α-Pinene, a Main Component of <i>Pinus</i> Essential Oils, Enhances the Expression of Insulin-Sensitive Glucose Transporter Type 4 in Murine Skeletal Muscle Cells by Giordana Feriotto, Federico Tagliati, Valentina Costa, Marcello Monesi, Claudio Tabolacci, Simone Beninati, Carlo Mischiati

“…Glucose transporter-4 (GLUT4) represents the major glucose transporter isoform responsible for glucose uptake into insulin-sensitive cells, primarily in skeletal muscle and adipose tissues. …”
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Glucose Uptake Is Increased by Estradiol Dipropionate in L6 Skeletal Muscle Cells by Yanhong Yao, Xinzhou Yang, Jinhua Shen, Ping Zhao

“…GLUT4 is an important glucose transporter, which is closely related to insulin resistance and type 2 diabetes. …”
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Effect of Exercise and Insulin Signaling on Glucose Transporter Type 4 in Skeletal Muscles: A narrative review by Akbar Ghalavand, Marya Rahmani Ghobadi

“…Introduction: Glucose transporter type 4 (GLUT4) is a membrane glucose transporter that is influenced by insulin signaling and muscle contraction. …”
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PPAR-alpha activation required for decreased glucose uptake and increased susceptibility to injury during ischemia. by Panagia, M, Gibbons, G, Radda, G, Clarke, K

“…We conclude that elevated plasma free fatty acids are associated with increased injury during ischemia due to decreased cardiac glucose uptake resulting from lower cardiac GLUT-4 protein levels, the levels of GLUT-4 being regulated, probably indirectly, through PPAR-alpha activation.…”

Epigenetic Regulation of Glucose Transporters in Non-Small Cell Lung Cancer by Steven G. Gray, Calen Sacevich, Lisa Kilmartin, Jennifer Leonard, Anne-Marie Baird, Kenneth J. O'Byrne

“…Similar results for GLUT-4 were observed in cells derived from liver, muscle, kidney and pre-adipocytes. …”
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Rosuvastatin Calcium with Metformin Improves Kidney Function in a Rat Model of Diabetes by Regulating the Expression of Glucose Transporter 4 by Gechu SHANG, Xiaoyong WANG, Yan GAO

“…The expression of glucose transporter 4 (GLUT4) mRNA in the renal tissue was measured by real-time polymerase chain reaction (PCR) , and the protein levels of GLUT4 were detected by Western-blotting. …”
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Exercise increases MEF2A abundance in rat cardiac muscle by downregulating microRNA-223-5p by Elba D. Carrillo, Dulce I. Hernández, Maikel Valle Clara, Ivonne Lezama, María C. García, Jorge A. Sánchez

“…Abstract Exercise plays an important role in cardiac health and enhances the transport of glucose in cardiac muscle by increasing the glucose transporter-4 (GLUT4) content at the cell membrane. The GLUT4 gene is a target of myocyte enhancer transcription factor 2A (MEF2A). …”
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The Exocyst Is Required for CD36 Fatty Acid Translocase Trafficking and Free Fatty Acid Uptake in Skeletal Muscle Cells by Nicole K. Nakamura, Darcy S. Tokunaga, Herena Y. Ha, Noemi Polgar

“…This ectopic lipid accumulation promotes insulin resistance by inhibiting insulin-induced GLUT4 glucose transporter trafficking and glucose uptake. …”
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The Effect of Eccentric Activity on Glucose Transporter Type 4 in Gastrocnemius Muscle of Streptozotocin-induced Diabetes Mellitus Mice by Adelia Handoko, Bambang Purwanto, Arifa Mustika

“…Diabetes mellitus (DM) is a metabolic disorder with increasing mortality rate. Decrease in GLUT-4 levels was found in diabetics resulting in an increase in postprandial blood glucose levels. …”
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Insulin Resistance Is Not Sustained Following Denervation in Glycolytic Skeletal Muscle by Shawna L. McMillin, Erin C. Stanley, Luke A. Weyrauch, Jeffrey J. Brault, Barbara B. Kahn, Carol A. Witczak

“…To assess the contribution of GLUT4 to the enhanced EDL muscle glucose uptake, muscle-specific GLUT4 knockout mice were examined. …”
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Conditioning-induced expression of novel glucose transporters in canine skeletal muscle homogenate. by Montana Renae Barrett, Michael Scott Davis

