Genetically modified animals for use in biopharmacology: from research to production by Alexey V. Deykin, Olesya V. Shcheblykina, Elena E. Povetka, Polina A. Golubinskaya, Vladimir M. Pokrovsky, Liliya V. Korokina, Olesya A. Vanchenko, Elena V. Kuzubova, Konstantin S. Trunov, Viktor V. Vasyutkin, Alexandra I. Radchenko, Anton P. Danilenko, Julia V. Stepenko, Indira S. Kochkarova, Veronika S. Belyaeva, Vladimir I. Yakushev

“…Special attention is paid to genetically modified animals as bioreactors for the pharmaceutical industry of a new type. …”
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Manipulations with early mouse embryos for generation of genetically modified animals by A. N. Korablev, I. A. Serova, B. V. Skryabin

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Genetically modified animal models of hereditary diseases for testing of gene-directed therapy by Anna V. Polikarpova, Tatiana V. Egorova, Maryana V. Bardina

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Recent Progress on Genetically Modified Animal Models for Membrane Skeletal Proteins: The 4.1 and MPP Families by Nobuo Terada, Yurika Saitoh, Masaki Saito, Tomoki Yamada, Akio Kamijo, Takahiro Yoshizawa, Takeharu Sakamoto

“…In this review, we focus on our previous studies regarding genetically modified animal models, especially on 4.1G, MPP6, and MPP2, to describe their functional roles in the peripheral nervous system, the central nervous system, the testis, and bone formation. …”
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<i>piggy</i>Bac-Based Non-Viral In Vivo Gene Delivery Useful for Production of Genetically Modified Animals and Organs by Masahiro Sato, Emi Inada, Issei Saitoh, Satoshi Watanabe, Shingo Nakamura

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The emerging role of estrogen's non-nuclear signaling in the cardiovascular disease by Hiroyuki Tokiwa, Kazutaka Ueda, Eiki Takimoto, Eiki Takimoto

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Recent Advances in In Vivo Somatic Cell Gene Modification in Newborn Pups by Shingo Nakamura, Kazunori Morohoshi, Emi Inada, Yoko Sato, Satoshi Watanabe, Issei Saitoh, Masahiro Sato

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Acceptance of beef obtained through genetic modification and cloning in university students and working adults in southern Chile by Berta Schnettler, Carlos Velásquez, Germán Lobos, Ligia Orellana, José Sepúlveda, Natalia Salinas-Oñate, Cristian Adasme-Berríos, Klaus G. Grunert

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Dopamine transporter knockout rats as the new preclinical model of hyper- and hypo-dopaminergic disorders by I. Sukhanov, D. Leo, M. A. Tur, I. V. Belozertseva, A. Savchenko, R. R. Gainetdinov

Subjects: “…dopamine, genetically modified animals, rats, preclinical studies, adhd, parkinson’s disease…”
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Degeneration of Bioprosthetic Heart Valves: Update 2020 by Alexander E. Kostyunin, Arseniy E. Yuzhalin, Maria A. Rezvova, Evgeniy A. Ovcharenko, Tatiana V. Glushkova, Anton G. Kutikhin

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Exercise acutely exacerbates derangement of cardiac energy metabolism in hypertrophic cardiomyopathy, a 31 phosphorus magnetic resonance study at 3 Telsa by Dass, S, Cochlin, L, Suttie, J, Holloway, C, Rodgers, C, Tyler, D, Karamitsos, T, Clarke, K, Watkins, H, Neubauer, S

“…The underlying sarcomere mutations increase the energy cost of contraction, and impaired resting energetics (i.e. phosphocreatine/adenosine triphosphate, PCr/ATP, as measured by 31Phosphorus MR Spectroscopy, 31P MRS) has been documented in genetically modified animal models and in patients with HCM.Hypothesis: Our hypothesis is that the high incidence of exercise-related death in HCM may be explained by an acute impairment of myocardial energetics. …”

Progress in and Prospects of Genome Editing Tools for Human Disease Model Development and Therapeutic Applications by Hong Thi Lam Phan, Kyoungmi Kim, Ho Lee, Je Kyung Seong

