Recent Advancements in Gremlin-1: Breast cancer by Nimrah Inam, Ayesha Hameed, Lubna Vohra, Sana Zeeshan

“… One of the bone’s morphogenic protein (BMP) antagonists, Gremlin-1 or GREM-1, can bind directly to BMPs. GREM-1 can act in either BMP-dependent or -independent pathways, according to research. …”
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Production and Biochemical Characterization of Dimeric Recombinant Gremlin-1 by Stefania Mitola, Cosetta Ravelli, Michela Corsini, Alessandra Gianoncelli, Federico Galvagni, Kurt Ballmer-Hofer, Marco Presta, Elisabetta Grillo

Subjects: “…gremlin-1…”
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Tudor gremlins (Errors in the TLS of March 10, 2000) by MacCulloch, D

Pancreatic stromal Gremlin 1 expression during pancreatic tumorigenesis by Joy M. Davis, Binglu Cheng, Madeline M. Drake, Qiang Yu, Baibing Yang, Jing Li, Chunhui Liu, Mamoun Younes, Xiurong Zhao, Jennifer M. Bailey, Qiang Shen, Tien C. Ko, Yanna Cao

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The inhibitory effect of Gremlin-2 on adipogenesis suppresses breast cancer cell growth and metastasis by Jiwoo Jung, Na Hui Kim, Minji Kwon, Jayeon Park, Dayeon Lim, Youjin Kim, World Gil, Ye Hwang Cheong, Sin-Aye Park

Subjects: “…Gremlin-2…”
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Epigenetic Modulation of Gremlin-1/NOTCH Pathway in Experimental Crescentic Immune-Mediated Glomerulonephritis by Lucia Tejedor-Santamaria, Jose Luis Morgado-Pascual, Laura Marquez-Exposito, Beatriz Suarez-Alvarez, Raul R. Rodrigues-Diez, Antonio Tejera-Muñoz, Vanessa Marchant, Sergio Mezzano, Carlos Lopez-Larrea, Anna Sola, Gema Maria Fernandez-Juarez, Alberto Ortiz, Sandra Rayego-Mateos, Marta Ruiz-Ortega

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Gremlin 1 — small protein, big impact: the multiorgan consequences of disrupted BMP antagonism by Gooding, S, Leedham, SJ

“…Localised expression of ligand sequestering BMP antagonists, such as Gremlin 1 (Grem1), necessarily restricts BMP activity within the stem cell niche and facilitate stemness and self‐renewal. …”

BMP4 activation and secretion are negatively regulated by an intracellular gremlin-BMP4 interaction. by Sun, J, Zhuang, F, Mullersman, J, Chen, H, Robertson, E, Warburton, D, Liu, Y, Shi, W

“…This novel Gremlin-mediated BMP4 posttranslational regulatory mechanism implies that the level of BMP4 mRNA expression does not truly reflect BMP4 activity when Gremlin and BMP4 are coexpressed within the same cell. …”

Insights into the Role of Gremlin-1, a Bone Morphogenic Protein Antagonist, in Cancer Initiation and Progression by Noha Mousaad Elemam, Abdullah Imadeddin Malek, Esraa Elaraby Mahmoud, Waseem El-Huneidi, Iman M. Talaat

Subjects: “…Gremlin-1…”
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Gremlin 1 Identifies a Skeletal Stem Cell with Bone, Cartilage, and Reticular Stromal Potential by Muthupalani, Sureshkumar, Fox, James G

“…We demonstrate here that expression of the bone morphogenetic protein (BMP) antagonist gremlin 1 defines a population of osteochondroreticular (OCR) stem cells in the bone marrow. …”
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Evolution of gremlin 2 in cetartiodactyl mammals: gene loss coincides with lack of upper jaw incisors in ruminants by Juan C. Opazo, Kattina Zavala, Paola Krall, Rodrigo A. Arias

“…Results from our analyses indicate that gremlin 2 has experienced a mixture of gene loss, gene duplication, and rate acceleration. …”
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Gremlin-1 and BMP-4 Overexpressed in Osteoarthritis Drive an Osteochondral-Remodeling Program in Osteoblasts and Hypertrophic Chondrocytes by Maria-Luisa Pérez-Lozano, Laure Sudre, Sandy van Eegher, Danièle Citadelle, Audrey Pigenet, Marie-Helène Lafage-Proust, Philippe Pastoureau, Frédéric De Ceuninck, Francis Berenbaum, Xavier Houard

Subjects: “…gremlin-1…”
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Discovery of ginisortamab, a potent and novel anti-gremlin-1 antibody in clinical development for the treatment of cancer by Gareth C. G. Davies, Neesha Dedi, Paul S. Jones, Lara Kevorkian, David McMillan, Cristina Ottone, Monika-Sarah E. D. Schulze, Anthony Scott-Tucker, Roohi Tewari, Shauna West, Michael Wright, Tania F. Rowley

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Gremlin-1 level in polycystic ovary syndrome and its clinical correlations; A case control study by Ahmed Mohamed Abdelkarim, Ahmed Youssef Rezk, Nahla Abd El Azeez Nosair, Mostafa Farag Ellakany, Ahmed Mohamed Fathy

“… Objective: To evaluate the involvement of the level of Gremlin-1 in serum and follicular fluid in the diagnosis of polycystic ovary syndrome. …”
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Gremlin-1 Promotes Metastasis of Breast Cancer Cells by Activating STAT3-MMP13 Signaling Pathway by Nam Ji Sung, Na Hui Kim, Young-Joon Surh, Sin-Aye Park

Subjects: “…Gremlin-1…”
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Gremlin-1 Promotes Colorectal Cancer Cell Metastasis by Activating ATF6 and Inhibiting ATF4 Pathways by Ruohan Li, Huaixiang Zhou, Mingzhe Li, Qiuyan Mai, Zhang Fu, Youheng Jiang, Changxue Li, Yunfei Gao, Yunping Fan, Kaiming Wu, Clive Da Costa, Xia Sheng, Yulong He, Ningning Li

Subjects: “…Gremlin-1…”
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Nox1/Ref-1-mediated activation of CREB promotes Gremlin1-driven endothelial cell proliferation and migration by Daniel S. de Jesus, Evan DeVallance, Yao Li, Micol Falabella, Danielle Guimaraes, Sruti Shiva, Brett A. Kaufman, Mark T. Gladwin, Patrick J. Pagano

“…Keywords: Nox1, CREB, Proliferation, Gremlin1, Ref-1, Migration…”
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Relationship of Plasma Gremlin 1 Levels with Body Adiposity and Glycemic Control in Saudi Female Type 2 Diabetes Patients by Al-Regaiey KA, Habib SS, Alshamasi AR, Alnuwaybit AF, Alwhaibi BA, Alsulais NM, Alothman AI, Alomar FM, Iqbal M

Subjects: “…gremlin 1…”
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Targeted Disruption of Bone Marrow Stromal Cell-Derived Gremlin1 Limits Multiple Myeloma Disease Progression In Vivo by Kimberley C. Clark, Duncan R. Hewett, Vasilios Panagopoulos, Natalya Plakhova, Khatora S. Opperman, Alanah L. Bradey, Krzysztof M. Mrozik, Kate Vandyke, Siddhartha Mukherjee, Gareth C.G. Davies, Daniel L. Worthley, Andrew C.W. Zannettino

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Neoliberal gremlins? How a scheme to help disadvantaged young people thrive online fell short of its ambitions by Davies, H, Eynon, R, Wilkin, S