Development of T-cell engagers selective for cells co-expressing two antigens by Danielle M. Dicara, Sunil Bhakta, Mary Ann Go, James Ziai, Ron Firestein, Bill Forrest, Chen Gu, Steven R. Leong, Genee Lee, Shang-Fan Yu, Andrew G. Polson, Nicholas J. Agard

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CD25 targeting with the afucosylated human IgG1 antibody RG6292 eliminates regulatory T cells and CD25+ blasts in acute myeloid leukemia by Laurène Pousse, Koorosh Korfi, Bruno C. Medeiros, Marco Berrera, Nadine Kumpesa, Jan Eckmann, Idil Karakoc Hutter, Vera Griesser, Vaios Karanikas, Christian Klein, Maria Amann

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Multi-range ERK responses shape the proliferative trajectory of single cells following oncogene induction by Jia-Yun Chen, Clemens Hug, José Reyes, Chengzhe Tian, Luca Gerosa, Fabian Fröhlich, Bas Ponsioen, Hugo J.G. Snippert, Sabrina L. Spencer, Ashwini Jambhekar, Peter K. Sorger, Galit Lahav

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Baseline risk factors associated with immune related adverse events and atezolizumab by Katrin Madjar, Rajat Mohindra, Gonzalo Durán-Pacheco, Rashad Rasul, Laurent Essioux, Vidya Maiya, G. Scott Chandler

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The role of mitochondrial genes on nuclear gene expression in neovascular age related macular degeneration: analysis of nuclear VEGF gene expression after ranibizumab treatment in... by Rodrigo Donato Costa, Farid José Thomaz Neto, M. Tarek Moustafa, Shari R. Atilano, Marilyn Chwa, Javier Cáceres-del-Carpi, Mohamed Hamid Mohamed, M. Cristina Kenney, Baruch D. Kuppermann

“…The cybrids were treated with Ranibizumab (Lucentis, Genentech, San Francisco, CA), at 4 different concentrations for 24 h, and subsequently the levels of reactive oxygen species (ROS), gene expression for VEGF-A, hypoxia-inducible factor 1-alpha (HIF1-a) and manganese superoxide dismutase (SOD2) were measured. …”
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Inhibition of Angiopoietin-2 Production by Myofibrocytes Inhibits Neointimal Hyperplasia After Endoluminal Injury in Mice by Daxin Chen, Ke Li, El-Li Tham, Lin-Lin Wei, Ning Ma, Philippa C. Dodd, Yi Luo, Daniel Kirchhofer, John H. McVey, Anthony Dorling

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Assessing the impact of digital patient monitoring on health outcomes and healthcare resource usage in addition to the feasibility of its combination with at-home treatment, in par... by Manuela Eicher, Sanna Iivanainen, Maria Reig, Amparo Yovanna Castro Sanchez, Anne-Marie Baird, Bogdana Balas, Alberto Bustillos, Sophie Golding, Mathis Mueller-Ohldach, Manfred Welslau, Johannes Ammann

“…Hoffmann-La Roche Ltd/Genentech) and local standard-of-care support, with/without the Roche DPM Module. …”
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Evaluation of Alectinib Metabolic Stability in HLMs Using Fast LC-MS/MS Method: In Silico ADME Profile, P450 Metabolic Lability, and Toxic Alerts Screening by Mohamed W. Attwa, Haitham AlRabiah, Gamal A. E. Mostafa, Adnan A. Kadi

“…(Basel, Switzerland)/Genentech, Inc. (South San Francisco, CA, USA), on 6 November 2017. …”
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Prognostic MicroRNA Panel for HCV-Associated HCC: Integrating Computational Biology and Clinical Validation by Areeg M. Dabbish, Hana M. Abdelzaher, Moustafa Abohawya, Samir Shamma, Yosra H. Mahmoud, Amr Maged, Mohamed Manaa, Mohamed Hassany, Firas Kobeissy, Omid Bazgir, Hassan El-Fawal, Hassan M. E. Azzazy, Anwar Abdelnaser

