A Novel Dextran-Based Dual Drug Conjugate Targeted Tumors with High Biodistribution Ratio of Tumors to Normal Tissues by Liu J, Zhang N, Wu J, Dong P, Lv H, Wang Q, Wang S, Yang H, Wang S, Li X, Hu J, Wang A, Li DJ, Shi Y

“…Jiaojiao Liu,1 Naining Zhang,1 Jiaan Wu,1 Peng Dong,1 Hongshuai Lv,1 Qi Wang,1 Shenxu Wang,1 Haotong Yang,1 Si Wang,2 Xiaohai Li,2 Jinghua Hu,2 Anny Wang,2 Daisy J Li,2 Yikang Shi1 1National Glycoengineering Research Center, Shandong Key Laboratory of Carbohydrate Chemistry and Glycobiology, NMPA Key Laboratory for Quality Research and Evaluation of Carbohydrate Based Medicine, Shandong University, Qingdao, Shandong, 266237, People’s Republic of China; 2Santolecan Pharmaceuticals LLC, Jupiter, Florida, 33458, USACorrespondence: Yikang Shi, Shandong University, 72 Binhai Road, Jimo, Qingdao, 266237, People’s Republic of China, Tel/Fax +86-532-5863-1418, Email shiyikang@sdu.edu.cnPurpose: Most chemotherapeutic agents possess poor water solubility and show more significant accumulations in normal tissues than in tumor tissues, resulting in serious side effects. …”
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GlycoVHH: optimal sites for introducing N-glycans on the camelid VHH antibody scaffold and use for macrophage delivery by Loes van Schie, Wander Van Breedam, Charlotte Roels, Bert Schepens, Martin Frank, Ahmad Reza Mehdipour, Bram Laukens, Wim Nerinckx, Francis Santens, Simon Devos, Iebe Rossey, Karel Thooft, Sandrine Vanmarcke, Annelies Van Hecke, Xavier Saelens, Nico Callewaert

“…The set of optimal artificial VHH N-glycosylation sites identified in this study can serve as a blueprint for targeted glyco-engineering of other VHHs, enabling site-specific functionalization through the rapidly expanding toolbox of synthetic glycobiology.…”
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Upregulation of Human ST8Sia VI (α2,8-Sialyltransferase) Gene Expression by Physcion in SK-N-BE(2)-C Human Neuroblastoma Cells by Hyun-Kyoung Yoon, Hyun-Kyu An, Min Jung Ko, Kyoung-Sook Kim, Seo-Won Mun, Dong-Hyun Kim, Cheol Min Kim, Cheorl-Ho Kim, Young Whan Choi, Young-Choon Lee

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Elicitation of Neutralizing Antibodies Targeting the V2 Apex of the HIV Envelope Trimer in a Wild-Type Animal Model by James E. Voss, Raiees Andrabi, Laura E. McCoy, Natalia de Val, Roberta P. Fuller, Terrence Messmer, Ching-Yao Su, Devin Sok, Salar N. Khan, Fernando Garces, Laura K. Pritchard, Richard T. Wyatt, Andrew B. Ward, Max Crispin, Ian A. Wilson, Dennis R. Burton

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A sialyltransferases-related gene signature serves as a potential predictor of prognosis and therapeutic response for bladder cancer by Penglong Cao, Mingying Chen, Tianya Zhang, Qin Zheng, Mulin Liu

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Genetic and Epigenetic Association of Hepatocyte Nuclear Factor-1α with Glycosylation in Post-Traumatic Stress Disorder by Lucija Tudor, Marcela Konjevod, Gordana Nedic Erjavec, Matea Nikolac Perkovic, Suzana Uzun, Oliver Kozumplik, Vlatka Zoldos, Gordan Lauc, Dubravka Svob Strac, Nela Pivac

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Prolactin-induced protein (PIP) increases the sensitivity of breast cancer cells to drug-induced apoptosis by Anna Urbaniak, Karolina Jablonska, Jaroslaw Suchanski, Aleksandra Partynska, Katarzyna Szymczak-Kulus, Rafal Matkowski, Adam Maciejczyk, Maciej Ugorski, Piotr Dziegiel

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A Review of Alpha-1 Antitrypsin Binding Partners for Immune Regulation and Potential Therapeutic Application by Michael E. O’Brien, Grace Murray, Debananda Gogoi, Azeez Yusuf, Cormac McCarthy, Mark R. Wormald, Michelle Casey, Claudie Gabillard-Lefort, Noel G. McElvaney, Emer P. Reeves

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Efficient and versatile formation of glycosidic bonds via catalytic strain-release glycosylation with glycosyl ortho-2,2-dimethoxycarbonylcyclopropylbenzoate donors by Ding, Han, Lyu, Jian, Zhang, Xiao-Lin, Xiao, Xiong, Liu, Xue-Wei

