Domestic Parasitic Infections in Patients with Asthma and Eosinophilia in Germany – Three Cases with Learnings in the Era of Anti- IL5 Treatments by Barnikel M, Grabmaier U, Mertsch P, Ceelen F, Janke C, Behr J, Kneidinger N, Milger K

“…Michaela Barnikel,1,2 Ulrich Grabmaier,3 Pontus Mertsch,1,2 Felix Ceelen,4 Christian Janke,5 Jürgen Behr,1,2 Nikolaus Kneidinger,1,2 Katrin Milger1,2 1Department of Medicine V, LMU University Hospital, Munich, Germany; 2Comprehensive Pneumology Center, Member of the German Center for Lung Research (DZL), Munich, Germany; 3Department of Medicine I, LMU University Hospital, Munich, Germany; 4Department of Pneumology, Asklepios-Fachkliniken Munich-Gauting, Gauting, Germany; 5Department of Infectious Diseases and Tropical Medicine, LMU University Hospital, Munich, GermanyCorrespondence: Katrin Milger, Department of Medicine V, LMU University Hospital, Marchioninistraße 15, Munich, 81377, Germany, Tel +49 89 4400 73071, Email Katrin.Milger@med.uni-muenchen.deAbstract: Eosinophilic inflammation is a hallmark of asthma, and blood eosinophilia has been established as a biomarker for phenotyping asthma and predicting the response to anti-IL5 treatments. …”
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Outcome after cytoreductive surgery combined with hyperthermic intrathoracic chemotherapy in patients with secondary pleural metastases by Mohamed Hassan, Mohamed Hassan, Julia Zimmermann, Severin Schmid, Severin Schmid, Bernward Passlick, Bernward Passlick, Julia Kovács, Rudolf Hatz, Hauke Winter, Hauke Winter, Laura V. Klotz, Laura V. Klotz, Martin E. Eichhorn, Martin E. Eichhorn, Till Markowiak, Karolina Müller, Gunnar Huppertz, Michael Koller, Hans-Stefan Hofmann, Hans-Stefan Hofmann, Michael Ried

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Non-Oncogene Addiction of <i>KRAS</i>-Mutant Cancers to IL-1β via Versican and Mononuclear IKKβ by Magda Spella, Giannoula Ntaliarda, Georgios Skiadas, Anne-Sophie Lamort, Malamati Vreka, Antonia Marazioti, Ioannis Lilis, Eleni Bouloukou, Georgia A. Giotopoulou, Mario A. A. Pepe, Stefanie A. I. Weiss, Agnese Petrera, Stefanie M. Hauck, Ina Koch, Michael Lindner, Rudolph A. Hatz, Juergen Behr, Kristina A. M. Arendt, Ioanna Giopanou, David Brunn, Rajkumar Savai, Dieter E. Jenne, Maarten de Château, Fiona E. Yull, Timothy S. Blackwell, Georgios T. Stathopoulos

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Multi-centre evaluation of the speed-oligo Mycobacteria assay for differentiation of <it>Mycobacterium </it>spp. in clinical isolates by Hofmann-Thiel Sabine, Turaev Laziz, Alnour Tarig, Drath Lore, Müllerova Maria, Hoffmann Harald

“…</p> <p>Results</p> <p>Two hundred forty-two clinical isolates were recovered from consecutive positive mycobacterial cultures at two German (IML Gauting, Bioscientia Ingelheim), one Czech (KLINLAB Prague), and at a Sudanese (Khartoum) laboratory. …”
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Perioperative Application of Levosimendan Optimizes Postoperative Renal Function and Organ Perfusion in Patients with Severe Heart Failure by Vasileios Leivaditis, Manfred Dahm, Anastasia Papaporfyriou, Michail Galanis, Efstratios Koletsis, Nikolaos Charokopos, Benjamin Ehle, Athanasios Papatriantafyllou, Erich Haussmann, Vladislav Kaplunov, Konstantinos Grapatsas

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Soluble High Mobility Group Box 1 (HMGB1) Is a Promising Biomarker for Prediction of Therapy Response and Prognosis in Advanced Lung Cancer Patients by Nikolaus A. Handke, Alexander B. A. Rupp, Nicolai Trimpop, Joachim von Pawel, Stefan Holdenrieder

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Best Practices for the Management of Patients with Non-Tuberculous Mycobacterial Pulmonary Disease According to a German Nationwide Analysis of Expert Centers by Gernot Rohde, Monika Eichinger, Sven Gläser, Marion Heiß-Neumann, Jan Kehrmann, Claus Neurohr, Marko Obradovic, Tim Kröger-Kilian, Tobias Loebel, Christian Taube

