Marked neurotropism and potential adaptation of H5N1 clade 2.3.4.4.b virus in naturally infected domestic cats por Shubhada K. Chothe, Surabhi Srinivas, Sougat Misra, Noel Chandan Nallipogu, Elizabeth Gilbride, Lindsey LaBella, Swastidipa Mukherjee, Christian H. Gauthier, Heidi L. Pecoraro, Brett T. Webb, James M. Pipas, Santhamani Ramasamy, Suresh V. Kuchipudi

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Cocirculation of Genetically Distinct Highly Pathogenic Avian Influenza H5N5 and H5N1 Viruses in Crows, Hokkaido, Japan por Yik Lim Hew, Takahiro Hiono, Isabella Monne, Kei Nabeshima, Saki Sakuma, Asuka Kumagai, Shunya Okamura, Kosuke Soda, Hiroshi Ito, Mana Esaki, Kosuke Okuya, Makoto Ozawa, Toshiyo Yabuta, Hiroki Takakuwa, Linh Bao Nguyen, Norikazu Isoda, Kohtaro Miyazawa, Manabu Onuma, Yoshihiro Sakoda

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Highly pathogenic avian H5N1 influenza A virus replication in ex vivo cultures of bovine mammary gland and teat tissues por Masaki Imai, Hiroshi Ueki, Mutsumi Ito, Kiyoko Iwatsuki-Horimoto, Maki Kiso, Asim Biswas, Sanja Trifkovic, Nigel Cook, Peter J. Halfmann, Gabriele Neumann, Amie J. Eisfeld, Yoshihiro Kawaoka

Assuntos: “…Highly pathogenic avian H5N1 influenza A virus…”
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Examination of pathological process pecularities caused by A/duck/Altai/469/14 H5N1 isolate of avian influenza virus in chickens por V. Yu. Sosipatorova, D. A. Altunin, M. A. Tsivanyuk, I. A. Chvala

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Host DNA released by NETosis in neutrophils exposed to seasonal H1N1 and highly pathogenic H5N1 influenza viruses por Chan, Louisa L. Y., Nicholls, John M., Peiris, Joseph Sriyal Malik, Lau, Yu Lung, Chan, Michael Chi Wai, Chan, Renee W. Y.

“…Conclusion: Our data is the first to demonstrate that NET formation is abrogated in H5N1 influenza virus infection and might contribute to the severity of H5N1 disease.…”
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Receptor Binding and Antigenic Site Analysis of Hemagglutinin Gene Fragments of Avian Influenza Virus Serotype H5N1 Isolated from Indonesia por Wibowo, Michael Haryadi, Anggoro, Dito, Amanu, Surya, Wahyuni, Agnesia Endang Tri Hastuti, Untari, Tri, Artanto, Sidna, Asmara, Widya

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Analisis molekuler regio Cleavage Site hemaglutinin virus Avian Influenza H5N1 isolat unggas dari bantul dan Purworejo por , RAHMIATI, , Prof.drh. Widya Asmara, SU.,Ph.D

Evaluation of a genetically modified reassortant H5N1 influenza A virus vaccine candidate generated by plasmid-based reverse genetics. por Subbarao, K, Chen, H, Swayne, D, Mingay, L, Fodor, E, Brownlee, G, Xu, X, Lu, X, Katz, J, Cox, N, Matsuoka, Y

“…Such reassortant candidate vaccine viruses are currently not licensed for the prevention of human infections by H5N1 influenza viruses. A transfectant H5N1/PR8 virus was generated by plasmid-based reverse genetics. …”

Memory T cells established by seasonal human influenza A infection cross-react with avian influenza A (H5N1) in healthy individuals por Lee, L, Ha, D, Simmons, C, Jong, D, Chau, N, Schumacher, R, Peng, Y, McMichael, A, Farrar, J, Smith, G, Townsend, A, Askonas, B, Rowland-Jones, S, Dong, T

“…The threat of avian influenza A (H5N1) infection in humans remains a global health concern. …”

Emergence of multiple clade 2.3.2.1 influenza A (H5N1) virus subgroups in Vietnam and detection of novel reassortants. por Creanga, A, Thi Nguyen, D, Gerloff, N, Thi, H, Balish, A, Dang Nguyen, H, Jang, Y, Thi Dam, V, Thor, S, Jones, J, Simpson, N, Shu, B, Emery, S, Berman, L, Nguyen, H, Bryant, J, Lindstrom, S, Klimov, A, Donis, R, Davis, C, Nguyen, T

