A splice variant of PGRP-LC required for expression of antimicrobial peptides in Anopheles gambiae by Lin, H, Zhang, L, Luna, C, Hoa, N, Zheng, L

“…PGRP-LC, one of seven members of this family in the malaria vector Anopheles gambiae produced several spliced variants. Here we show that PGRP-LC, and not other members of the PGRP family nor the six members of the Gram-negative binding protein families, is required for the expression of antimicrobial peptide genes (such as CEC1 and GAMI) under the control of the Imd-Rel2 pathway in an A. gambiae cell line, 4a3A. …”

Potential metabolic resistance mechanisms to ivermectin in Anopheles gambiae: a synergist bioassay study by Nicolas, P, Kiuru, C, Wagah, MG, Muturi, M, Duthaler, U, Hammann, F, Maia, MF, Chaccour, C

“…<br> <strong>Methods</strong> We determined the lethal concentration 50 for ivermectin in colonized Anopheles gambiae; then we used chemical inhibitors and inducers of xenobiotic pumps and cytochrome P450 enzymes in combination with ivermectin to probe the mechanism of ivermectin detoxification. …”

A national DNA bank in The Gambia, West Africa, and genomic research in developing countries. by Sirugo, G, Schim van der Loeff, M, Sam, O, Nyan, O, Pinder, M, Hill, A, Kwiatkowski, D, Prentice, A, de Toma, C, Cann, H, Diatta, M, Jallow, M, Morgan, G, Clarke, M, Corrah, T, Whittle, H, McAdam, K

Absence of crisis form factor in subjects immune to Plasmodium falciparum in The Gambia, West Africa. by Marsh, K, Otoo, L, Greenwood, B

Anopheles gambiae laminin interacts with the P25 surface protein of Plasmodium berghei ookinetes. by Vlachou, D, Lycett, G, Sidén-Kiamos, I, Blass, C, Sinden, R, Louis, C

“…In this report we describe the cloning of the Anopheles gambiae gene encoding the laminin gamma 1 polypeptide and follow its expression during mosquito development. …”

Immune signaling pathways regulating bacterial and malaria parasite infection of the mosquito Anopheles gambiae. by Meister, S, Kanzok, S, Zheng, X, Luna, C, Li, T, Hoa, N, Clayton, JR, White, K, Kafatos, F, Christophides, G, Zheng, L

“…We show that, in the malaria vector Anopheles gambiae, expression of Cecropin 1 is regulated by REL2, an NF-kappaB-like transcription factor orthologous to Drosophila Relish. …”

Foul wind, spirits and witchcraft : illness conceptions and health-seeking behaviour for malaria in the Gambia by O'Neill, S, Gryseels, C, Dierickx, S, Mwesigwa, J, Okebe, J, d’Alessandro, U, Grietens, K

“…<strong>Background</strong> As the disease burden in the Gambia has reduced considerably over the last decade, heterogeneity in malaria transmission has become more marked, with infected but asymptomatic individuals maintaining the reservoir. …”

Impact of personality traits on work performance in tidal paddy production in the Gambia: a review by Hassan, Salim, Sanyang, Demba, Asmuni, Azizan, Sanyang, Saikou E.

“…Improve rice productivity in the Gambia is essential for stakeholders as it is main actor in achieving food self-sufficiency and security. …”
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Vehicle emission control measures for environmental sustainability (pollution control) regulation: case of the Gambia by Krubally, Morro, Singh, Harcharanjit, Fanneh, Momodou Mustapha

“…Reports in 2018 showed that the Gambia ranked 170 ($22.5 Million) in vehicleimports in the world. …”
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Is chronic malnutrition associated with an increase in malaria incidence? A cohort study in children aged under 5 years in rural Gambia by Anne L. Wilson, John Bradley, Ballah Kandeh, Kolawole Salami, Umberto D’Alessandro, Margaret Pinder, Steven W. Lindsay

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O Conflito de Casamansa e as Relações de Poderna Senegâmbia: Senegal, Guiné-Bissau e Gâmbia by Antonieta Rosa Gomes

