Targeting RAS–RAF–MEK–ERK signaling pathway in human cancer: Current status in clinical trials by Yanlin Song, Zhenfei Bi, Yu Liu, Furong Qin, Yuquan Wei, Xiawei Wei

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Pharmacological perspectives and molecular mechanisms of coumarin derivatives against virus disease by Zhoupeng Li, Dehui Kong, Yongsheng Liu, Mingkai Li

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The genomic and epigenomic landscape of iridocorneal endothelial syndrome by Yaoming Liu, Gen Li, Jiaxuan Jiang, Sujie Fan, Lan Lu, Ting Wang, Guigang Li, Wenzong Zhou, Xuequn Liu, Yingjie Li, Hong Sun, Liang Liang, Yuhong Tang, Yang Chen, Jianjun Gu, Fei Li, Xiuli Fang, Tao Sun, Aiguo Lv, Yayi Wang, Peiyuan Wang, Tao Wen, Jiayu Deng, Yuhong Liu, Mingying Lai, Jingni Yu, Danyan Liu, Hua Wang, Meizhu Chen, Li Li, Xiaodan Huang, Jingming Shi, Xu Zhang, Kang Zhang, Lingyi Liang, Xiulan Zhang

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Differential expression profile of circular RNAs in mouse peritoneum with peritoneal fibrosis and the potential regulatory role of novel_circ_0007527 by Yingfeng Shi, Yan Hu, Hui Chen, Jinqing Li, Min Tao, Xun Zhou, Qin Zhong, Andong Qiu, Shougang Zhuang, Na Liu

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BET bromodomain inhibitor JQ1 regulates spermatid development by changing chromatin conformation in mouse spermatogenesis by Xiaorong Wang, Mengmeng Sang, Shengnan Gong, Zhichuan Chen, Xi Zhao, Guishuan Wang, Zhiran Li, Yingying Huang, Shitao Chen, Gangcai Xie, Enkui Duan, Fei Sun

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Novel function of biguanides in inhibition of phospholipase D1 expression via a translational mechanism in cancer cells by Yuanfa Yao, Hanbing Li, Xinyi Wang, Yuanhai Sun, Xuqin Zhao, Weiwei Zha, Jiaqiang Zhou, Derek Toomre, Junfen Fu, Yingke Xu

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The importance of expert review to clarify ambiguous situations for (Q)SAR predictions under ICH M7 by Robert S. Foster, Adrian Fowkes, Alex Cayley, Andrew Thresher, Anne-Laure D. Werner, Chris G. Barber, Grace Kocks, Rachael E. Tennant, Richard V. Williams, Steven Kane, Susanne A. Stalford

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Evaluation of risk due to chronic low dose ionizing radiation exposure on the birth prevalence of congenital heart diseases (CHD) among the newborns from high-level natural radiati... by K. R. Sudheer, P. K. Mohammad Koya, Anu J. Prakash, Ambily M. Prakash, R. Manoj Kumar, S. Shyni, C. K. Jagadeesan, G. Jaikrishan, Birajalaxmi Das

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Identification of miRNA signature associated with BMP2 and chemosensitivity of TMZ in glioblastoma stem-like cells by Xiaoyu Guo, Ziguo Luo, Tong Xia, Lanxiang Wu, Yanshu Shi, Ying Li

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The m6A regulator KIAA1429 stabilizes RAB27B mRNA and promotes the progression of chronic myeloid leukemia and resistance to targeted therapy by Fangyi Yao, Fangmin Zhong, Junyao Jiang, Ying Cheng, Shuai Xu, Jing Liu, Jin Lin, Jing Zhang, Shuqi Li, Meiyong Li, Yanmei Xu, Bo Huang, Xiaozhong Wang

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Chloroethylating anticancer drug-induced mutagenesis and its repair in Escherichia coli by Yoko Yamada, Shinji Watanabe, Keinosuke Okamoto, Sakae Arimoto, Eizo Takahashi, Kazuo Negishi, Tomoe Negishi

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Inhibition of lysine-specific demethylase 1 (LSD1) prevented tumor growth and metastasis by downregulating PD-L1 expression in lung adenocarcinoma by Pengxing He, Linna Du, Pan Hao, Han Yang, Yufei Ren, Huiqin Kang, Yanli Ding, Wen Zhao, Yichao Xu, Hongmin Liu

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Development of novel 5-FU modified siRNA against BCL-2 with enhanced efficacy and vehicle-free cellular uptake by Andrew Fesler, Ga-Ram Hwang, Jingfang Ju

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The transcriptional regulators of virulence for Pseudomonas aeruginosa: Therapeutic opportunity and preventive potential of its clinical infections by Xiaolong Shao, Chunyan Yao, Yiqing Ding, Haiyan Hu, Guoliang Qian, Mingliang He, Xin Deng

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Insights into the role of RNA m6A modification in the metabolic process and related diseases by Haiming Hu, Zhibin Li, Xia Xie, Qiushi Liao, Yiyang Hu, Chunli Gong, Nannan Gao, Huan Yang, Yufeng Xiao, Yang Chen

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Why are red haired individuals so prone to developing melanoma? by Rutao Cui

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Ubiquitination and degradation of SIK2 by DNA-PKcs deficiency promote radiation-induced mitotic catastrophe by Jiaojiao Zhu, Ying Zhang, Ziyan Yan, Jianxiao Wang, Ping Wang, Xinxin Liang, Yuhao Liu, Xingkun Ao, Maoxiang Zhu, Pingkun Zhou, Yongqing Gu

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The inflammatory microenvironment and the urinary microbiome in the initiation and progression of bladder cancer by Xingxing Huang, Ting Pan, Lili Yan, Ting Jin, Ruonan Zhang, Bi Chen, Jiao Feng, Ting Duan, Yu Xiang, Mingming Zhang, Xiaying Chen, Zuyi Yang, Wenzheng Zhang, Xia Ding, Tian Xie, Xinbing Sui

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Tetratricopeptide repeat domain 36 deficiency mitigates renal tubular injury by inhibiting TGF-β1-induced epithelial–mesenchymal transition in a mouse model of chronic kidney disea... by Xin Yan, Rui Peng, Yilu Ni, Lei Chen, Qingling He, Qianyin Li, Qin Zhou

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Deciphering the role of microRNA 21 in cancer stem cells (CSCs) by Durairaj Sekar, Ramalingam Krishnan, Mani Panagal, Pethanen Sivakumar, Vincent Gopinath, Venugopal Basam

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