Impacts of additional cycles of neoadjuvant immunotherapy on surgery in non‐small‐cell lung cancer by Jiawei Chen, Keng‐Leong Ang, Zhufeng Wang, Fan Lei, Jiaxi He, Shuben Li

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Long-Term Follow-Up of Survivors of Extracorporeal Life Support Therapy for Cardiogenic Shock: Are They Really Survivors? by Rafal Berger, Attila Nemeth, Rodrigo Sandoval Boburg, Louise Vöhringer, Henning Florian Lausberg, Metesh Acharya, Christian Schlensak, Aron-Frederik Popov

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Current practice and attitudes of stroke physicians towards rhythm-control therapy for stroke prevention: results of an international survey by Märit Jensen, Rustam Al-Shahi Salman, G. Andre Ng, H. Bart van der Worp, Peter Loh, Bruce C. V. Campbell, Jonathan M. Kalman, Michael D. Hill, Luciano A. Sposato, Jason G. Andrade, Andreas Metzner, Paulus Kirchhof, Götz Thomalla

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Long COVID Clinical Severity Types Based on Symptoms and Functional Disability: A Longitudinal Evaluation by Manoj Sivan, Adam B. Smith, Thomas Osborne, Madeline Goodwin, Román Rocha Lawrence, Sareeta Baley, Paul Williams, Cassie Lee, Helen Davies, Kumaran Balasundaram, Darren C. Greenwood

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Sexual dimorphism in selenium deficiency is associated with metabolic syndrome and prevalence of heart disease by Eerde H. Weening, Ali A. Al-Mubarak, Martin M. Dokter, Kenneth Dickstein, Chim C. Lang, Leong L. Ng, Marco Metra, Dirk J. van Veldhuisen, Daan J. Touw, Rudolf A. de Boer, Ron T. Gansevoort, Adriaan A. Voors, Stephan J. L. Bakker, Peter van der Meer, Nils Bomer

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Fevipiprant, a prostaglandin D2 receptor 2 antagonist, in patients with persistent eosinophilic asthma: a single-centre, randomised, double-blind, parallel-group, placebo-controlle... by Gonem, S, Berair, R, Singapuri, A, Hartley, R, Laurencin, M, Bacher, G, Holzhauer, B, Bourne, M, Mistry, V, Pavord, I, Mansur, A, Wardlaw, A, Siddiqui, S, Kay, R, Brightling, C

“…We hypothesised that fevipiprant (QAW039), an antagonist of prostaglandin D2 receptor 2, might reduce eosinophilic airway inflammation in patients with moderate-to-severe eosinophilic asthma.We performed a single-centre, randomised, double-blind, parallel-group, placebo-controlled trial at Glenfield Hospital (Leicester, UK). We recruited patients with persistent, moderate-to-severe asthma and an elevated sputum eosinophil count (≥2%). …”

Baseline risk factors of in-hospital mortality after surgery for acute type A aortic dissection: an ERTAAD study by Fausto Biancari, Fausto Biancari, Till Demal, Francesco Nappi, Francesco Onorati, Alessandra Francica, Sven Peterss, Joscha Buech, Joscha Buech, Antonio Fiore, Thierry Folliguet, Andrea Perrotti, Amélie Hervé, Lenard Conradi, Andreas Rukosujew, Angel G. Pinto, Javier Rodriguez Lega, Marek Pol, Jan Rocek, Petr Kacer, Konrad Wisniewski, Enzo Mazzaro, Igor Vendramin, Daniela Piani, Luisa Ferrante, Mauro Rinaldi, Eduard Quintana, Robert Pruna-Guillen, Sebastien Gerelli, Dario Di Perna, Metesh Acharya, Giovanni Mariscalco, Mark Field, Manoj Kuduvalli, Matteo Pettinari, Stefano Rosato, Paola D’Errigo, Mikko Jormalainen, Caius Mustonen, Timo Mäkikallio, Angelo M. Dell’Aquila, Angelo M. Dell’Aquila, Tatu Juvonen, Tatu Juvonen, Giuseppe Gatti

