807 A vaccine targeting the recurrent driver mutation H3K27M induces mutation specific T- and B- cell responses in patients with diffuse midline Gliomas by Isabel Poschke, Michael Platten, Edward Green, Katharina Lindner, Tamara Boschert, Taga Lerner, Kristina Kromer, Iris Mildenberger, Gordon Haltenhof, Katharina Sahm, John Lindner

ADCK2 Knockdown Affects the Migration of Melanoma Cells via MYL6 by Marlene Vierthaler, Qian Sun, Yiman Wang, Tamara Steinfass, Juliane Poelchen, Thomas Hielscher, Daniel Novak, Viktor Umansky, Jochen Utikal

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352 Targeting glioblastoma with a TCR specific to the HLA-A*02-restricted, glioblastoma-associated antigen PTPRZ1 by Michael Platten, Wolfgang Wick, Christopher Kramer, Agnieszka Blum, Michael Kilian, Lukas Bunse, Dennis A Agardy, Alexandros Kourtesakis, Yu-Chan Chih, Philipp Koopmann, Amelie Christina Dietsch, Alice De Roia, Edward Wilhelm Green, Victor Murcia Pieńkowski

Acute expression of human APOBEC3B in mice results in RNA editing and lethality by Alicia Alonso de la Vega, Nuri Alpay Temiz, Rafail Tasakis, Kalman Somogyi, Lorena Salgueiro, Eleni Zimmer, Maria Ramos, Alberto Diaz-Jimenez, Sara Chocarro, Mirian Fernández-Vaquero, Bojana Stefanovska, Eli Reuveni, Uri Ben-David, Albrecht Stenzinger, Tanja Poth, Mathias Heikenwälder, Nina Papavasiliou, Reuben S. Harris, Rocio Sotillo

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Photoacoustic image synthesis with generative adversarial networks by Melanie Schellenberg, Janek Gröhl, Kris K. Dreher, Jan-Hinrich Nölke, Niklas Holzwarth, Minu D. Tizabi, Alexander Seitel, Lena Maier-Hein

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P416: DNA METHYLATION-BASED CHARACTERIZATION OF ACUTE MYELOID LEUKEMIA POINTS TOWARDS KDM3B AS A 5Q HAPLOINSUFFICIENCY CANDIDATE by Katherine Kelly, Etienne Sollier, Anna Riedel, Linda Welte, Ekaterina Jahn, Hartmut Döhner, Konstanze Döhner, Pavlo Lutsik, Christoph Plass

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Epigenetic Modulation of Radiation-Induced Diacylglycerol Kinase Alpha Expression Prevents Pro-Fibrotic Fibroblast Response by Chun-Shan Liu, Reka Toth, Ali Bakr, Ashish Goyal, Md Saiful Islam, Kersten Breuer, Anand Mayakonda, Yu-Yu Lin, Peter Stepper, Tomasz P. Jurkowski, Marlon R. Veldwijk, Elena Sperk, Carsten Herskind, Pavlo Lutsik, Dieter Weichenhan, Christoph Plass, Peter Schmezer, Odilia Popanda

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P480: DNMT AND HDAC INHIBITION INDUCES IMMUNOGENIC NEOANTIGENS FROM HUMAN ENDOGENOUS RETROVIRAL ELEMENT-DERIVED TRANSCRIPTS by Ashish Goyal, Jens Bauer, Joschka Hey, Dimitris Papageorgiou, Ekaterina Stepanova, Michael Daskalakis, Marissa Dubbelaar, Boris Klimovich, Melanie Maerklin, Malte Roerden, Oliver Muecke, Hans-Georg Rammensee, Fabricio Loayza-Puch, Jeroen Krijgsveld, Michael Lübbert, Juliane Walz, Christoph Plass

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Dynamics within the CD95 death‐inducing signaling complex decide life and death of cells by Leo Neumann, Carina Pforr, Joel Beaudouin, Alexander Pappa, Nicolai Fricker, Peter H Krammer, Inna N Lavrik, Roland Eils

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Development of an Orthotopic HPV16-Dependent Base of Tongue Tumor Model in MHC-Humanized Mice by Christoph Schifflers, Samantha Zottnick, Jonas D. Förster, Sebastian Kruse, Ruwen Yang, Hendrik Wiethoff, Matthias Bozza, Karin Hoppe-Seyler, Mathias Heikenwälder, Richard P. Harbottle, Carine Michiels, Angelika B. Riemer

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ONCO-FETAL REPROGRAMMING DRIVES HIGH-RISK JUVENILE MYELOMONOCYTIC LEUKEMIA, WHICH CAN BE TARGETED BY ANTI-CD52 TREATMENT by Mark Hartmann, Maximilian Schönung, Jovana Rajak, Joschka Hey, Valentin Maurer, Ling Hai, Sina Staeble, Jens Langstein, Katharina Bauer, Mariam Hakobyan, Laura Jardine, Sheila Bohler, Dominik Vonficht, Abdul-Habib Maag, Dirk Lebrecht, Katrin M. Bernt, Roland Roelz, Tobias Boch, Eleonora Khabirova, Pavlo Lutsik, Simon Haas, Muzlifah Haniffa, Sam Behjati, Jan-Philipp Mallm, Christian Buske, Michael D. Milsom, Stefan Fröhling, Marc-Jan Bonder, Charlotte Niemeyer, Christian Flotho, Christoph Plass, Miriam Erlacher, Matthias Schlesner, Daniel B. Lipka

