Misfolded proteins bind and activate death receptor 5 to trigger apoptosis during unresolved endoplasmic reticulum stress by Mable Lam, Scot A Marsters, Avi Ashkenazi, Peter Walter

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Real-World Comparative Effectiveness of First-Line Alectinib Versus Crizotinib in Patients With Advanced ALK-Positive NSCLC With or Without Baseline Central Nervous System Metastas... by Qing Zhang, PhD, Jessica J. Lin, MD, Navdeep Pal, M.B.B.S., MPH, Letizia Polito, PhD, Huong Trinh, MD, Magalie Hilton, MSc, Vlatka Smoljanović, MD, Nino Kurtsikidze, MD, Venice Archer, MD, Matthew G. Krebs, MD, PhD

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23 Building quality improvement capability city-wide to improve child health and well-being by Laura Mitchell, Jennifer Oehler, Robert Kahn, Susan Sprigg, Grant Mussman, Melinda Corcoran, Chris Alexander

Brief Report: Safety and Antitumor Activity of Alectinib Plus Atezolizumab From a Phase 1b Study in Advanced ALK-Positive NSCLC by Dong-Wan Kim, MD, PhD, Shirish Gadgeel, MD, Scott N. Gettinger, MD, Gregory J. Riely, MD, PhD, Geoffrey R. Oxnard, MD, Tarek Mekhail, MD, Peter Schmid, MD, PhD, Afshin Dowlati, MD, Rebecca S. Heist, MD, MPH, Antoinette J. Wozniak, MD, Jatinder Singh, PhD, Edward Cha, MD, PhD, Jessica Spahn, PhD, Sai-Hong Ignatius Ou, MD, PhD

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568 Tumor-intrinsic Sox2 signaling induces regulatory T cell-mediated CD8 T cell exclusion, promoting resistance to checkpoint blockade therapy in lung cancer by Stefani Spranger, Ellen Duong, Kim Nguyen, Elen Torres, Leon Yim, Sally Weng

145 Proteogenomic approaches for exploring the dark immunopeptidome by Daniel Le, Kristin Leskoske, Hem Gurung, Ana Magalhaes, Samir Vaidya, Hang Xu, Yuxin Liang, Susan Klaeger

Conformation selection by ATP-competitive inhibitors and allosteric communication in ERK2 by Jake W Anderson, David Vaisar, David N Jones, Laurel M Pegram, Guy P Vigers, Huifen Chen, John G Moffat, Natalie G Ahn

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A disease model predicting placebo response and remission status of patients with ulcerative colitis using modified Mayo score by Anita Moein, Jurgen Langenhorst, Elodie L. Plan, Jin Y. Jin, Matts Kågedal, Nastya Kassir

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Author Correction: Tumour gene expression signature in primary melanoma predicts long-term outcomes by Manik Garg, Dominique-Laurent Couturier, Jérémie Nsengimana, Nuno A. Fonseca, Matthew Wongchenko, Yibing Yan, Martin Lauss, Göran B. Jönsson, Julia Newton-Bishop, Christine Parkinson, Mark R. Middleton, D. Timothy Bishop, Sarah McDonald, Nikki Stefanos, John Tadross, Ismael A. Vergara, Serigne Lo, Felicity Newell, James S. Wilmott, John F. Thompson, Georgina V. Long, Richard A. Scolyer, Pippa Corrie, David J. Adams, Alvis Brazma, Roy Rabbie

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Transcriptomic and proteomic assessment of tocilizumab response in a randomized controlled trial of patients hospitalized with COVID-19 by Haridha Shivram, Jason A. Hackney, Carrie M. Rosenberger, Anastasia Teterina, Aditi Qamra, Olusegun Onabajo, Jacqueline McBride, Fang Cai, Min Bao, Larry Tsai, Aviv Regev, Ivan O. Rosas, Rebecca N. Bauer

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Relative bioavailability and food effect study of an oral suspension of alectinib in healthy volunteers using venipuncture and capillary microsampling by Stephanie N. Liu, Priya Agarwal, Katja Heinig, Asim Datye, Carolina Sturm‐Pellanda, Andrea Crugnola, Marc Arca, Dale Miles