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Integrative analysis of cell state changes in lung fibrosis with peripheral protein biomarkers by Christoph H Mayr, Lukas M Simon, Gabriela Leuschner, Meshal Ansari, Janine Schniering, Philipp E Geyer, Ilias Angelidis, Maximilian Strunz, Pawandeep Singh, Nikolaus Kneidinger, Frank Reichenberger, Edith Silbernagel, Stephan Böhm, Heiko Adler, Michael Lindner, Britta Maurer, Anne Hilgendorff, Antje Prasse, Jürgen Behr, Matthias Mann, Oliver Eickelberg, Fabian J Theis, Herbert B Schiller

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Durvalumab after Chemoradiotherapy for PD-L1 Expressing Inoperable Stage III NSCLC Leads to Significant Improvement of Local-Regional Control and Overall Survival in the Real-World... by Julian Taugner, Lukas Käsmann, Chukwuka Eze, Amanda Tufman, Niels Reinmuth, Thomas Duell, Claus Belka, Farkhad Manapov

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Comparison of machine learning methods with logistic regression analysis in creating predictive models for risk of critical in-hospital events in COVID-19 patients on hospital admi... by Aaron W. Sievering, Peter Wohlmuth, Nele Geßler, Melanie A. Gunawardene, Klaus Herrlinger, Berthold Bein, Dirk Arnold, Martin Bergmann, Lorenz Nowak, Christian Gloeckner, Ina Koch, Martin Bachmann, Christoph U. Herborn, Axel Stang

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Industry 4.0 from An Entrepreneurial Transformation and Financing Perspective by Kai Lucks

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Performance of T-Track^® TB, a Novel Dual Marker RT-qPCR-Based Whole-Blood Test for Improved Detection of Active Tuberculosis by Johannes P. Meier, Selina Möbus, Florian Heigl, Alexandra Asbach-Nitzsche, Hans Helmut Niller, Annelie Plentz, Korkut Avsar, Marion Heiß-Neumann, Bernhard Schaaf, Uwe Cassens, Bernd Seese, Daniel Teschner, Sabin Handzhiev, Uwe Graf, Christoph Lübbert, Monika Steinmaurer, Konstantina Kontogianni, Christoph Berg, Andreas Maieron, Stefan H. Blaas, Ralf Wagner, Ludwig Deml, Sascha Barabas

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Survival benefit with checkpoint inhibitors versus chemotherapy is modified by brain metastases in patients with recurrent small cell lung cancer by Friederike C. Althoff, Lisa V. Schäfer, Fabian Acker, Lukas Aguinarte, Sophie Heinzen, Maximilian Rost, Akin Atmaca, Vivian Rosery, Jürgen Alt, Cornelius F. Waller, Niels Reinmuth, Gernot Rohde, Felix C. Saalfeld, Aaron Becker von Rose, Miriam Möller, Nikolaj Frost, Martin Sebastian, Jan A. Stratmann

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Differential effects of Nintedanib and Pirfenidone on lung alveolar epithelial cell function in ex vivo murine and human lung tissue cultures of pulmonary fibrosis by Mareike Lehmann, Lara Buhl, Hani N. Alsafadi, Stephan Klee, Sarah Hermann, Kathrin Mutze, Chiharu Ota, Michael Lindner, Jürgen Behr, Anne Hilgendorff, Darcy E. Wagner, Melanie Königshoff

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Quantitative proteomic profiling of extracellular matrix and site-specific collagen post-translational modifications in an in vitro model of lung fibrosis by Juliane Merl-Pham, Trayambak Basak, Larissa Knüppel, Deepak Ramanujam, Mark Athanason, Jürgen Behr, Stefan Engelhardt, Oliver Eickelberg, Stefanie M. Hauck, Roberto Vanacore, Claudia A. Staab-Weijnitz

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Characteristics of Current Smokers versus Former Smokers with COPD and Their Associations with Smoking Cessation Within 4.5 Years: Results from COSYCONET by Alter P, Stoleriu C, Kahnert K, Henke MO, Bals R, Trudzinski FC, Watz H, Speicher T, Söhler S, Welte T, Rabe KF, Wouters EFM, Vogelmeier CF, Jörres RA

