Functional validation of the albinism-associated tyrosinase T373K SNP by CRISPR/Cas9-mediated homology-directed repair (HDR) in rabbitsResearch in context by Yuning Song, Yuxin Zhang, Mao Chen, Jichao Deng, Tingting Sui, Liangxue Lai, Zhanjun Li

“…Interpretation: Our study provides the first animal-level functional validation of the albinism-associated TYR K373T SNP in rabbits, and these results will facilitate gene therapy of OCA1 in pre-clinical settings in the future. Fund: The National Key Research and Development Program of China Stem Cell and Translational Research, the Strategic Priority Research Program of the Chinese Academy of Sciences, the Guangdong Province Science and Technology Plan Project, and the Program for JLU Science and Technology Innovative Research Team. …”
Get full text

SARS-CoV-2 Omicron BA.5: Evolving tropism and evasion of potent humoral responses and resistance to clinical immunotherapeutics relative to viral variants of concern by Anupriya Aggarwal, Anouschka Akerman, Vanessa Milogiannakis, Mariana Ruiz Silva, Gregory Walker, Alberto Ospina Stella, Andrea Kindinger, Thomas Angelovich, Emily Waring, Supavadee Amatayakul-Chantler, Nathan Roth, Sandro Manni, Thomas Hauser, Thomas Barnes, Anna Condylios, Malinna Yeang, Maureen Wong, Tyra Jean, Charles S.P. Foster, Daniel Christ, Alexandra Carey Hoppe, Mee Ling Munier, David Darley, Melissa Churchill, Damien J. Stark, Gail Matthews, William D. Rawlinson, Anthony D. Kelleher, Stuart G. Turville

“…Funding: This work was primarily supported by Australian Medical Foundation research grants MRF2005760 (ST, GM & WDR), MRF2001684 (ADK and ST) and Medical Research Future Fund Antiviral Development Call grant (WDR), Medical Research Future Fund COVID-19 grant (MRFF2001684, ADK & SGT) and the New South Wales Health COVID-19 Research Grants Round 2 (SGT).…”
Get full text

Reduced IL-2 response from peripheral blood mononuclear cells exposed to bacteria at 6 months of age is associated with elevated total-IgE and allergic rhinitis during the first 7 ... by Ni Wang, Ann-Marie M. Schoos, Jeppe M. Larsen, Susanne Brix, Anna H. Thysen, Morten A. Rasmussen, Jakob Stokholm, Klaus Bønnelykke, Hans Bisgaard, Bo L. Chawes

“…These findings suggest that suppressed Treg activity in early life may herald onset of allergy in early childhood, which could be a target for low-dose IL-2 trials in the future. Fund: COPSAC is funded by private and public research funds all listed on www.copsac.com. …”
Get full text

Multimodal learning for emergency department triage implementation: experiences from Papua New Guinea during the COVID-19 pandemicResearch in context by Rob Mitchell, Sarah Bornstein, Donna Piamnok, Wilma Sebby, Carl Kingston, Rayleen Tefatu, Mangu Kendino, Betty Josaiah, Jasper Pole, Sylvia Kuk, Sarah Körver, Jean-Philippe Miller, Travis Cole, Andrew Erbs, Gerard O'Reilly, Peter Cameron, Duncan Sengiromo, Colin Banks

“…RM is supported by a National Health and Medical Research Council Postgraduate Scholarship and a Monash Graduate Excellence Scholarship, while PC is supported by a Medical Research Future Fund Practitioner Fellowship. Funders had no role in study design, results analysis or manuscript preparation.…”
Get full text

Host gene expression signatures to identify infection type and organ dysfunction in children evaluated for sepsis: a multicentre cohort study by Schlapbach, LJ, Ganesamoorthy, D, Wilson, C, Raman, S, George, S, Snelling, PJ, Phillips, N, Irwin, A, Sharp, N, Le Marsney, R, Chavan, A, Hempenstall, A, Bialasiewicz, S, MacDonald, AD, Grimwood, K, Cling, JC, McPherson, SJ, Blumenthal, A, Kaforou, M, Levin, M, Herberg, JA, Gibbons, KS, Coin, LJM

