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Autoantibodies to the NY-ESO-1 Tumor Antigen in Metastatic Melanoma: Sialylation of the Fc Region of Immunoglobulin G Induces Differential Expression Signatures of Inflammatory Mol...
Published 2014-11-01“…Conclusions: Our findings support the concept that alternate glycoforms of IgG induce differing functional programs of dendritic cell differentiation and maturation. …”
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322
Tumor-associated macrophages respond to chemotherapy by detrimental transcriptional reprogramming and suppressing stabilin-1 mediated clearance of EGF
Published 2023-03-01“…In cohort of patients with breast cancer, the effect of platinum therapy on the transcriptome of TAMs was validated, and differential expression of regulators of endocytosis was identified.ResultsHere we show that chemotherapeutic agent cisplatin can initiate detrimental transcriptional and functional programs in TAMs, without significant impairment of their viability. …”
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323
DCA for Sparse Quadratic Kernel-Free Least Squares Semi-Supervised Support Vector Machine
Published 2022-08-01“…One important method for solving the nonconvex problem is the DC (difference of convex function) programming. Therefore, we first approximate the <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msub><mo>ℓ</mo><mn>0</mn></msub></semantics></math></inline-formula> norm by a polyhedral DC function. …”
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Interaction of production areas of settlements with regional settlement systems at the municipal level of territorial planning
Published 2023-08-01“…However, the planning of the territory of this level is able to reduce the acuteness of contradictions between short-term and long-term prospects of regional development, as well as to ensure the accuracy of linking the formed objects of different sizes with non-typical functional programs.Materials and methods. The methodological basis was provided by general scientific methods (system approach, system-structural analysis, comparative analysis, theoretical modelling) and special interdisciplinary methods (methods of graph-analytical modelling), scientific literature, data from official sites of statistical bodies and municipalities, open cartographic sources, urban planning documents of territorial planning.Results. …”
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La salud ambiental en el modelo de gestión sanitaria andaluza Environmental health policy in the Andalussian health management system
Published 2002-06-01“…This paper, which was presented at the VI National Congress of Environmental Health, describes the structure, functions, programs and activities developed in the Environmental Health area in Andalussia.…”
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The Role of Premorbid IQ and Age of Onset as Useful Predictors of Clinical, Functional Outcomes, and Recovery of Individuals with a First Episode of Psychosis
Published 2021-06-01“…Intensive cognitive and functional programs for these individuals merit testing to improve long-term recovery rates in this subgroup.…”
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328
Made in the Womb: Maternal Programming of Offspring Cardiovascular Function by an Obesogenic Womb
Published 2023-07-01“…Currently, despite diet supplementation, effective therapeutical solutions to prevent the deleterious cardiac offspring function programming by an obesogenic womb are lacking. In this review, we discuss the mechanisms by which an obesogenic intrauterine environment could program the offspring’s cardiovascular metabolism in a sex-divergent way, with a special focus on cardiac mitochondrial function, and debate possible strategies to implement during MO pregnancy that could ameliorate, revert, or even prevent deleterious effects of MO on the offspring’s cardiovascular system. …”
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329
CREB Is Indispensable to KIT Function in Human Skin Mast Cells—A Positive Feedback Loop between CREB and KIT Orchestrates Skin Mast Cell Fate
Published 2023-12-01“…KIT represents the cells‘ crucial receptor tyrosine kinase, which orchestrates proliferation, survival, and functional programs throughout the lifespan. cAMP response element binding protein (CREB), an evolutionarily well-conserved transcription factor (TF), regulates multiple cellular programs, but its function in MCs is poorly understood. …”
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Different states of stemness of glioblastoma stem cells sustain glioblastoma subtypes indicating novel clinical biomarkers and high-efficacy customized therapies
Published 2023-09-01“…Results Here, distinct biomarker signatures together with aberrant functional programs were shown to stratify GBM patients as well as their sibling GSCs population into TCGA clusters. …”
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331
Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy
Published 2024-04-01Get full text
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Intrauterine exposure to di(2-ethylhexyl) phthalate (DEHP) disrupts the function of the hypothalamus-pituitary-thyroid axis of the F1 rats during adult life
Published 2023-01-01“…This study aimed to investigate the impact of intrauterine exposure to DEHP on the HPT axis function programming of the offspring animals during adulthood.MethodsPregnant Wistar rats were orally treated with corn oil or corn oil supplemented with DEHP (0.48 or 4.8 mg/kg/day) throughout the gestational period. …”
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333
Computing spaces in type theory
Published 2023“…Using the example of the powerset, we show how both mathematical <em>definitions</em> and <em>programs</em> can be expressed and related with one another in type theory. We show how a functional program implementing the powerset can be shown to satisfy the mathematical definition of the powerset, thereby allowing for using interchangeably the program and its mathematical specification.…”
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3560 Using Research Performance Progress Report data to Explore CTSI-Stakeholder Engagement through Network Analysis
Published 2019-03-01“…The first were CTSI internal functions/programs, i.e. the entities that submitted RPPR sections and formed an interconnected sub-network. …”
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Nitrosyl-Heme and Heme Iron Intake from Processed Meats in Subjects from the EPIC-Spain Cohort
Published 2024-03-01Get full text
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Tumor-Derived cGAMP Regulates Activation of the Vasculature
Published 2020-09-01Get full text
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