Dolutegravir resistance in sub-Saharan Africa: should resource-limited settings be concerned for future treatment? by Doreen Kamori, Doreen Kamori, Godfrey Barabona

Subjects: “…HIV drug resistance…”
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Relating CYP2B6 genotype and efavirenz resistance among post-partum women living with HIV with high viremia in Uganda: a nested cross-sectional study by Allan Buzibye, Kara Wools-Kaloustian, Adeniyi Olagunju, Ellon Twinomuhwezi, Constantin Yiannoutsos, Andrew Owen, Megan Neary, Joshua Matovu, Grace Banturaki, Barbara Castelnuovo, Mohammed Lamorde, Saye Khoo, Catriona Waitt, Agnes Kiragga

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Dolutegravir Plus Lamivudine Two-Drug Regimen: Safety, Efficacy and Diagnostic Considerations for Its Use in Real-Life Clinical Practice—A Refined Approach in the COVID-19 Era by Valeria Cento, Carlo Federico Perno

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Pre-Treatment Integrase Inhibitor Resistance and Natural Polymorphisms among HIV-1 Subtype C Infected Patients in Ethiopia by Dawit Assefa Arimide, Zsófia Ilona Szojka, Kidist Zealiyas, Atsbeha Gebreegziabxier, Fekadu Adugna, Sviataslau Sasinovich, Per Björkman, Patrik Medstrand

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Insights into HIV-1 Transmission Dynamics Using Routinely Collected Data in the Mid-Atlantic United States by Seble G. Kassaye, Zehava Grossman, Priyanka Vengurlekar, William Chai, Megan Wallace, Soo-Yon Rhee, William A. Meyer, Harvey W. Kaufman, Amanda Castel, Jeanne Jordan, Keith A. Crandall, Alisa Kang, Princy Kumar, David A. Katzenstein, Robert W. Shafer, Frank Maldarelli

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Preexposure prophylaxis will have a limited impact on HIV-1 drug resistance in sub-Saharan Africa: a comparison of mathematical models by van de Vijver, DAMC, Nichols, BE, Abbas, UL, Boucher, CAB, Cambiano, V, Eaton, JW, Glaubius, R, Katrina Lythgoe, Mellors, J, Phillips, A, Sigaloff, KC, Hallett, TB

“…Preexposure prophylaxis (PrEP) with tenofovir and emtricitabine can prevent new HIV-1 infections, but there is a concern that use of PrEP could increase HIV drug resistance resulting in loss of treatment options. …”

A Review: Understanding Molecular Mechanisms of Antibody-Dependent Enhancement in Viral Infections by Jyoti Sawant, Ajit Patil, Swarali Kurle

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Exploring the Evolutionary History and Phylodynamics of Human Immunodeficiency Virus Type 1 Outbreak From Unnao, India Using Phylogenetic Approach by Ajit Patil, Sandip Patil, Amrita Rao, Sharda Gadhe, Swarali Kurle, Samiran Panda

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HIV-1 Drug Resistance Detected by Next-Generation Sequencing among ART-Naïve Individuals: A Systematic Review and Meta-Analysis by Fei Ouyang, Defu Yuan, Wenjing Zhai, Shanshan Liu, Ying Zhou, Haitao Yang

“…Background: There are an increasing number of articles focused on the prevalence and clinical impact of pretreatment HIV drug resistance (PDR) detected by Sanger sequencing (SGS). …”
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Dolutegravir for first-line antiretroviral therapy in low-income and middle-income countries: uncertainties and opportunities for implementation and research by Dorward, J, Lessells, R, Drain, P, Naidoo, K, De Oliveira, T, Pillay, Y, Abdool Karim, S, Garrett, N

“…Clinical trials, cohorts and surveillance of HIV drug resistance will be required to answer these questions and to maximise the benefits of this new regimen.…”

Point-of-care testing, new antiretroviral regimens and community-based treatment to enhance primary care HIV services in South Africa by Dorward, J

“…However, there are new challenges in a) providing HIV viral load testing to monitor the effectiveness of ART, b) combating HIV drug resistance, and c) efficiently providing treatment to the 39 million people living with HIV globally. …”

HIV-1 pretreatment drug resistance and genetic transmission network in the southwest border region of China by Difei Li, Huichao Chen, Huilan Li, Yanling Ma, Lijuan Dong, Jie Dai, Xiaomei Jin, Min Yang, Zhijun Zeng, Pengyan Sun, Zhizhong Song, Min Chen