“…</p> <p><strong>Funding:</strong> Australian Government Medical Research Future Fund Genomic Health Futures Mission, Children’s Hospital Foundation Queensland, Brisbane Diamantina Health Partners, Emergency Medicine Foundation, Gold Coast Hospital Foundation, Far North Queensland Foundation, Townsville Hospital and Health Services SERTA Grant, and Australian Infectious Diseases Research Centre.…”

Neutralising antibody titres as predictors of protection against SARS-CoV-2 variants and the impact of boosting: a meta-analysis by Deborah Cromer, PhD, Megan Steain, PhD, Arnold Reynaldi, PhD, Timothy E Schlub, PhD, Adam K Wheatley, PhD, Jennifer A Juno, PhD, Stephen J Kent, MD, James A Triccas, PhD, David S Khoury, PhD, Miles P Davenport, DPhil

“…Funding: The National Health and Medical Research Council (Australia), the Medical Research Future Fund (Australia), and the Victorian Government.…”
Get full text

Long-term expiratory airflow of infants born moderate-late preterm: A systematic review and meta-analysis by Cassidy Du Berry, Christopher Nesci, Jeanie L.Y. Cheong, Tara FitzGerald, Rheanna Mainzer, Sarath Ranganathan, Lex W. Doyle, Elianne J.L.E. Vrijlandt, Liam Welsh

“…Funding: This work is supported by grants from the National Health and Medical Research Council (Centre of Research Excellence #1153176, Project grant #1161304); Medical Research Future Fund (Career Development Fellowship to J.L.Y Cheong #1141354) and from the Victorian Government's Operational Infrastructure Support Programme. …”
Get full text

Population impact and cost-effectiveness of artificial intelligence-based diabetic retinopathy screening in people living with diabetes in Australia: a cost effectiveness analysisR... by Wenyi Hu, Sanil Joseph, Rui Li, Ekaterina Woods, Jason Sun, Mingwang Shen, Catherine Lingxue Jan, Zhuoting Zhu, Mingguang He, Lei Zhang

“…Funding: This project received grant funding from the Australian Government: the National Critical Research Infrastructure Initiative, Medical Research Future Fund (MRFAI00035) and the NHMRC Investigator Grant (APP1175405). …”
Get full text

Favipiravir in early symptomatic COVID-19, a randomised placebo-controlled trial by James H. McMahon, Jillian S.Y. Lau, Anna Coldham, Janine Roney, Michelle Hagenauer, Sally Price, Mellissa Bryant, Jill Garlick, Anne Paterson, Sue J. Lee, Jess O'Bryan, Anna Hearps, Gilda Tachedjian, Henry Pinskier, Cameron Phillips, Stuart Garrow, Nathan Pinskier, Robert Melvin, Luke Blakeway, Jessica A. Wisniewski, Sally Byers, Gnei Z. Badoordeen, Stephanie Pereira, Katherine Pragastis, Jason A. Trubiano, Kyra Y.L. Chua, Marion Kainer, James S. Molton, Bradley J. Gardiner, Anna B. Pierce, Allen Cheng, Benjamin A. Rogers, Anton Y. Peleg

“…JHM is supported by the Medical Research Future Fund, AYP, JT are supported by the Australian National Health and Medical Research Council.…”
Get full text

State-wide genomic epidemiology investigations of COVID-19 in healthcare workers in 2020 Victoria, Australia: Qualitative thematic analysis to provide insights for future pandemic... by Anne E. Watt, Norelle L. Sherry, Patiyan Andersson, Courtney R. Lane, Sandra Johnson, Mathilda Wilmot, Kristy Horan, Michelle Sait, Susan A. Ballard, Christina Crachi, Dianne J. Beck, Caroline Marshall, Marion A. Kainer, Rhonda Stuart, Christian McGrath, Jason C. Kwong, Pauline Bass, Peter G. Kelley, Amy Crowe, Stephen Guy, Nenad Macesic, Karen Smith, Deborah A. Williamson, Torsten Seemann, Benjamin P. Howden