“…Phylogenetic analyses of 169 influenza A(H5N1) virus genomes were conducted for samples collected through active surveillance and outbreak responses in Vietnam between September 2010 and September 2012. …”

Why are so few people infected with influenza A (H5N1) despite a large exposed population? The role of host genetics por Horby, P

Viral factors associated with the high mortality related to human infections with clade 2.1 influenza A/H5N1 virus in Indonesia por Pawestri, HA, Eggink, D, Isfandari, S, Thanh, TT, van Doorn, HR, Setiawaty, V, de Jong, MD

“…To provide potential clues towards understanding this high mortality, detailed clinical virological analyses were performed in specimens from 180 H5N1 patients, representing 90% of all Indonesian patients and 20% of reported H5N1-infected patients globally.…”

Emergence of multiple clade 2.3.2.1 influenza A (H5N1) virus subgroups in Vietnam and detection of novel reassortants por Creanga, A, Thi Nguyen, D, Gerloff, N, Thi, H, Balish, A, Dang Nguyen, H, Jang, Y, Thi Dam, V, Thor, S, Jones, J, Simpson, N, Shu, B, Emery, S, Berman, L, Nguyen, H, Bryant, J, Lindstrom, S, Klimov, A, Donis, R, Davis, C, Nguyen, T

“…Phylogenetic analyses of 169 influenza A(H5N1) virus genomes were conducted for samples collected through active surveillance and outbreak responses in Vietnam between September 2010 and September 2012. …”

Memory T cells established by seasonal human influenza A infection cross-react with avian influenza A (H5N1) in healthy individuals. por Lee, L, Ha, D, Simmons, C, Jong, d, Chau, N, Schumacher, R, Peng, Y, Mcmichael, A, Farrar, J, Smith, G, Townsend, A, Askonas, B, Rowland-Jones, S, Dong, T

“…The threat of avian influenza A (H5N1) infection in humans remains a global health concern. …”

Serological evidence of human infections with highly pathogenic avian influenza A(H5N1) virus: a systematic review and meta-analysis por Chen, X, Wang, W, Wang, Y, Lai, S, Yang, J, Cowling, BJ, Horby, PW, Uyeki, TM, Yu, H

“…Background Highly pathogenic avian influenza A(H5N1) virus poses a global public health threat given severe and fatal zoonotic infections since 1997 and ongoing A(H5N1) virus circulation among poultry in several countries. …”

Molecular epidemiology and pathogenicity of H5N1 and H9N2 avian influenza viruses in clinically affected chickens on farms in Bangladesh por Ripa, RN, Sealy, JE, Raghwani, J, Das, T, Barua, H, Masuduzzaman, M, Saifuddin, AKM, Huq, MR, Uddin, MI, Iqbal, M, Brown, I, Lewis, NS, Pfeiffer, D, Fournie, G, Biswas, PK

“…Avian influenza virus (AIV) subtypes H5N1 and H9N2 co-circulate in poultry in Bangladesh, causing significant bird morbidity and mortality. …”

Molecular cloning of full-length haemagglutinin (H5HA) gene of highly pathogenic avian influenza virus (HPAI) H5N1 por Abubakar, Mustapha Bala, Ideris, Aini, Omar, Abdul Rahman, Bejo, Mohd Hair

“…After extraction of RNA from the cell culture of strain influenza A/Chicken/Malaysia/2004(H5N1) of AIV, the viral RNA was converted to cDNA by a specific primer. …”
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Are we cultivating the perfect storm for a human avian influenza pandemic? por Tomas Perez-Acle, Cesar Ravello, Mario Rosemblatt

Assuntos: “…H5N1…”
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Genome‐wide siRNA library screening identifies human host factors that influence the replication of the highly pathogenic H5N1 influenza virus por Guangwen Wang, Li Jiang, Jinliang Wang, Qibing Li, Jie Zhang, Fandi Kong, Ya Yan, Yuqin Wang, Guohua Deng, Jianzhong Shi, Guobin Tian, Xianying Zeng, Liling Liu, Zhigao Bu, Hualan Chen, Chengjun Li

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U4 at the 3' UTR of PB1 segment of H5N1 influenza virus promotes RNA polymerase activity and contributes to viral pathogenicity. por Wei Sun, Jing Li, Pengfei Han, Yinhui Yang, Xiaoping Kang, Yuchang Li, Jiaming Li, Yu Zhang, Xiaoyan Wu, Tao Jiang, Chengfeng Qin, Yi Hu, Qingyu Zhu

“…The viral RNA-dependent RNA polymerase has been found to contribute to efficient replication in mammalian systems and to the high pathogenicity of H5N1 influenza A virus in humans and other mammals. …”
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