Zebrafish (Danio rerio) meets bioethics: the 10Rs ethical principles in research by Aryelle Canedo, Patrícia Saiki, Andressa Liberal Santos, Karla da Silva Carneiro, Andreza Martins de Souza, Gabriel Qualhato, Rafaella da Silva Brito, Francyelli Mello-Andrade, Thiago Lopes Rocha

“…The development of genetically modified animals and the increasing number of zebrafish breeding facilities due to their emerging use in several research fields, opened room for new ethical challenges for research carried out with this species. …”
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The Role of the Endocannabinoid System in Binge Eating Disorder by Romain Bourdy, Katia Befort

“…Pharmacological approaches together with research using genetically modified animals have strongly highlighted a predominant role of the endocannabinoid system in feeding behaviors, with the specific modulation of addictive-like eating behaviors. …”
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Transgenic Rabbit Models: Now and the Future by Fumikazu Matsuhisa, Shuji Kitajima, Kazutoshi Nishijima, Toshiaki Akiyoshi, Masatoshi Morimoto, Jianglin Fan

“…Despite these limitations, the emergence of novel genome editing technology has changed the production of genetically modified animals including the rabbit. We are finally able to produce both transgenic and knockout rabbit models to analyze gain- and loss-of-functions of specific genes. …”
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Burrowing in rodents: a sensitive method for detecting behavioral dysfunction. by Deacon, R

“…The simplicity, sensitivity and robustness of burrowing make it ideal for assessing genetically modified animals, which in most cases would be mice. …”

Animal Model for Glucocorticoid Induced Osteoporosis: A Systematic Review from 2011 to 2021 by Andy Xavier, Hechmi Toumi, Eric Lespessailles

“…In mice studies, males (58%) were preferred and genetically modified animals accounted for 28%. Our work calls for a standardization of the establishment of the GIOP animal model with better precision for model selection. …”
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Molecular Targeted Intervention for Pancreatic Cancer by Altaf Mohammed, Naveena B. Janakiram, Shubham Pant, Chinthalapally V. Rao

“…With the advent of genetically modified animals, significant advances have been made in understanding the molecular biology and pathogenesis of PC. …”
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Development of transgenic animals for optogenetic manipulation of mammalian nervous system function: Progress and prospects for behavioral neuroscience by Feng, Guoping, Ting, Jonathan Thomas

“…Lastly, we propose strategies that can be implemented to develop and refine the next generation of genetically modified animals for behaviorally-focused optogenetics-based applications.…”
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Adipose tissue: a key target for diabetes pathophysiology and treatment? by Frayn, K, Tan, G, Karpe, F

“…If the normal mechanisms regulating adipocyte fat storage are interfered with (either in genetically-modified animals or by increasing the size of the adipocytes), then perhaps some sort of cellular stress sets in, leading to the inflammatory and endocrine changes. …”

Production of transgenic cattle by somatic cell nuclear transfer (SCNT) with the human granulocyte colony-stimulation factor (hG-CSF) by Bruno P. Carvalho, Andrielle T. M. Cunha, Bianca D. M. Silva, Regivaldo V. Sousa, Ligiane O. Leme, Margot A. N. Dode, Eduardo O. Melo

“…For these reasons, the production of hG-CSF in a bioreactor system using the mammary gland of genetic modified animals is a possibility of adding value to the bovine genetic material and reducing the costs of hG-CSF production in pharmaceutical industry. …”
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Current status of the application of gene editing in pigs by Fuminori TANIHARA, Maki HIRATA, Takeshige OTOI

“…Genetically modified animals, especially rodents, are widely used in biomedical research. …”
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Application of Genetically Engineered Pigs in Biomedical Research by Magdalena Hryhorowicz, Daniel Lipiński, Szymon Hryhorowicz, Agnieszka Nowak-Terpiłowska, Natalia Ryczek, Joanna Zeyland