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Introducing assisted reproductive technologies in The Gambia, a survey on the perspectives of Gambian healthcare professionals and medical students by Haddy Bittaye, Jason P. Mooney, Anna Afferri, Julie Balen, Vanessa Kay

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Impact of the COVID-19 pandemic on the coverage and timeliness of routine childhood vaccinations in the Gambia, 2015–2021 by Chris Grundy, Uduak Okomo, Golam Sarwar, Kris A Murray, Lamin Saidy, Chigozie Edson Utazi, Alieu Sowe, Malick Sogur, Sidat Fofanna, Esu Ezeani, Bai-Lamin Dondeh

“…This study examined coverage and timeliness of routine childhood immunisation during the pandemic in The Gambia, a country with an immunisation system considered robust.Methods We obtained prospective birth cohort data of 57 286 children in over 300 communities in two health and demographic surveillance system sites, including data from the pre-pandemic period (January 2015–February 2020) and the three waves of the pandemic period (March 2020–December 2021). …”
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Losing identity: structural diversity of transposable elements belonging to different classes in the genome of <it>Anopheles gambiae</it> by Fernández-Medina Rita D, Ribeiro José M C, Carareto Claudia M A, Velasque Luciane, Struchiner Cláudio J

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Clinical manifestations and outcomes of severe malaria in adult patients admitted to a tertiary hospital in the Gambia by Sheikh Omar Bittaye, Abubacarr Jagne, Lamin ES Jaiteh, Behzad Nadjm, Alfred Amambua-Ngwa, Abdul Karim Sesay, Yankuba Singhateh, Emmanuel Effa, Ousman Nyan, Ramou Njie

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Identification of morphological and chemical markers of dry- and wet-season conditions in female Anopheles gambiae mosquitoes by Kaira M Wagoner, Tovi Lehmann, Diana L Huestis, Brandie M Ehrmann, Nadja B Cech, Gideon Wasserberg

“…Abstract Background Increased understanding of the dry-season survival mechanisms of Anopheles gambiae in semi-arid regions could benefit vector control efforts by identifying weak links in the transmission cycle of malaria. …”
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Prevalence of five treatable sexually transmitted infections among women in Lower River region of The Gambia by Robert Butcher, Sheikh Jarju, Dolapo Obayemi, Adedapo Olufemi Bashorun, Hristina Vasileva, Hannah Bransbury-Hare, Orighomisan Agboghoroma, Lamin Drammeh, Martin Holland, Emma Harding-Esch, Ed Clarke

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Perceptions and acceptability of the controlled human malaria infection (CHMI) model in The Gambia: a qualitative study by Edgard Diniba Dabira, Alexandra Fehr, Nathalie Beloum, Jean-Pierre Van geertruyden, Jane Achan, Annette Erhart, Melisa Martinez-Alvarez, Umberto D’Alessandro

“…This qualitative study assessed the perception and acceptability of such studies in The Gambia following the first CHMI study conducted in the country in March–May 2018. …”
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Continuous exposure to <it>Plasmodium </it>results in decreased susceptibility and transcriptomic divergence of the <it>Anopheles gambiae </it>immune system by Dimopoulos George, Dong Yuemei, Das Suchismita, Aguilar Ruth

“…</p> <p>Results</p> <p>In the present study we have addressed the effect of a continuous <it>Plasmodium berghei </it>infection on the resistance to infection and global gene expression in <it>Anopheles gambiae</it>.</p> <p>Exposure of <it>A. gambiae </it>to <it>P. berghei</it>-infected blood and infection for 16 generations resulted in a decreased susceptibility to infection, altered constitutive expression levels for approximately 2.4% of the mosquito's total transcriptome and a lower basal level of immune genes expression, including several anti-<it>Plasmodium </it>factors. …”
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Dynamic miRNA-mRNA interactions coordinate gene expression in adult Anopheles gambiae. by Xiaonan Fu, Pengcheng Liu, George Dimopoulos, Jinsong Zhu

“…It also provides a roadmap for additional studies focused on regulatory functions of miRNAs in Anopheles gambiae.…”
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