Optimized Protocol for Isolation of Small Extracellular Vesicles from Human and Murine Lymphoid Tissues by Marie Bordas, Géraldine Genard, Sibylle Ohl, Michelle Nessling, Karsten Richter, Tobias Roider, Sascha Dietrich, Kendra K. Maaß, Martina Seiffert

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Prostate cancer survivors: Risk and mortality in second primary cancers by Subhayan Chattopadhyay, Guoqiao Zheng, Otto Hemminki, Asta Försti, Kristina Sundquist, Kari Hemminki

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Number of medically prescribed pharmaceutical agents as predictor of mortality risk: a longitudinal, time-variable analysis in the EPIC-Heidelberg cohort by Verena A. Katzke, Rashmita Bajracharya, Mohamad I. Nasser, Ben Schöttker, Rudolf Kaaks

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Cell Line Secretome and Tumor Tissue Proteome Markers for Early Detection of Colorectal Cancer: A Systematic Review by Megha Bhardwaj, Vanessa Erben, Petra Schrotz-King, Hermann Brenner

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Comparison of intraoperative radiotherapy as a boost vs. simultaneously integrated boosts after breast-conserving therapy for breast cancer by Raluca Stoian, Raluca Stoian, Raluca Stoian, Jan-Philipp Harald Exner, Jan-Philipp Harald Exner, Jan-Philipp Harald Exner, Mark Gainey, Mark Gainey, Mark Gainey, Thalia Erbes, Thalia Erbes, Eleni Gkika, Eleni Gkika, Eleni Gkika, Ilinca Popp, Ilinca Popp, Ilinca Popp, Simon K. B. Spohn, Simon K. B. Spohn, Simon K. B. Spohn, David Krug, Ingolf Juhasz-Böss, Ingolf Juhasz-Böss, Anca-Ligia Grosu, Anca-Ligia Grosu, Anca-Ligia Grosu, Tanja Sprave, Tanja Sprave, Tanja Sprave

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HDAC Family Members Intertwined in the Regulation of Autophagy: A Druggable Vulnerability in Aggressive Tumor Entities by Emily Koeneke, Olaf Witt, Ina Oehme

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Retrospective Side Effect Profiling of the Metastatic Melanoma Combination Therapy Ipilimumab-Nivolumab Using Adverse Event Data by Theodoros G. Soldatos, Antonia Dimitrakopoulou-Strauss, Lionel Larribere, Jessica C. Hassel, Christos Sachpekidis

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Prognostic Value of Post-Operative C-Reactive Protein-Based Inflammatory Biomarkers in Colorectal Cancer Patients: Systematic Review and Meta-Analysis by Gwenzi T, Zhu A, Schrotz-King P, Schöttker B, Hoffmeister M, Edelmann D, Brenner H

“…Tafirenyika Gwenzi,1,2 Anna Zhu,2,3 Petra Schrotz-King,1 Ben Schöttker,3 Michael Hoffmeister,3 Dominic Edelmann,4 Hermann Brenner1,3,5,6 1Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, 69120, Germany; 2Medical Faculty Heidelberg, Heidelberg University, Heidelberg, 69120, Germany; 3Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, 69120, Germany; 4Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, 69120, Germany; 5Network Aging Research, Heidelberg University, Heidelberg, 69115, Germany; 6German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, 69120, GermanyCorrespondence: Hermann Brenner, Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, Heidelberg, 69120, Germany, Tel +49 6221 42 1300, Fax +49-6221 42 1302, Email h.brenner@Dkfz-Heidelberg.deAbstract: Post-operative inflammation in cancer patients can be modulated by drugs and diets, but evidence on its prognostic role, which would be crucial for personalized treatment and surveillance schemes, remains rather limited. …”
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Progression Patterns in Non-Contrast-Enhancing Gliomas Support Brain Tumor Responsiveness to Surgical Lesions by Steffen Brenner, Sebastian Hartzendorf, Philip Vogt, Elena Maier, Nima Etminan, Erik Jung, Erik Jung, Wolfgang Wick, Wolfgang Wick, Felix Sahm, Felix Sahm, Frank Winkler, Frank Winkler, Miriam Ratliff, Miriam Ratliff

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Treatment selection bias for chemotherapy persists in colorectal cancer patient cohort studies even in comprehensive propensity score analyses by Boakye D, Walter V, Martens UM, Chang-Claude J, Hoffmeister M, Jansen L, Brenner H