“…Abstract Background HIV drug resistance increased with the widespread use of antiretroviral drugs, and posed great threat to antiretroviral therapy (ART). …”
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Different frequencies of drug resistance mutations among HIV-1 subtypes circulating in China: a comprehensive study. by Hongshuai Sui, Tao Gui, Lei Jia, Wei Guo, Jingwan Han, Yongjian Liu, Zuoyi Bao, Hanping Li, Jingyun Li, Lin Li

“…The rapid spreading of HIV drug resistance is threatening the overall success of free HAART in China. …”
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Quality Control of Next-Generation Sequencing-Based HIV-1 Drug Resistance Data in Clinical Laboratory Information Systems Framework by Rupert Capina, Katherine Li, Levon Kearney, Anne-Mieke Vandamme, P. Richard Harrigan, Kristel Van Laethem

“…Here, we focus in particular on the quality control measures applied on the final sequencing product aligned with the recommendations from the World Health Organization HIV Drug Resistance Laboratory Network.…”
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Analysis of prevalence of HIV-1 primary resistance to antiretroviral drugs in the territory of Moscow and Moscow region by M. N. Nosik, K. A. Ryzhov, A. V. Kravchenko, S. E. Sevostyanihin, U. A. Kuimova, А. B. Potapova, A. L. Sobkin

“…To analyze the level of HIV drug resistance among primary patients (who did not receive antiretroviral therapy (ART)) living in the Moscow region, where access to the antiretroviral therapy is quite high.Material and methods. …”
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Retrospective Study on Genetic Diversity and Drug Resistance among People Living with HIV at an AIDS Clinic in Beijing by Yan-Ze Shi, Hui-Huang Huang, Xin-Hua Wang, Bing Song, Tian-Jun Jiang, Min-Rui Yu, Ze-Rui Wang, Rui-Ting Li, Yan-Mei Jiao, Xin Su, Fu-Sheng Wang

“…Nested polymerase chain reaction (PCR) was utilized to amplify the pol gene from plasma RNA samples obtained from the participants. Genotypic and HIV drug resistance were determined using the Stanford University HIV Drug Resistance Database. …”
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Effect of misclassification of antiretroviral treatment status on the prevalence of transmitted HIV-1 drug resistance by Castro Hannah, Pillay Deenan, Sabin Caroline, Dunn David T

“…<p>Abstract</p> <p>Background</p> <p>Estimates of the prevalence of transmitted HIV drug resistance (TDR) in a population are derived from resistance tests performed on samples from patients thought to be naïve to antiretroviral treatment (ART). …”
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The incidence of multidrug and full class resistance in HIV-1 infected patients is decreasing over time (2001–2006) in Portugal by Peres Susana, Duque Luis, Debruyne Michiel, Theys Kristof, Deforche Koen, Vercauteren Jurgen, Carvalho Ana, Mansinho Kamal, Vandamme Anne-Mieke, Camacho Ricardo

“…This is most probably reflecting the changing drug prescription, the increasing efficiency of HAART and the improved management of HIV drug resistance. This work was presented in part at the Eighth International Congress on Drug Therapy in HIV Infection, Glasgow (UK), 12-16 November 2006 (PL5.5); and at the Fifth European HIV Drug Resistance Workshop, Cascais (Portugal), 28-30 March 2007 (Abstract 1).…”
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Longitudinal Trends in HIV-1 Subtypes and Drug Resistance in Children from Argentina over a 15-Year Period (2006-2021) by Natalia J. López, Solange Arazi-Caillaud, Rosa M. Bologna, Andrea M. Mangano, Cristina P. Aulicino

“…Background: Human immunodeficiency virus (HIV) drug resistance is a major cause of treatment failure in children and adolescents infected with the virus. …”
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Screening for and verification of novel mutations associated with drug resistance in the HIV type 1 subtype B(') in China. by Hanping Li, Qingmao Geng, Wei Guo, Daomin Zhuang, Lin Li, Yongjian Liu, Zuoyi Bao, Siyang Liu, Jingyun Li

“…OBJECTIVE: Mutations associated with HIV drug resistance have been extensively characterized at the HIV-1 polymerase domain, but more studies have verified that mutations outside of the polymerase domain also results in resistance to antiviral drugs. …”
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