Diazaquinomycins E–G, Novel Diaza-Anthracene Analogs from a Marine-Derived Streptomyces sp. by Michael W. Mullowney, Eoghainín Ó hAinmhire, Anam Shaikh, Xiaomei Wei, Urszula Tanouye, Bernard D. Santarsiero, Joanna E. Burdette, Brian T. Murphy

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1040-G Novel phytochemicals-based media (added as a supplement) improves the exhaustion and activation phenotype of NK cells cultured in commercially available NK cell media by Rachit Ohri, Marc A Gillig, Nicholas Ingala, Karissa Mennes, Borom Chean, Mirok German, Jeffrey Bowler

Diagnostic implications of pitfalls in causal variant identification based on 4577 molecularly characterized families by Lama AlAbdi, Sateesh Maddirevula, Hanan E. Shamseldin, Ebtissal Khouj, Rana Helaby, Halima Hamid, Aisha Almulhim, Mais O. Hashem, Firdous Abdulwahab, Omar Abouyousef, Mashael Alqahtani, Norah Altuwaijri, Amal Jaafar, Tarfa Alshidi, Fatema Alzahrani, Mendeliome Group, Fowzan S. Alkuraya

“…We describe categories of challenges that cover the phenotype (e.g. novel allelic disorders), pedigree structure (e.g. imprinting disorders masquerading as autosomal recessive phenotypes), positional mapping (e.g. double recombination events abrogating candidate autozygous intervals), gene (e.g. novel gene-disease assertion) and variant (e.g. complex compound inheritance). …”
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TARGETgene: a tool for identification of potential therapeutic targets in cancer. by Chia-Chin Wu, David D'Argenio, Shahab Asgharzadeh, Timothy Triche

“…Users can find, select, and explore identified target genes and compounds of interest (e.g., novel cancer genes and their enriched biological processes), and validate predictions using user-defined benchmark genes (e.g., target genes detected in RNAi screens) and curated cancer genes via TARGETgene. …”
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Couples vacations and romantic passion and intimacy by John K. Coffey, Moji Shahvali, Deborah Kerstetter, Arthur Aron

“…Using the self-expansion model as a foundation, we tested how self-expanding (e.g., novel, interesting, challenging) vacation experiences are associated with passion, physical intimacy, and relationship satisfaction. …”
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Sexual imprinting leads to speciation in locally adapted populations by Richard M. Sibly, Robert N. Curnow

“…Our results suggest that sexual imprinting leads to speciation in locally‐adapted populations if a neutral mating cue—e.g., novel plumage coloration—arises through mutation. …”
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Differences between Monolinguals and Bilinguals in Phonetic and Phonological Learning and the Connection with Auditory Sensory Memory by Laura Spinu, Jiwon Hwang, Mariana Vasilita

“…Bilingualism has been linked with improved function regarding certain aspects of linguistic processing, e.g., novel word acquisition and learning unfamiliar sound patterns. …”
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Compositional Networks Enable Systematic Generalization for Grounded Language Understanding by Kuo, Yen-Ling, Katz, Boris, Barbu, Andrei

“…We demonstrate that these limitations can be overcome by addressing the generalization challenges in the gSCAN dataset, which explicitly measures how well an agent is able to interpret novel linguistic commands grounded in vision, e.g., novel pairings of adjectives and nouns. The key principle we employ is compositionality: that the compositional structure of networks should reflect the compositional structure of the problem domain they address, while allowing other parameters to be learned end-to-end. …”
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On the effects of tangential air inlets distribution configurations to the combustion characteristics of a direct injection liquid fueled swirl flameless combustor (SFC by Adam, K., Wahid, M. A.

On the effects of tangential air inlets distribution configurations to the combustion characteristics of a direct injection liquid fueled swirl flameless combustor (SFC) by Adam, K., Abdul Wahid, Mazlan

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Migratory New World blackbirds (icterids) are more neophobic than closely related resident icterids. by Claudia Mettke-Hofmann, Hans Winkler, Paul B Hamel, Russell Greenberg

“…Lower neophobia allows them approaching changes in the environment (e.g. novel objects) quickly, thereby securing access to resources. …”
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Hepatocyte Thorns, A Novel Drug-Induced Stress Response in Human and Mouse Liver Spheroids by Chris S. Pridgeon, Dian P. Bolhuis, Filip Milosavljević, Marina Manojlović, Ákos Végvári, Massimiliano Gaetani, Marin M. Jukić, Magnus Ingelman-Sundberg

“…The in vivo-relevant phenotype of 3D liver spheroids allows for long-term studies of, e.g., novel mechanisms of chronic drug-induced liver toxicity. …”
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Towards Privacy Paradigm Shift Due to the Pandemic: A Brief Perspective by Abdul Majeed, Sungchang Lee