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High p16 expression and heterozygous RB1 loss are biomarkers for CDK4/6 inhibitor resistance in ER+ breast cancer by Marta Palafox, Laia Monserrat, Meritxell Bellet, Guillermo Villacampa, Abel Gonzalez-Perez, Mafalda Oliveira, Fara Brasó-Maristany, Nusaibah Ibrahimi, Srinivasaraghavan Kannan, Leonardo Mina, Maria Teresa Herrera-Abreu, Andreu Òdena, Mònica Sánchez-Guixé, Marta Capelán, Analía Azaro, Alejandra Bruna, Olga Rodríguez, Marta Guzmán, Judit Grueso, Cristina Viaplana, Javier Hernández, Faye Su, Kui Lin, Robert B. Clarke, Carlos Caldas, Joaquín Arribas, Stefan Michiels, Alicia García-Sanz, Nicholas C. Turner, Aleix Prat, Paolo Nuciforo, Rodrigo Dienstmann, Chandra S. Verma, Nuria Lopez-Bigas, Maurizio Scaltriti, Monica Arnedos, Cristina Saura, Violeta Serra

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Tumor biomarkers and efficacy in patients treated with trastuzumab emtansine + pertuzumab versus standard of care in HER2-positive early breast cancer: an open-label, phase III stu... by Sanne L. de Haas, Dennis J. Slamon, Miguel Martin, Michael F. Press, Gail D. Lewis, Chiara Lambertini, Aleix Prat, Vanesa Lopez-Valverde, Thomas Boulet, Sara A. Hurvitz

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SMO Inhibition Modulates Cellular Plasticity and Invasiveness in Colorectal Cancer by Paolo Magistri, Cecilia Battistelli, Raffaele Strippoli, Niccolò Petrucciani, Teijo Pellinen, Lucia Rossi, Livia Mangogna, Paolo Aurello, Francesco D'Angelo, Marco Tripodi, Giovanni Ramacciato, Giuseppe Nigri

“…HIGHLIGHTSPreliminary results of this work were presented at the 2016 Academic Surgical Congress, Jacksonville (FL), February 2–4 2016 (Original title: Selective Smo-Inhibition Interferes With Cellular Energetic Metabolism In Colorectal Cancer)This study was funded by “Sapienza—University of Rome” (Funds for young researchers) and “AIRC” (Italian Association for Cancer Research)Hedgehog inhibitor was kindly provided by Genentech, Inc.®.Colon Cancer (CC) is the fourth most frequently diagnosed tumor and the second leading cause of death in the USA. …”
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Two-year visual and psychological outcomes of ranibizumab and subsequent treatment for diabetic macular oedema in Japan (MERCURY) by Takao Hirano, Yuichi Toriyama, Tatsuro Ishibashi, Taiji Sakamoto, Tomoaki Murakami, Nahoko Ogata, Yuichiro Ogura, Masahiko Shimura, Shigehiko Kitano, Yoshihiro Takamura, Jiro Kogo, Yoshinori Mitamura, Fumiki Okamoto, Masahiko Sugimoto, Sentaro Kusuhara, Hitoshi Takagi, Masaru Takeuchi, Akito Hirakata, Hidetoshi Yamashita, Katsuhiro Nishi, Keijiro Ishikawa, Masahito Ohji, Osamu Sawada, Shigeo Yoshida, Toshio Hisatomi, Miho Nozaki, Hideyasu Oh, Makoto Suzaki, Kimie Mori, Masanari Kozawa, Poh Sin Yap, Takeumi Kaneko, Hiroko Imaizumi, Sachi Abe

