Evolutionary trade-offs associated with copy number variations in resistance alleles in Culex pipiens mosquitoes by Pascal Milesi, Jean-Loup Claret, Sandra Unal, Mylène Weill, Pierrick Labbé

“…As a response, the same amino acid substitution in the ace-1 gene (G119S), conferring resistance to both insecticides, has been selected independently in many mosquito species. In Anopheles gambiae, it has recently been shown that the G119S mutation is actually part of homogeneous duplications that associate multiple resistance copies of the ace-1 gene. …”
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The Crystal Structure of <i>Bacillus thuringiensis</i> Tpp80Aa1 and Its Interaction with Galactose-Containing Glycolipids by Hannah L. Best, Lainey J. Williamson, Magdalena Lipka-Lloyd, Helen Waller-Evans, Emyr Lloyd-Evans, Pierre J. Rizkallah, Colin Berry

“…Here, we demonstrate an expanded target range, showing Tpp80Aa1 is also active against the larvae of <i>Anopheles gambiae</i> and <i>Aedes aegypti</i> mosquitoes. We report the first crystal structure of Tpp80Aa1 at a resolution of 1.8 Å, which shows Tpp80Aa1 consists of two domains: an N-terminal β-trefoil domain resembling a ricin B lectin and a C-terminal putative pore-forming domain sharing structural similarity with the aerolysin family. …”
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Enhanced dimensionality reduction methods for classifying malaria vector dataset using decision tree by Arowolo, Micheal Olaolu, Adebiyi, Marion Olubunmi, Adebiyi, Ayodele Ariyo

“…The classifier uses Decision tree on the reduced mosquito anopheles gambiae dataset to enhance the accuracy and scalability in the gene expression analysis. …”
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Anopheles larval habitats seasonality and environmental factors affecting larval abundance and distribution in Arjo-Didessa sugar cane plantation, Ethiopia by Arega Tsegaye, Assalif Demissew, Dawit Hawaria, Ashenafi Abossie, Hallelujah Getachew, Kassahun Habtamu, Teshome Degefa, Xiaoming Wang, Ming-Chieh Lee, Guofa Zhou, Delenasaw Yewhalaw, Guiyun Yan

“…Results The study revealed that Anopheles gambiae sensu lato (s.l.) was the most predominant 4197(57%) vector species, followed by Anopheles coustani complex 2388 (32.8%). …”
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Evaluation du paludisme dans une cohorte randomisée d’enfants (6 mois- 6 ans) au niveau de deux sites de transmission différente au cours de la saison 2001: Sotuba et Donéguébougou... by Ba M, Sow MY, Maiga B, Diawara S, Oumar AA, Dolo A, Doumbo O, Koita O

“…Donéguébougou pourrait être un bon site pour l’essai vaccinal de phase I. Les espèces An. gambiae sl, et An. funestus étaient les principaux vecteurs de la transmission.…”
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Higher temperature accelerates the aging-dependent weakening of the melanization immune response in mosquitoes. by Lindsay E Martin, Julián F Hillyer

“…Here, we evaluated the independent and combined effects of temperature (27°C, 30°C and 32°C) and aging (1, 5, 10 and 15 days old) on the melanization immune response of the adult female mosquito, Anopheles gambiae. Using a spectrophotometric assay that measures phenoloxidase activity (a rate limiting enzyme) in hemolymph, and therefore, the melanization potential of the mosquito, we discovered that the strength of melanization decreases with higher temperature, aging, and infection. …”
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Shifting suitability for malaria vectors across Africa with warming climates by Peterson A Townsend

“…</p> <p>Methods</p> <p>I derive spatially explicit estimates of human populations living in regions newly suitable climatically for populations of two key <it>Anopheles gambiae </it>vector complex species in Africa over the coming 50 years, based on ecological niche model projections over two global climate models, two scenarios of climate change, and detailed spatial summaries of human population distributions.…”
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Comparative genomic analysis of Drosophila melanogaster and vector mosquito developmental genes. by Susanta K Behura, Morgan Haugen, Ellen Flannery, Joseph Sarro, Charles R Tessier, David W Severson, Molly Duman-Scheel

“…Genome sequencing projects have presented the opportunity for analysis of developmental genes in three vector mosquito species: Aedes aegypti, Culex quinquefasciatus, and Anopheles gambiae. A comparative genomic analysis of developmental genes in Drosophila melanogaster and these three important vectors of human disease was performed in this investigation. …”
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Subsidio para a história do paludismo em S. Tomé. Considerações sobre uma epidemia. by J L Baptista

“…Between 1946 and 1967, localities were stratified according to their endemicity, the major vectorial species (Anopheles gambiae sp.) were identified and the parasitological indices were calculated. …”
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The Plasmodium falciparum cell-traversal protein for ookinetes and sporozoites as a candidate for preerythrocytic and transmission-blocking vaccines. by Espinosa, D, Vega-Rodriguez, J, Flores-Garcia, Y, Noe, A, Muñoz, C, Coleman, R, Bruck, T, Haney, K, Stevens, A, Retallack, D, Allen, J, Vedvick, T, Fox, C, Reed, S, Howard, R, Salman, A, Janse, C, Khan, S, Zavala, F, Gutierrez, G

“…Notably, monoclonal antibodies against PfCelTOS strongly inhibited oocyst development of P. falciparum and Plasmodium berghei expressing PfCelTOS in Anopheles gambiae mosquitoes. Taken together, our results demonstrate that anti-CelTOS responses elicited by vaccination or passive immunization can inhibit sporozoite and ookinete infection and impair vector transmission.…”

