Specifically on NK Cells With CD226 Activating Receptor From HIV-Infected Individuals by Xiaowan Yin, Xiaowan Yin, Xiaowan Yin, Tingting Liu, Tingting Liu, Zhuo Wang, Zhuo Wang, Meichen Ma, Meichen Ma, Meichen Ma, Jie Lei, Jie Lei, Jie Lei, Zining Zhang, Zining Zhang, Zining Zhang, Shuai Fu, Shuai Fu, Shuai Fu, Yajing Fu, Yajing Fu, Yajing Fu, Qinghai Hu, Qinghai Hu, Qinghai Hu, Haibo Ding, Haibo Ding, Haibo Ding, Xiaoxu Han, Xiaoxu Han, Xiaoxu Han, Junjie Xu, Junjie Xu, Junjie Xu, Hong Shang, Hong Shang, Hong Shang, Hong Shang, Yongjun Jiang, Yongjun Jiang, Yongjun Jiang

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Evaluation of Blood-Based Antibody Rapid Testing for HIV Early Therapy: A Meta-Analysis of the Evidence by Xiaojie Huang, Xinchao Liu, Jieqing Chen, Yugang Bao, Jianhua Hou, Xiaofan Lu, Wei Xia, Huan Xia, Aixin Song, Zhiying Liu, Bin Su, Hui Chen, Yaokai Chen, Yaokai Chen, Hao Wu

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Deciphering imprints of impaired memory B-cell maturation in germinal centers of three patients with common variable immunodeficiency by Pauline van Schouwenburg, Pauline van Schouwenburg, Susanne Unger, Susanne Unger, Susanne Unger, Kathryn J. Payne, Kathryn J. Payne, Kathryn J. Payne, Fabian M. P. Kaiser, Fabian M. P. Kaiser, Ingrid Pico-Knijnenburg, Jens Pfeiffer, Oliver Hausmann, David Friedmann, David Friedmann, David Friedmann, Michelle Erbel, Maximilian Seidl, Maximilian Seidl, David van Zessen, Andrew P. Stubbs, Mirjam van der Burg, Klaus Warnatz, Klaus Warnatz

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The Effect of Hypothermic Machine Perfusion to Ameliorate Ischemia-Reperfusion Injury in Donor Organs by Laura W. D. Knijff, Laura W. D. Knijff, Cees van Kooten, Cees van Kooten, Rutger J. Ploeg, Rutger J. Ploeg

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Identification of TRIM14 as a Type I IFN-Stimulated Gene Controlling Hepatitis B Virus Replication by Targeting HBx by Guangyun Tan, Fengchao Xu, Hongxiao Song, Ye Yuan, Qingfei Xiao, Feng Ma, F. Xiao-Feng Qin, Genhong Cheng, Genhong Cheng, Genhong Cheng

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A strategy for high antibody expression with low anti-drug antibodies using AAV9 vectors by Meredith E. Davis-Gardner, Jesse A. Weber, Jun Xie, Jun Xie, Katja Pekrun, Eric A. Alexander, Kim L. Weisgrau, Jessica R. Furlott, Eva G. Rakasz, Mark A. Kay, Guangping Gao, Guangping Gao, Michael Farzan, Matthew R. Gardner, Matthew R. Gardner

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