Closing in on HIV drug resistance. by Larder, B, Stammers, D

HIV drug resistance: past and current trends by Ekaterina N. Ozhmegova, Marina R. Bobkova

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Recommendations on data sharing in HIV drug resistance research. by Seth C Inzaule, Mark J Siedner, Susan J Little, Santiago Avila-Rios, Alisen Ayitewala, Ronald J Bosch, Vincent Calvez, Francesca Ceccherini-Silberstein, Charlotte Charpentier, Diane Descamps, Susan H Eshleman, Joseph Fokam, Lisa M Frenkel, Ravindra K Gupta, John P A Ioannidis, Pontiano Kaleebu, Rami Kantor, Seble G Kassaye, Sergei L Kosakovsky Pond, Vinie Kouamou, Roger D Kouyos, Daniel R Kuritzkes, Richard Lessells, Anne-Genevieve Marcelin, Lawrence Mbuagbaw, Brian Minalga, Nicaise Ndembi, Richard A Neher, Roger Paredes, Deenan Pillay, Elliot G Raizes, Soo-Yon Rhee, Douglas D Richman, Kiat Ruxrungtham, Pardis C Sabeti, Jonathan M Schapiro, Sunee Sirivichayakul, Kim Steegen, Wataru Sugiura, Gert U van Zyl, Anne-Mieke Vandamme, Annemarie M J Wensing, Joel O Wertheim, Huldrych F Gunthard, Michael R Jordan, Robert W Shafer

“… • Human immunodeficiency virus (HIV) drug resistance has implications for antiretroviral treatment strategies and for containing the HIV pandemic because the development of HIV drug resistance leads to the requirement for antiretroviral drugs that may be less effective, less well-tolerated, and more expensive than those used in first-line regimens…”
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Transmitted and acquired HIV drug resistance in Viet Nam by Thao, V

Next-generation sequencing and HIV drug resistance surveillance by Hamers, R, Paredes, R

Overview of the Analytes Applied in Genotypic HIV Drug Resistance Testing by Hezhao Ji, Paul Sandstrom

“…The close monitoring of HIV drug resistance using genotypic HIV drug resistance testing (HIVDRT) has become essential for effective HIV/AIDS management at both individual and population levels. …”
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Epidemic Characteristics of HIV Drug Resistance in Hefei, Anhui Province by Shan Zheng, Jianjun Wu, Jingjing Hao, Dong Wang, Zhongwang Hu, Lei Liu, Chang Song, Jing Hu, Yanhua Lei, Hai Wang, Lingjie Liao, Yi Feng, Yiming Shao, Yuhua Ruan, Hui Xing

“…To study the characteristics of HIV pretreatment drug resistance (PDR) and acquired drug resistance (ADR) in Hefei, a cross-sectional survey was used to collect 816 samples from newly reported HIV infections from 2017 to 2020 and 127 samples from HIV infections with virological failure from 2018 to 2019 in Hefei. HIV drug resistance levels and drug resistance mutations were interpreted using the Stanford Drug Resistance Database. …”
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Strategies to overcome HIV drug resistance-current and future perspectives by Aura Temereanca, Aura Temereanca, Simona Ruta, Simona Ruta

“…According to the latest WHO HIV Drug Resistance Report, the prevalence of acquired and transmitted HIV drug resistance in ART naive individuals has exponentially increased in the recent years, being an important obstacle in ending HIV-1 epidemic as a public health threat by 2030. …”
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Extracting causal relations on HIV drug resistance from literature by Bui, Quoc-Chinh, Nuallain, Breanndan O., Boucher, Charles A. B., Sloot, Peter M. A.

“…Conclusions The proposed relation extraction and combination method has a good performance on extracting HIV drug resistance data. It can be used in large-scale relation extraction experiments. …”
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The effect of intrinsic stochasticity on transmitted HIV drug resistance patterns by Marks, A, Pillay, D, McLean, A

“…Estimates of transmitted HIV drug-resistance prevalence vary widely among and within epidemiological surveys. …”

HIV drug resistance in low-income and middle-income countries by Hamers, R, De Wit, T, Holmes, C

“…After 15 years of global scale-up of antiretroviral therapy (ART), rising prevalence of HIV drug resistance in many low-income and middle-income countries (LMICs) poses a growing threat to the HIV response, with the potential to drive an increase in mortality, HIV incidence, and costs. …”

The effect of intrinsic stochasticity on transmitted HIV drug resistance patterns. by Marks, A, Pillay, D, Mclean, A

“…Estimates of transmitted HIV drug-resistance prevalence vary widely among and within epidemiological surveys. …”

Point-of-Care Tests for HIV Drug Resistance Monitoring: Advances and Potentials by Rayeil J. Chua, Rupert Capiña, Hezhao Ji

“…Effective management of HIV drug resistance (HIVDR) supported by close resistance monitoring is essential in achieving the WHO 95-95-95 targets, aiming to end the AIDS epidemic by 2030. …”
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Is increasing pretreatment HIV drug resistance a real menace or minor detail? by Inzaule, SC, Hamers, RL, Bertagnolio, S

Current Research on HIV Drug Resistance—A Topical Collection with “<i>Pathogens</i>” by Hezhao Ji

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Next-Generation Sequencing for HIV Drug Resistance Testing: Laboratory, Clinical, and Implementation Considerations by Santiago Ávila-Ríos, Neil Parkin, Ronald Swanstrom, Roger Paredes, Robert Shafer, Hezhao Ji, Rami Kantor

Subjects: “…HIV drug resistance…”
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Are We Ready for NGS HIV Drug Resistance Testing? The Second “Winnipeg Consensus” Symposium by Hezhao Ji, Paul Sandstrom, Roger Paredes, P. Richard Harrigan, Chanson J. Brumme, Santiago Avila Rios, Marc Noguera-Julian, Neil Parkin, Rami Kantor

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Current ART, determinants for virologic failure and implications for HIV drug resistance: an umbrella review by SeyedAhmad SeyedAlinaghi, Amir Masoud Afsahi, Ali Moradi, Zohal Parmoon, Pedram Habibi, Pegah Mirzapour, Mohsen Dashti, Afsaneh Ghasemzadeh, Elaheh Karimi, Foziye Sanaati, Zahra Hamedi, Ayoob Molla, Esmaeil Mehraeen, Omid Dadras

“…The bulk of these studies concurred on several major factors contributing to HIV drug resistance and virological failure. Key among these were medication adherence, baseline and therapeutic CD4 levels, the presence of co-infections, and the advanced clinical stage of the infection. …”
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Affordable HIV drug-resistance testing for monitoring of antiretroviral therapy in sub-Saharan Africa. by Inzaule, S, Ondoa, P, Peter, T, Mugyenyi, P, Stevens, W, de Wit, T, Hamers, R

“…In this Personal View, we discuss the potential role of HIV drug resistance testing for population-based surveillance and individual patient management in sub-Saharan Africa. …”

The evolving landscape of HIV drug resistance diagnostics for expanding testing in resource-limited settings by Inzaule, S, Hamers, R, Paredes, R, Yang, C, Schuurman, R, Rinke de Wit, T

“…Affordable technologies to monitor ART are needed to ensure long-term durability of limited available drug regimens. HIV drug resistance tests can complement existing strategies in optimizing clinical decision-making for patients with treatment failure, in addition to facilitating population-based surveillance of HIV drug resistance. …”