Viral vectored transmission blocking vaccines against Plasmodium falciparum by Kapulu, M, Biswas, S, Blagborough, A, Gilbert, S, Sinden, R, Hill, A

“…Antibodies raised against Pfs48/45, Pfs230 Region C, PfHAP2, and Anopheles gambiae Alanyl Aminopeptidase N1 (AgAPN1) proteins reduce transmission i.e. have transmission blocking activity [1–5]. …”

Requirements for effective malaria control with homing endonuclease genes. by Deredec, A, Godfray, H, Burt, A

“…Our model, combined with currently available data, indicates that populations of Anopheles gambiae could be eliminated by releasing 2-3 HEGs targeting female fertility genes, or a driving-Y chromosome that is transmitted to 75-96% of progeny. …”

Evolution and assembly of Anopheles aquasalis's immune genes: primary malaria vector of coastal Central and South America and the Caribbean Islands by Cesar Camilo Prado Sepulveda, Rodrigo Maciel Alencar, Rosa Amélia Santana, Igor Belém de Souza, Gigliola Mayra Ayres D'Elia, Raquel Soares Maia Godoy, Ana Paula Duarte, Stefanie Costa Pinto Lopes, Marcus Vinicius Guimarães de Lacerda, Wuelton Marcelo Monteiro, Rafael Nacif-Pimenta, Nágila Francinete Costa Secundino, Leonardo Barbosa Koerich, Paulo Filemon Paolucci Pimenta

“…Comparatively, the American anophelines possess fewer genes than Anopheles gambiae s. s., the most dangerous African vector. …”
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The immune deficiency and c-Jun N-terminal kinase pathways drive the functional integration of the immune and circulatory systems of mosquitoes by Yan Yan, Leah T. Sigle, David C. Rinker, Tania Y. Estévez-Lao, John A. Capra, Julián F. Hillyer

“…Here, we conducted RNA sequencing in the African malaria mosquito, Anopheles gambiae, and discovered that an infection upregulates multiple components of the immune deficiency (IMD) and c-Jun N-terminal kinase (JNK) pathways in the heart with periostial haemocytes. …”
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Pyrethroid Resistance Aggravation in Ugandan Malaria Vectors Is Reducing Bednet Efficacy by Magellan Tchouakui, Leon M. J. Mugenzi, Benjamin D. Menze, Jude N. T. Khaukha, Williams Tchapga, Micareme Tchoupo, Murielle J. Wondji, Charles S. Wondji

“…High intensity of resistance to the discriminating concentration (DC), 5× DC, and 10× DC of pyrethroids was observed in both <i>Anopheles funestus</i> and <i>Anopheles gambiae</i> in Mayuge and Busia leading to significant reduced performance of long-lasting insecticidal nets (LLINs) including the piperonyl butoxide (PBO)-based nets (Olyset Plus). …”
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Mosquito host-seeking diel rhythm and chemosensory gene expression is affected by age and Plasmodium stages by Melika Hajkazemian, Sharon R. Hill, Raimondas Mozūraitis, Lisa Ranford-Cartwright, S. Noushin Emami, Rickard Ignell

“…Abstract Malaria parasites can affect vector-related behaviours, increasing transmission success. Using Anopheles gambiae and Plasmodium falciparum, we consider the effect of interaction between infection stage and vector age on diel locomotion in response to human odour and the expression of antennal chemosensory genes. …”
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Comparative genomic analysis of malaria mosquito vector-associated novel pathogen Elizabethkingia anophelis by Teo, Jeanette, Tan, Sean Yang-Yi, Liu, Yang, Tay, Martin, Ding, Yichen, Li, Yingying, Kjelleberg, Staffan, Givskov, Michael, Lin, Raymond T. P., Yang, Liang

“…We showed that unlike the hospital-isolated pathogen E. meningoseptica ATCC 12535 strain, the hospital-isolated E. anophelis strains have genome content and organization similar to the E. anophelis Ag1 and R26 strains isolated from the midgut microbiota of the malaria mosquito vector Anopheles gambiae. Both the core- and accessory genomes of Elizabethkingia spp. possess genes conferring antibiotic resistance and virulence. …”
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Selection for insecticide resistance can promote Plasmodium falciparum infection in Anopheles. by Kelsey L Adams, Emily K Selland, Bailey C Willett, John W Carew, Charles Vidoudez, Naresh Singh, Flaminia Catteruccia

“…From pyrethroid-resistant field-derived Anopheles gambiae s.l. mosquitoes, we established resistant (RES) and susceptible (SUS) colonies by either selection for, or loss of insecticide resistance. …”
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The interaction between permethrin exposure and malaria infection affects the host-seeking behaviour of mosquitoes by Kevin Thiévent, Gaël Hauser, Obada Elaian, Jacob C. Koella

“…Results In this laboratory setting, sub-lethal exposure to permethrin inhibited the blood-seeking behaviour of Anopheles gambiae mosquitoes for almost 48 h. Although infection by malaria did not affect the irritancy of the mosquitoes to permethrin at either the developmental stage or the infectious stage, both stages of infection shortened the duration of inhibition of blood-seeking. …”
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A resistência aos inseticidas e sua medida em mosquitos by Mario B. Aragão

“…Menciona os processos de controle biológico por machos esterilizados, parasitas e predadores, e lembra que as duas campanhas contra insetos de importância sanitária que tiveram maior êxito no Brasil, a do Aedes aegypti e a do Anopheles gambiae, utilizaram táticas ecléticas, como é hoje preconizado pelos cntomologistas de vanguarda, no que se convencionou chamar de luta integrada.…”
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