“…Peter Alter,1 Cosmina Stoleriu,2 Kathrin Kahnert,3,4 Markus Oliver Henke,5 Robert Bals,6 Franziska C Trudzinski,7 Henrik Watz,8 Tim Speicher,1 Sandra Söhler,1 Tobias Welte,9 Klaus F Rabe,10,11 Emiel FM Wouters,12,13 Claus F Vogelmeier,1 Rudolf A Jörres14 1Department of Medicine, Pulmonary, Critical Care and Sleep Medicine, Philipps University of Marburg (UMR), Member of the German Center for Lung Research (DZL), Marburg, Germany; 2Asklepios Lungenklinik Gauting, Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research (DZL), Gauting, Germany; 3Department of Medicine V, LMU University Hospital, LMU Munich, Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research (DZL), Munich, Germany; 4MediCenterGermering, Germering, Germany; 5Klinik für Innere Medizin und Pneumologie, Krankenhaus Martha-Maria, Munich, Germany; 6Department of Internal Medicine V, Pulmonology, Allergology, Intensive Care Medicine, Saarland University Hospital, Homburg, Germany; 7Department of Pneumology and Critical Care Medicine, Thoraxklinik, University of Heidelberg, Translational Lung Research Center Heidelberg (TLRC-H), Member of the Center for Lung Research (DZL), Heidelberg, Germany; 8Pulmonary Research Institute at LungenClinic Grosshansdorf, Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL), Grosshansdorf, Germany; 9Clinic for Pneumology, Hannover Medical School, Member of the German Center for Lung Research (DZL), Hannover, Germany; 10LungenClinic Grosshansdorf, Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL), Grosshansdorf, Germany; 11Department of Medicine, Christian-Albrechts-University, Kiel, Germany; 12Department of Respiratory Medicine, Maastricht University Medical Centre, Maastricht, Netherlands; 13Ludwig Boltzmann Institute for Lung Health, Vienna, Austria; 14Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, LMU University Hospital, LMU Munich, Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research (DZL), Munich, GermanyCorrespondence: Peter Alter, Department of Medicine, Pulmonary, Critical Care and Sleep Medicine, Philipps University of Marburg (UMR), Member of the German Center for Lung Research (DZL), Baldingerstrasse 1, Marburg, 35033, Germany, Tel +49 6421 5866140, Email Alter@uni-marburg.deBackground: Many patients with chronic obstructive pulmonary disease (COPD) continue smoking. …”
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Comparison of the sensitivity of different criteria to select lung cancer patients for screening in a cohort of German patients by Julia Walter, Diego Kauffmann‐Guerrero, Thomas Muley, Martin Reck, Jan Fuge, Andreas Günther, Raphael W. Majeed, Rajkumar Savai, Ina Koch, Julien Dinkel, Christian Schneider, Karsten Senghas, Sonja Kobinger, Farkhad Manapov, Michael Thomas, Kathrin Kahnert, Hauke Winter, Jürgen Behr, Martin Tammemägi, Amanda Tufman

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Prolonged weaning: From the intensive care unit to home by P. Navalesi, P. Frigerio, A. Patzlaff, S. HäuÃermann, P. Henseke, M. Kubitschek

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Experimental Test of Non-Destructive Methods to Assess the Anchorage of Trees by Andreas Detter, Steffen Rust, Oskars Krišāns

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Two-Year Outcomes for the Double-Blind, Randomized, Sham-Controlled Study of Targeted Lung Denervation in Patients with Moderate to Severe COPD: AIRFLOW-2 by Valipour A, Shah PL, Herth FJ, Pison C, Schumann C, Hübner RH, Bonta PI, Kessler R, Gesierich W, Darwiche K, Lamprecht B, Perez T, Skowasch D, Deslee G, Marceau A, Sciurba FC, Gosens R, Hartman JE, Conway F, Duller M, Mayse M, Norman HS, Slebos DJ

“…Infektiologie und Pneumologie, Campus Virchow, Berlin, Germany; 7Department of Respiratory Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; 8Service de Pneumologie, Nouvel H&ocirc;pital Civil, Universit&eacute; de Strasbourg, Strasbourg, France; 9Asklepios-Fachkliniken Munich-Gauting, Comprehensive Pneumology Center Munich, Gauting, Germany; 10Department of Pulmonary Medicine, Section of Interventional Pneumology, Ruhrlandklinik - University Hospital Essen, University of Duisburg-Essen, Essen, Germany; 11Department of Pulmonary Medicine, Kepler Universitatsklinikum GmbH, Linz, Austria; 12CHU de Lille &ndash; H&ocirc;pital Calmette, Lille, France; 13Department of Internal Medicine II - Cardiology/Pneumology, University of Bonn, Bonn, Germany; 14CHU de Reims, H&ocirc;pital Maison Blanche, Service de Pneumologie, Reims, France; 15Service de Pneumologie, H&ocirc;pital Universitaire Bichat, Paris, France; 16University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; 17Department of Molecular Pharmacology, University of Groningen, Groningen, the Netherlands; 18Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands; 19Nuvaira, Inc., Minneapolis, MN, USACorrespondence: Dirk-Jan SlebosDepartment of Pulmonary Diseases/Interventional Bronchoscopy AA11, University Medical Center Groningen, PO Box 30001, Groningen, the NetherlandsTel +31 503612357Fax +31503619320Email d.j.slebos@umcg.nlPurpose: COPD exacerbations are associated with worsening clinical outcomes and increased healthcare costs, despite use of optimal medical therapy. …”
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