“…Daniel Boakye1,2, Viola Walter1, Uwe M Martens3, Jenny Chang-Claude4, Michael Hoffmeister1, Lina Jansen1,*, Hermann Brenner1,5,6,* 1Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; 2Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany; 3SLK-Clinics, Cancer Center Heilbronn-Franken, Heilbronn, Germany; 4Unit of Genetic Epidemiology, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; 5Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany; 6German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany*These authors contributed equally to this workCorrespondence: Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, Heidelberg 69120, GermanyTel +49 622 142 1300Fax +49 622 142 1302Email h.brenner@dkfz.deIntroduction: Propensity score methods are increasingly used to address confounding related to treatment selection in observational studies. …”
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Single chest drain is not inferior to double chest drain after robotic esophagectomy: a propensity score-matched analysis by F. Eckert, F. Eckert, F. Eckert, F. Eckert, F. Eckert, F. Merboth, F. Merboth, F. Merboth, F. Merboth, F. Merboth, E. Giehl-Brown, E. Giehl-Brown, E. Giehl-Brown, E. Giehl-Brown, E. Giehl-Brown, J. Hasanovic, J. Hasanovic, J. Hasanovic, J. Hasanovic, J. Hasanovic, B. Müssle, V. Plodeck, T. Richter, T. Welsch, C. Kahlert, C. Kahlert, C. Kahlert, C. Kahlert, C. Kahlert, J. Fritzmann, J. Fritzmann, J. Fritzmann, J. Fritzmann, J. Fritzmann, M. Distler, M. Distler, M. Distler, M. Distler, M. Distler, J. Weitz, J. Weitz, J. Weitz, J. Weitz, J. Weitz, J. Kirchberg, J. Kirchberg, J. Kirchberg, J. Kirchberg, J. Kirchberg

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Immunosuppressive capacity of circulating MDSC predicts response to immune checkpoint inhibitors in melanoma patients by Vera Petrova, Vera Petrova, Vera Petrova, Vera Petrova, Christopher Groth, Christopher Groth, Christopher Groth, Christopher Groth, Rebekka Bitsch, Rebekka Bitsch, Rebekka Bitsch, Rebekka Bitsch, Ihor Arkhypov, Ihor Arkhypov, Ihor Arkhypov, Ihor Arkhypov, Sonja C. S. Simon, Svetlana Hetjens, Verena Müller, Jochen Utikal, Jochen Utikal, Jochen Utikal, Jochen Utikal, Viktor Umansky, Viktor Umansky, Viktor Umansky, Viktor Umansky

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Common T-Cell-Receptor Motifs and Features in Patients with Cytomegalovirus (CMV)-Seronegative End-Stage Renal Disease Receiving a Peptide Vaccination against CMV by Lukas Bunse, Claudia Sommerer, Chin Leng Tan, Felix Korell, Anita Schmitt, Angela Hückelhoven-Krauss, Brigitte Neuber, Thomas Mertens, Michael Platten, Edward W. Green, Martin Zeier, Michael Schmitt

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Clustering phenotype populations by genome‐wide RNAi and multiparametric imaging by Florian Fuchs, Gregoire Pau, Dominique Kranz, Oleg Sklyar, Christoph Budjan, Sandra Steinbrink, Thomas Horn, Angelika Pedal, Wolfgang Huber, Michael Boutros

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Single-Fluorescent Protein Reporters Allow Parallel Quantification of Natural Killer Cell-Mediated Granzyme and Caspase Activities in Single Target Cells by Clarissa Liesche, Patricia Sauer, Isabel Prager, Doris Urlaub, Maren Claus, Roland Eils, Joël Beaudouin, Carsten Watzl

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Digital clinical empathy in a live chat: multiple findings from a formative qualitative study and usability tests by Hanna Luetke Lanfer, Doreen Reifegerste, Winja Weber, Paula Memenga, Eva Baumann, Julia Geulen, Stefanie Klein, Anne Müller, Andrea Hahne, Susanne Weg-Remers

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Comparison of Proteomic Technologies for Blood-Based Detection of Colorectal Cancer by Megha Bhardwaj, Tobias Terzer, Petra Schrotz-King, Hermann Brenner

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Protocol of the OPTIMAL study: Optimization of polypharmacy in geriatric oncology - A randomized controlled trial by Ben Schöttker, Li-Ju Chen, Reiner Caspari, Hermann Brenner

“…All necessary information about the patients will be provided to a pharmacist at the coordinating center (German Cancer Research Center, Heidelberg), who will perform randomization (1:1) and conduct the medication review with the FORTA list. …”
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Expression of Potential Targets for Cell-Based Therapies on Melanoma Cells by Sophia B. Strobel, Devayani Machiraju, Ingrid Hülsmeyer, Jürgen C. Becker, Annette Paschen, Dirk Jäger, Winfried S. Wels, Michael Bachmann, Jessica C. Hassel

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Quantitative Dynamic ¹⁸F-FDG PET/CT in Survival Prediction of Metastatic Melanoma under PD-1 Inhibitors by Christos Sachpekidis, Jessica C. Hassel, Annette Kopp-Schneider, Uwe Haberkorn, Antonia Dimitrakopoulou-Strauss

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