“…Moreover, rapid advances in genome editing tools have accelerated the ability to produce various genetically modified animal models for studying human diseases. …”
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The New Frontier in Oxytocin Physiology: The Oxytonic Contraction by Claudia Camerino

“…Specifically, low Oxt levels are associated with obesity in human subjects and diet-induced or genetically modified animal models. The striking evidence that Oxt is linked to energy regulation is that Oxt- and oxytocin receptor (Oxtr)-deficient mice show a phenotype characterized by late onset obesity. …”
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Emerging Roles of Estrogen-Related Receptors in the Brain: Potential Interactions with Estrogen Signaling by Kenji Saito, Huxing Cui

“…Over the past few decades, genetically modified animal models have greatly increased our knowledge about the roles of estrogen receptor (ER) signaling in the brain in behavioral and physiological regulations. …”
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Novel acridone derivatives probed using DFT, including design, synthesis, characterization with anti-oxidant and anti-mitotic screening by S. Sulthanudeen, Predhanekar Mohamed Imran, M. Selvakumaran, Attar Kubaib

“…In-vitro human cancer cell lines, in-vivo tumor xenograft models and genetically modified animal models are a few of the preclinical screening techniques that were used to evaluate the anticancer efficacy of the drug. …”
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SHMT2 reduces fatty liver but is necessary for liver inflammation and fibrosis in mice by Guohua Chen, Guoli Zhou, Lidong Zhai, Xun Bao, Nivedita Tiwari, Jing Li, Emilio Mottillo, Jian Wang

“…However, the contribution of SHMT2 to hepatic 1C homeostasis and biological functions has yet to be defined in genetically modified animal models. We created a mouse strain with targeted SHMT2 knockout in hepatocytes to investigate this. …”
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Radiochemical HPLC detection of arginine metabolism: measurement of nitric oxide synthesis and arginase activity in vascular tissue. by de Bono, J, Warrick, N, Bendall, J, Channon, K, Alp, N

“…Accurate measurement of NO production by endothelial nitric oxide synthase (eNOS) is critical for the investigation of vascular disease mechanisms using genetically modified animal models. Previous assays of NO production measuring the conversion of arginine to citrulline have required homogenisation of tissue and reconstitution with cofactors including NADPH and tetrahydrobiopterin. …”

Utilizing Coagulant Plants in the Development of Functional Dairy Foods and Beverages: A Mini Review by Bathmanathan, Rupbansraaj, Yasmin Amira, Che Yahya, M. M., Yusoff, Jaya Vejayan, Palliah

“…Dairy products like cheese require coagulation of milk by using enzymes such as rennet either in its original state, purified or genetically modified. Animal and microbe sourced coagulants have been facing many challenges due to increasing public awareness. …”
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Guidelines for the Selection of Animal Models and Preclinical Drug Trials for Spontaneous Intracerebral Hemorrhage (2024 Edition)

“…The existing sICH animal models can be broadly categorized into three classes: (1) induced intracerebral hemorrhage models, including autologous blood injection model, collagenase injection model, microballoon inflation model, and hyperglycemia-induced sICH hematoma expansion model; (2) spontaneous hypertensive intracerebral hemorrhage models mainly include stroke-prone spontaneously hypertensive rats (SHRsp) and stroke-prone renovascular hypertensive rats (RHRsp); (3) gene-modified models encompassing transgentic hypertensive intracerebral hemorrhage, transgentic cerebral amyloid angiopathy, arteriovenous malformation-related, cerebral cavernous malformation-related and collagen-related genetically modified animal models for sICH. These models contribute not only to unraveling the pathogenesis of sICH and exploring preventive or therapeutic interventions, but also serve as invaluable tools for conducting preclinical drug trials to advance novel treatments. …”
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The Non-Linear Path from Gene Dysfunction to Genetic Disease: Lessons from the MICPCH Mouse Model by Konark Mukherjee, Leslie E. W. LaConte, Sarika Srivastava

“…Here we discuss the implications of our observations from the pathogenesis of MICPCH as a cautionary narrative against oversimplifying molecular interpretations of data obtained from genetically modified animal models of human diseases.…”
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