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Trimethylamine N-Oxide Levels Are Associated with Severe Aortic Stenosis and Predict Long-Term Adverse Outcome by Yuchao Guo, Shaojun Xu, Hong Zhan, Han Chen, Po Hu, Dao Zhou, Hanyi Dai, Xianbao Liu, Wangxing Hu, Gangjie Zhu, Toru Suzuki, Jian’an Wang

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Variation in human herpesvirus 6B telomeric integration, excision, and transmission between tissues and individuals by Michael L Wood, Colin D Veal, Rita Neumann, Nicolás M Suárez, Jenna Nichols, Andrei J Parker, Diana Martin, Simon PR Romaine, Veryan Codd, Nilesh J Samani, Adriaan A Voors, Maciej Tomaszewski, Louis Flamand, Andrew J Davison, Nicola J Royle

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Role of vitamin D supplementation in modifying outcomes after surgery: a systematic review of randomised controlled trials by Akshay Patel, Babu Naidu, Roxanna Zakeri, David Thickett, James Hodson, Martin Hewison, Ruth Benson, Eric Lim, Paul Baker, Dimitri J Pournaras, Luke Rogers, Savannah Gysling, Edward J Caruana, Rory Morrison, Bo Khor, Jason Trevis, Tobin Mangel, Jennifer Manders, Ricky Vaja

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Pragmatic randomized controlled trials: strengthening the concept through a robust international collaborative network: PRIME-9—Pragmatic Research and Innovation through Multinatio... by Elmir Omerovic, Mark Petrie, Björn Redfors, Stephen Fremes, Gavin Murphy, Guillaume Marquis-Gravel, Alexandra Lansky, Eric Velazquez, Divaka Perera, Christopher Reid, Julian Smith, Peter van der Meer, Eric Lipsic, Peter Juni, John McMurray, Johann Bauersachs, Lars Køber, Jean L. Rouleau, Torsten Doenst

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Effect of AZD9977 and spironolactone on serum potassium in heart failure with preserved or mildly reduced ejection fraction, and renal impairment: A randomized trial by Iain B. Squire, Anders Gabrielsen, Peter J. Greasley, Linda Wernevik, Judith Hartleib‐Geschwindner, Julie Holden, Susanne Johansson, Anna Rudvik, José Sánchez, Krister Bamberg, Johanna Melin, Andrew Whittaker

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Mapping brain endophenotypes associated with idiopathic pulmonary fibrosis genetic riskResearch in context by Ali-Reza Mohammadi-Nejad, Richard J. Allen, Luke M. Kraven, Olivia C. Leavy, R. Gisli Jenkins, Louise V. Wain, Dorothee P. Auer, Stamatios N. Sotiropoulos

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Combination Therapy Is Superior to Sequential Monotherapy for the Initial Treatment of Hypertension: A Double‐Blind Randomized Controlled Trial by Thomas M. MacDonald, Bryan Williams, David J. Webb, Steve Morant, Mark Caulfield, J. Kennedy Cruickshank, Ian Ford, Peter Sever, Isla S. Mackenzie, Sandosh Padmanabhan, Gerald P. McCann, Jackie Salsbury, Gordon McInnes, Morris J. Brown

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Randomised controlled trial and parallel economic evaluation of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CE... by Peek, G, Elbourne, D, Mugford, M, Tiruvoipati, R, Wilson, A, Allen, E, Clemens, F, Firmin, R, Hardy, P, Hibbert, C, Jones, N, Killer, H, Thalanany, M, Truesdale, A

“…SETTING: The ECMO centre at Glenfield Hospital, Leicester, and approved conventional treatment centres and referring hospitals throughout the UK. …”