“…Athletic conditioning can increase the capacity for insulin-stimulated skeletal muscle glucose uptake through increased sarcolemmal expression of GLUT4 and potentially additional novel glucose transporters. …”
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Chronic Hyperglycaemia Inhibits Tricarboxylic Acid Cycle in Rat Cardiomyoblasts Overexpressing Glucose Transporter Type 4 by Bernd Stratmann, Britta Eggers, Yvonne Mattern, Tayana Silva de Carvalho, Katrin Marcus, Diethelm Tschoepe

“…Rat cardiomyoblasts overexpressing GLUT4 (H9C2KE2) were cultured under normo- and hyperglycaemic conditions for long-term. …”
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Alterations in Glucose Metabolism During the Transition to Heart Failure: The Contribution of UCP-2 by Hanna Sarah Kutsche, Rolf Schreckenberg, Martin Weber, Christine Hirschhäuser, Susanne Rohrbach, Ling Li, Bernd Niemann, Rainer Schulz, Klaus-Dieter Schlüter

“…During compensatory hypertrophy, we found low UCP-2 levels with an upregulation of Glut-4, while the decompensatory state with impaired function was associated with an increase of UCP-2 and reduced Glut-4 expression. …”
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Scopariadulcis (SDF7) endowed with glucose uptake properties on L6 myotubes compared insulin. by Joo, Ee Beh, Latip, Jalifah, Abdullah, Mohd Puad, Ismail, Amin, Hamid, Muhajir

“…Aim of the study Insulin stimulates glucoseuptake and promotes the translocation of glucose transporter 4 (Glut 4) to the plasma membrane on L6myotubes. The aim of this study is to investigate affect of Scopariadulcis Linn water extracts on glucoseuptake activity and the Glut 4 translocation components (i.e., IRS-1, PI 3-kinase, PKB/Akt2, PKC and TC 10) in L6myotubescompared to insulin. …”
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Novel Expression of <i>GLUT3</i>, <i>GLUT6</i> and <i>GLUT10</i> in Equine Gluteal Muscle Following Glycogen-Depleting Exercise: Impact of Dietary Starch and Fat by Stephanie J. Valberg, Deborah Velez-Irizarry, Zoe J. Williams, Joe D. Pagan, Vanesa Mesquita, Brian Waldridge, Hailey Maresca-Fichter

“…Our aim was to determine the expression of glucose transporters (<i>GLUT</i>) and genes impacting GLUT4 expression and translocation in the gluteal muscle. …”
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Glucose uptake mechanism of muscle cells and adipocytes stimulated by Scoparia dulcis linn extract by Beh, Joo Ee

“…Furthermore, the expression of Glut 4 protein on the L6 myotubes plasma membrane was confirmed by an immunofluorescence assay. …”
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Effects of tumor necrosis factor-α on glucose uptake in human granulosa cells under high androgen conditions by Dongxia Sun, Yuanyuan Zhao, Xiaohua Wu

“…Glucose uptake and GLUT4 expression were detected by immunofluorescence (IF). …”
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Comparison of the expression of PI3K/AKT pathway components in type 2 diabetic and non- diabetic human volunteers ex vivo by Khorami, Somayeh Alsadat Hosseini

“…Insulin-stimulated glucose transport occurs via PI3K/AKT-dependent pathway which results in GLUT4 translocation from intracellular vesicles to the plasma membrane and increased glucose uptake. …”
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Protocol for preparing sensor molecules and analyzing heterotypic endomembrane fusion in insulin-responsive cells using live-cell imaging by Hiroyasu Hatakeyama, Makoto Kanzaki

“…Summary: Heterotypic endomembrane fusion between static GLUT4-containing vesicles and traveling transferrin receptor-containing endosomes triggers insulin-responsive translocation of the GLUT4 glucose transporter. …”
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Hibiscus sabdariffa linn fruits methanolic extract and fractions mediated glucose uptake stimulation and glucose transporter 4 regulation by Shadhan, R., Bohari, S., Adam, Z., Jamaluddin, H.

“…Objective: As such, this study reports the effects of Hibiscus sabdariffa Linn fruit methanolic extract and fractions (ethyl acetate, n-hexane, and butanol) on glucose uptake stimulation, as well as regulation of glucose transporter-4 (GLUT4) in L6 myotubes and 3T3F442A adipocytes cells. …”