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Bayesian risk prediction model for colorectal cancer mortality through integration of clinicopathologic and genomic data by Melissa Zhao, Mai Chan Lau, Koichiro Haruki, Juha P. Väyrynen, Carino Gurjao, Sara A. Väyrynen, Andressa Dias Costa, Jennifer Borowsky, Kenji Fujiyoshi, Kota Arima, Tsuyoshi Hamada, Jochen K. Lennerz, Charles S. Fuchs, Reiko Nishihara, Andrew T. Chan, Kimmie Ng, Xuehong Zhang, Jeffrey A. Meyerhardt, Mingyang Song, Molin Wang, Marios Giannakis, Jonathan A. Nowak, Kun-Hsing Yu, Tomotaka Ugai, Shuji Ogino

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Histology of Type 3 Macular Neovascularization and Microvascular Anomalies in Treated Age-Related Macular Degeneration by Andreas Berlin, MD, MS, Diogo Cabral, MD, Ling Chen, MD, PhD, Jeffrey D. Messinger, DC, Chandrakumar Balaratnasingam, MD, PhD, Randev Mendis, MD, Daniela Ferrara, MD, PhD, K. Bailey Freund, MD, Christine A. Curcio, PhD

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Lower frequencies of circulating suppressive regulatory T cells and higher frequencies of CD4+ naïve T cells at baseline are associated with severe immune-related adverse events in... by Siwen Hu-Lieskovan, Ngan Nguyen, Magdalena Kovacsovics-Bankowski, John Hyngstrom, Li-Chun Cheng, Jordan P McPherson, Umang Swami, Matthew H Spitzer, Johanna M Sweere, Connor P Healy, Natalia Sigal, William D Chronister, Shane A Evans, John Marsiglio, Berit Gibson, Alyssa Erickson-Wayman, Yoko S Derose, Annaleah Larson Eliason, Carlos O Medina, Ramji Srinivasan

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Transcriptional immunogenomic analysis reveals distinct immunological clusters in paediatric nervous system tumours by Arash Nabbi, Pengbo Beck, Alberto Delaidelli, Derek A. Oldridge, Sumedha Sudhaman, Kelsey Zhu, S. Y. Cindy Yang, David T. Mulder, Jeffrey P. Bruce, Joseph N. Paulson, Pichai Raman, Yuankun Zhu, Adam C. Resnick, Poul H. Sorensen, Martin Sill, Sebastian Brabetz, Sander Lambo, David Malkin, Pascal D. Johann, Marcel Kool, David T. W. Jones, Stefan M. Pfister, Natalie Jäger, Trevor J. Pugh

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Tissue factor targeting peptide enhances nanoparticle binding and delivery of a synthetic specialized pro-resolving lipid mediator to injured arteries by Elizabeth S. Levy, PhD, Alexander S. Kim, MD, Evan Werlin, MD, Mian Chen, MD, Brian E. Sansbury, PhD, Matthew Spite, PhD, Tejal A. Desai, PhD, Michael S. Conte, MD

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Risk of relapse of ANCA-associated vasculitis among patients homozygous for the proteinase 3 gene Val119Ile polymorphism by John H Stone, Peter C Grayson, Ulrich Specks, E William St Clair, Peter A Merkel, Philip Seo, Carol A Langford, Paul A Monach, Cees G M Kallenberg, Robert F Spiera, Fernando C Fervenza, Zuoming Deng, Wei Tew, Marta Casal Moura, Stephen R Brooks, Marco Prunotto

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Inherited ARPC5 mutations cause an actinopathy impairing cell motility and disrupting cytokine signaling by Cristiane J. Nunes-Santos, HyeSun Kuehn, Brigette Boast, SuJin Hwang, Douglas B. Kuhns, Jennifer Stoddard, Julie E. Niemela, Danielle L. Fink, Stefania Pittaluga, Mones Abu-Asab, John S. Davies, Valarie A. Barr, Tomoki Kawai, Ottavia M. Delmonte, Marita Bosticardo, Mary Garofalo, Magda Carneiro-Sampaio, Raz Somech, Mohammad Gharagozlou, Nima Parvaneh, Lawrence E. Samelson, Thomas A. Fleisher, Anne Puel, Luigi D. Notarangelo, Bertrand Boisson, Jean-Laurent Casanova, Beata Derfalvi, Sergio D. Rosenzweig

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