The genomics of heart failure: design and rationale of the HERMES consortium by R. Thomas Lumbers, Sonia Shah, Honghuang Lin, Tomasz Czuba, Albert Henry, Daniel I. Swerdlow, Anders Mälarstig, Charlotte Andersson, Niek Verweij, Michael V. Holmes, Johan Ärnlöv, Per Svensson, Harry Hemingway, Neneh Sallah, Peter Almgren, Krishna G. Aragam, Geraldine Asselin, Joshua D. Backman, Mary L. Biggs, Heather L. Bloom, Eric Boersma, Jeffrey Brandimarto, Michael R. Brown, Hans‐Peter Brunner‐La Rocca, David J. Carey, Mark D. Chaffin, Daniel I. Chasman, Olympe Chazara, Xing Chen, Xu Chen, Jonathan H. Chung, William Chutkow, John G.F. Cleland, James P. Cook, Simon deDenus, Abbas Dehghan, Graciela E. Delgado, Spiros Denaxas, Alexander S. Doney, Marcus Dörr, Samuel C. Dudley, Gunnar Engström, Tõnu Esko, Ghazaleh Fatemifar, Stephan B. Felix, Chris Finan, Ian Ford, Francoise Fougerousse, René Fouodjio, Mohsen Ghanbari, Sahar Ghasemi, Vilmantas Giedraitis, Franco Giulianini, John S. Gottdiener, Stefan Gross, Daníel F. Guðbjartsson, Hongsheng Gui, Rebecca Gutmann, Christopher M. Haggerty, Pim van derHarst, Åsa K. Hedman, Anna Helgadottir, Hans Hillege, Craig L. Hyde, Jaison Jacob, J. Wouter Jukema, Frederick Kamanu, Isabella Kardys, Maryam Kavousi, Kay‐Tee Khaw, Marcus E. Kleber, Lars Køber, Andrea Koekemoer, Bill Kraus, Karoline Kuchenbaecker, Claudia Langenberg, Lars Lind, Cecilia M. Lindgren, Barry London, Luca A. Lotta, Ruth C. Lovering, Jian'an Luan, Patrik Magnusson, Anubha Mahajan, Douglas Mann, Kenneth B. Margulies, Nicholas A. Marston, Winfried März, John J.V. McMurray, Olle Melander, Giorgio Melloni, Ify R. Mordi, Michael P. Morley, Andrew D. Morris, Andrew P. Morris, Alanna C. Morrison, Michael W. Nagle, Christopher P. Nelson, Christopher Newton‐Cheh, Alexander Niessner, Teemu Niiranen, Christoph Nowak, Michelle L. O'Donoghue, Anjali T. Owens, Colin N.A. Palmer, Guillaume Paré, Markus Perola, Louis‐Philippe Lemieux Perreault, Eliana Portilla‐Fernandez, Bruce M. Psaty, Kenneth M. Rice, Paul M. Ridker, Simon P.R. Romaine, Carolina Roselli, Jerome I. Rotter, Christian T. Ruff, Marc S. Sabatine, Perttu Salo, Veikko Salomaa, Jessica vanSetten, Alaa A. Shalaby, Diane T. Smelser, Nicholas L. Smith, Kari Stefansson, Steen Stender, David J. Stott, Garðar Sveinbjörnsson, Mari‐Liis Tammesoo, Jean‐Claude Tardif, Kent D. Taylor, Maris Teder‐Laving, Alexander Teumer, Guðmundur Thorgeirsson, Unnur Thorsteinsdottir, Christian Torp‐Pedersen, Stella Trompet, Danny Tuckwell, Benoit Tyl, Andre G. Uitterlinden, Felix Vaura, Abirami Veluchamy, Peter M. Visscher, Uwe Völker, Adriaan A. Voors, Xiaosong Wang, Nicholas J. Wareham, Peter E. Weeke, Raul Weiss, Harvey D. White, Kerri L. Wiggins, Heming Xing, Jian Yang, Yifan Yang, Laura M. Yerges‐Armstrong, Bing Yu, Faiez Zannad, Faye Zhao, Regeneron Genetics Center, Jemma B. Wilk, Hilma Holm, Naveed Sattar, Steven A. Lubitz, David E. Lanfear, Svati Shah, Michael E. Dunn, Quinn S. Wells, Folkert W. Asselbergs, Aroon D. Hingorani, Marie‐Pierre Dubé, Nilesh J. Samani, Chim C. Lang, Thomas P. Cappola, Patrick T. Ellinor, Ramachandran S. Vasan, J. Gustav Smith