“…Funding: The Victorian Government, the National Health and Medical Research Council Australia, and the Medical Research Future Fund.…”
Get full text

Interim results from a phase I randomized, placebo-controlled trial of novel SARS-CoV-2 beta variant receptor-binding domain recombinant protein and mRNA vaccines as a 4th dose boo... by Terry M. Nolan, Georgia Deliyannis, Maryanne Griffith, Sabine Braat, Lilith F. Allen, Jennifer Audsley, Amy W. Chung, Marcin Ciula, Nicholas A. Gherardin, Michelle L. Giles, Tom P. Gordon, Samantha L. Grimley, Lana Horng, David C. Jackson, Jennifer A. Juno, Katherine Kedzierska, Stephen J. Kent, Sharon R. Lewin, Mason Littlejohn, Hayley A. McQuilten, Francesca L. Mordant, Thi H.O. Nguyen, Vanessa Pac Soo, Briony Price, Damian F.J. Purcell, Pradhipa Ramanathan, Samuel J. Redmond, Steven Rockman, Zheng Ruan, Joseph Sasadeusz, Julie A. Simpson, Kanta Subbarao, Stewart A. Fabb, Thomas J. Payne, Asuka Takanashi, Chee Wah Tan, Joseph Torresi, Jing Jing Wang, Lin-Fa Wang, Hareth Al-Wassiti, Chinn Yi Wong, Sophie Zaloumis, Colin W. Pouton, Dale I. Godfrey

“…Funding: Australian Government Medical Research Future Fund, and philanthropies Jack Ma Foundation and IFM investors.…”
Get full text

Emergence and antibody evasion of BQ, BA.2.75 and SARS-CoV-2 recombinant sub-lineages in the face of maturing antibody breadth at the population levelResearch in context by Anouschka Akerman, Vanessa Milogiannakis, Tyra Jean, Camille Esneau, Mariana Ruiz Silva, Timothy Ison, Christina Fichter, Joseph A. Lopez, Deborah Chandra, Zin Naing, Joanna Caguicla, Daiyang Li, Gregory Walker, Supavadee Amatayakul-Chantler, Nathan Roth, Sandro Manni, Thomas Hauser, Thomas Barnes, Anna Condylios, Malinna Yeang, Maureen Wong, Charles S.P. Foster, Kenta Sato, Sharon Lee, Yang Song, Lijun Mao, Allison Sigmund, Amy Phu, Ann Marie Vande More, Stephanie Hunt, Mark Douglas, Ian Caterson, Warwick Britton, Kerrie Sandgren, Rowena Bull, Andrew Lloyd, Jamie Triccas, Stuart Tangye, Nathan W. Bartlett, David Darley, Gail Matthews, Damien J. Stark, Kathy Petoumenos, William D. Rawlinson, Ben Murrell, Fabienne Brilot, Anthony L. Cunningham, Anthony D. Kelleher, Anupriya Aggarwal, Stuart G. Turville

“…Funding: This work was primarily supported by Australian Medical Foundation research grants MRF2005760 (SGT, GM &amp; WDR), Medical Research Future Fund Antiviral Development Call grant (WDR), the New South Wales Health COVID-19 Research Grants Round 2 (SGT &amp; FB) and the NSW Vaccine Infection and Immunology Collaborative (VIIM) (ALC). …”
Get full text