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Neuronal regulated ire-1-dependent mRNA decay controls germline differentiation in Caenorhabditis elegans by Mor Levi-Ferber, Rewayd Shalash, Adrien Le-Thomas, Yehuda Salzberg, Maor Shurgi, Jennifer IC Benichou, Avi Ashkenazi, Sivan Henis-Korenblit

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Exposure‐response relationships of etrolizumab in patients with moderately‐to‐severely active ulcerative colitis by Nastya Kassir, Rui Zhu, Anita Moein, Jurgen Langenhorst, Jakob Ribbing, Rong Zhang, Meina T. Tang, Young S. Oh, Wenhui Zhang

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Biophysical characterization of PVR family interactions and therapeutic antibody recognition to TIGIT by SJ J. Diong, Aarti Jashnani, Andrew W. Drake, Christine Bee, Felix Findeisen, Gavin Dollinger, Feng Wang, Arvind Rajpal, Pavel Strop, Peter S. Lee

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Antitussive Use in Patients with Inadequately Controlled Moderate-to-Severe Asthma: A Post Hoc Analysis of the Omalizumab EXTRA Trial by Rutland CJ, Iweala OI, Anders K, Ko J, Mital P, Gupta S, Mohan A

“…Cedric J Rutland,1 Onyinye I Iweala,2 Kyle Anders,3 Jinnie Ko,3 Parul Mital,3 Sachin Gupta,3 Arjun Mohan4 1Rutland Medical Group, Newport Beach, CA, USA; 2Division of Rheumatology, Allergy, and Immunology, University of North Carolina, Chapel Hill, NC, USA; 3Genentech, Inc., South San Francisco, CA, USA; 4Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI, USACorrespondence: Sachin Gupta, Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA, Tel +1 650-763-7791, Email Guptas71@gene.comAbstract: Acute and chronic cough are common symptoms in patients with severe allergic asthma. …”
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Mitigating ipatasertib‐induced glucose increase through dose and meal timing modifications by Dhruvitkumar S. Sutaria, Priya Agarwal, Kuan‐Chieh Huang, Dale R. Miles, Jacob Rotmensch, Heather Hinton, Jorge Daniel Gallo, Grozdana Rasuo, Rucha S. Sane

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An interleukin 6 responsive plasma cell signature is associated with disease progression in systemic sclerosis interstitial lung disease by Guiquan Jia, Thirumalai R. Ramalingam, Jason Vander Heiden, Xia Gao, Daryle DePianto, Katrina B. Morshead, Zora Modrusan, Nandhini Ramamoorthi, Paul Wolters, Celia Lin, Dinesh Khanna, Joseph R. Arron

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Automated detection of progressive speech changes in early Alzheimer's disease by Jessica Robin, Mengdan Xu, Aparna Balagopalan, Jekaterina Novikova, Laura Kahn, Abdi Oday, Mohsen Hejrati, Somaye Hashemifar, Mohammadreza Negahdar, William Simpson, Edmond Teng

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P519: TRANSFUSION INDEPENDENCE AMONG NEWLY DIAGNOSED ACUTE MYELOID LEUKEMIA PATIENTS RECEIVING VENETOCLAX-BASED COMBINATIONS VS OTHER THERAPIES: RESULTS FROM THE AML REAL WORLD EVI... by O. Wolach, J. S. Garcia, P. Vachhani, J. Zeidner, C. Lai, Y. Moshe, M. Xavier, S. Lee, T. Zuckerman, D. A. Pollyea, S. Abedin, E. C. Chen, S. Bathini, W. Edwards, C. N. Bui, W. W.-H. Cheng, A. Svensson, A. Guérin, J. Maitland, E. Ma, M. Montez, M. Grunspan, A. D. Goldberg

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Editorial: NK cells in viral immunology and immunotherapy by Sachin Mulik, Pranay Dogra, Nabila Jabrane-Ferrat

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