Acute respiratory distress syndrome and acute lung injury in a trauma population with and without long bone fractures by Julia L. Larson, Henry T. Robertson, Henry T. Robertson, Henry T. Robertson, Scott F. Grey, Scott F. Grey, Scott F. Grey, Seth A. Schobel, Seth A. Schobel, Seth A. Schobel, Benjamin K. Potter, Benjamin K. Potter, Benjamin K. Potter, Eric A. Elster, Eric A. Elster, Eric A. Elster

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Forecasting SARS-CoV-2 spike protein evolution from small data by deep learning and regression by Samuel King, Samuel King, Samuel King, Xinyi E. Chen, Xinyi E. Chen, Xinyi E. Chen, Sarah W. S. Ng, Sarah W. S. Ng, Sarah W. S. Ng, Kimia Rostin, Kimia Rostin, Kimia Rostin, Samuel V. Hahn, Samuel V. Hahn, Tylo Roberts, Tylo Roberts, Janella C. Schwab, Janella C. Schwab, Parneet Sekhon, Parneet Sekhon, Madina Kagieva, Madina Kagieva, Madina Kagieva, Taylor Reilly, Taylor Reilly, Taylor Reilly, Ruo Chen Qi, Ruo Chen Qi, Paarsa Salman, Paarsa Salman, Paarsa Salman, Ryan J. Hong, Ryan J. Hong, Eric J. Ma, Steven J. Hallam, Steven J. Hallam, Steven J. Hallam, Steven J. Hallam, Steven J. Hallam, Steven J. Hallam

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Batch correction and harmonization of –Omics datasets with a tunable median polish of ratio by Eric B. Dammer, Eric B. Dammer, Nicholas T. Seyfried, Nicholas T. Seyfried, Nicholas T. Seyfried, Erik C. B. Johnson, Erik C. B. Johnson

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An adaptive, negative feedback circuit in a biohybrid device reprograms dynamic networks of systemic inflammation in vivo by Rami A. Namas, Rami A. Namas, Maxim Mikheev, Jinling Yin, Derek Barclay, Bahiyyah Jefferson, Qi Mi, Timothy R. Billiar, Timothy R. Billiar, Ruben Zamora, Ruben Zamora, Jorg Gerlach, Jorg Gerlach, Yoram Vodovotz, Yoram Vodovotz

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MEMMAL: A tool for expanding large-scale mechanistic models with machine learned associations and big datasets by Cemal Erdem, Marc R. Birtwistle, Marc R. Birtwistle

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What’s next for computational systems biology? by Eberhard O. Voit, Ashti M. Shah, Daniel Olivença, Yoram Vodovotz, Yoram Vodovotz

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Contribution of farms to the microbiota in the swine value chain by Pascal Laforge, Pascal Laforge, Pascal Laforge, Antony T. Vincent, Antony T. Vincent, Antony T. Vincent, Caroline Duchaine, Caroline Duchaine, Perrine Feutry, Annick Dion-Fortier, Pier-Luc Plante, Éric Pouliot, Sylvain Fournaise, Linda Saucier, Linda Saucier, Linda Saucier

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Is there room in epilepsy for the claustrum? by Glenn D. R. Watson, Stefano Meletti, Stefano Meletti, Anil K. Mahavadi, Pierre Besson, S. Kathleen Bandt, Jared B. Smith

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Uncertainty quantified discovery of chemical reaction systems via Bayesian scientific machine learning by Emily Nieves, Emily Nieves, Raj Dandekar, Chris Rackauckas

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In silico biomarker analysis of the adverse effects of perfluorooctane sulfonate (PFOS) exposure on the metabolic physiology of embryo-larval zebrafish by Rayna M. Nolen, Lene H. Petersen, Karl Kaiser, Karl Kaiser, Antonietta Quigg, Antonietta Quigg, Antonietta Quigg, David Hala

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A workflow for the creation of regulatory networks integrating miRNAs and lncRNAs associated with exposure to ionizing radiation using open source data and tools by Sherry Freiesleben, Sherry Freiesleben, Marcus Unverricht-Yeboah, Lea Gütebier, Dagmar Waltemath, Dagmar Waltemath, Ralf Kriehuber, Olaf Wolkenhauer, Olaf Wolkenhauer

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An enhanced transcription factor repressilator that buffers stochasticity and entrains to an erratic external circadian signal by Steven A. Frank

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scMODD: A model-driven algorithm for doublet identification in single-cell RNA-sequencing data by Xinye Zhao, Alexander Du, Peng Qiu

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Erratum: Research-driven education: An introductory course to systems and synthetic biology by Frontiers Production Office

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Editorial: Education in systems biology 2022 by Edoardo Saccenti

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Computational inference of chemokine-mediated roles for the vagus nerve in modulating intra- and inter-tissue inflammation by Ashti M. Shah, Ruben Zamora, Ruben Zamora, Derek Barclay, Jinling Yin, Fayten El-Dehaibi, Meghan Addorisio, Tea Tsaava, Aisling Tynan, Kevin Tracey, Sangeeta S. Chavan, Yoram Vodovotz, Yoram Vodovotz

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Generating synthetic multidimensional molecular time series data for machine learning: considerations by Gary An, Chase Cockrell

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An approach to learn regulation to maximize growth and entropy production rates in metabolism by Ethan King, Jesse Holzer, Justin A. North, William R. Cannon, William R. Cannon

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What can go wrong when observations are not independently and identically distributed: A cautionary note on calculating correlations on combined data sets from different experiment... by Edoardo Saccenti

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The development of an ingestible biosensor for the characterization of gut metabolites related to major depressive disorder: hypothesis and theory by Amanda Densil, Mya Elisabeth George, Hala Mahdi, Andrew Chami, Alyssa Mark, Chantal Luo, Yifan Wang, Aribah Ali, Pengpeng Tang, Audrey Yihui Dong, Sin Yu Pao, Rubani Singh Suri, Isabella Valentini, Lila Al-Arabi, Fanxiao Liu, Alesha Singh, Linda Wu, Helen Peng, Anjana Sudharshan, Zoha Naqvi, Jayda Hewitt, Catherine Andary, Vincent Leung, Paul Forsythe, Jianping Xu

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