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Author Correction: Glycosylated nanoparticle-based PfCSP vaccine confers long-lasting antibody responses and sterile protection in mouse malaria model by Julia Ludwig, Stephen W. Scally, Giulia Costa, Sandro Hoffmann, Rajagopal Murugan, Jana Lossin, Katherine Prieto, Anna Obraztsova, Nina Lobeto, Blandine Franke-Fayard, Chris J. Janse, Celia Lebas, Nicolas Collin, Spela Binter, Paul Kellam, Elena A. Levashina, Hedda Wardemann, Jean-Philippe Julien

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PB1759: RETAINED FUNCTIONAL NORMAL AND/OR PRE-LEUKEMIC HSCS IN THE BONE MARROW ARE ASSOCIATED TO GOOD PROGNOSIS IN DNMT3AMUTNPM1MUT AML PATIENTS by Elisa Donato, Nadia Correia, Carolin Andresen, Darja Karpova, Roberto Würth, Corinna Klein, Markus Sohn, Adriana Przybylla, Petra Zeisberger, Kathrin Rothfelder, Helmut Salih, Halvard Bonig, Sebastian Stasik, Christoph Röllig, Anna Dolnik, Lars Bullinger, Frank Buchholz, Christian Thiede, Daniel Hübschmann, Andreas Trumpp

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Adherence and Dietary Composition during Intermittent vs. Continuous Calorie Restriction: Follow-Up Data from a Randomized Controlled Trial in Adults with Overweight or Obesity by Sarah T. Pannen, Sandra González Maldonado, Tobias Nonnenmacher, Solomon A. Sowah, Laura F. Gruner, Cora Watzinger, Karin Nischwitz, Cornelia M. Ulrich, Rudolf Kaaks, Ruth Schübel, Mirja Grafetstätter, Tilman Kühn

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DNMT and HDAC inhibition induces immunogenic neoantigens from human endogenous retroviral element-derived transcripts by Ashish Goyal, Jens Bauer, Joschka Hey, Dimitris N. Papageorgiou, Ekaterina Stepanova, Michael Daskalakis, Jonas Scheid, Marissa Dubbelaar, Boris Klimovich, Dominic Schwarz, Melanie Märklin, Malte Roerden, Yu-Yu Lin, Tobias Ma, Oliver Mücke, Hans-Georg Rammensee, Michael Lübbert, Fabricio Loayza-Puch, Jeroen Krijgsveld, Juliane S. Walz, Christoph Plass

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Correlated magnetic resonance imaging and ultramicroscopy (MR-UM) is a tool kit to assess the dynamics of glioma angiogenesis by Michael O Breckwoldt, Julia Bode, Felix T Kurz, Angelika Hoffmann, Katharina Ochs, Martina Ott, Katrin Deumelandt, Thomas Krüwel, Daniel Schwarz, Manuel Fischer, Xavier Helluy, David Milford, Klara Kirschbaum, Gergely Solecki, Sara Chiblak, Amir Abdollahi, Frank Winkler, Wolfgang Wick, Michael Platten, Sabine Heiland, Martin Bendszus, Björn Tews

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The drug-induced phenotypic landscape of colorectal cancer organoids by Johannes Betge, Niklas Rindtorff, Jan Sauer, Benedikt Rauscher, Clara Dingert, Haristi Gaitantzi, Frank Herweck, Kauthar Srour-Mhanna, Thilo Miersch, Erica Valentini, Kim E. Boonekamp, Veronika Hauber, Tobias Gutting, Larissa Frank, Sebastian Belle, Timo Gaiser, Inga Buchholz, Ralf Jesenofsky, Nicolai Härtel, Tianzuo Zhan, Bernd Fischer, Katja Breitkopf-Heinlein, Elke Burgermeister, Matthias P. Ebert, Michael Boutros

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A Set of Cell Lines Derived from a Genetic Murine Glioblastoma Model Recapitulates Molecular and Morphological Characteristics of Human Tumors by Barbara Costa, Michael N. C. Fletcher, Pavle Boskovic, Ekaterina L. Ivanova, Tanja Eisemann, Sabrina Lohr, Lukas Bunse, Martin Löwer, Stefanie Burchard, Andrey Korshunov, Nadia Coltella, Melania Cusimano, Luigi Naldini, Hai-Kun Liu, Michael Platten, Bernhard Radlwimmer, Peter Angel, Heike Peterziel

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FDG-PET Radiomics for Response Monitoring in Non-Small-Cell Lung Cancer Treated with Radiation Therapy by Montserrat Carles, Tobias Fechter, Gianluca Radicioni, Tanja Schimek-Jasch, Sonja Adebahr, Constantinos Zamboglou, Nils H. Nicolay, Luis Martí-Bonmatí, Ursula Nestle, Anca L. Grosu, Dimos Baltas, Michael Mix, Eleni Gkika

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Sphingosine-1-Phosphate Recruits Macrophages and Microglia and Induces a Pro-Tumorigenic Phenotype That Favors Glioma Progression by Lavinia Arseni, Rakesh Sharma, Norman Mack, Deepthi Nagalla, Sibylle Ohl, Thomas Hielscher, Mahak Singhal, Robert Pilz, Hellmut Augustin, Roger Sandhoff, Christel Herold-Mende, Björn Tews, Peter Lichter, Martina Seiffert

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