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Diazaquinomycins E–G, Novel Diaza-Anthracene Analogs from a Marine-Derived Streptomyces sp.
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Diagnostic implications of pitfalls in causal variant identification based on 4577 molecularly characterized families
Published 2023-08-01“…We describe categories of challenges that cover the phenotype (e.g. novel allelic disorders), pedigree structure (e.g. imprinting disorders masquerading as autosomal recessive phenotypes), positional mapping (e.g. double recombination events abrogating candidate autozygous intervals), gene (e.g. novel gene-disease assertion) and variant (e.g. complex compound inheritance). …”
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TARGETgene: a tool for identification of potential therapeutic targets in cancer.
Published 2012-01-01“…Users can find, select, and explore identified target genes and compounds of interest (e.g., novel cancer genes and their enriched biological processes), and validate predictions using user-defined benchmark genes (e.g., target genes detected in RNAi screens) and curated cancer genes via TARGETgene. …”
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Couples vacations and romantic passion and intimacy
Published 2024-05-01“…Using the self-expansion model as a foundation, we tested how self-expanding (e.g., novel, interesting, challenging) vacation experiences are associated with passion, physical intimacy, and relationship satisfaction. …”
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Sexual imprinting leads to speciation in locally adapted populations
Published 2022-11-01“…Our results suggest that sexual imprinting leads to speciation in locally‐adapted populations if a neutral mating cue—e.g., novel plumage coloration—arises through mutation. …”
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Differences between Monolinguals and Bilinguals in Phonetic and Phonological Learning and the Connection with Auditory Sensory Memory
Published 2023-03-01“…Bilingualism has been linked with improved function regarding certain aspects of linguistic processing, e.g., novel word acquisition and learning unfamiliar sound patterns. …”
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Compositional Networks Enable Systematic Generalization for Grounded Language Understanding
Published 2022“…We demonstrate that these limitations can be overcome by addressing the generalization challenges in the gSCAN dataset, which explicitly measures how well an agent is able to interpret novel linguistic commands grounded in vision, e.g., novel pairings of adjectives and nouns. The key principle we employ is compositionality: that the compositional structure of networks should reflect the compositional structure of the problem domain they address, while allowing other parameters to be learned end-to-end. …”
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Migratory New World blackbirds (icterids) are more neophobic than closely related resident icterids.
Published 2013-01-01“…Lower neophobia allows them approaching changes in the environment (e.g. novel objects) quickly, thereby securing access to resources. …”
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Hepatocyte Thorns, A Novel Drug-Induced Stress Response in Human and Mouse Liver Spheroids
Published 2022-05-01“…The in vivo-relevant phenotype of 3D liver spheroids allows for long-term studies of, e.g., novel mechanisms of chronic drug-induced liver toxicity. …”
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Towards Privacy Paradigm Shift Due to the Pandemic: A Brief Perspective
Published 2021-03-01“…With the advent of the pandemic (e.g., novel corona virus disease 2019 (COVID-19)), a tremendous amount of data about individuals are collected by the health authorities on daily basis for curbing the disease’s spread. …”
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Allelochemical run-off from the invasive terrestrial plant Impatiens glandulifera decreases defensibility in Daphnia
Published 2023-01-01“…They are reducing the biodiversity in invaded ecosystems, by outcompeting native species with e. g. novel substances. Invasive terrestrial plants can release allelochemicals, thereby reducing biodiversity due to the suppression of growth of native plants in invaded habitats. …”
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Community-acquired acute bacterial meningitis in adults: a clinical update
Published 2019“…<p><strong>Areas timely for developing research</strong></p> Research should be focused on optimization of vaccines (e.g. pneumococcal conjugate vaccines with extended serotype coverage), targeting groups at risk for disease and reservoirs for transmission; improving adherence to management guidelines; development of new faster, more accurate diagnostic platforms (e.g. novel point-of-care molecular diagnostics); and development of new adjunctive therapies (aimed at the host-inflammatory response and bacterial virulence factors).…”
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Identification of microRNAs actively involved in fatty acid biosynthesis in developing Brassica napus seeds using high-throughput sequencing
Published 2016-10-01“…A total of 85 known miRNAs from 30 families and 1,160 novel miRNAs were identified, of which 24, including 5 known and 19 novel miRNAs, were found to be involved in fatty acid biosynthesis. bna-miR156b, bna-miR156c, bna-miR156g, novel_mir_1706, novel_mir_1407, novel_mir_173, and novel_mir_104 were significantly down-regulated at 21 DAF and 28 DAF, whereas bna-miR159, novel_mir_1081, novel_mir_19 and novel_mir_555 were significantly up-regulated. …”
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A simple, efficient, mass-conservative approach to solving Richards' equation (openRE, v1.0)
Published 2023-01-01“…There are two advantages of our approach: (i) the code is concise, making it ideal for teaching purposes; and (ii) the method can be easily extended to represent alternative properties (e.g., novel ways to parameterize the <span class="inline-formula"><i>K</i>(<i>ψ</i>)</span> relationship) and processes (e.g., it is straightforward to couple heat or solute transport), making it ideal for testing alternative hypotheses.…”
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Comprehensive Analysis of Differentially Expressed CircRNAs in the Ovaries of Low- and High-Fertility Sheep
Published 2023-01-01“…Functional circRNAs (e.g., novel_circ_0003851, novel_circ_0015526, novel_circ_0008117) were found to act as ceRNAs for follicle growth and development-related mRNAs (<i>CUEDC1</i>, <i>KPNB1</i>, <i>ZFPM2</i>) by sponging functional miRNAs (miR-29a, miR-29b, miR-17-5p). …”
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Characterization of drug‐induced transcriptional modules: towards drug repositioning and functional understanding
Published 2013-01-01“…We then illustrate the utility of conserved and cell‐type‐specific drug‐induced modules by predicting and experimentally validating (i) gene functions, e.g., 10 novel regulators of cellular cholesterol homeostasis and (ii) new mechanisms of action for existing drugs, thereby providing a starting point for drug repositioning, e.g., novel cell cycle inhibitors and new modulators of α‐adrenergic receptor, peroxisome proliferator‐activated receptor and estrogen receptor. …”
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New Hemodynamic Parameters in Peri-Operative and Critical Care—Challenges in Translation
Published 2023-02-01“…The new devices mainly aim to monitor the well-known hemodynamic variables (e.g., novel pulse contour, bioreactance methods are aimed at measuring widely-used variables such as blood pressure, cardiac output). …”
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