“…Catalytic glycosylation is a vital transformation in synthetic carbohydrate chemistry due to its ability to expediate the large-scale oligosaccharide synthesis for glycobiology studies with the consumption of minimal amounts of promoters. …”
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Cryo-EM Structures of Eastern Equine Encephalitis Virus Reveal Mechanisms of Virus Disassembly and Antibody Neutralization by S. Saif Hasan, Chengqun Sun, Arthur S. Kim, Yasunori Watanabe, Chun-Liang Chen, Thomas Klose, Geeta Buda, Max Crispin, Michael S. Diamond, William B. Klimstra, Michael G. Rossmann

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Analysis of genetic profiling, pathomics signature, and prognostic features of primary lymphoepithelioma‐like carcinoma of the renal pelvis by Bo Fan, Yuanbin Huang, Hongshuo Zhang, Tingyu Chen, Shenghua Tao, Xiaogang Wang, Shuang Wen, Honglong Wang, Zhe Lin, Tianqing Liu, Hongxian Zhang, Tao He, Xiancheng Li

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Enforced mesenchymal stem cell tissue colonization counteracts immunopathology by David García-Bernal, Miguel Blanquer, Carlos M. Martínez, Ana I. García-Guillén, Ana M. García-Hernández, M. Carmen Algueró, Rosa Yáñez, María L. Lamana, Jose M. Moraleda, Robert Sackstein

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Bittersweet Sugars: How Unusual Glycan Structures May Connect Epithelial-to-Mesenchymal Transition and Multidrug Resistance in Cancer by Leonardo Marques da Fonseca, Israel Diniz-Lima, Marcos André Rodrigues da Costa Santos, Tatiany Nunes Franklim, Kelli Monteiro da Costa, Ariely Costa dos Santos, Alexandre Morrot, Debora Decote-Ricardo, Raphael do Carmo Valente, Celio Geraldo Freire-de-Lima, Jhenifer Santos dos Reis, Leonardo Freire-de-Lima

“…Herein, we will address the importance of glycobiology in modern medi-cine, focusing on the ability of unusual/truncated <i>O</i>-linked glycans to modulate two complex and essential phenomena for cancer progression: the acquisition of the multidrug resistance (MDR) phenotype and the activation of molecular pathways associated with the epithelial–mesenchymal transition (EMT) process, an event deeply linked with cancer metastasis.…”
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Acylation of glycerolipids in mycobacteria by Shiva Kumar Angala, Ana Carreras-Gonzalez, Emilie Huc-Claustre, Itxaso Anso, Devinder Kaur, Victoria Jones, Zuzana Palčeková, Juan M. Belardinelli, Célia de Sousa-d’Auria, Libin Shi, Nawel Slama, Christine Houssin, Annaïk Quémard, Michael McNeil, Marcelo E. Guerin, Mary Jackson

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Nornicotine-typed insecticides: The potential insecticides with strong activity against Diaphorina citri by Pengfei Hu, Xiaoping Ye, Xiaoping Song, Mingxin Yang, Yunsheng Zhong, Yijing Cen, Yanxin Zhang, Yiming Song, Qingchao Liu

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Venturing beyond donor-controlled glycosylation : new perspectives toward anomeric selectivity by Leng, Wei-Lin, Yao, Hui, He, Jing-Xi, Liu, Xue-Wei

“…However, their diversity coupled with physiochemical similarities makes it challenging to isolate them in large quantities for biochemical studies, hence hampering progress in glycobiology and glycomedicine. Glycochemistry presents an alternative strategy to obtain pure glycan compounds through artificial synthetic methods. …”
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Galectin-1 induces a tumor-associated macrophage phenotype and upregulates indoleamine 2,3-dioxygenase-1 by Asha M. Rudjord-Levann, Zilu Ye, Lise Hafkenscheid, Sabrina Horn, Renske Wiegertjes, Mathias A.I. Nielsen, Ming Song, Caroline B.K. Mathiesen, Jesse Stoop, Sean Stowell, Per Thor Straten, Hakon Leffler, Sergey Y. Vakhrushev, Sally Dabelsteen, Jesper V. Olsen, Hans H. Wandall

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Complement C1s deficiency in a male Caucasian patient with systemic lupus erythematosus: a case report by Jessica S. Kleer, Jessica S. Kleer, Lillemor Skattum, Denise Dubler, Ingeborg Fischer, Armin Zgraggen, Esther Mundwiler, Min Jeong Kim, Marten Trendelenburg, Marten Trendelenburg

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Carbohydrate-binding protein from stinging nettle as fusion inhibitor for SARS-CoV-2 variants of concern by Emiel Vanhulle, Thomas D’huys, Becky Provinciael, Joren Stroobants, Anita Camps, Sam Noppen, Dominique Schols, Els J. M. Van Damme, Piet Maes, Annelies Stevaert, Kurt Vermeire

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Optimizing cryopreservation conditions for use of fucosylated human mesenchymal stromal cells in anti-inflammatory/immunomodulatory therapeutics by Jesús I. Gil-Chinchilla, Carlos Bueno, Carlos M. Martínez, Ana Ferrández-Múrtula, Ana M. García-Hernández, Miguel Blanquer, Miguel Blanquer, Mar Molina-Molina, Agustín G. Zapata, Robert Sackstein, Jose M. Moraleda, Jose M. Moraleda, David García-Bernal, David García-Bernal

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