Broad immunity to SARS-CoV-2 variants of concern mediated by a SARS-CoV-2 receptor-binding domain protein vaccineResearch in context by Georgia Deliyannis, Nicholas A. Gherardin, Chinn Yi Wong, Samantha L. Grimley, James P. Cooney, Samuel J. Redmond, Paula Ellenberg, Kathryn C. Davidson, Francesca L. Mordant, Tim Smith, Marianne Gillard, Ester Lopez, Julie McAuley, Chee Wah Tan, Jing J. Wang, Weiguang Zeng, Mason Littlejohn, Runhong Zhou, Jasper Fuk-Woo Chan, Zhi-wei Chen, Airn E. Hartwig, Richard Bowen, Jason M. Mackenzie, Elizabeth Vincan, Joseph Torresi, Katherine Kedzierska, Colin W. Pouton, Tom P. Gordon, Lin-fa Wang, Stephen J. Kent, Adam K. Wheatley, Sharon R. Lewin, Kanta Subbarao, Amy W. Chung, Marc Pellegrini, Trent Munro, Terry Nolan, Steven Rockman, David C. Jackson, Damian F.J. Purcell, Dale I. Godfrey

“…Funding: This work was supported by grants from the Medical Research Future Fund (MRFF) (2005846), The Jack Ma Foundation, National Health and Medical Research Council of Australia (NHMRC; 1113293) and Singapore National Medical Research Council (MOH-COVID19RF-003). …”
Get full text

Genomics-informed responses in the elimination of COVID-19 in Victoria, Australia: an observational, genomic epidemiological study by Courtney R Lane, MAE, Norelle L Sherry, MBBS, Ashleigh F Porter, PhD, Sebastian Duchene, PhD, Kristy Horan, PhD, Patiyan Andersson, PhD, Mathilda Wilmot, MPH, Annabelle Turner, MPH, Sally Dougall, MPH, Sandra A Johnson, MPH, Michelle Sait, PhD, Anders Gonçalves da Silva, PhD, Susan A Ballard, PhD, Tuyet Hoang, MPH, Timothy P Stinear, ProfPhD, Leon Caly, PhD, Vitali Sintchenko, ProfPhD, Rikki Graham, PhD, Jamie McMahon, BSc, David Smith, ProfMBBS, Lex EX Leong, PhD, Ella M Meumann, MBBS, Louise Cooley, MBBS, Benjamin Schwessinger, PhD, William Rawlinson, ProfPhD, Sebastiaan J van Hal, ProfPhD, Nicola Stephens, PhD, Mike Catton, MBChB, Clare Looker, MBBS, Simon Crouch, PhD, Brett Sutton, MBBS, Charles Alpren, MBChB, Deborah A Williamson, ProfPhD, Torsten Seemann, PhD, Benjamin P Howden, ProfPhD

“…Funding: The Victorian Government, the National Health and Medical Research Council Australia, and the Medical Research Future Fund.…”
Get full text

Toward the effective and fair funding of CO2 removal technologies by Matthias Honegger

“…This comment discusses these issues and offers suggestions for future funding efforts in this area.…”
Get full text

You, me, the BBC and the license fee by Jo Henderson

“…A theme that will be central is the future funding arrangements, with the intention to abolish the license fee already announced by the government minister responsible for the review. …”
Get full text

Funding, Sustainability, and Governance by Matti Heikkurinen

“…While a computing centre or network technology might be considered obsolete after a few years, data management requirements often extend decades or even centuries into the future. Funding commitments need to be made for long periods of time, and decisions about sustainability and governance models could be seen as setting a precedent that ties down parties for years into the future. …”
Get full text

Financial and Related Issues Among Historically Black Colleges and Universities by Melvin Norman Johnson

“…Although the program has no guarantees of future funding, the support amount of the grants is anticipated to be an instrumental change factor.…”
Get full text

Analysing the vulnerability of buildings to climate change: Summer heat and flooding by Johannes Nikolowski, Valeri Goldberg, Jakob Zimm, Thomas Naumann

“…The REGKLAM project (Development and Testing of an Integrated Regional Climate Change Adaption Programme for the Model Region Dresden) forms part of the KLIMZUG programme (Managing Climate Change in the Regions for the Future) funded by the German Federal Ministry of Education and Research. …”
Get full text

Data dependencies and funding prospects: A 1930s cautionary tale by Jefferson Pooley

“…Could ongoing access to data, and the prospect of future funding, lead today’s researchers—and even other, non-corporate patrons—to conclude that certain questions are too incendiary to pose?…”
Get full text