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Prognostic Impact of Multiple Prior Percutaneous Coronary Interventions in Patients Undergoing Coronary Artery Bypass Grafting by Fausto Biancari, Magnus Dalén, Vito G. Ruggieri, Till Demal, Giuseppe Gatti, Francesco Onorati, Giuseppe Faggian, Antonino S. Rubino, Daniele Maselli, Riccardo Gherli, Antonio Salsano, Matteo Saccocci, Giuseppe Santarpino, Francesco Nicolini, Tuomas Tauriainen, Marisa De Feo, Juhani Airaksinen, Stefano Rosato, Andrea Perrotti, Giovanni Mariscalco

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Real-world experience of nintedanib for progressive fibrosing interstitial lung disease in the UK by Giles Dixon, Samuel Hague, Sarah Mulholland, Huzaifa Adamali, Aye Myat Noe Khin, Hannah Thould, Roisin Connon, Paul Minnis, Eoin Murtagh, Fasihul Khan, Sameen Toor, Alexandra Lawrence, Marium Naqvi, Alex West, Robina K. Coker, Katie Ward, Leda Yazbeck, Simon Hart, Theresa Garfoot, Kate Newman, Pilar Rivera-Ortega, Lachlan Stranks, Paul Beirne, Jessica Bradley, Catherine Rowan, Sarah Agnew, Mahin Ahmad, Lisa G. Spencer, Joshua Aigbirior, Ahmed Fahim, Andrew M. Wilson, Elizabeth Butcher, Sy Giin Chong, Gauri Saini, Sabrina Zulfikar, Felix Chua, Peter M. George, Maria Kokosi, Vasileios Kouranos, Philip Molyneaux, Elisabetta Renzoni, Benedetta Vitri, Athol U. Wells, Lisa M. Nicol, Stephen Bianchi, Raman Kular, HuaJian Liu, Alexander John, Sarah Barth, Melissa Wickremasinghe, Ian A. Forrest, Ian Grimes, A. John Simpson, Sophie V. Fletcher, Mark G. Jones, Emma Kinsella, Jennifer Naftel, Nicola Wood, Jodie Chalmers, Anjali Crawshaw, Louise E. Crowley, Davinder Dosanjh, Christopher C. Huntley, Gareth I. Walters, Timothy Gatheral, Catherine Plum, Shiva Bikmalla, Raja Muthusami, Helen Stone, Jonathan C.L. Rodrigues, Krasimira Tsaneva-Atanasova, Chris J. Scotton, Michael A. Gibbons, Shaney L. Barratt

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Natural history and outcomes in paediatric RASopathy‐associated hypertrophic cardiomyopathy by Olga Boleti, Gabrielle Norrish, Ella Field, Kathleen Dady, Kim Summers, Gauri Nepali, Vinay Bhole, Orhan Uzun, Amos Wong, Piers E. F. Daubeney, Graham Stuart, Precylia Fernandes, Karen McLeod, Maria Ilina, Muhammad Najih Liaqath Ali, Tara Bharucha, Grazia Delle Donne, Elspeth Brown, Katie Linter, Caroline B. Jones, Jonathan Searle, William Regan, Sujeev Mathur, Nicola Boyd, Zdenka Reinhardt, Sophie Duignan, Terence Prendiville, Satish Adwani, Juan Pablo Kaski

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Ethnic inequalities in COVID-19 infection, hospitalisation, intensive care admission, and death: a global systematic review and meta-analysis of over 200 million study participants... by Patricia Irizar, Daniel Pan, Dharmi Kapadia, Laia Bécares, Shirley Sze, Harry Taylor, Sarah Amele, Eliud Kibuchi, Pip Divall, Laura J. Gray, Laura B. Nellums, Srinivasa Vittal Katikireddi, Manish Pareek

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