“…The further aspect discussed is the use of genetically modified animals as a source of cells, tissues, and organs for transplantation into human recipients, i.e., xenotransplantation. …”
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The neuromedin U system: Pharmacological implications for the treatment of obesity and binge eating behavior by Luca Botticelli, Emanuela Micioni Di Bonaventura, Fabio Del Bello, Gianfabio Giorgioni, Alessandro Piergentili, Wilma Quaglia, Alessandro Bonifazi, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura

“…This has been observed through direct administration of NMU and by studies using genetically modified animals, which revealed an obesity phenotype when the NMU gene is deleted. …”
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Efficient activation of reconstructed rat embryos by cyclin-dependent kinase inhibitors. by Robin L Webb, Kirk A Findlay, Michael A Green, Tina L Beckett, M Paul Murphy

“…This technique has the potential to revolutionize the way that genetically modified animals are made. In its current state, the process of SCNT is very inefficient (<5% success rate), with several technical and biological hurdles hindering development. …”
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Development of assisted reproductive technologies in small animal species for their efficient preservation and production by Keiji MOCHIDA

“…In small laboratory animal species such as mice, ARTs are essential for the production of animals for experiments, the preservation of genetic resources, and for the generation of new strains of genetically modified animals. The RIKEN BioResource Research Center (BRC) is one of the largest repositories of such animal bioresources, and maintains approximately 9,500 strains of mice with a variety of genetic backgrounds. …”
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Fear Conditioning by Proxy: The Role of High Affinity Nicotinic Acetylcholine Receptors by Zinovia Stavroula Chalkea, Danai Papavranoussi-Daponte, Alexia Polissidis, Marinos Kampisioulis, Marina Pagaki-Skaliora, Eleni Konsolaki, Irini Skaliora

“…Observational fear-learning studies in genetically modified animals enable the investigation of the mechanisms underlying the social transmission of fear-related information. …”
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Transcriptome Analyses Reveal Differential Transcriptional Profiles in Early- and Late-Dividing Porcine Somatic Cell Nuclear Transfer Embryos by Zhiguo Liu, Guangming Xiang, Kui Xu, Jingjing Che, Changjiang Xu, Kui Li, Bingyuan Wang, Yulian Mu

“…Somatic cell nuclear transfer (SCNT) is not only a valuable tool for understanding nuclear reprogramming, but it also facilitates the generation of genetically modified animals. However, the development of SCNT embryos has remained an uncontrollable process. …”
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ZIF-8 Nanoparticle: A Valuable Tool for Improving Gene Delivery in Sperm-Mediated Gene Transfer by Marzieh Sameni, Parisa Moradbeigi, Sara Hosseini, Sayyed Mohammad Hossein Ghaderian, Vahid Jajarmi, Amir Hossein Miladipour, Hojat Basati, Maryam Abbasi, Mohammad Salehi

“…These results suggest that ZIF-8 is a valuable tool for enhancing genetic transfer in SMGT, with important implications for developing genetically modified animals for research and commercial purposes. …”
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Arguments for Human Therapeutic Cloning by Krešimir Pavelić

“…The main practical purpose of cloning is to generate genetically modified animals to serve as bioreactors. The cloning of mammals is a fascinating biological problem, although it is difficult to perform and attempts are rarely successful. …”
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The development and application of new hyperpolarized magnetic resonance spectroscopy techniques for the non-invasive assessment of metabolism in the rodent heart by Dodd, MS

“…This requires the study of genetically modified animals, namely transgenic mouse models. …”

Nociceptive sensitizers are regulated in damaged joint tissues, including the articular cartilage, when osteoarthritic mice display pain behaviour by Driscoll, C, Chanalaris, A, Knights, C, Ismail, H, Sacitharan, P, Gentry, C, Bevan, S, Vincent, A

“…Cartilage injury assays were performed using avulsed immature murine hips from wild type or genetically modified animals, or by explanting articular cartilage from porcine joints pre-injected with pharmacological inhibitors. …”