“…With the advent of the pandemic (e.g., novel corona virus disease 2019 (COVID-19)), a tremendous amount of data about individuals are collected by the health authorities on daily basis for curbing the disease’s spread. …”
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Allelochemical run-off from the invasive terrestrial plant Impatiens glandulifera decreases defensibility in Daphnia by Jens Georg Peter Diller, Frederic Hüftlein, Darleen Lücker, Heike Feldhaar, Christian Laforsch

“…They are reducing the biodiversity in invaded ecosystems, by outcompeting native species with e. g. novel substances. Invasive terrestrial plants can release allelochemicals, thereby reducing biodiversity due to the suppression of growth of native plants in invaded habitats. …”
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Community-acquired acute bacterial meningitis in adults: a clinical update by Ellis, J, Luintel, A, Chandna, A, Heyderman, RS

“…<p><strong>Areas timely for developing research</strong></p> Research should be focused on optimization of vaccines (e.g. pneumococcal conjugate vaccines with extended serotype coverage), targeting groups at risk for disease and reservoirs for transmission; improving adherence to management guidelines; development of new faster, more accurate diagnostic platforms (e.g. novel point-of-care molecular diagnostics); and development of new adjunctive therapies (aimed at the host-inflammatory response and bacterial virulence factors).…”

Identification of microRNAs actively involved in fatty acid biosynthesis in developing Brassica napus seeds using high-throughput sequencing by Jia Wang, Hongju Jian, Tengyue Wang, Lijuan Wei, Jiana Li, Chao Li, Liezhao Liu

“…A total of 85 known miRNAs from 30 families and 1,160 novel miRNAs were identified, of which 24, including 5 known and 19 novel miRNAs, were found to be involved in fatty acid biosynthesis. bna-miR156b, bna-miR156c, bna-miR156g, novel_mir_1706, novel_mir_1407, novel_mir_173, and novel_mir_104 were significantly down-regulated at 21 DAF and 28 DAF, whereas bna-miR159, novel_mir_1081, novel_mir_19 and novel_mir_555 were significantly up-regulated. …”
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A simple, efficient, mass-conservative approach to solving Richards' equation (openRE, v1.0) by A. M. Ireson, A. M. Ireson, R. J. Spiteri, M. P. Clark, S. A. Mathias

“…There are two advantages of our approach: (i) the code is concise, making it ideal for teaching purposes; and (ii) the method can be easily extended to represent alternative properties (e.g., novel ways to parameterize the <span class="inline-formula"><i>K</i>(<i>ψ</i>)</span> relationship) and processes (e.g., it is straightforward to couple heat or solute transport), making it ideal for testing alternative hypotheses.…”
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Comprehensive Analysis of Differentially Expressed CircRNAs in the Ovaries of Low- and High-Fertility Sheep by Jinglei Wang, Hanying Chen, Yongsheng Zhang, Song Jiang, Xiancun Zeng, Hong Shen

“…Functional circRNAs (e.g., novel_circ_0003851, novel_circ_0015526, novel_circ_0008117) were found to act as ceRNAs for follicle growth and development-related mRNAs (<i>CUEDC1</i>, <i>KPNB1</i>, <i>ZFPM2</i>) by sponging functional miRNAs (miR-29a, miR-29b, miR-17-5p). …”
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Characterization of drug‐induced transcriptional modules: towards drug repositioning and functional understanding by Murat Iskar, Georg Zeller, Peter Blattmann, Monica Campillos, Michael Kuhn, Katarzyna H Kaminska, Heiko Runz, Anne‐Claude Gavin, Rainer Pepperkok, Vera van Noort, Peer Bork

“…We then illustrate the utility of conserved and cell‐type‐specific drug‐induced modules by predicting and experimentally validating (i) gene functions, e.g., 10 novel regulators of cellular cholesterol homeostasis and (ii) new mechanisms of action for existing drugs, thereby providing a starting point for drug repositioning, e.g., novel cell cycle inhibitors and new modulators of α‐adrenergic receptor, peroxisome proliferator‐activated receptor and estrogen receptor. …”
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New Hemodynamic Parameters in Peri-Operative and Critical Care—Challenges in Translation by Laura Bogatu, Simona Turco, Massimo Mischi, Lars Schmitt, Pierre Woerlee, Rick Bezemer, Arthur R. Bouwman, Erik H. H. M. Korsten, Jens Muehlsteff

“…The new devices mainly aim to monitor the well-known hemodynamic variables (e.g., novel pulse contour, bioreactance methods are aimed at measuring widely-used variables such as blood pressure, cardiac output). …”
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